Title:
THERAPEUTIC USE OF EXOSOME CONTAINING SUPER-REPRESSOR- IκB(SRIκB) FOR LIVER DISEASE
Document Type and Number:
WIPO Patent Application WO/2023/244071
Kind Code:
A1
Abstract:
The present invention relates to the therapeutic use of exosome comprising super-repressor-IκB (srIκB) for liver disease. The present invention provides a pharmaceutical composition for preventing or treating liver disease, comprising an exosome containing super-repressor-IκB (srIκB) as an active ingredient, wherein the liver disease is liver fibrosis, liver cirrhosis, fatty liver, alcoholic liver disease, cholestasis, or a combination thereof.
Inventors:
CHOI CHULHEE (KR)
YOO JAEKWANG (KR)
OH BYUNG-KOO (KR)
YOO JAEKWANG (KR)
OH BYUNG-KOO (KR)
Application Number:
PCT/KR2023/008367
Publication Date:
December 21, 2023
Filing Date:
June 16, 2023
Export Citation:
Assignee:
ILIAS BIOLOGICS INC (KR)
International Classes:
A61K38/00; A61K9/50; A61K38/17; A61P1/16; C07K14/47
Foreign References:
| KR20180036134A | 2018-04-09 |
Other References:
NANJI AMIN A., JOKELAINEN KALLE, TIPOE GEORGE L., RAHEMTULLA AMIR, THOMAS PETER, DANNENBERG ANDREW J.: "Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-κB-dependent genes", AMERICAN JOURNAL OF PHYSIOLOGY - GASTROINTESTINAL AND LIVER PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, US, vol. 284, no. 2, 1 February 2003 (2003-02-01), US , pages G321 - G327, XP093117650, ISSN: 0193-1857, DOI: 10.1152/ajpgi.00230.2002
SONG YONGHEE, KIM YOUNGEUN, HA SUNHYUNG, SHELLER‐MILLER SAMANTHA, YOO JAEKWANG, CHOI CHULHEE, PARK CHEOL HYOUNG: "The emerging role of exosomes as novel therapeutics: Biology, technologies, clinical applications, and the next", AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 85, no. 2, 1 February 2021 (2021-02-01), US , XP093117653, ISSN: 1046-7408, DOI: 10.1111/aji.13329
CHOI HOJUN, KIM YOUNGEUN, MIRZAAGHASI AMIN, HEO JAENYOUNG, KIM YU NA, SHIN JU HYE, KIM SEONGHUN, KIM NAM HEE, CHO EUNAE SANDRA, YO: "Exosome-based delivery of super-repressor IκBα relieves sepsis-associated organ damage and mortality", SCIENCE ADVANCES, vol. 6, no. 15, 8 April 2020 (2020-04-08), XP055854716, DOI: 10.1126/sciadv.aaz6980
KIM HEE-HOON, SHIM YOUNG-RI, CHOI SUNG EUN, FALANA TOLULOPE ESTHER, YOO JAE-KWANG, AHN SO-HEE, PARK MINHYE, SEO HYANGMI, CHOI CHUL: "Exosome-Based Delivery of Super-Repressor IκBα Alleviates Alcohol-Associated Liver Injury in Mice", PHARMACEUTICS, MDPI AG, CH, vol. 15, no. 2, 14 February 2023 (2023-02-14), CH , pages 636, XP093117655, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics15020636
SONG YONGHEE, KIM YOUNGEUN, HA SUNHYUNG, SHELLER‐MILLER SAMANTHA, YOO JAEKWANG, CHOI CHULHEE, PARK CHEOL HYOUNG: "The emerging role of exosomes as novel therapeutics: Biology, technologies, clinical applications, and the next", AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 85, no. 2, 1 February 2021 (2021-02-01), US , XP093117653, ISSN: 1046-7408, DOI: 10.1111/aji.13329
CHOI HOJUN, KIM YOUNGEUN, MIRZAAGHASI AMIN, HEO JAENYOUNG, KIM YU NA, SHIN JU HYE, KIM SEONGHUN, KIM NAM HEE, CHO EUNAE SANDRA, YO: "Exosome-based delivery of super-repressor IκBα relieves sepsis-associated organ damage and mortality", SCIENCE ADVANCES, vol. 6, no. 15, 8 April 2020 (2020-04-08), XP055854716, DOI: 10.1126/sciadv.aaz6980
KIM HEE-HOON, SHIM YOUNG-RI, CHOI SUNG EUN, FALANA TOLULOPE ESTHER, YOO JAE-KWANG, AHN SO-HEE, PARK MINHYE, SEO HYANGMI, CHOI CHUL: "Exosome-Based Delivery of Super-Repressor IκBα Alleviates Alcohol-Associated Liver Injury in Mice", PHARMACEUTICS, MDPI AG, CH, vol. 15, no. 2, 14 February 2023 (2023-02-14), CH , pages 636, XP093117655, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics15020636
Attorney, Agent or Firm:
HANOL INTELLECTUAL PROPERTY & LAW (KR)
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