Title:
THERAPUTIC METHODS AND USES OF SAPOGENINS AND THEIR DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2003082893
Kind Code:
A3
Abstract:
The invention discloses therapeutic methods and uses of certain steroidal sapogenins, related compounds and derivatives thereof, in the treatment of non-cognitive neurodegeneration, non-cognitive neuromuscular degeneration, motor-sensory neurodegeneration or receptor dysfunction or loss in the absence of cognitive, neural and neuromuscular impairment.
Inventors:
REES DARYL (GB)
GUNNING PHIL (GB)
ORSI ANTONIA (GB)
XIA ZONGQIN (CN)
HU YAER (CN)
GUNNING PHIL (GB)
ORSI ANTONIA (GB)
XIA ZONGQIN (CN)
HU YAER (CN)
Application Number:
PCT/GB2003/001380
Publication Date:
April 15, 2004
Filing Date:
March 27, 2003
Export Citation:
Assignee:
PHYTOPHARM PLC (GB)
REES DARYL (GB)
GUNNING PHIL (GB)
ORSI ANTONIA (GB)
XIA ZONGQIN (CN)
HU YAER (CN)
REES DARYL (GB)
GUNNING PHIL (GB)
ORSI ANTONIA (GB)
XIA ZONGQIN (CN)
HU YAER (CN)
International Classes:
A61K31/58; A61K31/585; A61K31/655; A61P9/02; A61P9/04; A61P11/06; A61P21/00; A61P21/04; A61P25/08; A61P25/16; A61P25/28; A61P27/00; C07J71/00; C07J; (IPC1-7): A61K31/585; A61P9/02; A61P9/04; A61P11/06; A61P21/00; A61P21/04; A61P25/08; A61P25/16; A61P25/28; A61P27/00
Domestic Patent References:
| WO2001049703A2 | 2001-07-12 | |||
| WO1999048507A2 | 1999-09-30 | |||
| WO2001023406A1 | 2001-04-05 | |||
| WO2001023408A1 | 2001-04-05 | |||
| WO2001023407A1 | 2001-04-05 | |||
| WO1998002450A2 | 1998-01-22 | |||
| WO2003077869A2 | 2003-09-25 |
Foreign References:
| EP1024146A1 | 2000-08-02 | |||
| DE4303214A1 | 1994-08-11 | |||
| US4680289A | 1987-07-14 | |||
| EP0659762A2 | 1995-06-28 | |||
| EP0162330A1 | 1985-11-27 |
Other References:
SUN, HUI ET AL: "Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease", JOURNAL OF BIOLOGICAL CHEMISTRY (1999), 274(12), 8269-8281, XP001165795
DATABASE WPI Section Ch Week 199343, Derwent World Patents Index; Class B04, AN 1993-339641, XP002157713
PATENT ABSTRACTS OF JAPAN vol. 2002, no. 05 3 May 2002 (2002-05-03)
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 05 30 May 1997 (1997-05-30)
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 05 30 May 1997 (1997-05-30)
INOUE K ET AL: "Cholestanol induces apoptosis of cerebellar neuronal cells.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. UNITED STATES 5 MAR 1999, vol. 256, no. 1, 5 March 1999 (1999-03-05), pages 198 - 203, XP001188107, ISSN: 0006-291X
KYOUNG SOOK KIM, ET AL.: "Effects of cholestanol feeding on corneal dystrophy in mice.", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1085, 1991, pages 343 - 349, XP008027217
DATABASE WPI Section Ch Week 199343, Derwent World Patents Index; Class B04, AN 1993-339641, XP002157713
PATENT ABSTRACTS OF JAPAN vol. 2002, no. 05 3 May 2002 (2002-05-03)
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 05 30 May 1997 (1997-05-30)
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 05 30 May 1997 (1997-05-30)
INOUE K ET AL: "Cholestanol induces apoptosis of cerebellar neuronal cells.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. UNITED STATES 5 MAR 1999, vol. 256, no. 1, 5 March 1999 (1999-03-05), pages 198 - 203, XP001188107, ISSN: 0006-291X
KYOUNG SOOK KIM, ET AL.: "Effects of cholestanol feeding on corneal dystrophy in mice.", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1085, 1991, pages 343 - 349, XP008027217
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