Title:
THERAPEUTICALLY EFFECTIVE COMBINATION OF A FLT3 INHIBITOR AND A BCL-2 INHIBITOR FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA
Document Type and Number:
WIPO Patent Application WO/2023/068858
Kind Code:
A1
Abstract:
This invention relates to pharmaceutical compositions, pharmaceutical combinations and methods for the treatment of acute myeloid leukemia by combined use of a therapeutically effective combination of a compound of Chemical Formula 1, or a pharmaceutically acceptable salt thereof, solvate thereof, stereoisomer thereof, tautomer thereof, or combination thereof, wherein Ea, Eb, Ec, Ed, Z', X', Q, and k are defined herein; and a Bcl-2 inhibitor, or a Bcl-2 inhibitor and a hypomethylating agent.
Inventors:
KIM JI SOOK (KR)
CHOI JAE YUL (KR)
AHN YOUNG GIL (KR)
CHOI JAE YUL (KR)
AHN YOUNG GIL (KR)
Application Number:
PCT/KR2022/016095
Publication Date:
April 27, 2023
Filing Date:
October 20, 2022
Export Citation:
Assignee:
HANMI PHARM IND CO LTD (KR)
International Classes:
A61K31/506; A61K31/496; A61K31/635; A61K31/704; A61K31/706; A61K45/06; A61P35/02
Domestic Patent References:
| WO2020022600A1 | 2020-01-30 |
Foreign References:
| CN113166110A | 2021-07-23 | |||
| KR20200016567A | 2020-02-17 |
Other References:
ZHU RUIQI, LI LI, NGUYEN BAO, SEO JAESUNG, WU MIN, SEALE TESSA, LEVIS MARK, DUFFIELD AMY, HU YU, SMALL DONALD: "FLT3 tyrosine kinase inhibitors synergize with BCL-2 inhibition to eliminate FLT3/ITD acute leukemia cells through BIM activation", SIGNAL TRANSDUCTION AND TARGETED THERAPY, vol. 6, no. 1, 1 January 2021 (2021-01-01), pages 1 - 11, XP093059092, DOI: 10.1038/s41392-021-00578-4
BRINTON LINDSEY T., ZHANG PU, WILLIAMS KATIE, CANFIELD DANIEL, ORWICK SHELLEY, SHER STEVEN, WASMUTH RONNI, BEAVER LARRY, CEMPRE CA: "Synergistic effect of BCL2 and FLT3 co-inhibition in acute myeloid leukemia", JOURNAL OF HEMATOLOGY & ONCOLOGY, vol. 13, no. 1, 1 December 2020 (2020-12-01), XP093059096, DOI: 10.1186/s13045-020-00973-4
BRINTON LINDSEY T., ZHANG PU, WILLIAMS KATIE, CANFIELD DANIEL, ORWICK SHELLEY, SHER STEVEN, WASMUTH RONNI, BEAVER LARRY, CEMPRE CA: "Synergistic effect of BCL2 and FLT3 co-inhibition in acute myeloid leukemia", JOURNAL OF HEMATOLOGY & ONCOLOGY, vol. 13, no. 1, 1 December 2020 (2020-12-01), XP093059096, DOI: 10.1186/s13045-020-00973-4
Attorney, Agent or Firm:
KIM, Tae-hun (KR)
Download PDF: