Title:
THERAPEUTICALLY USEFUL CURE-PRO MOLECULES FOR E3 LIGASE MEDIATED DEGRADATION OF PROTEINS, AND METHODS OF MAKING AND USING THEM
Document Type and Number:
WIPO Patent Application WO/2022/031777
Kind Code:
A3
Abstract:
The present application is directed to a therapeutically useful monomer comprising a linker element and an E3 ubiquitin ligase binding moiety. The linker and the E3 ubiquitin ligase binding moiety are covalently coupled to each other either directly or through an optional connector moiety.
Inventors:
BARANY FRANCIS (US)
GIARDINA SARAH (US)
BACOLOD MANNY (US)
SINGH PRADEEP (US)
WARREN J (US)
GIARDINA SARAH (US)
BACOLOD MANNY (US)
SINGH PRADEEP (US)
WARREN J (US)
Application Number:
PCT/US2021/044441
Publication Date:
March 17, 2022
Filing Date:
August 04, 2021
Export Citation:
Assignee:
UNIV CORNELL (US)
International Classes:
C07D401/14; A61K31/4439; C07D401/04
Domestic Patent References:
| WO2019148055A1 | 2019-08-01 |
Foreign References:
| US20180179183A1 | 2018-06-28 | |||
| US20190076540A1 | 2019-03-14 | |||
| US20140194383A1 | 2014-07-10 |
Other References:
CHIARA MANIACI, SCOTT J. HUGHES, ANDREA TESTA, WENZHANG CHEN, DOUGLAS J. LAMONT, SONIA ROCHA, DARIO R. ALESSI, ROBERTO ROMEO, ALES: "Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation", NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, UK, vol. 8, no. 1, 10 December 2017 (2017-12-10), UK, XP055476041, ISSN: 2041-1723, DOI: 10.1038/s41467-017-00954-1
Attorney, Agent or Firm:
GOLDMAN, Michael L. et al. (US)
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