Title:
THERAPEUTIC AND PROPHYLACTIC USE OF MICROORGANISMS
Document Type and Number:
WIPO Patent Application WO/2020/135689
Kind Code:
A1
Abstract:
Certain microorganism species in the gut and feces of fecal microbiota transplantation (FMT) donors can affect the outcome of FMT treatment. Thus, novel methods are provided for identifying subjects as suitable donor to optimize FMT outcome and for pre-treating donors and/or receipients for optimized FMT outcome. Also provided are kits and compositions for improving FMT outcome, including for specific purposes such as for weight loss or cholesterol reduction.
More Like This:
Inventors:
NG SIEW CHIEN (CN)
CHAN KA LEUNG FRANCIS (CN)
CHAN KA LEUNG FRANCIS (CN)
Application Number:
PCT/CN2019/129092
Publication Date:
July 02, 2020
Filing Date:
December 27, 2019
Export Citation:
Assignee:
UNIV HONG KONG CHINESE (CN)
International Classes:
C12Q1/68
Foreign References:
| CN105853464A | 2016-08-17 |
Other References:
ANONYMOUS: "May Your Flora Flourish in My Inner Garden", 19 December 2015 (2015-12-19), pages 1 - 9, XP055714999, Retrieved from the Internet
TAO ZUO ET AL: "Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection", NATURE COMMUNICATIONS, vol. 9, 3663, 10 September 2018 (2018-09-10), pages 1 - 11, XP055714974, ISSN: 2041-1723, DOI: 10.1038/s41467-018-06103-6
TAO ZUO ET AL: "Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome", GUT MICROBIOTA, vol. 67, 15 May 2017 (2017-05-15), pages 634 - 643, XP055714979, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2017-313952
CHRISTEL CHEHOUD ET AL: "Transfer of Viral Communities between Human Individuals during Fecal Microbiota Transplantation", AMERICAN SOCIETY FOR MICROBIOLOGY, vol. 7, no. 2, 29 March 2016 (2016-03-29), pages 1 - 8, XP055659983, DOI: doi.org/10.1128/mBio.00322-16
SIEW C NG ET AL: "Scientific frontiers in faecal microbiota transplantation: joint document of Asia-Pacific Association of Gastroenterology (APAGE) and Asia-Pacific Society for Digestive Endoscopy (APSDE)", GUT MICROBIOTA, vol. 69, 14 October 2019 (2019-10-14), pages 83 - 91, XP055714992, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2019-319407
TAO ZUO ET AL: "Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection", NATURE COMMUNICATIONS, vol. 9, 3663, 10 September 2018 (2018-09-10), pages 1 - 11, XP055714974, ISSN: 2041-1723, DOI: 10.1038/s41467-018-06103-6
TAO ZUO ET AL: "Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome", GUT MICROBIOTA, vol. 67, 15 May 2017 (2017-05-15), pages 634 - 643, XP055714979, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2017-313952
CHRISTEL CHEHOUD ET AL: "Transfer of Viral Communities between Human Individuals during Fecal Microbiota Transplantation", AMERICAN SOCIETY FOR MICROBIOLOGY, vol. 7, no. 2, 29 March 2016 (2016-03-29), pages 1 - 8, XP055659983, DOI: doi.org/10.1128/mBio.00322-16
SIEW C NG ET AL: "Scientific frontiers in faecal microbiota transplantation: joint document of Asia-Pacific Association of Gastroenterology (APAGE) and Asia-Pacific Society for Digestive Endoscopy (APSDE)", GUT MICROBIOTA, vol. 69, 14 October 2019 (2019-10-14), pages 83 - 91, XP055714992, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2019-319407
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
Download PDF: