Title:
THERAPEUTIC USE OF BETA-LACTAMS IN HEMATOPOIESIS, IMMUNO-ONCOLOGY THERAPY, AND REGULATION OF LIPOPROTEIN AND APOLIPOPROTEIN LEVELS
Document Type and Number:
WIPO Patent Application WO/2018/136647
Kind Code:
A3
Abstract:
A method for increasing the number of CD4+ T-lymphocytes in the serum of a subject in need of such treatment comprising administering to the subject a pharmaceutical composition comprising an amount of an L-isomer of β-lactam effective to increase the number of CD4+ T-lymphocytes in said patient's serum.
Inventors:
BRISTOW CYNTHIA L (US)
WINSTON RONALD (US)
WINSTON RONALD (US)
Application Number:
PCT/US2018/014258
Publication Date:
October 11, 2018
Filing Date:
January 18, 2018
Export Citation:
Assignee:
ALPHA 1 BIOLOGICS LLC (US)
International Classes:
A61K31/407; A61K31/43; A61K31/431; A61K31/545; A61K31/546; A61K39/395; A61P3/06; A61P11/00; A61P31/00; A61P35/00; A61P37/04
Domestic Patent References:
| WO2013042122A1 | 2013-03-28 |
Foreign References:
| US5760027A | 1998-06-02 | |||
| US20100137194A1 | 2010-06-03 |
Other References:
L JAYASHANKAR ET AL: "Human Leukocyte Elastase Inhibitors: Analog Based Studies to Design Novel Lead Compounds for the Treatment of COPD", JOURNAL OF BIOMEDICAL SCIENCE AND RESEARCH VOL 2(1), 1 January 2010 (2010-01-01), England, pages 60 - 72, XP055483252, Retrieved from the Internet [retrieved on 20180612]
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2000, NOUR, A. M. ET AL: "Effect of Garamycin and Cefobid on liver function of hyperlipidemic rats", XP002782018, retrieved from STN Database accession no. 2001:556577
WANG B ET AL: "[Cefodizime increases peripheral blood CD4/CD8 and Th1/Th2 ratios in senile patients with bacterial pneumonia]. - PubMed - NCBI", 1 January 2015 (2015-01-01), XP055484053, Retrieved from the Internet [retrieved on 20180613]
CYNTHIA L. BRISTOW ET AL: "[alpha]1Proteinase Inhibitor Regulates CD4+ Lymphocyte Levels and Is Rate Limiting in HIV-1 Disease", PLOS ONE, vol. 7, no. 2, 17 February 2012 (2012-02-17), pages e31383, XP055484435, DOI: 10.1371/journal.pone.0031383
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2000, NOUR, A. M. ET AL: "Effect of Garamycin and Cefobid on liver function of hyperlipidemic rats", XP002782018, retrieved from STN Database accession no. 2001:556577
WANG B ET AL: "[Cefodizime increases peripheral blood CD4/CD8 and Th1/Th2 ratios in senile patients with bacterial pneumonia]. - PubMed - NCBI", 1 January 2015 (2015-01-01), XP055484053, Retrieved from the Internet
CYNTHIA L. BRISTOW ET AL: "[alpha]1Proteinase Inhibitor Regulates CD4+ Lymphocyte Levels and Is Rate Limiting in HIV-1 Disease", PLOS ONE, vol. 7, no. 2, 17 February 2012 (2012-02-17), pages e31383, XP055484435, DOI: 10.1371/journal.pone.0031383
Attorney, Agent or Firm:
FRANKFORT, Howard M. (US)
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