Title:
THERAPEUTIC OR PROPHYLACTIC AGENT FOR PERIPHERAL NEUROPATHIES
Document Type and Number:
WIPO Patent Application WO/2018/181860
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a compound used for treatment or prevention of peripheral neuropathies. Provided is a therapeutic or prophylactic agent for peripheral neuropathies, the agent containing, as an active ingredient, a cyclic amine derivative represented by the chemical formula indicated herein or a pharmacologically acceptable salt thereof.
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Inventors:
HARA KOJIRO (JP)
SUZUKI TOMOHIKO (JP)
YOSHIDA CHIHIRO (JP)
TAKEO KOJI (JP)
SHIMODA KOJI (JP)
IZUMIMOTO NAOKI (JP)
NISHIMURA KAZUMI (JP)
NAGURO RIEKO (JP)
SUZUKI TOMOHIKO (JP)
YOSHIDA CHIHIRO (JP)
TAKEO KOJI (JP)
SHIMODA KOJI (JP)
IZUMIMOTO NAOKI (JP)
NISHIMURA KAZUMI (JP)
NAGURO RIEKO (JP)
Application Number:
PCT/JP2018/013536
Publication Date:
October 04, 2018
Filing Date:
March 30, 2018
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
International Classes:
A61K31/454; A61K31/4178; A61K31/496; A61P25/02; C07D401/06; C07D403/06
Domestic Patent References:
| WO2016136944A1 | 2016-09-01 | |||
| WO2016136944A1 | 2016-09-01 |
Foreign References:
| JP2017071329A | 2017-04-13 | |||
| JP2017071339A | 2017-04-13 |
Other References:
MASUDA RITSUKO: "Classification and diagnosis of neuropathic pain", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 247, no. 4, 2013, pages 317 - 321, XP009517013, ISSN: 0039-2359
SUMITANI MASAHIKO: "What is neuropathic pain? The definition and its clinical significiance", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 247, no. 4, 2013, pages 311 - 316, XP009517010, ISSN: 0039-2359
SHINDE ET AL., SUPPORT CARE CANCER, vol. 24, 2016, pages 547 - 553
VILHOLM ET AL., BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, vol. 115, 2014, pages 185 - 192
HERSHMAN ET AL., JOURNAL OF ONCOLOGY PRACTICE, vol. 10, 2014, pages e421 - e424
ATTAL ET AL., PAIN: CLINICAL UPDATES, vol. 18, 2010
ATTAL ET AL., EUROPEAN JOURNAL OF NEUROLOGY, vol. 17, 2010, pages l 113 - 1123
GEWANDTER ET AL., PAIN, vol. 158, 2017, pages 30 - 33
KUSUNOKI, CLINICAL NEUROLOGY, vol. 49, 2009, pages 956 - 958
HUGHES ET AL., THE LANCET, vol. 366, 2005, pages 1653 - 1666
KUSUNOKI, INTERNAL MEDICINE, THE JAPANESE SOCIETY OF INTERNAL MEDICINE, vol. 102, 2013, pages 1965 - 1970
RISON ET AL., BIOMED CENTRAL NEUROLOGY, vol. 16, no. 13, 2016
HUGHES ET AL., THE LANCET, vol. 349, 1997, pages 225 - 230
SINGH ET AL., PHARMACOLOGICAL RESEARCH, vol. 80, 2014, pages 21 - 35
SCHEMMEL ET AL., JOURNAL OF DIABETES AND ITS COMPLICATION, vol. 24, 2010, pages 354 - 360
SAPORTA ET AL., NEUROLOGIC CLINICS, vol. 31, 2013, pages 597 - 619
AZHARY ET AL., AMERICAN FAMILY PHYSICIAN, vol. 81, 2010, pages 887 - 892
MCMAHON ET AL., CURRENT OPINION IN NEUROBIOLOGY, vol. 5, 1995, pages 616 - 624
ARGYRIOU ET AL., CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY, vol. 82, 2012, pages 51 - 77
APFEL ET AL., JAMA, vol. 284, 2000, pages 2215 - 2221
"Development of pharmaceutical product", vol. 7, 1990, HIROKAWA-SHOTEN LTD., pages: 163 - 198
PROGRESS IN MEDICINE, vol. 5, 1985, pages 2157 - 2161
O'BRIEN ET AL., ILAR JOURNAL, vol. 54, 2014, pages 259 - 272
SOLIVEN, ILAR JOURNAL, vol. 54, 1994, pages 282 - 290
NICKS ET AL., NEUROBIOLOGY OF DISEASE, vol. 70, 2014, pages 224 - 236
CHAPLAN ET AL., JOURNAL OF NEUROSCIENCE METHODS, vol. 53, 1994, pages 55 - 63
See also references of EP 3603639A4
SUMITANI MASAHIKO: "What is neuropathic pain? The definition and its clinical significiance", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 247, no. 4, 2013, pages 311 - 316, XP009517010, ISSN: 0039-2359
SHINDE ET AL., SUPPORT CARE CANCER, vol. 24, 2016, pages 547 - 553
VILHOLM ET AL., BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, vol. 115, 2014, pages 185 - 192
HERSHMAN ET AL., JOURNAL OF ONCOLOGY PRACTICE, vol. 10, 2014, pages e421 - e424
ATTAL ET AL., PAIN: CLINICAL UPDATES, vol. 18, 2010
ATTAL ET AL., EUROPEAN JOURNAL OF NEUROLOGY, vol. 17, 2010, pages l 113 - 1123
GEWANDTER ET AL., PAIN, vol. 158, 2017, pages 30 - 33
KUSUNOKI, CLINICAL NEUROLOGY, vol. 49, 2009, pages 956 - 958
HUGHES ET AL., THE LANCET, vol. 366, 2005, pages 1653 - 1666
KUSUNOKI, INTERNAL MEDICINE, THE JAPANESE SOCIETY OF INTERNAL MEDICINE, vol. 102, 2013, pages 1965 - 1970
RISON ET AL., BIOMED CENTRAL NEUROLOGY, vol. 16, no. 13, 2016
HUGHES ET AL., THE LANCET, vol. 349, 1997, pages 225 - 230
SINGH ET AL., PHARMACOLOGICAL RESEARCH, vol. 80, 2014, pages 21 - 35
SCHEMMEL ET AL., JOURNAL OF DIABETES AND ITS COMPLICATION, vol. 24, 2010, pages 354 - 360
SAPORTA ET AL., NEUROLOGIC CLINICS, vol. 31, 2013, pages 597 - 619
AZHARY ET AL., AMERICAN FAMILY PHYSICIAN, vol. 81, 2010, pages 887 - 892
MCMAHON ET AL., CURRENT OPINION IN NEUROBIOLOGY, vol. 5, 1995, pages 616 - 624
ARGYRIOU ET AL., CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY, vol. 82, 2012, pages 51 - 77
APFEL ET AL., JAMA, vol. 284, 2000, pages 2215 - 2221
"Development of pharmaceutical product", vol. 7, 1990, HIROKAWA-SHOTEN LTD., pages: 163 - 198
PROGRESS IN MEDICINE, vol. 5, 1985, pages 2157 - 2161
O'BRIEN ET AL., ILAR JOURNAL, vol. 54, 2014, pages 259 - 272
SOLIVEN, ILAR JOURNAL, vol. 54, 1994, pages 282 - 290
NICKS ET AL., NEUROBIOLOGY OF DISEASE, vol. 70, 2014, pages 224 - 236
CHAPLAN ET AL., JOURNAL OF NEUROSCIENCE METHODS, vol. 53, 1994, pages 55 - 63
See also references of EP 3603639A4
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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