Therapy by Trans-Splicing of OPA1 Pre-messenger RNAs for the Treatment of Diseases Associated with OPA1 Gene Mutations Related Application The present application claims priority to European Patent Application No. EP 22199015 filed on September 30, 2023, which is incorporated herein by reference in its entirety. Background of the Invention Hereditary Optic Neuropathies (HONs) are a genetically diverse group of disorders mainly characterized by visual loss and optic atrophy. Several genetic defects altering primary mitochondrial functions have been proposed to contribute to the development of syndromic and non-syndromic optic neuropathies. A subset of HONs, including Autosomal Dominant Optic Atrophy (ADOA), Autosomal Dominant Optic Atrophy plus (ADOA+ or ADOAplus) and Behr’s Syndrome, is caused by mutations in the OPA1 gene. HONs collectively affect nearly 400,000 people worldwide, with 37,000 in Europe and 3,000 in France (Lenaers et al., Progress in Retinal and Eye Research, 2021, 83: 100935; Kjer et al., Acta Ophthalmol Scand., 1996, 74(1): 3-7). ADOA is believed to be the most common HON with a disease prevalence in the range of 1:10,000 to 1:50,000 (Kjer et al., Acta Ophthalmol. Scand., 1996, 4(1): 3-7). ADOA is characterized by bilateral loss of vision in the central visual field and impaired color perception due to progressive degeneration of the retinal ganglion cells (RGCs) and their axons forming the optic nerve. Because of this degeneration, visual information is no longer transmitted to the higher visual areas of the brain. ADOA onset generally occurs in the first decade of life, and is usually diagnosed before adulthood, but signs have been reported as early as 1 year of age. It is primarily a pediatric disease and those affected will typically show signs of nerve deterioration slowing by the age of 15. ADOA+ is a syndromic ADOA and accounts for approximately 20% of all ADOA cases. Symptoms of ADOA+ presentation typically start to occur within the first decade of life and are characterized by bilateral and symmetric progressive visual loss. Sensorineural deafness along with other extra-ocular manifestations may appear, such as chronic progressive external ophthalmoplegia, proximal myopathy, ataxia and axonal sensory motor polyneuropathy, beginning in the second and third decades of life. Behr’s syndrome, related to bi-allelic OPA1 variants, is characterized by the association of early onset optic atrophy with spinocerebellar degeneration resulting in ataxia, pyramidal signs, peripheral neuropathy and developmental delay. There is currently no established medical treatment for OPA1-related inherited optic neuropathies. Coenzyme Q-10 (CoQ), Idebenone, and nutritional supplements, such as vitamin B12, vitamin C and lutein, have been suggested to reduce reactive oxygen species-induced stress in the optic nerve (Carelli et al., Curr. Opin. Neurol., 2013, 26(1): 52-58). Topical agents deemed to be neuroprotective or antiapoptotic, such as brimonidine, have also been recommended, although evidence of their efficacy remains anecdotal (Carelli et al., Curr. Opin. Neurol., 2013, 26(1): 52-58). Glasses or contact lenses, which may correct coexisting farsightedness, nearsightedness and astigmatism, will not repair or correct the vision loss caused by ADOA. ADOA patients may find improvement in visual functioning with low-vision aids (e.g., magnifiers, large-print devices, talking watches, tinted lenses, electronic magnifiers, or other adaptive devices). AODA, AODA+ and Behr’s Syndrome are commonly associated with mutations in the nuclear OPA1 gene. OPA1 encodes a mitochondrial dynamin-related GTPase that is involved in mitochondrial membrane dynamics and structural organization (Newman et al., Am. J. Ophthal. 2005, 140(3): 517-523; Kline et al., Arch. Ophthalmol., 1979, 97(9): 245-251; Delettre et al., Mol. Genet. Metab., 2002, 75(2): 97-107). Abnormal mitochondrial metabolism and impaired oxidative phosphorylation lead to increases in reactive oxygen species levels and retinal ganglion cells (RGCs) apoptosis (Chun et al., Semin. Pediatr. Neurol., 2017, 24(2): 129-134; Chun et al., Curr. Opin. Ophthalmol. 2016, 27(6): 475-480). RGCs degeneration, predominantly in the papillomacular bundle, has been suggested as underlying the visual defect (Delettre et al., Mol. Genet. Metab., 2002, 75(2):97-107). The discovery of OPA1 mutations as causative for ADOA was pivotal to deepen the understanding of its pathogenesis, to possibly establish effective therapies, in particular strategies based on gene therapy approaches. Thus, adeno-associated virus (AAV) delivered OPA1 isoform 1 showed significant protection of RGCs in a heterozygous mouse model of pathogenic OPA1 mutation (Opa1 ^delTTAG/+ ) but did not result in a significant increase in visual acuity (Sarzi et al., Sci Rep., 2018, 8: 2468). Overexpression of OPA1 isoform 1 or 7 was found to correct mitochondrial dysfunctions and partially restore visual perception and integration (Maloney et al., Front. Neurosci., 2020, 14: 571479). However, this study also confirmed that overexpression of OPA1 isoforms is more deleterious than the pathological condition because it induces an alteration of the mitochondrial network. It has been reported (Amati-Bonneau et al., Brain, 2008, 131: 338-351; Hudson et al., Brain 2008, 131: 329-337) that OPA1 mutations can also be associated with other neuropathies such as for example sensorineural hearing loss or sensorimotor neuropathy, or with ataxia, progressive external ophthalmoplegia and mitochondrial myopathy. Although new therapeutic approaches are being developed and tested, no disease- modifying treatments of hereditary diseases, especially neuropathies, in particular optic neuropathies associated with mutations in the OPA1 gene are yet available. Therefore, there is still a need in the art for novel strategies, in particular strategies allowing a fine regulation of the expression of all the eight OPA1 protein isoforms, which is essential to obtain a therapeutic benefit. Summary of the Invention The present invention consists in the creation of a versatile gene therapy approach using Spliceosome-Mediated RNA Trans-splicing (SMaRT ^TM ) for the treatment of diseases associated with mutations of the OPA1 gene. In particular, the present Inventors have identified specific target intronic and exonic sequences on the mutated endogenous OPA1 pre-messenger RNA (pre-mRNA), which are located downstream of the alternatively spliced exons and upstream of the main exons carrying mutations. Therapeutic molecules, such as pre-mRNA trans-splicing molecules (RTMs or PTMs), have been designed based on the specific target intronic sequences, that function to compensate the defective OPA1 gene by trans-splicing of the OPA1 pre-mRNAs, in order to eliminate the mutations of the mature RNAs of OPA1. The present invention allows to maintain the endogenous regulation of gene expression as well as the respective abundance of the eight isoforms of OPA1. It makes possible the correction of transcripts resulting from dominant negative and haploinsufficient alleles. A pre- mRNA trans-splicing molecule according to the invention can correct nearly 90% of all known pathogenic mutations within the human OPA1 gene. In addition, a pre-mRNA trans-splicing molecule may be used to treat not only non-syndromic patients suffering from blindness but also syndromic patients who also experience sensorineural deafness and polyneuropathy. Indeed, only the vectorization of the pre-mRNA trans-splicing molecule needs to be adapted to the transduction of the target cells (either retinal ganglion cells or cells of the auditory nerve or cells of the Central Nervous System (CNS) or Peripheral Nervous System (PNS)), the pre-mRNA trans-splicing molecule remains unchanged. Consequently, the present invention provides a nucleic acid OPA1 pre-mRNA trans-splicing molecule comprising operatively linked in a 5’-to-3’ direction or a 3’-to- 5’ direction: (a) a binding domain configured to bind to an OPA1 target sequence comprising an intron, an intron/exon junction or an exon; (b) a splicing domain configured to mediate trans-splicing; and (c) a coding domain comprising at least one functional OPA1 exon, wherein the nucleic acid OPA1 pre-mRNA trans-splicing molecule is configured to trans-splice the endogenous mutated OPA1 pre-mRNA adjacent to the OPA1 target sequence, thereby replacing the endogenous mutated OPA1 exon with the functional OPA1 exon and correcting a mutation in OPA1 transcripts. In certain embodiments, the OPA1 target sequence comprising an intron, an intron/exon junction or an exon is Homo sapiens OPA1 intron 8-9/Exon 9. In certain embodiments, the OPA1 target sequence comprising an intron, an intron/exon junction or an exon is Homo sapiens OPA1 intron 8-9/Exon 9 consisting of SEQ ID NO: 1. In certain embodiments, the binding domain binds to the OPA1 target sequence at a binding site within or encompassing nucleotides 1 to 52 of SEQ ID NO: 1, or a binding site within or encompassing nucleotides 1 to 50 of SEQ ID NO: 1, or at a binding site within or encompassing nucleotides 261 to 315 of SEQ ID NO: 1, or at a binding site within or encompassing nucleotides 361 to 603 of SEQ ID NO: 1, or at a binding site within or encompassing nucleotides 361 to 460 of SEQ ID NO: 1, or at a binding site within or encompassing nucleotides 375 to 460 of SEQ ID NO: 1; or nucleotides 461 to 603 of SEQ ID NO: 1, or at a binding site within or encompassing nucleotides 510 to 784 of SEQ ID NO: 1, or at a binding site within or encompassing nucleotides 510 to 756 of SEQ ID NO 1, or at a binding site within or encompassing nucleotides 510 to 726 of SEQ ID NO 1, or at a binding site within or encompassing nucleotides 518 to 784 of SEQ ID NO 1, or at a binding site within or encompassing nucleotides 518 to 756 of SEQ ID NO 1, or at a binding site within or encompassing nucleotides 518 to 726 of SEQ ID NO 1, or at a binding site within or encompassing nucleotides 561 to 784 of SEQ ID NO 1, or at a binding site within or encompassing nucleotides 561 to 756 of SEQ ID NO 1, or at a binding site within or encompassing nucleotides 561 to 726 of SEQ ID NO 1, or at a binding site within or encompassing nucleotides 627 to 784 of SEQ ID NO 1, or at a binding site within or encompassing nucleotides 627 to 756 of SEQ ID NO 1, or at a binding site within or encompassing nucleotides 627 to 726 of SEQ ID NO 1, or at a combination of said binding sites. In certain embodiments, the binding domain is complementary to six or more consecutive nucleotides of a binding site within or encompassing nucleotides 1 to 52 of SEQ ID NO: 1, or nucleotides 1 to 50 of SEQ ID NO: 1, or nucleotides 261 to 315 of SEQ ID NO: 1, or nucleotides 361 to 603 of SEQ ID NO: 1, or nucleotides 361 to 460 of SEQ ID NO: 1, or nucleotides 375 to 460 of SEQ ID NO: 1; or nucleotides 461 to 603 of SEQ ID NO: 1, or nucleotides 510 to 784 of SEQ ID NO: 1, or nucleotides 510 to 756 of SEQ ID NO 1, or nucleotides 510 to 726 of SEQ ID NO 1, or nucleotides 518 to 784 of SEQ ID NO 1, or nucleotides 518 to 756 of SEQ ID NO 1, or nucleotides 518 to 726 of SEQ ID NO 1, or nucleotides 561 to 784 of SEQ ID NO 1, or nucleotides 561 to 756 of SEQ ID NO 1, or nucleotides 561 to 726 of SEQ ID NO 1, or nucleotides 627 to 784 of SEQ ID NO 1, or nucleotides 627 to 756 of SEQ ID NO 1, or nucleotides 627 to 726 of SEQ ID NO 1, or at a combination of said binding sites. In certain embodiments, the binding domain comprises, or consists of SEQ ID NO: 2 (BD#114) or is a fragment thereof; or the binding domain comprises, or consists of, SEQ ID NO: 3 (BD#128) or is a fragment thereof; or the binding domain comprises, or consists of, SEQ ID NO: 4 (BD#162) or is a fragment thereof; or the binding domain comprises, or consists of, SEQ ID NO: 5 (BD#135) or is a fragment thereof; or the binding domain comprises, or consists of, SEQ ID NO: 6 (BD#106) or is a fragment thereof; or the binding domain comprises, or consists of, SEQ ID NO: 7 (BD #100) or is a fragment thereof; or the binding domain comprises, or consists of, SEQ ID NO: 8 (BD #130) or is a fragment thereof; or the binding domain comprises, or consists of, SEQ ID NO: 9 (BD #158) or is a fragment thereof; or the binding domain comprises, or consists of, SEQ ID NO: 10 (BD #166) or is a fragment thereof; or the binding domain comprises, or consists of, SEQ ID NO: 11 (BD #196) or is a fragment thereof; or the binding domain comprises, or consists of, SEQ ID NO: 12 (BD #224) or is a fragment thereof; or the binding domain comprises, or consists of, SEQ ID NO: 13 (BD #209) or is a fragment thereof; or the binding domain comprises, or consists of, SEQ ID NO: 14 (BD #239) or is a fragment thereof; or the binding domain comprises, or consists of, SEQ ID NO: 15 (BD #267) or is a fragment thereof; or the binding domain comprises, or consists of, SEQ ID NO: 16 (BD #217) or is a fragment thereof; or the binding domain comprises, or consists of, SEQ ID NO: 17 (BD #247) or is a fragment thereof; or the binding domain comprises, or consists of, SEQ ID NO: 18 (BD #275) or is a fragment thereof; or the binding domain is a combination of said binding domains. In certain embodiments, the mutation is in any one of OPA1 exons 9 to 31. In certain embodiments, the mutation is associated with a hereditary optic neuropathy, in particular Autosomal Dominant Optic Atrophy (ADOA), Autosomal Dominant Optic Atrophy Plus (ADOA+) and Behr’s Syndrome, or an extra-ophthalmic disease, in particular sensorineural deafness, peripheral neuropathies, Parkinson syndrome, mitochondrial myopathy, and heart disease. In certain embodiments, the mutation is associated with a hereditary optic neuropathy selected from Autosomal Dominant Optic Atrophy (ADOA), Autosomal Dominant Optic Atrophy Plus (ADOA+) and Behr’s Syndrome. In certain embodiments, the mutation is associated with the optic neuropathy: susceptibility to normal tension glaucoma. In certain embodiments, the mutation is associated with an extra-ophthalmic disease selected from sensorineural deafness, peripheral neuropathies, Parkinson syndrome and mitochondrial myopathy. In certain embodiments, the mitochondrial myopathy is mitochondrial depletion syndrome 14. In certain embodiments, the coding domain comprises functional OPA1 exons 9 to 31. In certain embodiments, the nucleic acid OPA1 pre-mRNA trans-splicing molecule consists of SEQ ID NO: 27 (OPA1 RTMth#114), or SEQ ID NO: 28 (OPA1 RTMth#128), or SEQ ID NO: 30 (OPA1 RTMth#162), or SEQ ID NO: 29 (OPA1 RTMth#135) or SEQ ID NO: 26 (OPA1 RTMth#106), or SEQ ID NO: 31 (OPA1 RTM _th #100), or SEQ ID NO: 32 (OPA1 RTM _th #130), or SEQ ID NO: 33 (OPA1 RTM _th #158), or SEQ ID NO: 34 (OPA1 RTM _th #166),or SEQ ID NO: 35 (OPA1 RTMth#196), or SEQ ID NO: 36 (OPA1 RTMth#224), or SEQ ID NO: 37 (OPA1 RTMth#209), or SEQ ID NO: 38 (OPA1 RTMth#239), or SEQ ID NO: 39 (OPA1 RTM _th #267), or SEQ ID NO: 40 (OPA1 RTM _th #217), or SEQ ID NO: 41 (OPA1 RTMth#247), or SEQ ID NO: 42 (OPA1 RTMth#275). The present invention further provides a cloning vector recombinant adeno- associated virus comprising a nucleic acid OPA1 trans-splicing molecule as described above. In certain embodiments, the cloning vector is selected from plasmids, minicircles, cosmids, YAC vectors, BAC vectors, and viral vectors. The viral vector may be an Adeno-Associated Virus (AAV), in particular a recombinant Adeno-Associated Virus (rAAV), a single-stranded Adeno-Associated Virus (ssAAV) or a self-complementary Adeno-Associated Virus (scAAV). In certain embodiments, the recombinant adeno-associated virus targets retinal ganglion cells, photoreceptor cells, amacrine cells, horizontal cells, bipolar cells, or cells of the auditory nerve. The present invention further provides a cell comprising a nucleic acid OPA1 trans-splicing molecule as described above or a cloning vector as described above. The present invention also provides a pharmaceutical composition comprising a nucleic acid OPA1 trans-splicing molecule as described above, or a cloning vector as described above, or a cell as described above, and at least one pharmaceutically acceptable carrier or excipient. The present invention further provides a nucleic acid OPA1 trans-splicing molecule as described above, or a cloning vector as described above, or a cell as described above, or a pharmaceutical composition as described above, for use in the treatment or prevention of a disease or disorder associated with a OPA1 gene mutation in subject. In certain embodiments, the disease or disorder associated with a OPA1 gene mutation is a hereditary optic neuropathy, in particular Autosomal Dominant Optic Atrophy (ADOA), Autosomal Dominant Optic Atrophy Plus (ADOA+) and Behr’s Syndrome, or an extra-ophthalmic disease, in particular sensorineural deafness, peripheral neuropathies, Parkinson syndrome, mitochondrial myopathy, and heart disease. In certain embodiments, the disease or disorder associated with a OPA1 gene mutation is a hereditary optic neuropathy selected from Autosomal Dominant Optic Atrophy (ADOA), Autosomal Dominant Optic Atrophy Plus (ADOA+) and Behr’s Syndrome. In certain embodiments, the disease or disorder associated with OPA1 gene mutation is the optic neuropathy: susceptibility to normal tension glaucoma. In certain embodiments, the disease or disorder associated with a OPA1 gene mutation is an extra-ophthalmic disease selected from sensorineural deafness, peripheral neuropathies, Parkinson syndrome and mitochondrial myopathy. In certain embodiments, the mitochondrial myopathy is mitochondrial depletion syndrome 14. These and other objects, advantages and features of the present invention will become apparent to those of ordinary skill in the art having read the following detailed description of the preferred embodiments. Brief Description of the Drawing Figure 1. Schematization of endogenous OPA1 pre-mRNA cis-splicing regulation and OPA1 pre-mRNA trans-splicing therapeutic approach. In the pathogenic context, alternate splicing of endogenous OPA1 pre-mRNA generates eight pathogenic OPA1 transcripts leading to ADOA/ADOA+/Behr syndrome either by haploinsufficiency or negative dominance of OPA1 protein isoforms. In the therapeutic context, the OPA1 trans-splicing approach allows the correction of the eight pathogenic OPA1 transcripts by OPA1-specific pre-mRNA trans-splicing molecule (OPA1-RTM or OPA1-PTM) containing antisense and complementary OPA1 binding domain, intronic splicing enhancer and corrective exons. The trans-splicing reaction, mediated by the endogenous spliceosome ribonucleoprotein complex, leads to the pathogenic exons replacement by the exogenous corrective exons, generating eight trans-spliced (chimeric) mRNAs and the correction of the haploinsufficiency or negative dominance of the OPA1 protein isoforms. Figure 2. Homo sapiens intron8-9/EXON9 OPA1-minigene (6606 bp). Restriction map of the Homo sapiens intron8-9/EXON9 OPA1-minigene plasmid used in a minigene assay for the identification of efficient trans-splicing binding domains. The intron8-9/EXON9 sequence of the OPA1 Homo sapiens gene was cloned between the EcoRV and NotI restriction sites through the Gibson cloning assembly method. Figure 3. Agarose gel electrophoresis of Homo sapiens OPA1 intron8-9/EXON 9 antisense binding domains banks edition via CviJI* endonuclease digest (A) or sonication (B). Figure 4. Restriction map of the RTM0 plasmid used in the minigene assay for the identification of efficient trans-splicing binding domains. The RTM0 plasmid contains a 27-bp spacer, a 8-bp branch point (BP), a 16-pb polypyrimidine Tract (PPT), a 3’-Acceptor Splice Site (3’ASS), the 3’ half part of the AcGFP1 encoding sequence (384-bp), an Internal Ribosome Entry Site (IRES), a 678-bp DsRed monomer sequence preceded by a Kozak sequence. Figure 5. Intronic Splicing Enhancer (ISE) cassette into which Homo sapiens OPA1 antisense binding domains were linked. The ISE cassette contains a 27-bp spacer, an 8-bp branch point (BP), a 16-bp PolyPyrimidine Tract (PPT), and a 3’- Acceptor Splice Site (3’ASS). Figure 6. Homo sapiens OPA1-minigene GFP reconstitution assay. (A) Homo sapiens OPA1-minigene trans-splicing principle. Homo sapiens OPA1-minigene encodes a pre-mRNA containing the 5’ half part of the AcGFP1 encoding sequence (336bp) followed by the Homo sapiens OPA1 intron 8-9/EXON9 (193,637,282 - 193,638,065) considered as the target. Co-expression of OPA1-specific RTM containing Homo sapiens OPA1 antisense binding domain leads to the hybridization of both pre-mRNAs and competition between OPA1-minigene cis-splicing and trans-splicing with the RTM. Efficient trans-splicing induces the reconstitution of the complete open reading frame of the sequence encoding the fluorescent protein AcGFP1. Trans-splicing events are visualized with fluorescence microscopy (B) showing co-localization between RTM- expressing cells (DsRed+ cells) and trans-splicing-cells (AcGFP1+ cells). OPA1- targeting RTMs inducing the highest GFP+ cells were selected by fluorescence-activated cell sorting (FACS) (C-D) and confirmed by (E) anti-GFP western blotting and (F) RT- PCR analysis. Figure 7. Restriction map of the pEF1a-IRES-AcGFP1 bicistronic mammalian expression vector used for therapeutic OPA1 trans-splicing molecule expression. Figure 8. Therapeutic effects of OPA1 pre-mRNA trans-splicing in in vitro experiments on DOA-related patients’ fibroblasts with bi-allelic OPA1 variants. OPA1 pre-mRNA trans-splicing restored physiological levels of OPA1 isoforms in Western blot (A) and mitochondrial network fusion in comparison to control cell line, without negative impact on the mitochondrial network of control fibroblasts devoid of OPA1 pathogenic variants (B-C). Definitions Throughout the specification, several terms are employed that are defined in the following paragraphs. As used herein, the term “subject” refers to a human or another mammal (e.g., primate, mouse, rat, rabbit, dog, cat, horse, pig, livestock, and the like), including laboratory animals, that may or may not have a disease associated with a mutation in the OPA1 gene. Non-human subjects may be transgenic or otherwise modified animals. In many embodiments of the present invention, the subject is a human being. In such embodiments, the subject is often referred to as an “individual” or a “patient”. The terms “individual” and “patient” do not denote a particular age. The term “patient” or “affected subject” more specifically refers to an individual suffering from a disease or condition associated with mutation(s) in the OPA1 gene (i.e., to an individual showing clinical signs of the disease or disorder), or to an individual at risk of developing such a disease or disorder. A subject can be characterized as “at risk” of developing a disease by identifying a mutation in the OPA1 gene associated with the disease. In some embodiments, the subject who is at risk of developing a disease has one or more OPA1 mutations associated with the disease. Additionally, or alternatively, a subject can be characterized as “at risk” of developing a disease if the subject has a family history of the disease. The term “mutation”, as used herein, refers to any aberrant nucleic acid sequence that causes a defective protein product (e.g., a non-functional protein product, a protein product having reduced function, a protein product having aberrant function, and/or a protein product that is produced in less than normal or greater than normal quantities). Mutations include base pair mutations (e.g., single nucleotide polymorphisms), missense mutations, frameshift mutations, deletions, insertions, splice mutations, and cryptic mutations. In some embodiments, a mutation refers to a nucleic acid sequence that is different in one or more portions of its sequence than a corresponding wild-type nucleic acid sequence or functional variant thereof. In some embodiments, a mutation refers to a nucleic acid sequence that encodes a protein having an amino acid sequence that is different than the sequence of the wild-type protein or functional variant thereof. A “mutated exon” refers to an exon containing a mutation or an exon sequence that reflects a mutation in a different region, such as a cryptic exon resulting from a mutation in an intron. A “mutated intron” refers to an intron containing a mutation or a deletion or an insertion or an inversion that affects the sequence or the level of expression of the gene of interest. As used herein, the terms “disease or disorder associated with a mutation” or “mutation associated with a disease or disorder” refer to a correlation between a disease or disorder and a mutation. In some embodiments, a disease or disorder associated with a mutation is known or suspected to be wholly or partially, or directly or indirectly, caused by the mutation. For example, a subject having the mutation may be at risk of developing the disease or disorder, and the risk may additionally depend on other factors, such as other (e.g., independent) mutations (e.g., in the same or a different gene), or environmental factors. The term “OPA1” refers to the human nuclear gene that encodes a mitochondrial protein with similarity to dynamin-related GTPases. The encoded protein localizes to the inner mitochondrial membrane and helps to regulate mitochondrial membrane dynamics and structures. More specifically, the term “OPA1” refers to the human OPA1 gene that is located on chromosome 3q28-q29, and more precisely from base pair 193,593,144 to base pair 193,697,811 forward strand on chromosome 3. Mutations in this gene have been associated with neuro-pathologies, more particularly ocular pathologies and/or hearing pathologies. As used herein, the term “disease or disorder associated with mutation(s) in the OPA1 gene” refers to any disease or disorder that is known or suspected to be wholly or partially, or directly or indirectly, caused by a mutation in the human OPA1 gene. Examples of such diseases include Autosomal Dominant Optic Atrophy (ADOA), Autosomal Dominant Optic Atrophy plus (ADOA+) and Behr’s Syndrome. The term “treatment” is used herein to characterize a method or process that is aimed at (1) delaying or preventing the onset of a disease or condition (herein a disease or disorder associated with a mutation in the OPA1 gene); (2) slowing down or stopping the progression, aggravation, or deterioration of at least one symptom of the disease or condition; (3) bringing about amelioration of at least one symptom of the disease or condition; or (4) curing the disease or condition. A treatment may be administered prior to the onset of the disease or condition, for a prophylactic or preventive action. Alternatively, or additionally, a treatment may be administered after initiation of the disease or condition, for a therapeutic action. As used herein, the term “prevention” of a disorder is defined as reducing the risk of onset of a disease, e.g., as a prophylactic therapy for a subject who is at risk of developing a disorder associated with a mutation on the OPA1 gene. A “pharmaceutical composition” is defined herein as comprising an effective amount of at least one nucleic acid OPA1 trans-splicing molecule according to the invention, and at least one pharmaceutically acceptable carrier or excipient. As used herein, the term “effective amount” refers to any amount of a compound (e.g., a nucleic acid OPA1 trans-splicing molecule), or composition that is sufficient to fulfil its intended purpose(s), e.g., a desired biological or medicinal response in a cell, tissue, system or subject. An effective amount of a nucleic acid OPA1 trans-splicing molecule is an amount that can elicit a measurable amount of a desirable outcome, e.g., in a method of treatment, an effective amount is an amount that can reduce or ameliorate by a measurable amount, a symptom of the disease or condition that is being treated. As used herein, the term “pharmaceutically acceptable carrier or excipient” refers to a carrier medium which does not interfere with the effectiveness of the biological activity of the active ingredient(s) and which is not excessively toxic to the host at the concentration at which it is administered. The term includes solvents, dispersion media, antibacterial and antifungal agents, isotonic agents, and the like. The use of such media and agents for pharmaceutically active substances is well known in the art (see for example “Remington’s Pharmaceutical Sciences”, E.W. Martin, 18 ^th Ed., 1990, Mack Publishing Co.: Easton, PA, which is incorporated herein by reference in its entirety). In specific embodiments, the term “pharmaceutically acceptable” means approved by a regulatory agency or listed in the U.S./E.U. Pharmacopeia or other generally recognized pharmacopeia for use in mammals, and more particularly in humans. The terms “approximately” and “about”, as used herein in reference to a number, generally include numbers that fall within a range of 10% in either direction of the number (greater than or less than the number) unless otherwise stated or otherwise evident from the context (e.g., where such number would exceed 100% of a possible value). Detailed Description of Certain Preferred Embodiments As mentioned above, the present invention provides nucleic acid trans-splicing molecules (e.g., pre-mRNA trans-splicing molecules (RTMs also called PTMs)) that are useful for correcting mutations in the OPA1 gene. Also provided are methods of using the nucleic acid trans-splicing molecules as gene therapy (e.g., ex vivo and in vivo gene therapy) for the treatment or prevention of diseases or disorders associated with OPA1 mutations, in particular ADOA, ADOA+ and Behr’s Syndrome. I - Nucleic Acid OPA1 Trans-Splicing Molecules The present invention is based on the use of spliceosome-mediated RNA trans- splicing (SMaRT ^TM ), a technology with the ability to reprogram mRNAs and the proteins they encode. SMaRT ^TM is here employed to correct mutations in the human OPA1 gene. 1. OPA1 Gene Mutations The human OPA1 gene is composed of 30 coding exons (exons 1 to 28, exon 4b, exon 5b) distributed across more than 100 kb of genomic DNA on chromosome 3q28- q29. Alternative splicing of exons 4, 4b, and 5b leads to eight mRNA variants, encoding eight isoforms of 924 to 1015 amino acids (Delettre et al., Hum. Genet., 2001, 109(6): 584-591), the exact balance of which is essential for proper OPA1 functions. The OPA1 proteins are classified as large GTPases of the dynamin-like family, which are imported into the mitochondria by their amino-terminal import-sequence, mitochondrial targeting sequence (MTS), and which are necessary for mitochondrial inner and outer membrane fusions. As of April 2021, the Human Gene Mutation Database (HGMD) (Stenson et al., Hum. Genet., 2017; 136: 665-677; Weisschuch et al., PLoS One, 2021, 16(7): e0253987) lists more than 400 disease-causing variants in OPA1 while the Leiden Open Variation Database for OPA1 (website: www.lovd.nl/OPA1) (Le Roux et al., Orphanet J. Rare Dis., 2019, 14: 214), which entries overlap largely but not completely with HGMD, lists 593 unique public variants. Dominant-negative and haploinsufficiency effects have been proposed as the predominant pathomechanisms for OPA1 variants (Pesch et al., Hum. Mol. Genet., 2001, 10: 1359-1368; Le Roux et al., Orphanet J. Rare Dis., 2019, 14: 214). Accordingly, the majority of disease-causing variants are predicted to give rise to OPA1 missense amino acid changes, or truncated polypeptides, either due to nonsense, frameshift or splice variants, the latter including deep intronic variants causing the inclusion of pseudoexons into the transcript, or a partial gene deletions or duplications (Bonifert et al., Brain, 2014, 137: 2164-2177; Bonifert et al., Mol. Ther. Nucleic Acids, 2016, 5:e390). In addition, structural variants such as copy number variants (CNVs) and inversions are part of the mutation spectrum of OPA1 (Furhmann et al., J Med Genet., 2009; 46:136–44; Almind et al., BMC Med Genet. 2011; 12:49; Weisschuh et al., BMC Med Genet. 2020; 21:236). More than 95% of disease-causing variants are located downstream of the alternative exons in the OPA1 gene. 2. Spliceosome-Mediated RNA Trans-Splicing (SMaRT ^TM ) Splicing is a naturally occurring process that takes place during the generation of fully active messenger RNA (mRNA) and is mediated by the cell’s own spliceosome. Within a cell, a pre-mRNA intermediate exists that includes non-coding nucleic acid sequences (introns) and coding nucleic acid sequences (exons) that encode the amino acids forming the gene product. In the pre-mRNA, the introns are interspersed between the exons; they are ultimately excised from the pre-mRNA and the exons are fused together to form the mature RNA (mRNA). The predominant splicing form in eukaryotic cells is cis-splicing, where the exons from one pre-mRNA transcript are joint together. In contrast, RNA trans-splicing involves the joining of exons originating from more than one pre-mRNA transcript. Trans-spliced RNA can encode new proteins or non-coding regulatory transcripts, not only resulting in increased proteome complexity, but also contributing to the regulation of gene expression. Spliceosome-mediated RNA trans-splicing (SMaRT ^TM ), which utilizes the endogenous cellular splicing machinery to repair inherited genetic defects or mistakes at the pre-mRNA level by replacing mutant exon or exons by their wild-type counterparts, has emerged as a novel technology for the correction of monogenic disorders. It employs an engineered pre-mRNA trans-splicing molecule (RTM) that binds specifically to target pre-mRNA in the nucleus and triggers trans-splicing in a process mediated by the spliceosome. SMaRT ^TM can be used to replace 5’, 3’, or internal sequences in an exon-wise manner. This methodology is described in, for example, Puttaraju et al., Nature Biotechnol.1999, 17: 246-252; Gruber et al., Mol. Oncol., 2013, 7(6): 1056; Avale, Hum. Mol. Genet., 2013, 22(13): 2603-2611; Rindt et al., Cell Mol. Life Sci. 2012, 69(24): 4191; Liemberger et al., Int. J. Mol. Sci., 2018, 19: 762 ; US Patent Application Publication Nos. 2006/0246422, 2013/0059901, and U.S. Pat. Nos. 6,083,702; 6,013,487; 6,280,978; 7,399,753; 7,968,334 8,053,232; 8,735,366; 9,303,078 and 9,655,979, which are incorporated herein by reference. See also Berger et al., Mol. Ther., 2015, 23(5): 918-930; Koller et al., Nucleic Acids Res., 2011, 39(16): e108; Koller et al., Int. J. Mol. Sci., 2015, 16(1): 1179-1191; Murauer et al., Hum. Gene Ther. Methods, 2013, 24(1): 19-27; Rindt et al., Front. Neurosci., 2017, 11: 544; Tockner et al., Gene Ther., 2016, 23(11): 775-784. The replacement of exonic portions provides several advantages relative to other gene therapeutic approaches, such as complementary DNA (cDNA) therapy. First, for very large genes, the sequence to be replaced can be reduced to a size that facilitates viral packaging and transduction. Second, the increase of wild-type alleles and the concomitant decrease of mutated alleles leads to an enhanced shift in their quantitative proportions, making this technology suitable for the correction of dominant mutations. Third, as trans-splicing takes place at the pre-messenger RNA (pre-mRNA) level, target gene expression remains under the control of the respective endogenous promoter, and problems arising from transgene overexpression can be excluded. Spliceosome-mediated RNA trans-splicing requires the coexistence of three distinct components: the spliceosome, target pre-mRNA transcripts, and pre-mRNA trans-splicing molecules (RTMs). The spliceosome and target pre-mRNA transcripts are naturally provided by the cells, while the RTMs are artificially engineered molecules that are able to bind specifically to target pre-mRNAs in the nucleus. There, they trigger the trans-splicing event between the endogenous pre-mRNA and the exogenous RTM in a process mediated by the spliceosome. Each pre-mRNA trans-splicing molecule (RTM) is engineered to contain (a) a binding domain (BD) hybridizing to a selected target region to bring the RTM and target transcript into close proximity, (b) a splicing domain that includes splicing elements essential to mediate trans-splicing, and (c) a coding domain of a wild-type gene that is defective in the endogenous pre-mRNA. Similar to RNA cis-splicing processes, the binding domain and splicing domain sequences of the RTM are excised after trans-splicing and are not retained in the reprogrammed final mRNA products. Depending on the location of the mutation to be corrected or the region to be replaced, three types of SMaRT ^TM approaches are available. The two major types are replacement of upstream (5’) coding cassette (5’-trans-splicing) and replacement of a downstream (3’) coding cassette (3’-trans-splicing). The third type is internal exon(s) replacement. 3. Nucleic Acid OPA1 Trans-Splicing Molecules In a first aspect, the invention provides OPA1 pre-mRNA trans-splicing molecules. More specifically, the invention provides a nucleic acid OPA1 trans- splicing molecule comprising, operatively linked in a 5’-to-3’ direction or in a 3’-to-5’ direction: (a) a binding domain configured to bind to a OPA1 target sequence comprising an intron, an intron/exon junction or an exon; (b) a splicing domain configured to mediate trans-splicing; and (c) a coding domain comprising functional OPA1 exons, wherein the nucleic acid OPA1 trans-splicing molecule is configured to trans-splice the coding domain to an endogenous OPA1 exon adjacent to the OPA1 target sequence, thereby replacing the endogenous OPA1 exons with the functional OPA1 exons and correcting a mutation in OPA1. a. Human OPA1 Target Sequence. An OPA1 target sequence may be any fragment of the Homo sapiens OPA1 gene (Chromosome 3: 193,593,144 to 193,697,811), which comprises an intron, an intron/exon junction or an exon. However, the present invention is based, at least in part, on Applicant’s discovery that a particular region of the human OPA1 genomic sequence provides highly efficient binding sites for binding domains of trans-splicing molecules and efficiently mediates trans-splicing. This targeted region warranties both the conservation and the trans- splicing of the eight OPA1 pre-mRNA transcripts, to correct the eight different OPA1 mRNAs and the corresponding OPA1 protein isoforms. The human OPA1 trans-splicing targeted sequence is the Homo sapiens OPA1 intron 8-9 (193,637,282 to 193,637,951) / EXON 9 (ENSE00003604184: 193,637,952 to 193,638,065) genomic sequence. In certain embodiments, the Homo sapiens OPA1 intron 8-9/Exon 9 genomic sequence is the sequence set forth in SEQ ID NO: 1. SEQ ID NO: 1 gtatgtgaaa aattgatagt gaacttgcca attagcaaaa aaagaagcag cttagcttcc taaaaattat gtgtatatat gtacacatac acatatatac atactagatg taggcattta tattttttat gtaatcttac atgttccaag taatgtctta agcaatatta tttgactatt ttagttcatt ataaatatta ataaatataa gtacattata tttatgagtt actgtatgtg ttataaagga agatatttgg ctttatatgt cttaatatta gtaatattta aatactgaac agtggattaa attagccata tgcgtgaaat ttaagctaat agaattgaaa atgtgtttgt aaacagtaaa ctagctatgg aaaagattta tggaaagtta ataacctggt tttagaaata ctggtttaaa ttagcacaag tttttaaaat aaaaattagg ctataaacag tggatccagt tatagttttg ctgttcctat tttcaatgtg cacacatgca tcaatcacca tttttttacg gattttaaaa tattttttca cctgtagaaa ttttaaaaga ctaaaaaact cagagcagca ttacaaatag gttttaattt taatttggta tcagaaaaat atgaataagt gttctttgtt ttgtgggaag GTTGTTGTGG TTGGAGATCA GAGTGCTGGA AAGACTAGTG TGTTGGAAAT GATTGCCCAA GCTCGAATAT TCCCAAGAGG ATCTGGGGAG ATGATGACAC GTTCTCCAGT TAAG In this 784-nucleotide (nt) sequence, Homo sapiens OPA1 intron 8-9 (670 bp) and Homo sapiens OPA1 EXON 9 (114 bp) are respectively indicated in lowercases and uppercases. The human OPA1 trans-splicing targeted sequence is located downstream to OPA1 alternate spliced exons (4, 4b, 5b) and upstream to the pathogenic variants observed in Hereditary Optic Neuropathies associated with mutations in the OPA1 gene. Thus, in preferred embodiments of the present invention, the OPA1 target sequence comprising an intron, an intron/exon junction or an exon is the human OPA1 trans-splicing targeted sequence of SEQ ID NO: 1. b. Binding Domains. A binding domain present in a nucleic acid OPA1 trans- splicing molecule according to the invention is able to bind specifically to the human OPA1 intron 8-9/Exon 9 target sequence of SEQ ID NO: 1, or to the complementary sequence thereof. As used herein, the term “specific binding” between a binding domain and the OPA1 target sequence refers to hydrogen bonding between the binding domain and the OPA1 target sequence in a degree sufficient to mediate trans-splicing by bringing the trans-splicing molecule into association with the target pre-mRNA. Preferably, the hydrogen bonds between the binding domain and the OPA1 target sequence are between nucleotide bases that are complementary to and in antisense orientation from one another (in which case the term “specific binding” refers to “specific hybridization” to one another). As will be understood by one skilled in the art, the term “specific binding” encompasses the binding the binding domain and a portion of the OPA1 target sequence. Such a portion is called herein “binding site”. The binding domain may be 100% complementary to the OPA1 target sequence of SEQ ID NO: 1, or to the complementary sequence thereof, or have sufficient complementarity to be able to hybridize stably with the target pre-mRNA. For example, in some embodiments, the binding domain is 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% complementary to the OPA1 target sequence of SEQ ID NO: 1, or to the complementary sequence thereof. The degree of complementarity is selected by one of skill in the art based on the need to keep the trans-splicing molecule and the nucleic acid construct containing the necessary sequences for expression and for inclusion in a recombinant adeno-associated virus within a 3,000 or up to 4,000 nucleotide base limit. The selection of this sequence and strength of hybridization depends on the complementarity and the length of the nucleic acid (See, for example, Sambrook et al., 1989, Molecular Cloning, A Laboratory Manual, 2d Ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.). In the practice of the present invention, a binding domain can be 6 to 500 nucleotides in length. In some embodiments, the binding domain is from 20 to 400 nucleotides in length. In some embodiments, the binding domain is from 50 to 300 nucleotides in length. In some embodiments, the binding domain is from 100 to 200 nucleotides in length. In some embodiments, the binding domain is from 10-20 nucleotides in length (e.g., 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 nucleotides in length), 20-30 nucleotides in length (e.g., 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 nucleotides in length), 30-40 nucleotides in length (e.g., 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, or 40 nucleotides in length), 40-50 nucleotides in length (e.g., 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50 nucleotides in length), 50-60 nucleotides in length (e.g., 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, or 60 nucleotides in length), 60-70 nucleotides in length (e.g., 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, or 70 nucleotides in length), 70-80 nucleotides in length (e.g., 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, or 80 nucleotides in length), 80-90 nucleotides in length (e.g., 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, or 90 nucleotides in length), 90-100 nucleotides in length (e.g., 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, or 100 nucleotides in length), 100-110 nucleotides in length (e.g., 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, or 110 nucleotides in length), 110-120 nucleotides in length (e.g., 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, or 120 nucleotides in length), 120-130 nucleotides in length (e.g., 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, or 130 nucleotides in length), 130-140 nucleotides in length (e.g., 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, or 140 nucleotides in length), 140-150 nucleotides in length (e.g., 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, or 150 nucleotides in length), 150-160 nucleotides in length (e.g., 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, or 160 nucleotides in length), 160-170 nucleotides in length (e.g., 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, or 170 nucleotides in length), 170-180 nucleotides in length (e.g., 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, or 180 nucleotides in length), 180-190 nucleotides in length (e.g., 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, or 190 nucleotides in length), 190-200 nucleotides in length (e.g., 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, or 200 nucleotides in length), 200-210 nucleotides in length (e.g., 200, 201, 202, 203, 204, 205, 206, 207, 208, 209 or 210 nucleotides in length), 210-220 nucleotides in length (e.g., 210, 211, 212, 213, 214, 215, 216, 217, 218, 219 or 220 nucleotides in length), 220-230 nucleotides in length (e.g., 220, 221, 222, 223, 224, 225, 226, 227, 228, 229 or 230 nucleotides in length), 230-240 nucleotides in length (e.g., 230, 231, 232, 233, 234, 235, 236, 237, 238, 239 or 240 nucleotides in length), 240-250 nucleotides in length (e.g., 240, 241, 242, 243, 244, 245, 246, 247, 248, 249 or 250 nucleotides in length), 250-260 nucleotides in length (e.g., 250, 251, 252, 253, 254, 255, 256, 257, 258, 259 or 260 nucleotides in length), 260-270 nucleotides in length (e.g., 260, 261, 262, 263, 264, 265, 266, 267, 268, 269 or 270 nucleotides in length), 270-280 nucleotides in length (e.g., 270, 271, 272, 273, 274, 275, 276, 277, 278, 279 or 280 nucleotides in length), 280-290 nucleotides in length (e.g., 280, 281, 282, 283, 284, 285, 286, 287, 288, 289 or 290 nucleotides in length), 290-300 nucleotides in length (e.g., 290, 291, 292, 293, 294, 295, 296, 297, 298, 299 or 300 nucleotides in length), 300-350 nucleotides in length, 350-400 nucleotides in length, 400-450 nucleotides in length, or 450-500 nucleotides in length. In certain embodiments, the binding domain is a single binding domain, i.e., its sequence specifically hybridizes to a single portion (or binding site) of the OPA1 target sequence of SEQ ID NO: 1. In other embodiments, the binding domain contains sequences that specifically hybridize to more than one portion (or binding site) of the OPA1 target sequence of SEQ ID NO: 1. For example, the binding domain may be a double binding domain, specifically hybridizing to two distinct binding sites of the OPA1 target sequence of SEQ ID NO: 1, wherein the distinct binding sites are separated by tens or hundreds of nucleotides. More generally, the binding domain may be a multi-binding domain, specifically hybridizing to two or more distinct binding sites of the OPA1 target sequence of SEQ ID NO: 1, wherein the distinct binding sites are separated by tens or hundreds of nucleotides. A binding site within the OPA1 target sequence of SEQ ID NO: 1 may be 6 to 300 nucleotides in length. For example, a binding site within the OPA1 target sequence of SEQ ID NO: 1 may comprise from 6 to 12, from 12 to 18, from 18 to 24, from 24 to 50, from 50 to 100, from 100 to 150, or from 150 to 200 nucleotides, or from 200 to 250 nucleotides or yet from 250 to 300 nucleotides. In some embodiments, the binding domain of a nucleic acid OPA1 trans-splicing molecule according to the present invention is configured to bind (i.e., specifically binds to) the OPA1 target sequence at a binding site within or encompassing nucleotides 1 to 52 of SEQ ID NO: 1. Thus, in certain embodiments, the binding domain of a nucleic acid OPA1 trans-splicing molecule according to the present invention is complementary (e.g., antisense) to six or more consecutive nucleotides of a binding site within or encompassing nucleotides 1 to 52 of SEQ ID NO: 1. In particular, the binding domain may be complementary (e.g., antisense) to six or more consecutive nucleotides of a binding site within or encompassing nucleotides 1 to 50 of SEQ ID NO: 1. In certain embodiments, the binding site consists of nucleotides 1 to 52 of SEQ ID NO: 1. In certain embodiments, the binding site consists of nucleotides 1 to 50 of SEQ ID NO: 1. In some embodiments, the binding domain of a nucleic acid OPA1 trans-splicing molecule according to the present invention specifically binds to the OPA1 target sequence at a binding site within or encompassing nucleotides 261 to 315 of SEQ I NO: 1. Thus, in certain embodiments, the binding domain of a nucleic acid OPA1 trans- splicing molecule according to the present invention is complementary (e.g., antisense) to six or more consecutive nucleotides of a binding site within or encompassing nucleotides 261 to 315 of SEQ ID NO: 1. In certain embodiments, the binding site consists of nucleotides 261 to 315 of SEQ ID NO: 1. In some embodiments, the binding domain of a nucleic acid OPA1 trans-splicing molecule according to the present invention specifically binds to the OPA1 target sequence at a binding site within or encompassing nucleotides 361 to 603 of SEQ ID NO: 1, or at a binding site within or encompassing nucleotides 361 to 460 of SEQ ID NO: 1, or at a binding site within or encompassing nucleotides 375 to 460 of SEQ ID NO: 1 or at a binding site within or encompassing nucleotides 461 to 603 of SEQ ID NO: 1. Thus, in certain embodiments, the binding domain of a nucleic acid OPA1 trans-splicing molecule according to the present invention is complementary (e.g., antisense) to six or more consecutive nucleotides of a binding site within or encompassing nucleotides 361 to 603 of SEQ ID NO: 1. In particular, the binding domain may be complementary (e.g., antisense) to six or more consecutive nucleotides of a binding site within or encompassing nucleotides 361 to 460 of SEQ ID NO: 1, or of a binding site within or encompassing nucleotides 375 to 460 of SEQ ID NO: 1, or of a binding site within or encompassing nucleotides 461 to 603 of SEQ ID NO: 1. In certain embodiments, the binding site consists of nucleotides 361 to 603 of SEQ ID NO: 1. In other embodiments, the binding site consists of nucleotides 361 to 460 of SEQ ID NO: 1. In still other embodiments, the binding site consists of nucleotides 375 to 460 of SEQ ID NO: 1. In yet other embodiments, the binding site consists of nucleotides 461 to 603 of SEQ ID NO: 1. In some embodiments, the binding domain of a nucleic acid OPA1 trans-splicing molecule according to the present invention specifically binds to the OPA1 target sequence at a binding site within or encompassing nucleotides 510 to 784 of SEQ ID NO: 1, or at a binding site within or encompassing nucleotides 510 to 756 of SEQ ID NO 1, or at a binding site within or encompassing nucleotides 510 to 726 of SEQ ID NO 1, or at a binding site within or encompassing nucleotides 518 to 784 of SEQ ID NO 1, or at a binding site within or encompassing nucleotides 518 to 756 of SEQ ID NO 1, or at a binding site within or encompassing nucleotides 518 to 726 of SEQ ID NO 1, or at a binding site within or encompassing nucleotides 561 to 784 of SEQ ID NO 1, or at a binding site within or encompassing nucleotides 561 to 756 of SEQ ID NO 1, or at a binding site within or encompassing nucleotides 561 to 726 of SEQ ID NO 1, or at a binding site within or encompassing nucleotides 627 to 784 of SEQ ID NO 1, or at a binding site within or encompassing nucleotides 627 to 756 of SEQ ID NO 1, or at a binding site within or encompassing nucleotides 627 to 726 of SEQ ID NO 1. Thus, in certain embodiments, the binding domain of a nucleic acid OPA1 trans- splicing molecule according to the present invention is complementary (e.g., antisense) to six or more consecutive nucleotides of a binding site within or encompassing nucleotides 510 to 784 of SEQ ID NO: 1. In particular, the binding domain may be complementary (e.g., antisense) to six or more consecutive nucleotides of a binding site within or encompassing nucleotides 510 to 756 of SEQ ID NO 1, or nucleotides 510 to 726 of SEQ ID NO 1, or nucleotides 518 to 784 of SEQ ID NO 1, or nucleotides 518 to 756 of SEQ ID NO 1, or nucleotides 518 to 726 of SEQ ID NO 1, or nucleotides 561 to 784 of SEQ ID NO 1, or nucleotides 561 to 756 of SEQ ID NO 1, or nucleotides 561 to 726 of SEQ ID NO 1, or nucleotides 627 to 784 of SEQ ID NO 1, or nucleotides 627 to 756 of SEQ ID NO 1, or nucleotides 627 to 726 of SEQ ID NO 1. In certain embodiments, the binding site consists of nucleotides 510 to 784 of SEQ ID NO: 1. In other embodiments, the binding site consists of nucleotides 510 to 756 of SEQ ID NO 1, or nucleotides 510 to 726 of SEQ ID NO 1, or nucleotides 518 to 784 of SEQ ID NO 1, or nucleotides 518 to 756 of SEQ ID NO 1, or nucleotides 518 to 726 of SEQ ID NO 1, or nucleotides 561 to 784 of SEQ ID NO 1, or nucleotides 561 to 756 of SEQ ID NO 1, or nucleotides 561 to 726 of SEQ ID NO 1, or nucleotides 627 to 784 of SEQ ID NO 1, or nucleotides 627 to 756 of SEQ ID NO 1, or nucleotides 627 to 726 of SEQ ID NO 1. In some preferred embodiments, a binding domain of a nucleic acid OPA1 trans- splicing molecule according to the present invention comprises, or consists of, the single binding domain with the following 55-nt sequence (3’ to 5’): ctaatttaatccactgttcagtatttaaatattactaatattaagacatataaag (SEQ ID NO: 2 – BD#114), which hybridizes to the OPA1 target sequence at a binding site consisting of nucleotides 261 to 315 of SEQ ID NO: 1. In certain embodiments, the binding domain is a fragment of SEQ ID NO: 2. The term “fragment”, as used herein in relation to a binding domain refers to a portion of said binding domain which consists of consecutive nucleotides of the binding domain and which hybridizes to a binding site of the OPA1 target sequence of SEQ ID NO: 1. In other words, a fragment of a binding domain is a binding domain as defined herein. In some preferred embodiments, a binding domain of a nucleic acid OPA1 trans- splicing molecule according to the present invention comprises, or consists of, the single binding domain with the following 86-nt sequence (3’ to 5’): cctaatttttattttaaaaacttgtgctaatttaaaccagtatttctaaaaccaggttat taac tttccataaatcttttccatag (SEQ ID NO: 3 - BD#128), which hybridizes to the OPA1 target sequence at a binding site consisting of nucleotides 375 to 460 of SEQ ID NO:1. In certain embodiments, the binding domain is a fragment of SEQ ID NO: 3 - BD#128. In other preferred embodiments, a binding domain of a nucleic acid OPA1 trans- splicing molecule according to the present invention comprises, or consists of, the single binding domain with the following 143-nt sequence (3’ to 5’): taatgctgctctgagttttttagtcttttaaaatttctacaggtgaaaaaatattttaaa atcc gtaaaaaaatggtgattgatgcatgtgtgcacattgaaaataggaacagcaaaactataa ctgga tccactgtttatag (SEQ ID NO: 4 - BD#162), which hybridizes to the OPA1 target sequence at a binding site consisting of nucleotides 461 to 603 of SEQ ID NO: 1. In certain embodiments, the binding domain is a fragment of SEQ ID NO: 4 - BD#162. In yet other preferred embodiments, a binding domain of a nucleic acid OPA1 trans-splicing molecule according to the present invention comprises, or consists of, the binding domain with the following 105-nt sequence (1x antisense + 1x sense): ctgcttctttttttgctaattggcaagttcactatcaatttttcacatacctttatatgt ctta atattagtaatatttaaatactgaacagtggattaaattag (SEQ ID NO: 5 - BD#135), which hybridizes to the OPA1 target sequence at a binding site consisting of nucleotides 1 to 50 of SEQ ID NO: 1. In certain embodiments, the binding domain is a fragment of SEQ ID NO: 5 - BD#135. In still other preferred embodiments, a binding domain of a nucleic acid OPA1 trans-splicing molecule according to the present invention comprises, or consists of, the multiple binding domain with the following 250-nt sequence (4x antisense + 1 x sense): cctaatttttattttaaaaacttgtgctaatttaaaccagtatttctaaaaccaggttat taac tttccataaatcttttccatagctgcttctttttttgctaattggcaagttcactatcaa tttt tcacatacctttatatgtcttaatattagtaatatttaaatactgaacagtggattaaat tagc ttaaatttcacgcatatggctagtttactgtttacaaacacattttcaattctattag (SEQ ID NO: 6 - BD#106), which hybridizes to the OPA1 target sequence at a first binding site consisting of nucleotides 375 to 460 of SEQ ID NO: 1 (like BD#128), at a second binding site consisting of nucleotides 1 to 50 of SEQ ID NO: 1 (like BD#135), to a third binding site consisting of nucleotides 316 to 335 of SEQ ID NO: 1, and to a fourth binding site consisting of nucleotides 336 to 374 of SEQ ID NO: 1. In certain embodiments, a binding domain of a nucleic acid OPA1 trans-splicing molecule according to the present invention comprises, or consists of a combination of at least two of the binding domains described above, i.e., BD#114 (SEQ ID NO: 2), BD#128 (SEQ ID NO: 3), BD#162 (SEQ ID NO: 4), BD#135 (SEQ ID NO: 5), and BD#106 (SEQ ID NO: 6). For example, the binding domain may be a combination of BD#114 (SEQ ID NO: 2) and BD#128 (SEQ ID NO: 3), or of BD#114 (SEQ ID NO: 2) and BD#162 (SEQ ID NO: 4), or of BD#128 (SEQ ID NO: 3) and BD#162 (SEQ ID NO: 4), etc… Other antisense binding domains have also been generated by rational PCR. Thus, in certain preferred embodiments, a binding domain of a nucleic acid OPA1 trans-splicing molecule according to the present invention comprises, or consists of, the binding domain with the following 100-nt sequence (3’ to 5’): GCAATCATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACcttc ccac aaaacaaagaacacttattcatatttttctgatacc (SEQ ID NO: 7 - BD#100), which hybridizes to the OPA1 target sequence at a binding site consisting of nucleotides 627 to 726 of SEQ ID NO: 1. In certain embodiments, the binding domain is a fragment of SEQ ID NO: 7. In some preferred embodiments, a binding domain of a nucleic acid OPA1 trans- splicing molecule according to the present invention comprises, or consists of, the binding domain with the following 130-nt sequence (3’ to 5’): CCAGATCCTCTTGGGAATATTCGAGCTTGGGCAATCATTTCCAACACACTAGTCTTTCCA GCAC TCTGATCTCCAACCACAACAACcttcccacaaaacaaagaacacttattcatatttttct gata cc (SEQ ID NO: 8 - BD#130), which hybridizes to the OPA1 target sequence at a binding site consisting of nucleotides 627 to 756 of SEQ ID NO: 1. In certain embodiments, the binding domain is a fragment of SEQ ID NO: 8. In some preferred embodiments, a binding domain of a nucleic acid OPA1 trans- splicing molecule according to the present invention comprises, or consists of, the binding domain with the following 158-nt sequence (3’ to 5’): CTTAACTGGAGAACGTGTCATCATCTCCCCAGATCCTCTTGGGAATATTCGAGCTTGGGC AATC ATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACcttcccacaa aaca aagaacacttattcatatttttctgatacc (SEQ ID NO: 9 - BD#158), which hybridizes to the OPA1 target sequence at a binding site consisting of nucleotides 627 to 784 of SEQ ID NO: 1. In certain embodiments, the binding domain is a fragment of SEQ ID NO: 9. In some preferred embodiments, a binding domain of a nucleic acid OPA1 trans- splicing molecule according to the present invention comprises, or consists of, the binding domain with the following 166-nt sequence (3’ to 5’): GCAATCATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACcttc ccac aaaacaaagaacacttattcatatttttctgataccaaattaaaattaaaacctatttgt aatg ctgctctgagttttttagtcttttaaaatttctacagg (SEQ ID NO: 10 - BD#166), which hybridizes to the OPA1 target sequence at a binding site consisting of nucleotides 561 to 726 of SEQ ID NO: 1. In certain embodiments, the binding domain is a fragment of SEQ ID NO: 10. In some preferred embodiments, a binding domain of a nucleic acid OPA1 trans- splicing molecule according to the present invention comprises, or consists of, the binding domain with the following 196-nt sequence (3’ to 5’): CCAGATCCTCTTGGGAATATTCGAGCTTGGGCAATCATTTCCAACACACTAGTCTTTCCA GCAC TCTGATCTCCAACCACAACAACcttcccacaaaacaaagaacacttattcatatttttct gata ccaaattaaaattaaaacctatttgtaatgctgctctgagttttttagtcttttaaaatt tcta cagg (SEQ ID NO: 11 - BD#196), which hybridizes to the OPA1 target sequence at a binding site consisting of nucleotides 561 to 756 of SEQ ID NO: 1. In certain embodiments, the binding domain is a fragment of SEQ ID NO: 11. In some preferred embodiments, a binding domain of a nucleic acid OPA1 trans- splicing molecule according to the present invention comprises, or consists of, the binding domain with the following 224-nt sequence (3’ to 5’): CTTAACTGGAGAACGTGTCATCATCTCCCCAGATCCTCTTGGGAATATTCGAGCTTGGGC AATC ATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACcttcccacaa aaca aagaacacttattcatatttttctgataccaaattaaaattaaaacctatttgtaatgct gctc tgagttttttagtcttttaaaatttctacagg (SEQ ID NO: 12 - BD#224), which hybridizes to the OPA1 target sequence at a binding site consisting of nucleotides 561 to 784 of SEQ ID NO: 1. In certain embodiments, the binding domain is a fragment of SEQ ID NO: 12. In some preferred embodiments, a binding domain of a nucleic acid OPA1 trans- splicing molecule according to the present invention comprises, or consists of, the binding domain with the following 209-nt sequence (3’ to 5’): GCAATCATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACcttc ccac aaaacaaagaacacttattcatatttttctgataccaaattaaaattaaaacctatttgt aatg ctgctctgagttttttagtcttttaaaatttctacaggtgaaaaaatattttaaaatccg taaa aaaatggtgattgatgc (SEQ ID NO: 13 - BD#209), which hybridizes to the OPA1 target sequence at a binding site consisting of nucleotides 518 to 726 of SEQ ID NO: 1. In certain embodiments, the binding domain is a fragment of SEQ ID NO: 13. In some preferred embodiments, a binding domain of a nucleic acid OPA1 trans- splicing molecule according to the present invention comprises, or consists of, the binding domain with the following 239-nt sequence (3’ to 5’): CCAGATCCTCTTGGGAATATTCGAGCTTGGGCAATCATTTCCAACACACTAGTCTTTCCA GCAC TCTGATCTCCAACCACAACAACcttcccacaaaacaaagaacacttattcatatttttct gata ccaaattaaaattaaaacctatttgtaatgctgctctgagttttttagtcttttaaaatt tcta caggtgaaaaaatattttaaaatccgtaaaaaaatggtgattgatgc (SEQ ID NO: 14 - BD#239), which hybridizes to the OPA1 target sequence at a binding site consisting of nucleotides 518 to 756 of SEQ ID NO: 1. In certain embodiments, the binding domain is a fragment of SEQ ID NO: 14. In some preferred embodiments, a binding domain of a nucleic acid OPA1 trans- splicing molecule according to the present invention comprises, or consists of, the binding domain with the following 267-nt sequence (3’ to 5’): CTTAACTGGAGAACGTGTCATCATCTCCCCAGATCCTCTTGGGAATATTCGAGCTTGGGC AATC ATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACcttcccacaa aaca aagaacacttattcatatttttctgataccaaattaaaattaaaacctatttgtaatgct gctc tgagttttttagtcttttaaaatttctacaggtgaaaaaatattttaaaatccgtaaaaa aatg gtgattgatgc (SEQ ID NO: 15 - BD#267), which hybridizes to the OPA1 target sequence at a binding site consisting of nucleotides 518 to 784 of SEQ ID NO: 1. In certain embodiments, the binding domain is a fragment of SEQ ID NO: 15. In some preferred embodiments, a binding domain of a nucleic acid OPA1 trans- splicing molecule according to the present invention comprises, or consists of, the binding domain with the following 217-nt sequence (3’ to 5’): gcaatcatttccaacacactagtctttccagcactctgatctccaaccacaacaaccttc ccac aaaacaaagaacacttattcatatttttctgataccaaattaaaattaaaacctatttgt aatg ctgctctgagttttttagtcttttaaaatttctacaggtgaaaaaatattttaaaatccg taaa aaaatggtgattgatgcatgtgtgc (SEQ ID NO: 16 – BD#217), which hybridizes to the OPA1 target sequence at a binding site consisting of nucleotides 510 to 726 of SEQ ID NO: 1. In certain embodiments, the binding domain is a fragment of SEQ ID NO: 16. In some preferred embodiments, a binding domain of a nucleic acid OPA1 trans- splicing molecule according to the present invention comprises, or consists of, the binding domain with the following 247-nt sequence (3’ to 5’) : CCAGATCCTCTTGGGAATATTCGAGCTTGGGCAATCATTTCCAACACACTAGTCTTTCCA GCAC TCTGATCTCCAACCACAACAACcttcccacaaaacaaagaacacttattcatatttttct gata ccaaattaaaattaaaacctatttgtaatgctgctctgagttttttagtcttttaaaatt tcta caggtgaaaaaatattttaaaatccgtaaaaaaatggtgattgatgcatgtgtgc (SEQ ID NO: 17 - BD#247), which hybridizes to the OPA1 target sequence at a binding site consisting of nucleotides 510 to 756 of SEQ ID NO: 1. In certain embodiments, the binding domain is a fragment of SEQ ID NO: 17. In some preferred embodiments, a binding domain of a nucleic acid OPA1 trans- splicing molecule according to the present invention comprises, or consists of, the binding domain with the following 275-nt sequence (3’ to 5’): CTTAACTGGAGAACGTGTCATCATCTCCCCAGATCCTCTTGGGAATATTCGAGCTTGGGC AATC ATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACcttcccacaa aaca aagaacacttattcatatttttctgataccaaattaaaattaaaacctatttgtaatgct gctc tgagttttttagtcttttaaaatttctacaggtgaaaaaatattttaaaatccgtaaaaa aatg gtgattgatgcatgtgtgc (SEQ ID NO: 18 - BD#275), which is hybridizes to the OPA1 target sequence at a binding site consisting of nucleotides 510 to 784 of SEQ ID NO: 1. In certain embodiments, the binding domain is a fragment of SEQ ID NO: 18. c. Splicing Domain. A nucleic acid OPA1 trans-splicing molecule also comprises a splicing domain. The terms “splicing domain”, and “splice region” are used herein interchangeably. They refer to a nucleic acid sequence having motifs that are recognized by the spliceosome and that mediate trans-splicing. In a 3’-trans-splicing molecule such as a nucleic acid OPA1 trans-splicing molecule according to the present invention, a splicing domain comprises a branch point (BP), a polypyrimidine tract (PPT), and an acceptor splice site mediating trans-splicing. The splice site is a 3’ acceptor splice site (AG or YAG). Splicing domains may be selected by one skilled in the art according to known methods and principles. Consensus sequences for splicing domains used in RNA splicing are well known in the art (See Moore et al., 1993, The RNA World, Cold Spring Harbor Laboratory Press, p.303-358). However, modified consensus sequences that maintain the ability to function as a splicing domain may be used in the practice of the present invention. In certain embodiments, a splicing domain of a nucleic acid OPA1 trans-splicing molecule according to the present invention comprises a branch point (BP), a polypyrimidine tract (PPT) and a 3’ acceptor splice site, wherein the PPT is located between the branch point and the splice site. In certain embodiments, the branch point consists of the 8-nucleotides (nt) nucleic acid sequence: 5’-tactaact-3’ (SEQ ID NO: 19). In certain embodiments, the polypyrimidine tract consists of the 16-nt nucleic acid sequence: 5’-tcttcttttttttctg-3’ (SEQ ID NO: 20). In certain embodiments, the 3’ acceptor splice site consists of 3-nt the nucleic acid sequence: 5’-cag-3’ (SEQ ID NO: 21). The splicing domain may be included as part of an intronic splicing enhancer (ISE), which may include one or more additional components. For example, a spacer region may be present within an intronic splicing enhancer (ISE) to separate the splicing domain from the binding domain in the pre-mRNA trans-splicing molecule. The spacer region may be designed to include features such as (1) stop codons which function to block translation of any unspliced trans-splicing molecule and/or (2) sequences that enhance trans-splicing to the target pre-mRNA. The spacer may be 3 to 30 nucleotides or more depending on the lengths of the other components of the trans-splicing molecule. In certain embodiments, the spacer consists of the following 27-nt nucleic acid sequence: 5’-gagaacattattatagcgttgctcgag-3’ (SEQ ID NO: 22). In certain embodiments, the binding domain of a nucleic acid OPA1 trans-splicing molecule according to the present invention is linked to an Intronic Splicing Enhancer cassette, which contains the 27-nt spacer, the 8-nt branch point, the 16-nt polypyrimidine tract and the 3-nt 3’ acceptor splice site, defined above. For example, such an Intronic Splicing Enhancer cassette is as presented in Figure 5, and consists of the following nucleic acid sequence: 5’-gagaacattattatagcgttgctcgagtactaactggtacctcttcttttttttc tgcag-3’ (SEQ ID NO: 23). d. Coding Domain. The third component present in a nucleic acid OPA1 pre- mRNA trans-splicing molecule according to the present invention is a coding domain. The term “coding domain”, as used herein, refers to a sequence (e.g., a wild-type or corrected coding sequence of interest) configured to be trans-spliced onto the target OPA1 endogenous pre-mRNA, to replace one or more endogenous, mutated exons in the target pre-mRNA. Preferably, the coding domain comprises a wild-type or corrected coding sequence (usually corresponding to one or more functional OPA1 exons) that is necessary to repair the targeted mutation(s) or defect(s) that cause(s) diseases or disorders associated with OPA1 mutations, in particular the hereditary optic neuropathy of interest such as ADOA, ADOA+ and Behr’ syndrome. Thus, in one embodiment, the coding domain comprises a single exon of the target OPA1 gene, which contains the normal, wild-type sequence lacking the disease-causing mutation. In another embodiment, the coding domain comprises multiple exons of the target OPA1 gene, each exon containing the normal, wild-type sequence lacking the disease-causing mutation. In some embodiments of the present invention, the coding domain includes complementary DNA (cDNA). For example, one or more functional OPA1 exons within the coding domain can be a cDNA sequence. In some embodiments, the entire coding domain is a cDNA sequence. Additionally, or alternatively, all or a portion of the coding domain, or one or more functional OPA1 exons thereof, can be a naturally- occurring (i.e., wild-type) sequence (e.g., a sequence having 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity with an endogenous, normal OPA1 exon. All or a portion of the coding domain, or one or more functional OPA1 exons thereof, is a codon optimized sequence. Codon optimization refers to modifying a nucleic acid sequence to change individual nucleic acids without any resulting change in the encoded amino acid. Sequences modified in this way are referred to herein as “codon-optimized” in which a nucleic acid sequence has been modified, e.g., to enhance expression or stability, without resulting in a change in the encoded amino acid. Codon optimization is known in the art (see for example, U.S Pat. Nos. 7,561,972, 7,561,973, and 7,888,112). The sequence surrounding the translation start site can be converted to a consensus Kozak sequence according to known methods (See, e.g., Kozak et al., Nucleic Acids Res., 1987, 15(20): 8125-8148). For delivery via a recombinant Adeno-Associated Viral (AAV) vector, the coding domain can be a nucleic acid sequence of up to 4,000 nucleotide bases in length (e.g., from 1,000 to 4,000 nucleotide bases in length, from 1,500 to 3,000 nucleotide bases in length, or from 2,000 to 2,500 nucleotide bases in length). In preferred embodiments, the coding domain of a nucleic acid OPA1 3’-pre- mRNA trans-splicing molecule according to the present invention comprises functional OPA1 exons 9-31, i.e., all the exons that are 3’ to the binding region of the binding domain to the OPA1 target (i.e., of intron 8-9). In certain embodiments, the coding domain comprises the following 2013-nt nucleic acid sequence (an optimized and corrective OPA1 cDNA, which corresponds to the wild-type Homo sapiens OPA1 amino acid sequence, encoded by Exon9 to the Stop codon) (in 5’-3’): GTAGTAGTCGTAGGTGATCAGAGTGCTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAA GCTCGAA TATTCCCAAGAGGATCTGGGGAGATGATGACACGTTCTCCAGTTAAGGTGACTCTGAGTG AAGGTCC TCACCATGTGGCCCTATTTAAAGATAGTTCTCGGGAGTTTGATCTTACCAAAGAAGAAGA TCTTGCA GCATTAAGACATGAAATAGAACTTCGAATGAGGAAAAATGTGAAAGAAGGCTGTACCGTT AGCCCTG AGACCATATCCTTAAATGTAAAAGGCCCTGGACTACAGAGGATGGTGCTTGTTGACTTAC CAGGTGT GATTAATACTGTGACATCAGGCATGGCTCCTGACACAAAGGAAACTATTTTCAGTATCAG CAAAGCT TACATGCAGAATCCTAATGCCATCATACTGTGTATTCAAGATGGATCTGTGGATGCTGAA CGCAGTA TTGTTACAGACTTGGTCAGTCAAATGGACCCTCATGGAAGGAGAACCATATTCGTTTTGA CCAAAGT AGACCTGGCAGAGAAAAATGTAGCCAGTCCAAGCAGGATTCAGCAGATAATTGAAGGAAA GCTCTTC CCAATGAAAGCTTTAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAACAGCTCTGAAAGC ATTGAAG CTATAAGAGAATATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTAAAGACAAGCATGC TAAAGGC ACACCAAGTGACTACAAGAAATTTAAGCCTTGCAGTATCAGACTGCTTTTGGAAAATGGT ACGAGAG TCTGTTGAACAACAGGCTGATAGTTTCAAAGCAACACGTTTTAACCTTGAAACTGAATGG AAGAATA ACTATCCTCGCCTGCGGGAACTTGACCGGAATGAACTATTTGAAAAAGCTAAAAATGAAA TCCTTGA TGAAGTTATCAGTCTGAGCCAGGTTACACCAAAACATTGGGAGGAAATCCTTCAACAATC TTTGTGG GAAAGAGTATCAACTCATGTGATTGAAAACATCTACCTTCCAGCTGCGCAGACCATGAAT TCAGGAA CTTTTAACACCACAGTGGATATCAAGCTTAAACAGTGGACTGATAAACAACTTCCTAATA AAGCAGT AGAGGTTGCTTGGGAGACCCTACAAGAAGAATTTTCCCGCTTTATGACAGAACCGAAAGG GAAAGAG CATGATGACATATTTGATAAACTTAAAGAGGCTGTTAAGGAAGAAAGTATTAAACGACAC AAGTGGA ATGACTTTGCGGAGGACAGCTTGAGGGTTATTCAACACAATGCTTTGGAAGACCGATCCA TATCTGA TAAACAGCAATGGGATGCAGCTATTTATTTTATGGAAGAGGCTCTGCAGGCTCGTCTCAA GGATACT GAAAATGCAATTGAAAACATGGTGGGTCCAGACTGGAAAAAGAGGTGGTTATACTGGAAG AATCGGA CCCAAGAACAGTGTGTTCACAATGAAACCAAGAATGAATTGGAGAAGATGTTGAAATGTA ATGAGGA GCACCCAGCTTATCTTGCAAGTGATGAAATAACCACAGTCCGGAAGAACCTTGAATCCCG AGGAGTA GAAGTAGATCCAAGCTTGATTAAGGATACTTGGCATCAAGTTTATAGAAGACATTTTTTA AAAACAG CTCTAAACCATTGTAACCTTTGTCGAAGAGGTTTTTATTACTACCAAAGGCATTTTGTAG ATTCTGA GTTGGAATGCAATGATGTGGTCTTGTTTTGGCGTATACAGCGCATGCTTGCTATCACCGC AAATACT TTAAGGCAACAACTTACAAATACTGAAGTTAGGCGATTAGAGAAAAATGTTAAAGAGGTA TTGGAAG ATTTTGCTGAAGATGGTGAGAAGAAGATTAAATTGCTTACTGGTAAACGCGTTCAACTGG CGGAAGA CCTCAAGAAAGTTAGAGAAATTCAAGAAAAACTTGATGCTTTCATTGAAGCTCTTCATCA GGAGAAA TAA (SEQ ID NO: 24), or a codon-optimized version thereof. This coding domain may be made compatible with the Intronic Splicing Enhancer cassette described above (see SEQ ID NO: 25 presented in the Examples below) e. Optional Components and Modifications of a Nucleic Acid OPA1 pre- mRNA Trans-Splicing Molecule. In certain embodiments, a nucleic acid OPA1 trans- splicing molecule according to the present invention comprises 3’UTR sequences or ribozyme sequences added to the 3’ or 5’ end. In some embodiments, splicing enhancers such as, for example, sequences referred to as exonic splicing enhancers may also be included in the structure of synthetic nucleic acid OPA1 pre-mRNA trans-splicing molecules according to the present invention. Additional features can be added to a pre-mRNA trans-splicing molecule, such as polyadenylation signals to modify RNA expression/stability, additional binding regions, “safety”-self complementary regions, additional splice sites, or protective groups to modulate the stability of the molecule and prevent degradation. In addition, stop codons may be included in the pre-mRNA trans-splicing molecule structure to prevent translation of unspliced pre-mRNA trans-splicing molecules. Further elements such as a 3’ hairpin structure, circularized RNA, nucleotide base modification, or synthetic analogs can be incorporated into a nucleic acid OPA1 pre- mRNA trans-splicing molecule according to the present invention to promote or facilitate nuclear localization and spliceosomal incorporation, and intra-cellular stability. When nucleic acid OPA1 pre-mRNA trans-splicing molecules are synthesized in vitro, such trans-splicing molecules can be modified at the base moiety, sugar moiety, or phosphate backbone, for example, to improve stability of the molecule, hybridization to the target pre-mRNA, transport into the cell and/or nucleus, stability in the cells to enzymatic cleavage, etc. For example, modification of a pre-mRNA trans-splicing molecule to reduce the overall charge can enhance the cellular uptake of the molecule. In addition, modifications can be made to reduce susceptibility to nuclease or chemical degradation. The nucleic acid OPA1 pre-mRNA trans-splicing molecules may be synthesized in such a way as to be conjugated to another molecule, e.g., a peptide, hybridization triggered cross-linking agent, transport agent, hybridization-triggered cleavage agent, etc. Various other well-known modifications to the nucleic acid molecules can be introduced as a means of increasing intracellular stability and half-life. Possible modifications are known to the art. Modifications, which may be made to the structure of synthetic pre-mRNA trans-splicing molecules include backbone modifications. f. Specific Nucleic Acid OPA1 pre-mRNA Trans-Splicing Molecule. The present invention provides several specific nucleic acid OPA1 pre-mRNA trans-splicing molecules, each containing one of the Binding Domains defined above. In particular, the present invention provides several specific nucleic acid OPA1 pre-mRNA trans- splicing molecules, whose sequence, in the 5’-to-3’ direction, consists of: one of the specific Binding Domains defined above, the 27-nt spacer, the 8-nt Branch Point, KpnI (a restriction cloning site), the 16-nt polypyrimidine tract, the 3-nt 3’ acceptor splice site, and the Coding Domain corresponding to the 2013-nt wild-type or codon- optimized Homo sapiens OPA1 cDNA from Exon9 to the STOP codon, as defined above. The specific nucleic acid OPA1 trans-splicing molecules are: - The 2326-nt sequence SEQ ID NO: 26 (designed as OPA1 RTM _th #106 in the Examples section): CCTAATTTTTATTTTAAAAACTTGTGCTAATTTAAACCAGTATTTCTAAAACCAGGTTAT TAAC TTTCCATAAATCTTTTCCATAGCTGCTTCTTTTTTTGCTAATTGGCAAGTTCACTATCAA TTTT TCACATACCTTTATATGTCTTAATATTAGTAATATTTAAATACTGAACAGTGGATTAAAT TAGC TTAAATTTCACGCATATGGCTAGTTTACTGTTTACAAACACATTTTCAATTCTATTAGAA CGAG AACATTATTATAGCGTTGCTCGAGTACTAACTGGTACCTCTTCTTTTTTTTCTGCAGGTA GTAGT CGTAGGTGATCAGAGTGCTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAAT ATTCCCA AGAGGATCTGGGGAGATGATGACACGTTCTCCAGTTAAGGTGACTCTGAGTGAAGGTCCT CACCATG TGGCCCTATTTAAAGATAGTTCTCGGGAGTTTGATCTTACCAAAGAAGAAGATCTTGCAG CATTAAG ACATGAAATAGAACTTCGAATGAGGAAAAATGTGAAAGAAGGCTGTACCGTTAGCCCTGA GACCATA TCCTTAAATGTAAAAGGCCCTGGACTACAGAGGATGGTGCTTGTTGACTTACCAGGTGTG ATTAATA CTGTGACATCAGGCATGGCTCCTGACACAAAGGAAACTATTTTCAGTATCAGCAAAGCTT ACATGCA GAATCCTAATGCCATCATACTGTGTATTCAAGATGGATCTGTGGATGCTGAACGCAGTAT TGTTACA GACTTGGTCAGTCAAATGGACCCTCATGGAAGGAGAACCATATTCGTTTTGACCAAAGTA GACCTGG CAGAGAAAAATGTAGCCAGTCCAAGCAGGATTCAGCAGATAATTGAAGGAAAGCTCTTCC CAATGAA AGCTTTAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAACAGCTCTGAAAGCATTGAAGC TATAAGA GAATATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTAAAGACAAGCATGCTAAAGGCA CACCAAG TGACTACAAGAAATTTAAGCCTTGCAGTATCAGACTGCTTTTGGAAAATGGTACGAGAGT CTGTTGA ACAACAGGCTGATAGTTTCAAAGCAACACGTTTTAACCTTGAAACTGAATGGAAGAATAA CTATCCT CGCCTGCGGGAACTTGACCGGAATGAACTATTTGAAAAAGCTAAAAATGAAATCCTTGAT GAAGTTA TCAGTCTGAGCCAGGTTACACCAAAACATTGGGAGGAAATCCTTCAACAATCTTTGTGGG AAAGAGT ATCAACTCATGTGATTGAAAACATCTACCTTCCAGCTGCGCAGACCATGAATTCAGGAAC TTTTAAC ACCACAGTGGATATCAAGCTTAAACAGTGGACTGATAAACAACTTCCTAATAAAGCAGTA GAGGTTG CTTGGGAGACCCTACAAGAAGAATTTTCCCGCTTTATGACAGAACCGAAAGGGAAAGAGC ATGATGA CATATTTGATAAACTTAAAGAGGCTGTTAAGGAAGAAAGTATTAAACGACACAAGTGGAA TGACTTT GCGGAGGACAGCTTGAGGGTTATTCAACACAATGCTTTGGAAGACCGATCCATATCTGAT AAACAGC AATGGGATGCAGCTATTTATTTTATGGAAGAGGCTCTGCAGGCTCGTCTCAAGGATACTG AAAATGC AATTGAAAACATGGTGGGTCCAGACTGGAAAAAGAGGTGGTTATACTGGAAGAATCGGAC CCAAGAA CAGTGTGTTCACAATGAAACCAAGAATGAATTGGAGAAGATGTTGAAATGTAATGAGGAG CACCCAG CTTATCTTGCAAGTGATGAAATAACCACAGTCCGGAAGAACCTTGAATCCCGAGGAGTAG AAGTAGA TCCAAGCTTGATTAAGGATACTTGGCATCAAGTTTATAGAAGACATTTTTTAAAAACAGC TCTAAAC CATTGTAACCTTTGTCGAAGAGGTTTTTATTACTACCAAAGGCATTTTGTAGATTCTGAG TTGGAAT GCAATGATGTGGTCTTGTTTTGGCGTATACAGCGCATGCTTGCTATCACCGCAAATACTT TAAGGCA ACAACTTACAAATACTGAAGTTAGGCGATTAGAGAAAAATGTTAAAGAGGTATTGGAAGA TTTTGCT GAAGATGGTGAGAAGAAGATTAAATTGCTTACTGGTAAACGCGTTCAACTGGCGGAAGAC CTCAAGA AAGTTAGAGAAATTCAAGAAAAACTTGATGCTTTCATTGAAGCTCTTCATCAGGAGAAAT AA; - The 2131-nt sequence SEQ ID NO: 27 (designed as OPA1 RTMth#114 in the Examples section): CTAATTTAATCCACTGTTCAGTATTTAAATATTACTAATATTAAGACATATAAAGAACGA GAAC ATTATTATAGCGTTGCTCGAGTACTAACTGGTACCTCTTCTTTTTTTTCTGCAGGTAGTA GTCGT AGGTGATCAGAGTGCTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAATATT CCCAAGA GGATCTGGGGAGATGATGACACGTTCTCCAGTTAAGGTGACTCTGAGTGAAGGTCCTCAC CATGTGG CCCTATTTAAAGATAGTTCTCGGGAGTTTGATCTTACCAAAGAAGAAGATCTTGCAGCAT TAAGACA TGAAATAGAACTTCGAATGAGGAAAAATGTGAAAGAAGGCTGTACCGTTAGCCCTGAGAC CATATCC TTAAATGTAAAAGGCCCTGGACTACAGAGGATGGTGCTTGTTGACTTACCAGGTGTGATT AATACTG TGACATCAGGCATGGCTCCTGACACAAAGGAAACTATTTTCAGTATCAGCAAAGCTTACA TGCAGAA TCCTAATGCCATCATACTGTGTATTCAAGATGGATCTGTGGATGCTGAACGCAGTATTGT TACAGAC TTGGTCAGTCAAATGGACCCTCATGGAAGGAGAACCATATTCGTTTTGACCAAAGTAGAC CTGGCAG AGAAAAATGTAGCCAGTCCAAGCAGGATTCAGCAGATAATTGAAGGAAAGCTCTTCCCAA TGAAAGC TTTAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAACAGCTCTGAAAGCATTGAAGCTAT AAGAGAA TATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTAAAGACAAGCATGCTAAAGGCACAC CAAGTGA CTACAAGAAATTTAAGCCTTGCAGTATCAGACTGCTTTTGGAAAATGGTACGAGAGTCTG TTGAACA ACAGGCTGATAGTTTCAAAGCAACACGTTTTAACCTTGAAACTGAATGGAAGAATAACTA TCCTCGC CTGCGGGAACTTGACCGGAATGAACTATTTGAAAAAGCTAAAAATGAAATCCTTGATGAA GTTATCA GTCTGAGCCAGGTTACACCAAAACATTGGGAGGAAATCCTTCAACAATCTTTGTGGGAAA GAGTATC AACTCATGTGATTGAAAACATCTACCTTCCAGCTGCGCAGACCATGAATTCAGGAACTTT TAACACC ACAGTGGATATCAAGCTTAAACAGTGGACTGATAAACAACTTCCTAATAAAGCAGTAGAG GTTGCTT GGGAGACCCTACAAGAAGAATTTTCCCGCTTTATGACAGAACCGAAAGGGAAAGAGCATG ATGACAT ATTTGATAAACTTAAAGAGGCTGTTAAGGAAGAAAGTATTAAACGACACAAGTGGAATGA CTTTGCG GAGGACAGCTTGAGGGTTATTCAACACAATGCTTTGGAAGACCGATCCATATCTGATAAA CAGCAAT GGGATGCAGCTATTTATTTTATGGAAGAGGCTCTGCAGGCTCGTCTCAAGGATACTGAAA ATGCAAT TGAAAACATGGTGGGTCCAGACTGGAAAAAGAGGTGGTTATACTGGAAGAATCGGACCCA AGAACAG TGTGTTCACAATGAAACCAAGAATGAATTGGAGAAGATGTTGAAATGTAATGAGGAGCAC CCAGCTT ATCTTGCAAGTGATGAAATAACCACAGTCCGGAAGAACCTTGAATCCCGAGGAGTAGAAG TAGATCC AAGCTTGATTAAGGATACTTGGCATCAAGTTTATAGAAGACATTTTTTAAAAACAGCTCT AAACCAT TGTAACCTTTGTCGAAGAGGTTTTTATTACTACCAAAGGCATTTTGTAGATTCTGAGTTG GAATGCA ATGATGTGGTCTTGTTTTGGCGTATACAGCGCATGCTTGCTATCACCGCAAATACTTTAA GGCAACA ACTTACAAATACTGAAGTTAGGCGATTAGAGAAAAATGTTAAAGAGGTATTGGAAGATTT TGCTGAA GATGGTGAGAAGAAGATTAAATTGCTTACTGGTAAACGCGTTCAACTGGCGGAAGACCTC AAGAAAG TTAGAGAAATTCAAGAAAAACTTGATGCTTTCATTGAAGCTCTTCATCAGGAGAAATAA; - The 2162-nt sequence SEQ ID NO: 28 (designed as OPA1 RTMth#128 in the Examples section): CCTAATTTTTATTTTAAAAACTTGTGCTAATTTAAACCAGTATTTCTAAAACCAGGTTAT TAAC TTTCCATAAATCTTTTCCATAGAACGAGAACATTATTATAGCGTTGCTCGAGTACTAACT GGTA CCTCTTCTTTTTTTTCTGCAGGTAGTAGTCGTAGGTGATCAGAGTGCTGGAAAGACTAGT GTGTTG GAAATGATTGCCCAAGCTCGAATATTCCCAAGAGGATCTGGGGAGATGATGACACGTTCT CCAGTTA AGGTGACTCTGAGTGAAGGTCCTCACCATGTGGCCCTATTTAAAGATAGTTCTCGGGAGT TTGATCT TACCAAAGAAGAAGATCTTGCAGCATTAAGACATGAAATAGAACTTCGAATGAGGAAAAA TGTGAAA GAAGGCTGTACCGTTAGCCCTGAGACCATATCCTTAAATGTAAAAGGCCCTGGACTACAG AGGATGG TGCTTGTTGACTTACCAGGTGTGATTAATACTGTGACATCAGGCATGGCTCCTGACACAA AGGAAAC TATTTTCAGTATCAGCAAAGCTTACATGCAGAATCCTAATGCCATCATACTGTGTATTCA AGATGGA TCTGTGGATGCTGAACGCAGTATTGTTACAGACTTGGTCAGTCAAATGGACCCTCATGGA AGGAGAA CCATATTCGTTTTGACCAAAGTAGACCTGGCAGAGAAAAATGTAGCCAGTCCAAGCAGGA TTCAGCA GATAATTGAAGGAAAGCTCTTCCCAATGAAAGCTTTAGGTTATTTTGCTGTTGTAACAGG AAAAGGG AACAGCTCTGAAAGCATTGAAGCTATAAGAGAATATGAAGAAGAGTTTTTTCAGAATTCA AAGCTCC TAAAGACAAGCATGCTAAAGGCACACCAAGTGACTACAAGAAATTTAAGCCTTGCAGTAT CAGACTG CTTTTGGAAAATGGTACGAGAGTCTGTTGAACAACAGGCTGATAGTTTCAAAGCAACACG TTTTAAC CTTGAAACTGAATGGAAGAATAACTATCCTCGCCTGCGGGAACTTGACCGGAATGAACTA TTTGAAA AAGCTAAAAATGAAATCCTTGATGAAGTTATCAGTCTGAGCCAGGTTACACCAAAACATT GGGAGGA AATCCTTCAACAATCTTTGTGGGAAAGAGTATCAACTCATGTGATTGAAAACATCTACCT TCCAGCT GCGCAGACCATGAATTCAGGAACTTTTAACACCACAGTGGATATCAAGCTTAAACAGTGG ACTGATA AACAACTTCCTAATAAAGCAGTAGAGGTTGCTTGGGAGACCCTACAAGAAGAATTTTCCC GCTTTAT GACAGAACCGAAAGGGAAAGAGCATGATGACATATTTGATAAACTTAAAGAGGCTGTTAA GGAAGAA AGTATTAAACGACACAAGTGGAATGACTTTGCGGAGGACAGCTTGAGGGTTATTCAACAC AATGCTT TGGAAGACCGATCCATATCTGATAAACAGCAATGGGATGCAGCTATTTATTTTATGGAAG AGGCTCT GCAGGCTCGTCTCAAGGATACTGAAAATGCAATTGAAAACATGGTGGGTCCAGACTGGAA AAAGAGG TGGTTATACTGGAAGAATCGGACCCAAGAACAGTGTGTTCACAATGAAACCAAGAATGAA TTGGAGA AGATGTTGAAATGTAATGAGGAGCACCCAGCTTATCTTGCAAGTGATGAAATAACCACAG TCCGGAA GAACCTTGAATCCCGAGGAGTAGAAGTAGATCCAAGCTTGATTAAGGATACTTGGCATCA AGTTTAT AGAAGACATTTTTTAAAAACAGCTCTAAACCATTGTAACCTTTGTCGAAGAGGTTTTTAT TACTACC AAAGGCATTTTGTAGATTCTGAGTTGGAATGCAATGATGTGGTCTTGTTTTGGCGTATAC AGCGCAT GCTTGCTATCACCGCAAATACTTTAAGGCAACAACTTACAAATACTGAAGTTAGGCGATT AGAGAAA AATGTTAAAGAGGTATTGGAAGATTTTGCTGAAGATGGTGAGAAGAAGATTAAATTGCTT ACTGGTA AACGCGTTCAACTGGCGGAAGACCTCAAGAAAGTTAGAGAAATTCAAGAAAAACTTGATG CTTTCAT TGAAGCTCTTCATCAGGAGAAATAA; - The 2181-nt acid sequence SEQ ID NO: 29 (designed as OPA1 RTMth#135 in the Examples section): CTGCTTCTTTTTTTGCTAATTGGCAAGTTCACTATCAATTTTTCACATACCTTTATATGT CTTA ATATTAGTAATATTTAAATACTGAACAGTGGATTAAATTAGAACGAGAACATTATTATAG CGTT GCTCGAGTACTAACTGGTACCTCTTCTTTTTTTTCTGCAGGTAGTAGTCGTAGGTGATCA GAGTG CTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAGAGGATCTG GGGAGAT GATGACACGTTCTCCAGTTAAGGTGACTCTGAGTGAAGGTCCTCACCATGTGGCCCTATT TAAAGAT AGTTCTCGGGAGTTTGATCTTACCAAAGAAGAAGATCTTGCAGCATTAAGACATGAAATA GAACTTC GAATGAGGAAAAATGTGAAAGAAGGCTGTACCGTTAGCCCTGAGACCATATCCTTAAATG TAAAAGG CCCTGGACTACAGAGGATGGTGCTTGTTGACTTACCAGGTGTGATTAATACTGTGACATC AGGCATG GCTCCTGACACAAAGGAAACTATTTTCAGTATCAGCAAAGCTTACATGCAGAATCCTAAT GCCATCA TACTGTGTATTCAAGATGGATCTGTGGATGCTGAACGCAGTATTGTTACAGACTTGGTCA GTCAAAT GGACCCTCATGGAAGGAGAACCATATTCGTTTTGACCAAAGTAGACCTGGCAGAGAAAAA TGTAGCC AGTCCAAGCAGGATTCAGCAGATAATTGAAGGAAAGCTCTTCCCAATGAAAGCTTTAGGT TATTTTG CTGTTGTAACAGGAAAAGGGAACAGCTCTGAAAGCATTGAAGCTATAAGAGAATATGAAG AAGAGTT TTTTCAGAATTCAAAGCTCCTAAAGACAAGCATGCTAAAGGCACACCAAGTGACTACAAG AAATTTA AGCCTTGCAGTATCAGACTGCTTTTGGAAAATGGTACGAGAGTCTGTTGAACAACAGGCT GATAGTT TCAAAGCAACACGTTTTAACCTTGAAACTGAATGGAAGAATAACTATCCTCGCCTGCGGG AACTTGA CCGGAATGAACTATTTGAAAAAGCTAAAAATGAAATCCTTGATGAAGTTATCAGTCTGAG CCAGGTT ACACCAAAACATTGGGAGGAAATCCTTCAACAATCTTTGTGGGAAAGAGTATCAACTCAT GTGATTG AAAACATCTACCTTCCAGCTGCGCAGACCATGAATTCAGGAACTTTTAACACCACAGTGG ATATCAA GCTTAAACAGTGGACTGATAAACAACTTCCTAATAAAGCAGTAGAGGTTGCTTGGGAGAC CCTACAA GAAGAATTTTCCCGCTTTATGACAGAACCGAAAGGGAAAGAGCATGATGACATATTTGAT AAACTTA AAGAGGCTGTTAAGGAAGAAAGTATTAAACGACACAAGTGGAATGACTTTGCGGAGGACA GCTTGAG GGTTATTCAACACAATGCTTTGGAAGACCGATCCATATCTGATAAACAGCAATGGGATGC AGCTATT TATTTTATGGAAGAGGCTCTGCAGGCTCGTCTCAAGGATACTGAAAATGCAATTGAAAAC ATGGTGG GTCCAGACTGGAAAAAGAGGTGGTTATACTGGAAGAATCGGACCCAAGAACAGTGTGTTC ACAATGA AACCAAGAATGAATTGGAGAAGATGTTGAAATGTAATGAGGAGCACCCAGCTTATCTTGC AAGTGAT GAAATAACCACAGTCCGGAAGAACCTTGAATCCCGAGGAGTAGAAGTAGATCCAAGCTTG ATTAAGG ATACTTGGCATCAAGTTTATAGAAGACATTTTTTAAAAACAGCTCTAAACCATTGTAACC TTTGTCG AAGAGGTTTTTATTACTACCAAAGGCATTTTGTAGATTCTGAGTTGGAATGCAATGATGT GGTCTTG TTTTGGCGTATACAGCGCATGCTTGCTATCACCGCAAATACTTTAAGGCAACAACTTACA AATACTG AAGTTAGGCGATTAGAGAAAAATGTTAAAGAGGTATTGGAAGATTTTGCTGAAGATGGTG AGAAGAA GATTAAATTGCTTACTGGTAAACGCGTTCAACTGGCGGAAGACCTCAAGAAAGTTAGAGA AATTCAA GAAAAACTTGATGCTTTCATTGAAGCTCTTCATCAGGAGAAATAA; - The 2219-nt sequence SEQ ID NO: 30 (designed as OPA1 RTM _th #162 in the Examples section): TAATGCTGCTCTGAGTTTTTTAGTCTTTTAAAATTTCTACAGGTGAAAAAATATTTTAAA ATCC GTAAAAAAATGGTGATTGATGCATGTGTGCACATTGAAAATAGGAACAGCAAAACTATAA CTGGA TCCACTGTTTATAGAACGAGAACATTATTATAGCGTTGCTCGAGTACTAACTGGTACCTC TTCTT TTTTTTCTGCAGGTAGTAGTCGTAGGTGATCAGAGTGCTGGAAAGACTAGTGTGTTGGAA ATGATT GCCCAAGCTCGAATATTCCCAAGAGGATCTGGGGAGATGATGACACGTTCTCCAGTTAAG GTGACTC TGAGTGAAGGTCCTCACCATGTGGCCCTATTTAAAGATAGTTCTCGGGAGTTTGATCTTA CCAAAGA AGAAGATCTTGCAGCATTAAGACATGAAATAGAACTTCGAATGAGGAAAAATGTGAAAGA AGGCTGT ACCGTTAGCCCTGAGACCATATCCTTAAATGTAAAAGGCCCTGGACTACAGAGGATGGTG CTTGTTG ACTTACCAGGTGTGATTAATACTGTGACATCAGGCATGGCTCCTGACACAAAGGAAACTA TTTTCAG TATCAGCAAAGCTTACATGCAGAATCCTAATGCCATCATACTGTGTATTCAAGATGGATC TGTGGAT GCTGAACGCAGTATTGTTACAGACTTGGTCAGTCAAATGGACCCTCATGGAAGGAGAACC ATATTCG TTTTGACCAAAGTAGACCTGGCAGAGAAAAATGTAGCCAGTCCAAGCAGGATTCAGCAGA TAATTGA AGGAAAGCTCTTCCCAATGAAAGCTTTAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAA CAGCTCT GAAAGCATTGAAGCTATAAGAGAATATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTA AAGACAA GCATGCTAAAGGCACACCAAGTGACTACAAGAAATTTAAGCCTTGCAGTATCAGACTGCT TTTGGAA AATGGTACGAGAGTCTGTTGAACAACAGGCTGATAGTTTCAAAGCAACACGTTTTAACCT TGAAACT GAATGGAAGAATAACTATCCTCGCCTGCGGGAACTTGACCGGAATGAACTATTTGAAAAA GCTAAAA ATGAAATCCTTGATGAAGTTATCAGTCTGAGCCAGGTTACACCAAAACATTGGGAGGAAA TCCTTCA ACAATCTTTGTGGGAAAGAGTATCAACTCATGTGATTGAAAACATCTACCTTCCAGCTGC GCAGACC ATGAATTCAGGAACTTTTAACACCACAGTGGATATCAAGCTTAAACAGTGGACTGATAAA CAACTTC CTAATAAAGCAGTAGAGGTTGCTTGGGAGACCCTACAAGAAGAATTTTCCCGCTTTATGA CAGAACC GAAAGGGAAAGAGCATGATGACATATTTGATAAACTTAAAGAGGCTGTTAAGGAAGAAAG TATTAAA CGACACAAGTGGAATGACTTTGCGGAGGACAGCTTGAGGGTTATTCAACACAATGCTTTG GAAGACC GATCCATATCTGATAAACAGCAATGGGATGCAGCTATTTATTTTATGGAAGAGGCTCTGC AGGCTCG TCTCAAGGATACTGAAAATGCAATTGAAAACATGGTGGGTCCAGACTGGAAAAAGAGGTG GTTATAC TGGAAGAATCGGACCCAAGAACAGTGTGTTCACAATGAAACCAAGAATGAATTGGAGAAG ATGTTGA AATGTAATGAGGAGCACCCAGCTTATCTTGCAAGTGATGAAATAACCACAGTCCGGAAGA ACCTTGA ATCCCGAGGAGTAGAAGTAGATCCAAGCTTGATTAAGGATACTTGGCATCAAGTTTATAG AAGACAT TTTTTAAAAACAGCTCTAAACCATTGTAACCTTTGTCGAAGAGGTTTTTATTACTACCAA AGGCATT TTGTAGATTCTGAGTTGGAATGCAATGATGTGGTCTTGTTTTGGCGTATACAGCGCATGC TTGCTAT CACCGCAAATACTTTAAGGCAACAACTTACAAATACTGAAGTTAGGCGATTAGAGAAAAA TGTTAAA GAGGTATTGGAAGATTTTGCTGAAGATGGTGAGAAGAAGATTAAATTGCTTACTGGTAAA CGCGTTC AACTGGCGGAAGACCTCAAGAAAGTTAGAGAAATTCAAGAAAAACTTGATGCTTTCATTG AAGCTCT TCATCAGGAGAAATAA; and - The 2185-nt sequence SEQ ID NO: 31 (designed as OPA1 RTM _th #100 in the Examples section): GCAATCATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACCTTC CCAC AAAACAAAGAACACTTATTCATATTTTTCTGATACCATCGATGTTAACGAGAACATTATT ATAG CGTTGCTCGAGTACTAACTGGTACCTCTTCTTTTTTTTCTGCAGGTAGTAGTCGTAGGTG ATCA GAGTGCTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAGAGG ATCT GGGGAGATGATGACACGTTCTCCAGTTAAGGTGACTCTGAGTGAAGGTCCTCACCATGTG GCCC TATTTAAAGATAGTTCTCGGGAGTTTGATCTTACCAAAGAAGAAGATCTTGCAGCATTAA GACA TGAAATAGAACTTCGAATGAGGAAAAATGTGAAAGAAGGCTGTACCGTTAGCCCTGAGAC CATA TCCTTAAATGTAAAAGGCCCTGGACTACAGAGGATGGTGCTTGTTGACTTACCAGGTGTG ATTA ATACTGTGACATCAGGCATGGCTCCTGACACAAAGGAAACTATTTTCAGTATCAGCAAAG CTTA CATGCAGAATCCTAATGCCATCATACTGTGTATTCAAGATGGATCTGTGGATGCTGAACG CAGT ATTGTTACAGACTTGGTCAGTCAAATGGACCCTCATGGAAGGAGAACCATATTCGTTTTG ACCA AAGTAGACCTGGCAGAGAAAAATGTAGCCAGTCCAAGCAGGATTCAGCAGATAATTGAAG GAAA GCTCTTCCCAATGAAAGCTTTAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAACAGCTC TGAA AGCATTGAAGCTATAAGAGAATATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTAAAG ACAA GCATGCTAAAGGCACACCAAGTGACTACAAGAAATTTAAGCCTTGCAGTATCAGACTGCT TTTG GAAAATGGTACGAGAGTCTGTTGAACAACAGGCTGATAGTTTCAAAGCAACACGTTTTAA CCTT GAAACTGAATGGAAGAATAACTATCCTCGCCTGCGGGAACTTGACCGGAATGAACTATTT GAAA AAGCTAAAAATGAAATCCTTGATGAAGTTATCAGTCTGAGCCAGGTTACACCAAAACATT GGGA GGAAATCCTTCAACAATCTTTGTGGGAAAGAGTATCAACTCATGTGATTGAAAACATCTA CCTT CCAGCTGCGCAGACCATGAATTCAGGAACTTTTAACACCACAGTGGATATCAAGCTTAAA CAGT GGACTGATAAACAACTTCCTAATAAAGCAGTAGAGGTTGCTTGGGAGACCCTACAAGAAG AATT TTCCCGCTTTATGACAGAACCGAAAGGGAAAGAGCATGATGACATATTTGATAAACTTAA AGAG GCTGTTAAGGAAGAAAGTATTAAACGACACAAGTGGAATGACTTTGCGGAGGACAGCTTG AGGG TTATTCAACACAATGCTTTGGAAGACCGATCCATATCTGATAAACAGCAATGGGATGCAG CTAT TTATTTTATGGAAGAGGCTCTGCAGGCTCGTCTCAAGGATACTGAAAATGCAATTGAAAA CATG GTGGGTCCAGACTGGAAAAAGAGGTGGTTATACTGGAAGAATCGGACCCAAGAACAGTGT GTTC ACAATGAAACCAAGAATGAATTGGAGAAGATGTTGAAATGTAATGAGGAGCACCCAGCTT ATCT TGCAAGTGATGAAATAACCACAGTCCGGAAGAACCTTGAATCCCGAGGAGTAGAAGTAGA TCCA AGCTTGATTAAGGATACTTGGCATCAAGTTTATAGAAGACATTTTTTAAAAACAGCTCTA AACC ATTGTAACCTTTGTCGAAGAGGTTTTTATTACTACCAAAGGCATTTTGTAGATTCTGAGT TGGA ATGCAATGATGTGGTCTTGTTTTGGCGTATACAGCGCATGCTTGCTATCACCGCAAATAC TTTA AGGCAACAACTTACAAATACTGAAGTTAGGCGATTAGAGAAAAATGTTAAAGAGGTATTG GAAG ATTTTGCTGAAGATGGTGAGAAGAAGATTAAATTGCTTACTGGTAAACGCGTTCAACTGG CGGA AGACCTCAAGAAAGTTAGAGAAATTCAAGAAAAACTTGATGCTTTCATTGAAGCTCTTCA TCAG GAGAAATAA; - The 2215-nt sequence SEQ ID NO: 32 (designed as OPA1 RTMth#130 in the Examples section): CCAGATCCTCTTGGGAATATTCGAGCTTGGGCAATCATTTCCAACACACTAGTCTTTCCA GCAC TCTGATCTCCAACCACAACAACCTTCCCACAAAACAAAGAACACTTATTCATATTTTTCT GATA CCATCGATGTTAACGAGAACATTATTATAGCGTTGCTCGAGTACTAACTGGTACCTCTTC TTTT TTTTCTGCAGGTAGTAGTCGTAGGTGATCAGAGTGCTGGAAAGACTAGTGTGTTGGAAAT GATT GCCCAAGCTCGAATATTCCCAAGAGGATCTGGGGAGATGATGACACGTTCTCCAGTTAAG GTGA CTCTGAGTGAAGGTCCTCACCATGTGGCCCTATTTAAAGATAGTTCTCGGGAGTTTGATC TTAC CAAAGAAGAAGATCTTGCAGCATTAAGACATGAAATAGAACTTCGAATGAGGAAAAATGT GAAA GAAGGCTGTACCGTTAGCCCTGAGACCATATCCTTAAATGTAAAAGGCCCTGGACTACAG AGGA TGGTGCTTGTTGACTTACCAGGTGTGATTAATACTGTGACATCAGGCATGGCTCCTGACA CAAA GGAAACTATTTTCAGTATCAGCAAAGCTTACATGCAGAATCCTAATGCCATCATACTGTG TATT CAAGATGGATCTGTGGATGCTGAACGCAGTATTGTTACAGACTTGGTCAGTCAAATGGAC CCTC ATGGAAGGAGAACCATATTCGTTTTGACCAAAGTAGACCTGGCAGAGAAAAATGTAGCCA GTCC AAGCAGGATTCAGCAGATAATTGAAGGAAAGCTCTTCCCAATGAAAGCTTTAGGTTATTT TGCT GTTGTAACAGGAAAAGGGAACAGCTCTGAAAGCATTGAAGCTATAAGAGAATATGAAGAA GAGT TTTTTCAGAATTCAAAGCTCCTAAAGACAAGCATGCTAAAGGCACACCAAGTGACTACAA GAAA TTTAAGCCTTGCAGTATCAGACTGCTTTTGGAAAATGGTACGAGAGTCTGTTGAACAACA GGCT GATAGTTTCAAAGCAACACGTTTTAACCTTGAAACTGAATGGAAGAATAACTATCCTCGC CTGC GGGAACTTGACCGGAATGAACTATTTGAAAAAGCTAAAAATGAAATCCTTGATGAAGTTA TCAG TCTGAGCCAGGTTACACCAAAACATTGGGAGGAAATCCTTCAACAATCTTTGTGGGAAAG AGTA TCAACTCATGTGATTGAAAACATCTACCTTCCAGCTGCGCAGACCATGAATTCAGGAACT TTTA ACACCACAGTGGATATCAAGCTTAAACAGTGGACTGATAAACAACTTCCTAATAAAGCAG TAGA GGTTGCTTGGGAGACCCTACAAGAAGAATTTTCCCGCTTTATGACAGAACCGAAAGGGAA AGAG CATGATGACATATTTGATAAACTTAAAGAGGCTGTTAAGGAAGAAAGTATTAAACGACAC AAGT GGAATGACTTTGCGGAGGACAGCTTGAGGGTTATTCAACACAATGCTTTGGAAGACCGAT CCAT ATCTGATAAACAGCAATGGGATGCAGCTATTTATTTTATGGAAGAGGCTCTGCAGGCTCG TCTC AAGGATACTGAAAATGCAATTGAAAACATGGTGGGTCCAGACTGGAAAAAGAGGTGGTTA TACT GGAAGAATCGGACCCAAGAACAGTGTGTTCACAATGAAACCAAGAATGAATTGGAGAAGA TGTT GAAATGTAATGAGGAGCACCCAGCTTATCTTGCAAGTGATGAAATAACCACAGTCCGGAA GAAC CTTGAATCCCGAGGAGTAGAAGTAGATCCAAGCTTGATTAAGGATACTTGGCATCAAGTT TATA GAAGACATTTTTTAAAAACAGCTCTAAACCATTGTAACCTTTGTCGAAGAGGTTTTTATT ACTA CCAAAGGCATTTTGTAGATTCTGAGTTGGAATGCAATGATGTGGTCTTGTTTTGGCGTAT ACAG CGCATGCTTGCTATCACCGCAAATACTTTAAGGCAACAACTTACAAATACTGAAGTTAGG CGAT TAGAGAAAAATGTTAAAGAGGTATTGGAAGATTTTGCTGAAGATGGTGAGAAGAAGATTA AATT GCTTACTGGTAAACGCGTTCAACTGGCGGAAGACCTCAAGAAAGTTAGAGAAATTCAAGA AAAA CTTGATGCTTTCATTGAAGCTCTTCATCAGGAGAAATAA; - The 2243-nt sequence SEQ ID NO: 33 (designed as OPA1 RTM _th #158 in the Examples section): CTTAACTGGAGAACGTGTCATCATCTCCCCAGATCCTCTTGGGAATATTCGAGCTTGGGC AATC ATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACCTTCCCACAA AACA AAGAACACTTATTCATATTTTTCTGATACCATCGATGTTAACGAGAACATTATTATAGCG TTGC TCGAGTACTAACTGGTACCTCTTCTTTTTTTTCTGCAGGTAGTAGTCGTAGGTGATCAGA GTGC TGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAGAGGATCTGG GGAG ATGATGACACGTTCTCCAGTTAAGGTGACTCTGAGTGAAGGTCCTCACCATGTGGCCCTA TTTA AAGATAGTTCTCGGGAGTTTGATCTTACCAAAGAAGAAGATCTTGCAGCATTAAGACATG AAAT AGAACTTCGAATGAGGAAAAATGTGAAAGAAGGCTGTACCGTTAGCCCTGAGACCATATC CTTA AATGTAAAAGGCCCTGGACTACAGAGGATGGTGCTTGTTGACTTACCAGGTGTGATTAAT ACTG TGACATCAGGCATGGCTCCTGACACAAAGGAAACTATTTTCAGTATCAGCAAAGCTTACA TGCA GAATCCTAATGCCATCATACTGTGTATTCAAGATGGATCTGTGGATGCTGAACGCAGTAT TGTT ACAGACTTGGTCAGTCAAATGGACCCTCATGGAAGGAGAACCATATTCGTTTTGACCAAA GTAG ACCTGGCAGAGAAAAATGTAGCCAGTCCAAGCAGGATTCAGCAGATAATTGAAGGAAAGC TCTT CCCAATGAAAGCTTTAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAACAGCTCTGAAAG CATT GAAGCTATAAGAGAATATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTAAAGACAAGC ATGC TAAAGGCACACCAAGTGACTACAAGAAATTTAAGCCTTGCAGTATCAGACTGCTTTTGGA AAAT GGTACGAGAGTCTGTTGAACAACAGGCTGATAGTTTCAAAGCAACACGTTTTAACCTTGA AACT GAATGGAAGAATAACTATCCTCGCCTGCGGGAACTTGACCGGAATGAACTATTTGAAAAA GCTA AAAATGAAATCCTTGATGAAGTTATCAGTCTGAGCCAGGTTACACCAAAACATTGGGAGG AAAT CCTTCAACAATCTTTGTGGGAAAGAGTATCAACTCATGTGATTGAAAACATCTACCTTCC AGCT GCGCAGACCATGAATTCAGGAACTTTTAACACCACAGTGGATATCAAGCTTAAACAGTGG ACTG ATAAACAACTTCCTAATAAAGCAGTAGAGGTTGCTTGGGAGACCCTACAAGAAGAATTTT CCCG CTTTATGACAGAACCGAAAGGGAAAGAGCATGATGACATATTTGATAAACTTAAAGAGGC TGTT AAGGAAGAAAGTATTAAACGACACAAGTGGAATGACTTTGCGGAGGACAGCTTGAGGGTT ATTC AACACAATGCTTTGGAAGACCGATCCATATCTGATAAACAGCAATGGGATGCAGCTATTT ATTT TATGGAAGAGGCTCTGCAGGCTCGTCTCAAGGATACTGAAAATGCAATTGAAAACATGGT GGGT CCAGACTGGAAAAAGAGGTGGTTATACTGGAAGAATCGGACCCAAGAACAGTGTGTTCAC AATG AAACCAAGAATGAATTGGAGAAGATGTTGAAATGTAATGAGGAGCACCCAGCTTATCTTG CAAG TGATGAAATAACCACAGTCCGGAAGAACCTTGAATCCCGAGGAGTAGAAGTAGATCCAAG CTTG ATTAAGGATACTTGGCATCAAGTTTATAGAAGACATTTTTTAAAAACAGCTCTAAACCAT TGTA ACCTTTGTCGAAGAGGTTTTTATTACTACCAAAGGCATTTTGTAGATTCTGAGTTGGAAT GCAA TGATGTGGTCTTGTTTTGGCGTATACAGCGCATGCTTGCTATCACCGCAAATACTTTAAG GCAA CAACTTACAAATACTGAAGTTAGGCGATTAGAGAAAAATGTTAAAGAGGTATTGGAAGAT TTTG CTGAAGATGGTGAGAAGAAGATTAAATTGCTTACTGGTAAACGCGTTCAACTGGCGGAAG ACCT CAAGAAAGTTAGAGAAATTCAAGAAAAACTTGATGCTTTCATTGAAGCTCTTCATCAGGA GAAA TAA; - The 2251-nt sequence SEQ ID NO: 34 (designed as OPA1 RTM _th #166 in the Examples section): GCAATCATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACCTTC CCAC AAAACAAAGAACACTTATTCATATTTTTCTGATACCAAATTAAAATTAAAACCTATTTGT AATG CTGCTCTGAGTTTTTTAGTCTTTTAAAATTTCTACAGGATCGATGTTAACGAGAACATTA TTAT AGCGTTGCTCGAGTACTAACTGGTACCTCTTCTTTTTTTTCTGCAGGTAGTAGTCGTAGG TGAT CAGAGTGCTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAGA GGAT CTGGGGAGATGATGACACGTTCTCCAGTTAAGGTGACTCTGAGTGAAGGTCCTCACCATG TGGC CCTATTTAAAGATAGTTCTCGGGAGTTTGATCTTACCAAAGAAGAAGATCTTGCAGCATT AAGA CATGAAATAGAACTTCGAATGAGGAAAAATGTGAAAGAAGGCTGTACCGTTAGCCCTGAG ACCA TATCCTTAAATGTAAAAGGCCCTGGACTACAGAGGATGGTGCTTGTTGACTTACCAGGTG TGAT TAATACTGTGACATCAGGCATGGCTCCTGACACAAAGGAAACTATTTTCAGTATCAGCAA AGCT TACATGCAGAATCCTAATGCCATCATACTGTGTATTCAAGATGGATCTGTGGATGCTGAA CGCA GTATTGTTACAGACTTGGTCAGTCAAATGGACCCTCATGGAAGGAGAACCATATTCGTTT TGAC CAAAGTAGACCTGGCAGAGAAAAATGTAGCCAGTCCAAGCAGGATTCAGCAGATAATTGA AGGA AAGCTCTTCCCAATGAAAGCTTTAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAACAGC TCTG AAAGCATTGAAGCTATAAGAGAATATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTAA AGAC AAGCATGCTAAAGGCACACCAAGTGACTACAAGAAATTTAAGCCTTGCAGTATCAGACTG CTTT TGGAAAATGGTACGAGAGTCTGTTGAACAACAGGCTGATAGTTTCAAAGCAACACGTTTT AACC TTGAAACTGAATGGAAGAATAACTATCCTCGCCTGCGGGAACTTGACCGGAATGAACTAT TTGA AAAAGCTAAAAATGAAATCCTTGATGAAGTTATCAGTCTGAGCCAGGTTACACCAAAACA TTGG GAGGAAATCCTTCAACAATCTTTGTGGGAAAGAGTATCAACTCATGTGATTGAAAACATC TACC TTCCAGCTGCGCAGACCATGAATTCAGGAACTTTTAACACCACAGTGGATATCAAGCTTA AACA GTGGACTGATAAACAACTTCCTAATAAAGCAGTAGAGGTTGCTTGGGAGACCCTACAAGA AGAA TTTTCCCGCTTTATGACAGAACCGAAAGGGAAAGAGCATGATGACATATTTGATAAACTT AAAG AGGCTGTTAAGGAAGAAAGTATTAAACGACACAAGTGGAATGACTTTGCGGAGGACAGCT TGAG GGTTATTCAACACAATGCTTTGGAAGACCGATCCATATCTGATAAACAGCAATGGGATGC AGCT ATTTATTTTATGGAAGAGGCTCTGCAGGCTCGTCTCAAGGATACTGAAAATGCAATTGAA AACA TGGTGGGTCCAGACTGGAAAAAGAGGTGGTTATACTGGAAGAATCGGACCCAAGAACAGT GTGT TCACAATGAAACCAAGAATGAATTGGAGAAGATGTTGAAATGTAATGAGGAGCACCCAGC TTAT CTTGCAAGTGATGAAATAACCACAGTCCGGAAGAACCTTGAATCCCGAGGAGTAGAAGTA GATC CAAGCTTGATTAAGGATACTTGGCATCAAGTTTATAGAAGACATTTTTTAAAAACAGCTC TAAA CCATTGTAACCTTTGTCGAAGAGGTTTTTATTACTACCAAAGGCATTTTGTAGATTCTGA GTTG GAATGCAATGATGTGGTCTTGTTTTGGCGTATACAGCGCATGCTTGCTATCACCGCAAAT ACTT TAAGGCAACAACTTACAAATACTGAAGTTAGGCGATTAGAGAAAAATGTTAAAGAGGTAT TGGA AGATTTTGCTGAAGATGGTGAGAAGAAGATTAAATTGCTTACTGGTAAACGCGTTCAACT GGCG GAAGACCTCAAGAAAGTTAGAGAAATTCAAGAAAAACTTGATGCTTTCATTGAAGCTCTT CATC AGGAGAAATAA; - The 2281-nt sequence SEQ ID NO: 35 (designed as OPA1 RTMth#196 in the Examples section): CCAGATCCTCTTGGGAATATTCGAGCTTGGGCAATCATTTCCAACACACTAGTCTTTCCA GCAC TCTGATCTCCAACCACAACAACCTTCCCACAAAACAAAGAACACTTATTCATATTTTTCT GATA CCAAATTAAAATTAAAACCTATTTGTAATGCTGCTCTGAGTTTTTTAGTCTTTTAAAATT TCTA CAGGATCGATGTTAACGAGAACATTATTATAGCGTTGCTCGAGTACTAACTGGTACCTCT TCTT TTTTTTCTGCAGGTAGTAGTCGTAGGTGATCAGAGTGCTGGAAAGACTAGTGTGTTGGAA ATGA TTGCCCAAGCTCGAATATTCCCAAGAGGATCTGGGGAGATGATGACACGTTCTCCAGTTA AGGT GACTCTGAGTGAAGGTCCTCACCATGTGGCCCTATTTAAAGATAGTTCTCGGGAGTTTGA TCTT ACCAAAGAAGAAGATCTTGCAGCATTAAGACATGAAATAGAACTTCGAATGAGGAAAAAT GTGA AAGAAGGCTGTACCGTTAGCCCTGAGACCATATCCTTAAATGTAAAAGGCCCTGGACTAC AGAG GATGGTGCTTGTTGACTTACCAGGTGTGATTAATACTGTGACATCAGGCATGGCTCCTGA CACA AAGGAAACTATTTTCAGTATCAGCAAAGCTTACATGCAGAATCCTAATGCCATCATACTG TGTA TTCAAGATGGATCTGTGGATGCTGAACGCAGTATTGTTACAGACTTGGTCAGTCAAATGG ACCC TCATGGAAGGAGAACCATATTCGTTTTGACCAAAGTAGACCTGGCAGAGAAAAATGTAGC CAGT CCAAGCAGGATTCAGCAGATAATTGAAGGAAAGCTCTTCCCAATGAAAGCTTTAGGTTAT TTTG CTGTTGTAACAGGAAAAGGGAACAGCTCTGAAAGCATTGAAGCTATAAGAGAATATGAAG AAGA GTTTTTTCAGAATTCAAAGCTCCTAAAGACAAGCATGCTAAAGGCACACCAAGTGACTAC AAGA AATTTAAGCCTTGCAGTATCAGACTGCTTTTGGAAAATGGTACGAGAGTCTGTTGAACAA CAGG CTGATAGTTTCAAAGCAACACGTTTTAACCTTGAAACTGAATGGAAGAATAACTATCCTC GCCT GCGGGAACTTGACCGGAATGAACTATTTGAAAAAGCTAAAAATGAAATCCTTGATGAAGT TATC AGTCTGAGCCAGGTTACACCAAAACATTGGGAGGAAATCCTTCAACAATCTTTGTGGGAA AGAG TATCAACTCATGTGATTGAAAACATCTACCTTCCAGCTGCGCAGACCATGAATTCAGGAA CTTT TAACACCACAGTGGATATCAAGCTTAAACAGTGGACTGATAAACAACTTCCTAATAAAGC AGTA GAGGTTGCTTGGGAGACCCTACAAGAAGAATTTTCCCGCTTTATGACAGAACCGAAAGGG AAAG AGCATGATGACATATTTGATAAACTTAAAGAGGCTGTTAAGGAAGAAAGTATTAAACGAC ACAA GTGGAATGACTTTGCGGAGGACAGCTTGAGGGTTATTCAACACAATGCTTTGGAAGACCG ATCC ATATCTGATAAACAGCAATGGGATGCAGCTATTTATTTTATGGAAGAGGCTCTGCAGGCT CGTC TCAAGGATACTGAAAATGCAATTGAAAACATGGTGGGTCCAGACTGGAAAAAGAGGTGGT TATA CTGGAAGAATCGGACCCAAGAACAGTGTGTTCACAATGAAACCAAGAATGAATTGGAGAA GATG TTGAAATGTAATGAGGAGCACCCAGCTTATCTTGCAAGTGATGAAATAACCACAGTCCGG AAGA ACCTTGAATCCCGAGGAGTAGAAGTAGATCCAAGCTTGATTAAGGATACTTGGCATCAAG TTTA TAGAAGACATTTTTTAAAAACAGCTCTAAACCATTGTAACCTTTGTCGAAGAGGTTTTTA TTAC TACCAAAGGCATTTTGTAGATTCTGAGTTGGAATGCAATGATGTGGTCTTGTTTTGGCGT ATAC AGCGCATGCTTGCTATCACCGCAAATACTTTAAGGCAACAACTTACAAATACTGAAGTTA GGCG ATTAGAGAAAAATGTTAAAGAGGTATTGGAAGATTTTGCTGAAGATGGTGAGAAGAAGAT TAAA TTGCTTACTGGTAAACGCGTTCAACTGGCGGAAGACCTCAAGAAAGTTAGAGAAATTCAA GAAA AACTTGATGCTTTCATTGAAGCTCTTCATCAGGAGAAATAA; - The 2309-nt sequence SEQ ID NO: 36 (designed as OPA1 RTMth#224 in the Examples section): CTTAACTGGAGAACGTGTCATCATCTCCCCAGATCCTCTTGGGAATATTCGAGCTTGGGC AATC ATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACCTTCCCACAA AACA AAGAACACTTATTCATATTTTTCTGATACCAAATTAAAATTAAAACCTATTTGTAATGCT GCTC TGAGTTTTTTAGTCTTTTAAAATTTCTACAGGATCGATGTTAACGAGAACATTATTATAG CGTT GCTCGAGTACTAACTGGTACCTCTTCTTTTTTTTCTGCAGGTAGTAGTCGTAGGTGATCA GAGT GCTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAGAGGATCT GGGG AGATGATGACACGTTCTCCAGTTAAGGTGACTCTGAGTGAAGGTCCTCACCATGTGGCCC TATT TAAAGATAGTTCTCGGGAGTTTGATCTTACCAAAGAAGAAGATCTTGCAGCATTAAGACA TGAA ATAGAACTTCGAATGAGGAAAAATGTGAAAGAAGGCTGTACCGTTAGCCCTGAGACCATA TCCT TAAATGTAAAAGGCCCTGGACTACAGAGGATGGTGCTTGTTGACTTACCAGGTGTGATTA ATAC TGTGACATCAGGCATGGCTCCTGACACAAAGGAAACTATTTTCAGTATCAGCAAAGCTTA CATG CAGAATCCTAATGCCATCATACTGTGTATTCAAGATGGATCTGTGGATGCTGAACGCAGT ATTG TTACAGACTTGGTCAGTCAAATGGACCCTCATGGAAGGAGAACCATATTCGTTTTGACCA AAGT AGACCTGGCAGAGAAAAATGTAGCCAGTCCAAGCAGGATTCAGCAGATAATTGAAGGAAA GCTC TTCCCAATGAAAGCTTTAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAACAGCTCTGAA AGCA TTGAAGCTATAAGAGAATATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTAAAGACAA GCAT GCTAAAGGCACACCAAGTGACTACAAGAAATTTAAGCCTTGCAGTATCAGACTGCTTTTG GAAA ATGGTACGAGAGTCTGTTGAACAACAGGCTGATAGTTTCAAAGCAACACGTTTTAACCTT GAAA CTGAATGGAAGAATAACTATCCTCGCCTGCGGGAACTTGACCGGAATGAACTATTTGAAA AAGC TAAAAATGAAATCCTTGATGAAGTTATCAGTCTGAGCCAGGTTACACCAAAACATTGGGA GGAA ATCCTTCAACAATCTTTGTGGGAAAGAGTATCAACTCATGTGATTGAAAACATCTACCTT CCAG CTGCGCAGACCATGAATTCAGGAACTTTTAACACCACAGTGGATATCAAGCTTAAACAGT GGAC TGATAAACAACTTCCTAATAAAGCAGTAGAGGTTGCTTGGGAGACCCTACAAGAAGAATT TTCC CGCTTTATGACAGAACCGAAAGGGAAAGAGCATGATGACATATTTGATAAACTTAAAGAG GCTG TTAAGGAAGAAAGTATTAAACGACACAAGTGGAATGACTTTGCGGAGGACAGCTTGAGGG TTAT TCAACACAATGCTTTGGAAGACCGATCCATATCTGATAAACAGCAATGGGATGCAGCTAT TTAT TTTATGGAAGAGGCTCTGCAGGCTCGTCTCAAGGATACTGAAAATGCAATTGAAAACATG GTGG GTCCAGACTGGAAAAAGAGGTGGTTATACTGGAAGAATCGGACCCAAGAACAGTGTGTTC ACAA TGAAACCAAGAATGAATTGGAGAAGATGTTGAAATGTAATGAGGAGCACCCAGCTTATCT TGCA AGTGATGAAATAACCACAGTCCGGAAGAACCTTGAATCCCGAGGAGTAGAAGTAGATCCA AGCT TGATTAAGGATACTTGGCATCAAGTTTATAGAAGACATTTTTTAAAAACAGCTCTAAACC ATTG TAACCTTTGTCGAAGAGGTTTTTATTACTACCAAAGGCATTTTGTAGATTCTGAGTTGGA ATGC AATGATGTGGTCTTGTTTTGGCGTATACAGCGCATGCTTGCTATCACCGCAAATACTTTA AGGC AACAACTTACAAATACTGAAGTTAGGCGATTAGAGAAAAATGTTAAAGAGGTATTGGAAG ATTT TGCTGAAGATGGTGAGAAGAAGATTAAATTGCTTACTGGTAAACGCGTTCAACTGGCGGA AGAC CTCAAGAAAGTTAGAGAAATTCAAGAAAAACTTGATGCTTTCATTGAAGCTCTTCATCAG GAGA AATAA; - The 2294-nt sequence SEQ ID NO: 37 (designed as OPA1 RTM _th #209 in the Examples section): GCAATCATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACCTTC CCAC AAAACAAAGAACACTTATTCATATTTTTCTGATACCAAATTAAAATTAAAACCTATTTGT AATG CTGCTCTGAGTTTTTTAGTCTTTTAAAATTTCTACAGGTGAAAAAATATTTTAAAATCCG TAAA AAAATGGTGATTGATGCATCGATGTTAACGAGAACATTATTATAGCGTTGCTCGAGTACT AACT GGTACCTCTTCTTTTTTTTCTGCAGGTAGTAGTCGTAGGTGATCAGAGTGCTGGAAAGAC TAGT GTGTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAGAGGATCTGGGGAGATGATGACA CGTT CTCCAGTTAAGGTGACTCTGAGTGAAGGTCCTCACCATGTGGCCCTATTTAAAGATAGTT CTCG GGAGTTTGATCTTACCAAAGAAGAAGATCTTGCAGCATTAAGACATGAAATAGAACTTCG AATG AGGAAAAATGTGAAAGAAGGCTGTACCGTTAGCCCTGAGACCATATCCTTAAATGTAAAA GGCC CTGGACTACAGAGGATGGTGCTTGTTGACTTACCAGGTGTGATTAATACTGTGACATCAG GCAT GGCTCCTGACACAAAGGAAACTATTTTCAGTATCAGCAAAGCTTACATGCAGAATCCTAA TGCC ATCATACTGTGTATTCAAGATGGATCTGTGGATGCTGAACGCAGTATTGTTACAGACTTG GTCA GTCAAATGGACCCTCATGGAAGGAGAACCATATTCGTTTTGACCAAAGTAGACCTGGCAG AGAA AAATGTAGCCAGTCCAAGCAGGATTCAGCAGATAATTGAAGGAAAGCTCTTCCCAATGAA AGCT TTAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAACAGCTCTGAAAGCATTGAAGCTATA AGAG AATATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTAAAGACAAGCATGCTAAAGGCAC ACCA AGTGACTACAAGAAATTTAAGCCTTGCAGTATCAGACTGCTTTTGGAAAATGGTACGAGA GTCT GTTGAACAACAGGCTGATAGTTTCAAAGCAACACGTTTTAACCTTGAAACTGAATGGAAG AATA ACTATCCTCGCCTGCGGGAACTTGACCGGAATGAACTATTTGAAAAAGCTAAAAATGAAA TCCT TGATGAAGTTATCAGTCTGAGCCAGGTTACACCAAAACATTGGGAGGAAATCCTTCAACA ATCT TTGTGGGAAAGAGTATCAACTCATGTGATTGAAAACATCTACCTTCCAGCTGCGCAGACC ATGA ATTCAGGAACTTTTAACACCACAGTGGATATCAAGCTTAAACAGTGGACTGATAAACAAC TTCC TAATAAAGCAGTAGAGGTTGCTTGGGAGACCCTACAAGAAGAATTTTCCCGCTTTATGAC AGAA CCGAAAGGGAAAGAGCATGATGACATATTTGATAAACTTAAAGAGGCTGTTAAGGAAGAA AGTA TTAAACGACACAAGTGGAATGACTTTGCGGAGGACAGCTTGAGGGTTATTCAACACAATG CTTT GGAAGACCGATCCATATCTGATAAACAGCAATGGGATGCAGCTATTTATTTTATGGAAGA GGCT CTGCAGGCTCGTCTCAAGGATACTGAAAATGCAATTGAAAACATGGTGGGTCCAGACTGG AAAA AGAGGTGGTTATACTGGAAGAATCGGACCCAAGAACAGTGTGTTCACAATGAAACCAAGA ATGA ATTGGAGAAGATGTTGAAATGTAATGAGGAGCACCCAGCTTATCTTGCAAGTGATGAAAT AACC ACAGTCCGGAAGAACCTTGAATCCCGAGGAGTAGAAGTAGATCCAAGCTTGATTAAGGAT ACTT GGCATCAAGTTTATAGAAGACATTTTTTAAAAACAGCTCTAAACCATTGTAACCTTTGTC GAAG AGGTTTTTATTACTACCAAAGGCATTTTGTAGATTCTGAGTTGGAATGCAATGATGTGGT CTTG TTTTGGCGTATACAGCGCATGCTTGCTATCACCGCAAATACTTTAAGGCAACAACTTACA AATA CTGAAGTTAGGCGATTAGAGAAAAATGTTAAAGAGGTATTGGAAGATTTTGCTGAAGATG GTGA GAAGAAGATTAAATTGCTTACTGGTAAACGCGTTCAACTGGCGGAAGACCTCAAGAAAGT TAGA GAAATTCAAGAAAAACTTGATGCTTTCATTGAAGCTCTTCATCAGGAGAAATAA; - The 2324-nt sequence SEQ ID NO: 38 (designed as OPA1 RTM _th #239 in the Examples section): CCAGATCCTCTTGGGAATATTCGAGCTTGGGCAATCATTTCCAACACACTAGTCTTTCCA GCAC TCTGATCTCCAACCACAACAACCTTCCCACAAAACAAAGAACACTTATTCATATTTTTCT GATA CCAAATTAAAATTAAAACCTATTTGTAATGCTGCTCTGAGTTTTTTAGTCTTTTAAAATT TCTA CAGGTGAAAAAATATTTTAAAATCCGTAAAAAAATGGTGATTGATGCATCGATGTTAACG AGAA CATTATTATAGCGTTGCTCGAGTACTAACTGGTACCTCTTCTTTTTTTTCTGCAGGTAGT AGTC GTAGGTGATCAGAGTGCTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAATA TTCC CAAGAGGATCTGGGGAGATGATGACACGTTCTCCAGTTAAGGTGACTCTGAGTGAAGGTC CTCA CCATGTGGCCCTATTTAAAGATAGTTCTCGGGAGTTTGATCTTACCAAAGAAGAAGATCT TGCA GCATTAAGACATGAAATAGAACTTCGAATGAGGAAAAATGTGAAAGAAGGCTGTACCGTT AGCC CTGAGACCATATCCTTAAATGTAAAAGGCCCTGGACTACAGAGGATGGTGCTTGTTGACT TACC AGGTGTGATTAATACTGTGACATCAGGCATGGCTCCTGACACAAAGGAAACTATTTTCAG TATC AGCAAAGCTTACATGCAGAATCCTAATGCCATCATACTGTGTATTCAAGATGGATCTGTG GATG CTGAACGCAGTATTGTTACAGACTTGGTCAGTCAAATGGACCCTCATGGAAGGAGAACCA TATT CGTTTTGACCAAAGTAGACCTGGCAGAGAAAAATGTAGCCAGTCCAAGCAGGATTCAGCA GATA ATTGAAGGAAAGCTCTTCCCAATGAAAGCTTTAGGTTATTTTGCTGTTGTAACAGGAAAA GGGA ACAGCTCTGAAAGCATTGAAGCTATAAGAGAATATGAAGAAGAGTTTTTTCAGAATTCAA AGCT CCTAAAGACAAGCATGCTAAAGGCACACCAAGTGACTACAAGAAATTTAAGCCTTGCAGT ATCA GACTGCTTTTGGAAAATGGTACGAGAGTCTGTTGAACAACAGGCTGATAGTTTCAAAGCA ACAC GTTTTAACCTTGAAACTGAATGGAAGAATAACTATCCTCGCCTGCGGGAACTTGACCGGA ATGA ACTATTTGAAAAAGCTAAAAATGAAATCCTTGATGAAGTTATCAGTCTGAGCCAGGTTAC ACCA AAACATTGGGAGGAAATCCTTCAACAATCTTTGTGGGAAAGAGTATCAACTCATGTGATT GAAA ACATCTACCTTCCAGCTGCGCAGACCATGAATTCAGGAACTTTTAACACCACAGTGGATA TCAA GCTTAAACAGTGGACTGATAAACAACTTCCTAATAAAGCAGTAGAGGTTGCTTGGGAGAC CCTA CAAGAAGAATTTTCCCGCTTTATGACAGAACCGAAAGGGAAAGAGCATGATGACATATTT GATA AACTTAAAGAGGCTGTTAAGGAAGAAAGTATTAAACGACACAAGTGGAATGACTTTGCGG AGGA CAGCTTGAGGGTTATTCAACACAATGCTTTGGAAGACCGATCCATATCTGATAAACAGCA ATGG GATGCAGCTATTTATTTTATGGAAGAGGCTCTGCAGGCTCGTCTCAAGGATACTGAAAAT GCAA TTGAAAACATGGTGGGTCCAGACTGGAAAAAGAGGTGGTTATACTGGAAGAATCGGACCC AAGA ACAGTGTGTTCACAATGAAACCAAGAATGAATTGGAGAAGATGTTGAAATGTAATGAGGA GCAC CCAGCTTATCTTGCAAGTGATGAAATAACCACAGTCCGGAAGAACCTTGAATCCCGAGGA GTAG AAGTAGATCCAAGCTTGATTAAGGATACTTGGCATCAAGTTTATAGAAGACATTTTTTAA AAAC AGCTCTAAACCATTGTAACCTTTGTCGAAGAGGTTTTTATTACTACCAAAGGCATTTTGT AGAT TCTGAGTTGGAATGCAATGATGTGGTCTTGTTTTGGCGTATACAGCGCATGCTTGCTATC ACCG CAAATACTTTAAGGCAACAACTTACAAATACTGAAGTTAGGCGATTAGAGAAAAATGTTA AAGA GGTATTGGAAGATTTTGCTGAAGATGGTGAGAAGAAGATTAAATTGCTTACTGGTAAACG CGTT CAACTGGCGGAAGACCTCAAGAAAGTTAGAGAAATTCAAGAAAAACTTGATGCTTTCATT GAAG CTCTTCATCAGGAGAAATAA; - The 2352-nt sequence SEQ ID NO: 39 (designed as OPA1 RTMth#267 in the Examples section): CTTAACTGGAGAACGTGTCATCATCTCCCCAGATCCTCTTGGGAATATTCGAGCTTGGGC AATC ATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACCTTCCCACAA AACA AAGAACACTTATTCATATTTTTCTGATACCAAATTAAAATTAAAACCTATTTGTAATGCT GCTC TGAGTTTTTTAGTCTTTTAAAATTTCTACAGGTGAAAAAATATTTTAAAATCCGTAAAAA AATG GTGATTGATGCATCGATGTTAACGAGAACATTATTATAGCGTTGCTCGAGTACTAACTGG TACC TCTTCTTTTTTTTCTGCAGGTAGTAGTCGTAGGTGATCAGAGTGCTGGAAAGACTAGTGT GTTG GAAATGATTGCCCAAGCTCGAATATTCCCAAGAGGATCTGGGGAGATGATGACACGTTCT CCAG TTAAGGTGACTCTGAGTGAAGGTCCTCACCATGTGGCCCTATTTAAAGATAGTTCTCGGG AGTT TGATCTTACCAAAGAAGAAGATCTTGCAGCATTAAGACATGAAATAGAACTTCGAATGAG GAAA AATGTGAAAGAAGGCTGTACCGTTAGCCCTGAGACCATATCCTTAAATGTAAAAGGCCCT GGAC TACAGAGGATGGTGCTTGTTGACTTACCAGGTGTGATTAATACTGTGACATCAGGCATGG CTCC TGACACAAAGGAAACTATTTTCAGTATCAGCAAAGCTTACATGCAGAATCCTAATGCCAT CATA CTGTGTATTCAAGATGGATCTGTGGATGCTGAACGCAGTATTGTTACAGACTTGGTCAGT CAAA TGGACCCTCATGGAAGGAGAACCATATTCGTTTTGACCAAAGTAGACCTGGCAGAGAAAA ATGT AGCCAGTCCAAGCAGGATTCAGCAGATAATTGAAGGAAAGCTCTTCCCAATGAAAGCTTT AGGT TATTTTGCTGTTGTAACAGGAAAAGGGAACAGCTCTGAAAGCATTGAAGCTATAAGAGAA TATG AAGAAGAGTTTTTTCAGAATTCAAAGCTCCTAAAGACAAGCATGCTAAAGGCACACCAAG TGAC TACAAGAAATTTAAGCCTTGCAGTATCAGACTGCTTTTGGAAAATGGTACGAGAGTCTGT TGAA CAACAGGCTGATAGTTTCAAAGCAACACGTTTTAACCTTGAAACTGAATGGAAGAATAAC TATC CTCGCCTGCGGGAACTTGACCGGAATGAACTATTTGAAAAAGCTAAAAATGAAATCCTTG ATGA AGTTATCAGTCTGAGCCAGGTTACACCAAAACATTGGGAGGAAATCCTTCAACAATCTTT GTGG GAAAGAGTATCAACTCATGTGATTGAAAACATCTACCTTCCAGCTGCGCAGACCATGAAT TCAG GAACTTTTAACACCACAGTGGATATCAAGCTTAAACAGTGGACTGATAAACAACTTCCTA ATAA AGCAGTAGAGGTTGCTTGGGAGACCCTACAAGAAGAATTTTCCCGCTTTATGACAGAACC GAAA GGGAAAGAGCATGATGACATATTTGATAAACTTAAAGAGGCTGTTAAGGAAGAAAGTATT AAAC GACACAAGTGGAATGACTTTGCGGAGGACAGCTTGAGGGTTATTCAACACAATGCTTTGG AAGA CCGATCCATATCTGATAAACAGCAATGGGATGCAGCTATTTATTTTATGGAAGAGGCTCT GCAG GCTCGTCTCAAGGATACTGAAAATGCAATTGAAAACATGGTGGGTCCAGACTGGAAAAAG AGGT GGTTATACTGGAAGAATCGGACCCAAGAACAGTGTGTTCACAATGAAACCAAGAATGAAT TGGA GAAGATGTTGAAATGTAATGAGGAGCACCCAGCTTATCTTGCAAGTGATGAAATAACCAC AGTC CGGAAGAACCTTGAATCCCGAGGAGTAGAAGTAGATCCAAGCTTGATTAAGGATACTTGG CATC AAGTTTATAGAAGACATTTTTTAAAAACAGCTCTAAACCATTGTAACCTTTGTCGAAGAG GTTT TTATTACTACCAAAGGCATTTTGTAGATTCTGAGTTGGAATGCAATGATGTGGTCTTGTT TTGG CGTATACAGCGCATGCTTGCTATCACCGCAAATACTTTAAGGCAACAACTTACAAATACT GAAG TTAGGCGATTAGAGAAAAATGTTAAAGAGGTATTGGAAGATTTTGCTGAAGATGGTGAGA AGAA GATTAAATTGCTTACTGGTAAACGCGTTCAACTGGCGGAAGACCTCAAGAAAGTTAGAGA AATT CAAGAAAAACTTGATGCTTTCATTGAAGCTCTTCATCAGGAGAAATAA; - The 2302-nt sequence SEQ ID NO: 40 (designed as OPA1 RTMth#217 in the Examples section): GCAATCATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACCTTC CCAC AAAACAAAGAACACTTATTCATATTTTTCTGATACCAAATTAAAATTAAAACCTATTTGT AATG CTGCTCTGAGTTTTTTAGTCTTTTAAAATTTCTACAGGTGAAAAAATATTTTAAAATCCG TAAA AAAATGGTGATTGATGCATGTGTGCATCGATGTTAACGAGAACATTATTATAGCGTTGCT CGAG TACTAACTGGTACCTCTTCTTTTTTTTCTGCAGGTAGTAGTCGTAGGTGATCAGAGTGCT GGAA AGACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAGAGGATCTGGGGAGA TGAT GACACGTTCTCCAGTTAAGGTGACTCTGAGTGAAGGTCCTCACCATGTGGCCCTATTTAA AGAT AGTTCTCGGGAGTTTGATCTTACCAAAGAAGAAGATCTTGCAGCATTAAGACATGAAATA GAAC TTCGAATGAGGAAAAATGTGAAAGAAGGCTGTACCGTTAGCCCTGAGACCATATCCTTAA ATGT AAAAGGCCCTGGACTACAGAGGATGGTGCTTGTTGACTTACCAGGTGTGATTAATACTGT GACA TCAGGCATGGCTCCTGACACAAAGGAAACTATTTTCAGTATCAGCAAAGCTTACATGCAG AATC CTAATGCCATCATACTGTGTATTCAAGATGGATCTGTGGATGCTGAACGCAGTATTGTTA CAGA CTTGGTCAGTCAAATGGACCCTCATGGAAGGAGAACCATATTCGTTTTGACCAAAGTAGA CCTG GCAGAGAAAAATGTAGCCAGTCCAAGCAGGATTCAGCAGATAATTGAAGGAAAGCTCTTC CCAA TGAAAGCTTTAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAACAGCTCTGAAAGCATTG AAGC TATAAGAGAATATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTAAAGACAAGCATGCT AAAG GCACACCAAGTGACTACAAGAAATTTAAGCCTTGCAGTATCAGACTGCTTTTGGAAAATG GTAC GAGAGTCTGTTGAACAACAGGCTGATAGTTTCAAAGCAACACGTTTTAACCTTGAAACTG AATG GAAGAATAACTATCCTCGCCTGCGGGAACTTGACCGGAATGAACTATTTGAAAAAGCTAA AAAT GAAATCCTTGATGAAGTTATCAGTCTGAGCCAGGTTACACCAAAACATTGGGAGGAAATC CTTC AACAATCTTTGTGGGAAAGAGTATCAACTCATGTGATTGAAAACATCTACCTTCCAGCTG CGCA GACCATGAATTCAGGAACTTTTAACACCACAGTGGATATCAAGCTTAAACAGTGGACTGA TAAA CAACTTCCTAATAAAGCAGTAGAGGTTGCTTGGGAGACCCTACAAGAAGAATTTTCCCGC TTTA TGACAGAACCGAAAGGGAAAGAGCATGATGACATATTTGATAAACTTAAAGAGGCTGTTA AGGA AGAAAGTATTAAACGACACAAGTGGAATGACTTTGCGGAGGACAGCTTGAGGGTTATTCA ACAC AATGCTTTGGAAGACCGATCCATATCTGATAAACAGCAATGGGATGCAGCTATTTATTTT ATGG AAGAGGCTCTGCAGGCTCGTCTCAAGGATACTGAAAATGCAATTGAAAACATGGTGGGTC CAGA CTGGAAAAAGAGGTGGTTATACTGGAAGAATCGGACCCAAGAACAGTGTGTTCACAATGA AACC AAGAATGAATTGGAGAAGATGTTGAAATGTAATGAGGAGCACCCAGCTTATCTTGCAAGT GATG AAATAACCACAGTCCGGAAGAACCTTGAATCCCGAGGAGTAGAAGTAGATCCAAGCTTGA TTAA GGATACTTGGCATCAAGTTTATAGAAGACATTTTTTAAAAACAGCTCTAAACCATTGTAA CCTT TGTCGAAGAGGTTTTTATTACTACCAAAGGCATTTTGTAGATTCTGAGTTGGAATGCAAT GATG TGGTCTTGTTTTGGCGTATACAGCGCATGCTTGCTATCACCGCAAATACTTTAAGGCAAC AACT TACAAATACTGAAGTTAGGCGATTAGAGAAAAATGTTAAAGAGGTATTGGAAGATTTTGC TGAA GATGGTGAGAAGAAGATTAAATTGCTTACTGGTAAACGCGTTCAACTGGCGGAAGACCTC AAGA AAGTTAGAGAAATTCAAGAAAAACTTGATGCTTTCATTGAAGCTCTTCATCAGGAGAAAT AA; - The 2332-nt sequence SEQ ID NO: 41 (designed as OPA1 RTMth#247 in the Examples section): CCAGATCCTCTTGGGAATATTCGAGCTTGGGCAATCATTTCCAACACACTAGTCTTTCCA GCAC TCTGATCTCCAACCACAACAACCTTCCCACAAAACAAAGAACACTTATTCATATTTTTCT GATA CCAAATTAAAATTAAAACCTATTTGTAATGCTGCTCTGAGTTTTTTAGTCTTTTAAAATT TCTA CAGGTGAAAAAATATTTTAAAATCCGTAAAAAAATGGTGATTGATGCATGTGTGCATCGA TGTT AACGAGAACATTATTATAGCGTTGCTCGAGTACTAACTGGTACCTCTTCTTTTTTTTCTG CAGG TAGTAGTCGTAGGTGATCAGAGTGCTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAG CTCG AATATTCCCAAGAGGATCTGGGGAGATGATGACACGTTCTCCAGTTAAGGTGACTCTGAG TGAA GGTCCTCACCATGTGGCCCTATTTAAAGATAGTTCTCGGGAGTTTGATCTTACCAAAGAA GAAG ATCTTGCAGCATTAAGACATGAAATAGAACTTCGAATGAGGAAAAATGTGAAAGAAGGCT GTAC CGTTAGCCCTGAGACCATATCCTTAAATGTAAAAGGCCCTGGACTACAGAGGATGGTGCT TGTT GACTTACCAGGTGTGATTAATACTGTGACATCAGGCATGGCTCCTGACACAAAGGAAACT ATTT TCAGTATCAGCAAAGCTTACATGCAGAATCCTAATGCCATCATACTGTGTATTCAAGATG GATC TGTGGATGCTGAACGCAGTATTGTTACAGACTTGGTCAGTCAAATGGACCCTCATGGAAG GAGA ACCATATTCGTTTTGACCAAAGTAGACCTGGCAGAGAAAAATGTAGCCAGTCCAAGCAGG ATTC AGCAGATAATTGAAGGAAAGCTCTTCCCAATGAAAGCTTTAGGTTATTTTGCTGTTGTAA CAGG AAAAGGGAACAGCTCTGAAAGCATTGAAGCTATAAGAGAATATGAAGAAGAGTTTTTTCA GAAT TCAAAGCTCCTAAAGACAAGCATGCTAAAGGCACACCAAGTGACTACAAGAAATTTAAGC CTTG CAGTATCAGACTGCTTTTGGAAAATGGTACGAGAGTCTGTTGAACAACAGGCTGATAGTT TCAA AGCAACACGTTTTAACCTTGAAACTGAATGGAAGAATAACTATCCTCGCCTGCGGGAACT TGAC CGGAATGAACTATTTGAAAAAGCTAAAAATGAAATCCTTGATGAAGTTATCAGTCTGAGC CAGG TTACACCAAAACATTGGGAGGAAATCCTTCAACAATCTTTGTGGGAAAGAGTATCAACTC ATGT GATTGAAAACATCTACCTTCCAGCTGCGCAGACCATGAATTCAGGAACTTTTAACACCAC AGTG GATATCAAGCTTAAACAGTGGACTGATAAACAACTTCCTAATAAAGCAGTAGAGGTTGCT TGGG AGACCCTACAAGAAGAATTTTCCCGCTTTATGACAGAACCGAAAGGGAAAGAGCATGATG ACAT ATTTGATAAACTTAAAGAGGCTGTTAAGGAAGAAAGTATTAAACGACACAAGTGGAATGA CTTT GCGGAGGACAGCTTGAGGGTTATTCAACACAATGCTTTGGAAGACCGATCCATATCTGAT AAAC AGCAATGGGATGCAGCTATTTATTTTATGGAAGAGGCTCTGCAGGCTCGTCTCAAGGATA CTGA AAATGCAATTGAAAACATGGTGGGTCCAGACTGGAAAAAGAGGTGGTTATACTGGAAGAA TCGG ACCCAAGAACAGTGTGTTCACAATGAAACCAAGAATGAATTGGAGAAGATGTTGAAATGT AATG AGGAGCACCCAGCTTATCTTGCAAGTGATGAAATAACCACAGTCCGGAAGAACCTTGAAT CCCG AGGAGTAGAAGTAGATCCAAGCTTGATTAAGGATACTTGGCATCAAGTTTATAGAAGACA TTTT TTAAAAACAGCTCTAAACCATTGTAACCTTTGTCGAAGAGGTTTTTATTACTACCAAAGG CATT TTGTAGATTCTGAGTTGGAATGCAATGATGTGGTCTTGTTTTGGCGTATACAGCGCATGC TTGC TATCACCGCAAATACTTTAAGGCAACAACTTACAAATACTGAAGTTAGGCGATTAGAGAA AAAT GTTAAAGAGGTATTGGAAGATTTTGCTGAAGATGGTGAGAAGAAGATTAAATTGCTTACT GGTA AACGCGTTCAACTGGCGGAAGACCTCAAGAAAGTTAGAGAAATTCAAGAAAAACTTGATG CTTT CATTGAAGCTCTTCATCAGGAGAAATAA; and - The 2360-nt sequence SEQ ID NO: 42 (designed as OPA1 RTMth#275 in the Examples section): CTTAACTGGAGAACGTGTCATCATCTCCCCAGATCCTCTTGGGAATATTCGAGCTTGGGC AATC ATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACCTTCCCACAA AACA AAGAACACTTATTCATATTTTTCTGATACCAAATTAAAATTAAAACCTATTTGTAATGCT GCTC TGAGTTTTTTAGTCTTTTAAAATTTCTACAGGTGAAAAAATATTTTAAAATCCGTAAAAA AATG GTGATTGATGCATGTGTGCATCGATGTTAACGAGAACATTATTATAGCGTTGCTCGAGTA CTAA CTGGTACCTCTTCTTTTTTTTCTGCAGGTAGTAGTCGTAGGTGATCAGAGTGCTGGAAAG ACTA GTGTGTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAGAGGATCTGGGGAGATGATGA CACG TTCTCCAGTTAAGGTGACTCTGAGTGAAGGTCCTCACCATGTGGCCCTATTTAAAGATAG TTCT CGGGAGTTTGATCTTACCAAAGAAGAAGATCTTGCAGCATTAAGACATGAAATAGAACTT CGAA TGAGGAAAAATGTGAAAGAAGGCTGTACCGTTAGCCCTGAGACCATATCCTTAAATGTAA AAGG CCCTGGACTACAGAGGATGGTGCTTGTTGACTTACCAGGTGTGATTAATACTGTGACATC AGGC ATGGCTCCTGACACAAAGGAAACTATTTTCAGTATCAGCAAAGCTTACATGCAGAATCCT AATG CCATCATACTGTGTATTCAAGATGGATCTGTGGATGCTGAACGCAGTATTGTTACAGACT TGGT CAGTCAAATGGACCCTCATGGAAGGAGAACCATATTCGTTTTGACCAAAGTAGACCTGGC AGAG AAAAATGTAGCCAGTCCAAGCAGGATTCAGCAGATAATTGAAGGAAAGCTCTTCCCAATG AAAG CTTTAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAACAGCTCTGAAAGCATTGAAGCTA TAAG AGAATATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTAAAGACAAGCATGCTAAAGGC ACAC CAAGTGACTACAAGAAATTTAAGCCTTGCAGTATCAGACTGCTTTTGGAAAATGGTACGA GAGT CTGTTGAACAACAGGCTGATAGTTTCAAAGCAACACGTTTTAACCTTGAAACTGAATGGA AGAA TAACTATCCTCGCCTGCGGGAACTTGACCGGAATGAACTATTTGAAAAAGCTAAAAATGA AATC CTTGATGAAGTTATCAGTCTGAGCCAGGTTACACCAAAACATTGGGAGGAAATCCTTCAA CAAT CTTTGTGGGAAAGAGTATCAACTCATGTGATTGAAAACATCTACCTTCCAGCTGCGCAGA CCAT GAATTCAGGAACTTTTAACACCACAGTGGATATCAAGCTTAAACAGTGGACTGATAAACA ACTT CCTAATAAAGCAGTAGAGGTTGCTTGGGAGACCCTACAAGAAGAATTTTCCCGCTTTATG ACAG AACCGAAAGGGAAAGAGCATGATGACATATTTGATAAACTTAAAGAGGCTGTTAAGGAAG AAAG TATTAAACGACACAAGTGGAATGACTTTGCGGAGGACAGCTTGAGGGTTATTCAACACAA TGCT TTGGAAGACCGATCCATATCTGATAAACAGCAATGGGATGCAGCTATTTATTTTATGGAA GAGG CTCTGCAGGCTCGTCTCAAGGATACTGAAAATGCAATTGAAAACATGGTGGGTCCAGACT GGAA AAAGAGGTGGTTATACTGGAAGAATCGGACCCAAGAACAGTGTGTTCACAATGAAACCAA GAAT GAATTGGAGAAGATGTTGAAATGTAATGAGGAGCACCCAGCTTATCTTGCAAGTGATGAA ATAA CCACAGTCCGGAAGAACCTTGAATCCCGAGGAGTAGAAGTAGATCCAAGCTTGATTAAGG ATAC TTGGCATCAAGTTTATAGAAGACATTTTTTAAAAACAGCTCTAAACCATTGTAACCTTTG TCGA AGAGGTTTTTATTACTACCAAAGGCATTTTGTAGATTCTGAGTTGGAATGCAATGATGTG GTCT TGTTTTGGCGTATACAGCGCATGCTTGCTATCACCGCAAATACTTTAAGGCAACAACTTA CAAA TACTGAAGTTAGGCGATTAGAGAAAAATGTTAAAGAGGTATTGGAAGATTTTGCTGAAGA TGGT GAGAAGAAGATTAAATTGCTTACTGGTAAACGCGTTCAACTGGCGGAAGACCTCAAGAAA GTTA GAGAAATTCAAGAAAAACTTGATGCTTTCATTGAAGCTCTTCATCAGGAGAAATAA. II - Recombinant Vectors and Cells Comprising Nucleic Acid OPA1 Trans- Splicing Molecules The present invention also provides a recombinant vector comprising a nucleic acid OPA1 pre-mRNA trans-splicing molecule described herein. More particular, a nucleic acid OPA1 pre-mRNA trans-splicing molecule according to the invention may be recombinantly engineered into a variety of host vector systems that also provide for replication of the DNA in large scale and contain the necessary elements for directing the transcription of the pre-mRNA trans-splicing molecule. The use of such a construct to transduce target cells in the patient will result in the transcription of sufficient amounts of the pre-mRNA trans-splicing molecule that will form complementary bases pairing with the endogenously expressed OPA1 pre-mRNA targets and thereby facilitate the pre-mRNA trans-splicing reaction. Such a vector remains episomal, as long as it can be transcribed to produce the desired RNA. Methods for assembly of recombinant vectors, which generally include culturing a host cell, are known in the art. See, e.g., Ausubel et al., Current Protocols in Molecular Biology, John Wiley & Sons, New York, 1989; Kay, M. A. et al., Nat. Medic, 2001, 7(I):33-40; and Walther W. and Stein U., Drugs 2000, 60(2):249-71. Vectors comprising a nucleic acid OPA1 pre-mRNA trans-splicing molecule of interest can be plasmid, viral, or others known in the art, used for replication and expression in mammalian target cells. Expression of the pre-mRNA trans-splicing molecule can be regulated by any promoter/enhancer sequences known in the art to act in mammalian, preferably human cells. Such promoters/enhancers can be inducible or constitutive. Such promoters include, but are not limited to the SV40 early promoter region, the promoter contained in the 3’ long terminal repeat of the Rous sarcoma virus, the herpes thymidine kinase promoter, the regulatory sequences of the metallothionein gene, the viral cytomegalovirus CMV promoter, the human chorionic gonadotropin-P promoter, the CAG promoter (also known as CBA promoter or CAGGS promoter – CMV enhancer, chicken beta-actin promoter and rabbit beta-globin splice acceptor site), the human elongation factor-1 alpha (EF-1 ^) promoter, the ubiquitin UBC promoter, the phosphoglycerate kinase PGK promoter, the OPA1 promoter, and the like. In certain embodiments, promoters are able to give rise to gene expression in retinal cells, for example in RPE cells (e.g., RPE65, VMD2 or OA1 promoters), in photoreceptors (e.g., rhodopsin kinase (RHO), rhodopsin (RHO), or opsin (OP) human promoters) or preferably in retinal ganglion cells (RGCs) (e.g., human connexin36 (cx36) or SNCG promoters). According to certain preferred embodiments, the promoter is SNCG promoter (see US Publication No.2018/0355354). Any type of cloning vectors, including plasmids, minicircles, cosmids, YAC vectors, BAC vectors and viral vectors, can be used to prepare the recombinant DNA construct which can be introduced directly into the tissue site. Alternatively, viral vectors can be used which selectively infect the desired target cell according to the selected serotype and pseudotyping. Vectors for use in the practice of the invention include any eukaryotic expression vectors, including but not limited to viral expression vectors such as those derived from the class of retroviruses, Modified Vaccinia Virus Ankara, adenoviruses or adeno-associated viruses. In certain preferred embodiments, the recombinant vector is an Adeno-Associated Virus (AAV) or a recombinant Adeno-Associated Virus (rAAV) or a single-stranded Adeno-Associated Virus (ssAAV) or a self-complementary Adeno-Associated Virus (scAAV). The use of AAVs or rAAVs is a common mode of exogenous delivery of DNA as it is relatively non-toxic, provides efficient gene transfer, and can be easily optimized for specific purposes. In certain embodiments, the vector is a rAAV carrying the pre-mRNA trans-splicing molecule and driven by a promoter that expresses a pre- mRNA trans-splicing molecule in selected cells of a subject, e.g., ocular cells such as retinal ganglion cells (RGCs) or cells of the auditory nerve such as spiral ganglion neurons (SGNs), and the like. More than 30 naturally occurring serotypes of AAV are available. Many natural variants in the AAV capsid exist, allowing identification and use of an AAV with properties specifically suited for target cells. AAV viruses may be engineered by conventional molecular biology techniques, making it possible to optimize these particles for cell specific delivery of the pre-mRNA trans-splicing molecule nucleic acid sequences, for minimizing immunogenicity, for tuning stability and particle lifetime, for efficient degradation, for accurate delivery to the nucleus, etc. In certain embodiments, a pre-mRNA trans-splicing molecule according to the present invention is delivered to a target cell in vitro (or ex vivo). Various delivery systems are known and can be used to transfer a pre-mRNA trans-splicing molecule of the invention into cells, e.g., encapsulation in liposomes, microparticles, microcapsules, receptor-mediated endocytosis, construction of a nucleic acid as part of a retroviral, adenoviral, adeno-associated viruses or other vector, injection of DNA, electroporation, calcium phosphate mediated transfection, pure high-lipid based versus mixed lipid and non-lipid based transfection reagents (for a review, see Chong et al., PeerJ, 2021, 21, 9:e11165), etc. In this case, the nucleic acid OPA1 pre-mRNA trans-splicing molecule, which may be in any form used by one skilled in the art, binds to a pre-mRNA and mediates a trans-splicing reaction resulting in the formation of a chimeric mRNA comprising a portion of the exogenous and therapeutic nucleic acid pre-mRNA OPA1 trans-splicing molecule spliced to a portion of the endogenous OPA1 pre-mRNA. Thus, the present invention also relates to a cell comprising a nucleic acid OPA1 pre- mRNA trans-splicing molecule described herein or a recombinant vector comprising a nucleic acid OPA1 pre-mRNA trans-splicing molecule described herein. In certain embodiments, the cell is a target cell. As used herein, the term “target cell” refers to an ocular cell, which is any cell associated with the function of the eye and expressing the OPA1 gene. Such target cells include retinal ganglion cells (RGCs), photoreceptor cells, amacrine cells, horizontal cells, and bipolar cells. Preferentially, the target cells are RGCs. The target cell may also be cells of the auditory nerve such as SGNs. The OPA1 gene is expressed in the eye as well as in other organs, including in the brain, heart, skeletal muscle, liver and testis. The term “target cells” may also include these extra-ocular or auditory nerve cells. In certain embodiments, the cell is a host cell. As used herein, the term “host cell” refers to a packaging cell line in which the recombinant AAV is produced from a plasmid. III - Therapeutic Uses of Nucleic Acid OPA1 pre-mRNA Trans-Splicing Molecule et Methods of Treatment The present invention relates to a nucleic acid OPA1 pre-mRNA trans-splicing molecule according to the present invention, or a recombinant vector comprising the pre-mRNA trans-splicing molecule, or a cell comprising the pre-mRNA trans-splicing molecule or the recombinant vector (optionally after formulation with one or more appropriate pharmaceutically acceptable carriers or excipients (see below)) for use to correct a pathogenic mutation in the OPA1 gene of a subject. Thus, the compounds and compositions of the present invention are useful in methods of treating diseases or disorders caused by a mutation in the OPA1 gene. Such diseases and disorders include, in particular, Autosomal Dominant Optic Atrophy (ADOA), Autosomal Dominant Optic Atrophy Plus (ADOA+) and Behr’s Syndrome. Other diseases and disorders include susceptibility to normal tension glaucoma (OMIM #606657), which is a progressive optic neuropathy associated with glaucomatous optic nerve damage and visual field loss where the intraocular pressure (IOP) is measured consistently below 21 mm Hg. Extra-ophthalmic diseases and disorders linked to mutations in the OPA1 gene include sensorineural deafness, peripheral neuropathies, Parkinson syndrome, mitochondrial myopathy, and heart disease. In certain embodiments, the mitochondrial myopathy is mitochondrial depletion syndrome 14 (OMIN #616895), which is characterized by severe lethal infantile mitochondrial encephalomyopathy and hypertrophic cardiomyopathy, with hypotonia and peripheral hypertonia with opisthotonic posturing, as well as feeding difficulties and profound neurodevelopmental delay. A therapeutic method according to the present invention involves contacting a target OPA1 gene product (e.g., OPA1 pre-mRNA) with an OPA1 pre-mRNA trans- splicing molecule according to the present invention under conditions in which a coding domain of the pre-mRNA trans-splicing molecule is spliced to the target OPA1 gene product to replace a part of the targeted gene product carrying one or more mutations, with a functional (i.e., healthy), or normal or wild-type or corrected or optimized mRNA of the targeted gene, in order to correct expression and functions of OPA1 protein isoforms in the target cell. In certain embodiments, the contacting involves direct administration to the affected subject. In other embodiments, the contacting occurs ex vivo to the cultured cell and following repair, the ex vivo-treated cell is reimplanted in the subject from whom the cell was extracted. In certain embodiments, administration of a therapeutically effective amount of a compound or composition according to the present invention to an individual suffering from a disease or disorder associated with one or more OPA1 gene mutations and/or biallelic mutations in the OPA1 gene, alleviates one or more symptoms selected from the group consisting of: loss of visual acuity, loss of central vision, impairment of color vision, centrocecal scotomas, temporal pallor of the optic disc, circumpapillary telangiectatic microangiopathy, swelling of the retinal nerve fiber layer around the disc (pseudoedema), or optic atrophy. In certain embodiments, administration of a therapeutically effective amount of a compound or composition according to the present invention is able to stop progression of one or more of such symptoms. In certain embodiments, the treatment stops progression of visual acuity loss. In another embodiments, the treatment stops progression of color vision disturbances and/or loss. In certain embodiments, the treatment improves the visual acuity from below 20/400, or from below about 20/400, to 20/100, to about 20/100, or to better than 20/100. In other embodiments, the treatment improves color vision. In certain embodiments, administration of a therapeutically effective amount of a compound or composition according to the present invention to an individual suffering from syndromic disease or disorder associated with an OPA1 gene mutation (e.g., a subject suffering from ADOA+ or from Behr’s syndrome) alleviates one or more extra- ocular manifestations such as chronic progressive external ophthalmoplegia, proximal myopathy, ataxia and axonal sensory motor polyneuropathy, spinocerebellar degeneration resulting in ataxia, pyramidal signs, peripheral neuropathy and developmental delay. 1. Indications In many embodiments, the subject is a human being, and more specifically is a patient who has been diagnosed with a hereditary optic neuropathy associated with a mutation in the OPA1 gene, as listed above. In certain embodiments, the subject is known to be at risk of developing such a hereditary optic neuropathy. The subject may be of any age during which treatment or prophylactic therapy may be beneficial. For example, in some embodiments, the subject is 0-5 years of age, 5-10 years of age, 10-20 years of age, 20-30 years of age, 30-50 years of age, 50-70 years of age, or more than 70 years of age. In certain embodiments, the subject is 12 months of age or older, 18 months of age or older, 2 years of age or older, 3 years of age or older, 4 years of age or older, 5 years of age or older, 6 years of age or older, 7 years of age or older, 8 years of age or older, 9 years of age or older, or 10 years of age or older. 2. Administration A nucleic acid OPA1 pre-mRNA trans-splicing molecule according to the present invention, or a recombinant vector comprising the nucleic acid OPA1 pre-mRNA trans- splicing molecule, or an ex vivo-treated cell, optionally after formulation into a pharmaceutical composition, can be administered to a subject in need thereof by any suitable route. Suitable methods of administration include, but are not limited to, subretinal injection, intravitreal injection, or intravenous injection, intrathecal injection. Injection via the palpebral vein or any ophthalmic veins to ocular cells may also be used. Still other modes of administration may be selected by one skilled in the art. 3. Dosage Administration of a nucleic acid OPA1 pre-mRNA trans-splicing molecule according to the present invention, or of a recombinant vector comprising the nucleic acid OPA1 pre-mRNA trans-splicing molecule, or of a cell comprising the nucleic acid OPA1 pre-mRNA trans-splicing molecule or the recombinant vector, (optionally after formulation with one or more appropriate pharmaceutically acceptable carriers or excipients) will be in a dosage such that the amount delivered is effective for the intended purpose. The dose administered will depend upon the desired therapeutic effect, the degree to which the disorder has developed, the age, sex, weight and general health condition of the patient, and the targeted cell, as well as upon the use (or not) of concomitant therapies, and other clinical factors. These factors are readily determinable by the attending physician in the course of the therapy. Alternatively, or additionally, the dosage to be administered can be determined from studies using animal models. Adjusting the dose to achieve maximal efficacy based on these or other methods are well known in the art and are within the capabilities of trained physicians. As studies are conducted using compounds of the present invention, further information will emerge regarding the appropriate dosage levels. A treatment according to the present invention may consist of a single dose or multiple doses (e.g., multiple administrations over some period, e.g., throughout several years of the life of a patient). Exemplary courses of treatment may comprise weekly, biweekly, monthly, quarterly, biannually, or yearly treatments. Alternatively, treatment may proceed in phases whereby multiple doses are administered initially, and subsequently fewer and less frequent doses are needed. For example, in embodiments where the therapeutic agent is a recombinant adeno- associated virus carrying a nucleic acid OPA1 trans-splicing molecule according to the present invention, it is desirable that the lowest effective dosage (total genome copies delivered) of virus be utilized in order to reduce the risk of undesirable effects, such as toxicity, and other issues related to administration to the eye, e.g., retinal dysplasia and detachment. In certain embodiments, an effective dosage ranges between about 10 ⁸ and 10 ¹³ vector genomes (vg) per dose. The effective dosage may be comprised between 10 ⁹ and 10 ¹³ vg. For example, the effective dosage may be about 1.5×10 ¹¹ vg, or about 1.5×10 ¹⁰ vg, or about 2.8×10 ¹¹ vg, or about 5×10 ¹¹ vg, or about 1.5×10 ¹² vg, or yet about 1.5×10 ¹³ vg. Still other dosages in these ranges or in other units may be selected by the attending physician, taking into account the factors mentioned above. The dose may be delivered in a volume of from about 50 ^L to about 1 mL, including all numbers within the range, depending on the size of the area to be treated, the viral titer used, the route of administration and the desired effect of the method. In particular, the volume may be about 50 μL, about 75 μL, about 100 μL, about 125 μL, about 150 μL, about 175 μL, about 200 μL, about 250 μL, about 300 μL, about 350 μL, about 400 μL, about 450 μL, about 500 μL, about 600 μL, about 700 μL, about 800 μL, about 900 μL or about 1,000 μL. Alternatively, or additionally, the volume and/or concentration of a recombinant AAV composition according to the present invention are selected so that only certain anatomical regions having target cells are impacted. In other embodiments, the volume and/or concentration of a recombinant AAV composition according to the present invention are selected in order to reach larger portions of the eye. 4. Concomitant Therapies A therapeutic method according to the present invention may be performed in combination with another, or secondary therapy. The therapy may be any now known, or as yet unknown, therapy which helps prevent, arrest or ameliorate any of the effects associated with a pathogenic OPA1 mutation. The secondary therapy is selected such that it does not interfere with OPA1 pre-mRNA binding domain or its targeted site unless it can favor the interaction and the trans-splicing reaction between the endogenous mutated targeted pre-mRNA and the exogenous corrective pre-mRNA trans-splicing molecule, as scaffolding agent. The secondary therapy can be administered before, concurrent with, or after administration of a therapeutic method described herein. In one embodiment, a secondary therapy involves non-specific approaches for maintaining the health of the ocular cells, in particular retinal ganglion cells (RGCs), such as administration of neurotrophic factors, antioxidants, anti- apoptotic agents. 5. Monitoring of Therapeutic Efficacy of a Treatment The effects of a treatment according to the present invention may be assessed using any suitable method known in the art, for example by performing functional and/or imaging studies. These studies include, but are not limited to, electroretinography (ERG), perimetry, topographical mapping of the layers of the retina and measurement of the thickness of its layers by means of confocal scanning laser ophthalmoscopy (cSLO) and full field optical coherence tomography (OCT), optical coherence tomography angiography (OCTA), tomographical mapping of cone density via adaptive optics (OA). In addition, visual field studies, perimetry and microperimetry, mobility testing, visual acuity, color vision testing may be performed. The results of imaging and/or functional studies may be used to modify, adapt, or optimize the treatment. IV - Pharmaceutical Compositions and Kits 1. Pharmaceutical Compositions The present invention provides pharmaceutical compositions including a nucleic acid OPA1 pre-mRNA trans-splicing molecule described herein, or a recombinant vector comprising such trans-splicing molecule, or a cell comprising the trans-splicing molecule or the recombinant vector, and a pharmaceutically acceptable carrier or excipient. Preferable, a pharmaceutical composition comprises an effective amount of the nucleic acid OPA1 pre-mRNA trans-splicing molecule, recombinant vector, or cells. In some embodiments, a pharmaceutical composition further comprises one or more additional biologically active agents. The pharmaceutical compositions of the present invention may be formulated in dosage unit form for ease of administration and uniformity of dosage. The expression “unit dosage form”, as used herein, refers to a physically discrete unit of the nucleic acid OPA1 trans-splicing molecule, or the recombinant vector, or the cell for the patient to be treated. It will be understood, however, that the total dosage of the compositions will be decided by the attending physician, pharmacist or biologist within the scope of sound medical judgement. a. Formulation. A pharmaceutical composition described herein may be administered using any route of administration effective for achieving the desired therapeutic effect. The optimal pharmaceutical formulation can be varied depending upon the route of administration and desired dosage. A pharmaceutical composition according to the present invention can be in the form of an injectable solution. Injectable preparations, for example, sterile injectable aqueous or oleaginous suspensions may be formulated according to the known art using suitable dispersing or wetting agents, and suspending agents. The sterile injectable preparation may also be a sterile injectable solution, suspension or emulsion in a non- toxic diluent or solvent, such as mannitol, 1,3-butanediol, water (e.g., sterile, pyrogen- free water), Ringer’s solution, isotonic sodium chloride solution, sterile, pyrogen-free phosphate buffered saline other buffers, e.g., HEPES, to maintain pH at appropriate physiological levels, and the like. In addition, sterile, fixed oils are conventionally employed as a solution or suspending medium. For this purpose, any bland fixed oil can be employed including synthetic mono- or di-glycerides. Fatty acids such as oleic acid may also be used in the preparation of injectable formulations. In certain embodiments, a pharmaceutical composition according to the present invention comprises a surfactant. Appropriate surfactants such as PBS-Pluronic F-68 (Poloxamer 188, also known as LUTROL ^® F68), may be included as they are known to prevent AAV from sticking to inert surfaces and thus ensure delivery of the desired dose. Other appropriate surfactants include TWEEN ^® . For example, if the pharmaceutical composition is to be stored long-term, it may be frozen in the presence of TWEEN ^® 20 or in the presence of glycerol. Injectable formulations can be sterilized, for example, by filtration through a bacterial-retaining filter, or by incorporating sterilizing agents in the form of sterile solid compositions which can be dissolved or dispersed in sterile water or other sterile injectable medium prior to use. For injectable formulations, the pharmaceutical compositions can be in lyophilized power in admixture with suitable excipients in a suitable vial or tube. Before use in the clinic, the drugs may be reconstituted by dissolving the lyophilized powder in a suitable solvent system to form a composition suitable for injection (e.g., subretinal, intravitreal or subconjunctival injection). It is also envisaged that the pharmaceutical composition of the present invention is formulated/administered as eye drops. Materials and methods for producing various formulations are known in the art and may be adapted for practicing the subject invention. Suitable formulations for the delivery of DNA molecules, recombinants vectors or cells can be found, for example, in “Remington’s Pharmaceutical Sciences”, E.W. Martin, 19 ^th Ed., 1995, Mack Publishing Co.: Easton, PA; Liberman and Lachman, Eds., “Pharmaceutical Dosage Forms”, Marcel Decker, New York, N.Y., 1980; and “Pharmaceutical Dosage Forms and Drug Delivery Systems”, 17 ^th Ed., Lippincott Williams & Wilkins, l999. Ex vivo-treated cells may be formulated with a pharmaceutical carrier for administration in any convenient way for use in medicine, for example with a pharmaceutically acceptable ophthalmic formulation for intraocular injection. A pharmaceutical composition comprising ex vivo-treated cells used in a method according to the present invention may be transplanted in a suspension, gel, colloid, slurry, or mixture. The preparation may desirably be encapsulated or injected in a viscous form into the vitreous humor for delivery to the site of retinal damage. Also, at the time of injection, cryopreserved ex vivo-treated cells may be resuspended with commercially available balanced salt solution to achieve the desired osmolality and concentration for administration by subretinal injection. When administering the composition by intravitreal injection, for example, the solution may be concentrated so that minimized volumes may be delivered. Concentrations for injections may be at any amount that is effective and non-toxic. The pharmaceutical compositions of ex vivo- treated cells for treatment of a patient may be formulated at doses of at least about 10 ⁴ cells/mL, for example at doses of at least about 10 ³ , 10 ⁴ , 10 ⁵ , 10 ⁶ , 107, 10 ⁸ , 10 ⁹ , or 10 ¹⁰ cells/mL. b. Additional Biologically Active Agents. In certain embodiments, the nucleic acid OPA1 pre-mRNA trans-splicing molecule, or the recombinant vector comprising such trans-splicing molecule, or the cell comprising the trans-splicing molecule or recombinant vector is the only active ingredient in a pharmaceutical composition of the present invention. In other embodiments, the pharmaceutical composition further comprises one or more biologically active agents. Examples of suitable biologically active agents include, but are not limited to, anti-inflammatory agents, immunomodulatory agents, analgesics, antimicrobial agents, antibacterial agents, antibiotics, antioxidants, antiseptic agents, and combinations thereof. Where necessary or desired, a pharmaceutical composition may further include a local anaesthetic to ease pain at the site of injection. In such pharmaceutical compositions, the nucleic acid OPA1 pre-mRNA trans- splicing molecule, the recombinant vector, or the cell and the at least one additional biologically active agent may be combined in one or more preparations for simultaneous, separate or sequential administration. More specifically, an inventive composition may be formulated in such a way that the nucleic acid OPA1 pre-mRNA trans-splicing molecule, the recombinant vector, or the cell and the additional biologically active agent(s) can be administered together or independently from each other. For example, the nucleic acid OPA1 pre-mRNA trans-splicing molecule, the recombinant vector, or the cell and the additional biologically active agent(s) can be formulated together in a single pharmaceutical composition. Alternatively, they may be maintained (e.g., in different compositions and/or containers) and administered separately, thereby constituting a pharmaceutical kit or pack. 2. Pharmaceutical Kits In another aspect, the present invention provides a pharmaceutical kit comprising one or more containers (e.g., vials, ampoules, test tubes, flasks or bottles) containing one or more ingredients of an inventive pharmaceutical composition, allowing administration of a nucleic acid OPA1 pre-mRNA trans-splicing molecule described herein, or a recombinant vector comprising such trans-splicing molecule, or a cell comprising the trans-splicing molecule or the recombinant vector, to a subject in need thereof, for therapeutic purpose. Alternatively, the component for production or assembly of a pharmaceutical composition, including the nucleic acid OPA1 pre-mRNA trans-splicing molecule, carrier(s), rAAV particles, surfactants, and the like, as well as suitable laboratory hardware to prepare the composition may be incorporated into a kit. Different ingredients of a pharmaceutical kit may be supplied in a solid (e.g., lyophilized) or liquid form. Each ingredient will generally be suitable as aliquoted in its respective container or provided in a concentrated form. Kits according to the invention may include media for the reconstitution of lyophilized ingredients. Individual containers of the kits will preferably be maintained in close confinement for commercial sale. In certain embodiments, a pharmaceutical kit can include a device for administering the composition thereof, e.g., syringe needle, pen device, jet injector or another needle-free injector. In certain embodiments, a pharmaceutical kit includes one or more additional biologically active agent(s). Optionally associated with the container(s) can be a notice or package insert in the form prescribed by a governmental agency regulating the manufacture, use or sale of pharmaceutical or biological products, which notice reflects approval by the agency of manufacture, use or sale for human administration. The notice of package insert may contain instructions for use of a pharmaceutical composition according to methods of treatment disclosed herein. An identifier, e.g., a bar code, radio frequency, ID tags, etc., may be present in or on the kit. The identifier can be used, for example, to uniquely identify the kit for purposes of quality control, inventory control, tracking movement between workstations, etc. The invention will be further illustrated by the following figures and examples. However, these examples and figures should not be interpreted in any way as limiting the scope of the present invention. Examples The following examples describe some of the preferred modes of making and practicing the present invention. However, it should be understood that the examples are for illustrative purposes only and are not meant to limit the scope of the invention. Furthermore, unless the description in an Example is presented in the past tense, the text, like the rest of the specification, is not intended to suggest that experiments were actually carried out or data were actually obtained. Selection of the OPA1 Trans-Splicing Targeted Region The Homo sapiens (Hs) OPA1 intron 8-9 (193,637,282 to 193,637,951) / EXON 9 (ENSE00003604184: 193,637,952 to 193,638,065) genomic sequence, defined as the human OPA1 trans-splicing targeted sequence, was chosen as the region to hybridize to via antisense binding domains. Homo sapiens OPA1 intron 8-9 (670 bp) and Homo sapiens OPA1 EXON 9 (114 bp) are respectively indicated in lowercases and uppercases in the following 784-nucleotides sequence. Underlined nucleotides represent the forward primer (5’-gtatgtgaaaaattgatagtgaacttgcc-3’ = SEQ ID NO: 43) and reverse primer (5’-CTTAACTGGAGAACGTGTCATCATC-3’= SEQ ID NO: 44) used for PCR-amplification. The amplified 784-nucleotides fragment was used as a template for antisense binding domains genesis. SEQ ID NO: 1 gtatgtgaaaaattgatagtgaacttgccaattagcaaaaaaagaagcagcttagcttcc taaa aattatgtgtatatatgtacacatacacatatatacatactagatgtaggcatttatatt tttt atgtaatcttacatgttccaagtaatgtcttaagcaatattatttgactattttagttca ttat aaatattaataaatataagtacattatatttatgagttactgtatgtgttataaaggaag atat ttggctttatatgtcttaatattagtaatatttaaatactgaacagtggattaaattagc cata tgcgtgaaatttaagctaatagaattgaaaatgtgtttgtaaacagtaaactagctatgg aaaa gatttatggaaagttaataacctggttttagaaatactggtttaaattagcacaagtttt taaa ataaaaattaggctataaacagtggatccagttatagttttgctgttcctattttcaatg tgca cacatgcatcaatcaccatttttttacggattttaaaatattttttcacctgtagaaatt ttaa aagactaaaaaactcagagcagcattacaaataggttttaattttaatttggtatcagaa aaat atgaataagtgttctttgttttgtgggaagGTTGTTGTGGTTGGAGATCAGAGTGCTGGA AAGA CTAGTGTGTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAGAGGATCTGGGGAGATGA TGAC ACGTTCTCCAGTTAAG The HsOPA1 intron 8-9/EXON9 (193,637,282 - 193,638,065) sequence was chosen because of: - Its downstream position to OPA1 alternate spliced exons (4, 4b, 5b) and its upstream position to the pathogenic variants registered in OPA1-related Dominant Optic Atrophy (DOA) patients, OPA1-related Dominant Optic Atrophy Plus (DOA+) patients and patients with Behr’s syndrome (see Figure 1). This targeted region warranties both the conservation and the trans-splicing of the eight OPA1 pre-mRNA transcripts, to correct the eight different OPA1 mRNAs and corresponding OPA1 protein isoforms; and - Its size, which allows the generation of a wide diversity of antisense binding domains. The HsOPA1 intron 8-9/EXON9 (193,637,282 - 193,638,065) sequence was also PCR-amplified with flanking primers: forward primer: 5’-GCCGAGGTAAGAGATATCGTATGTGAAAAATTGATAGTGAACTTG-3’ (SEQ ID NO: 45); and reverse primer: 5’-TAGACTCGAGCGGCCGCCTTAACTGGAGAACGTGTCATC-3’ (SEQ ID NO: 46) for HsOPA1 intron 8-9/EXON9 OPA1-minigene edition used in a minigene GFP assay (see Figure 2). The resulting amplicon (819 bp) was cloned downstream to the 5’ half part of the AcGFP1 encoding sequence (336 bp), between EcoRV and NotI restriction sites, through the Gibson cloning assembly method, and confirmed by Sanger- sequencing using the following sequencing primers: Seq_HsOPA1-MG_Fw1 5’-ATCTTCTTCGAGGATGACGGCAA-3’ (SEQ ID NO: 47) Seq_HsOPA1-MG_Fw2: 5’-GCTATGGAAAAGATTTATGGAAAGTTAATAACCTGG-3’ (SEQ ID NO: 48) Seq_HsOPA1-MG_Rv1: 5’-GTTTAAACTCAATGGTGATGGTGATGATGA-3’ (SEQ ID NO: 49) Seq_HsOPA1-MG_Rv2: 5’-AAACTATAACTGGATCCACTGTTTATAGCCTAA-3’ (SEQ ID NO: 50) Genesis of OPA1 Antisense Binding Domains Starting from the HsOPA1 intron 8-9/EXON9 (193,637,282 - 193,638,065) PCR- amplified sequence (784bp), the methods described by Bauer et al. (Methods Mol. Biol., 2013, 961: 441-455) and Murauer et al. (Hum. Gene Ther. Methods, 2013, 24(1): 19-27) were used to create banks of antisense binding domains through a CviJI* (5’-PuG↕CPy-3’) endonuclease digestion or sonication (1 minute per 100 bp). CviJI* digested fragments ranked from 5 to 500 bp and sonicated fragments from 25 to 700 bp (see Figure 3). An additional bank of antisense binding domains was generated by rational PCR with intro 8-9/EXON9 (193,637,282 - 193,638,065) Homo sapiens OPA1 sequence as template and combination of the flanked PCR primers presented in Table 1 for downstream Gibson cloning assembly into RTM0 plasmid (see plasmid map in Figure 4). Table 1. Primers used for the rational PCR antisense binding domains genesis. Primers are flanked by Clal or EcoRI restriction sites and recipient plasmid sequence for efficient Gibson cloning assembly into RTM0 plasmid. Cloning of OPA1 Antisense-Binding Domains into RTM0 Plasmid for the Minigene Assay 400 putative antisense binding domains to Homo sapiens OPA1 intron 8-9/EXON9 (193,637,282 - 193,638,065) generated by CviJI* digestion or sonication were subcloned, according to Murauer et al. (Hum. Gene Ther. Methods, 2013, 24(1): 19-27), into the RTM0 plasmid (i.e., a plasmid without any antisense binding domains) at the HpaI blunt cloning site, while those generated by rational PCR were subcloned between EcoRI and ClaI cohesive cloning sites for OPA1-specific RTMs edition (see Figure 4). The RTM0 plasmid, which was published in Bauer et al. (Methods In Molecular Biology, 2013, vol. 961, DOI 10.1007/978-1-62703-227-8_30) and Murauer et al., (Hum. Gene Ther. Methods, 2013, 24(1): 19-27), was a gift from the group of Ulrich Koller (Austria). These Homo sapiens OPA1 antisense binding domains were linked to an Intronic Splicing Enhancer (ISE) cassette included in the RTM0 plasmid and containing a 27-bp spacer, a 8-bp branch point (BP), a 16-bp PolyPyrimidine Tract (PPT), a 3’ Acceptor Splice Site (3’ASS) as shown on Figure 5. Cloning of the OPA1 antisense binding domains was confirmed by Sanger- sequencing using forward (5’-GGCTAACTAGAGAACCCACTGC-3’ – SEQ ID NO: 58) and reverse (5’-CCATCCTCCTTGAAATCGGTGC-3’ – SEQ ID NO: 59) primers. Mechanistic Proof of Principle of Homo sapiens OPA1 Trans-Splicing and Selection of OPA1-Targeting RTMs Containing Antisense Binding Domains Inducing the Highest Trans-Splicing Rates According to Murauer et al. (Hum. Gene Ther. Methods, 2013, 24(1): 19-27) and to Koller et al. (Mol. Ther. Nucleic Acids, 2014, 3(4): e157) for recommendations in the design of a highly functional RNA Trans-splicing Molecule, individual OPA1-specific RTMs were tested in the minigene GFP reconstitution assay for their ability to trans- splice the co-transfected targeted Homo sapiens intron 8-9/EXON 9 OPA1 minigene. Efficient antisense binding domains to Homo sapiens OPA1 intron 8-9/EXON9 (193,637,282 – 193,638,065) were selected as those inducing the highest OPA1 trans- splicing rates revealed by the highest proportion of GFP expressing cells (see Figure 6). Identification of Efficient Binding Domains to Homo sapiens OPA1 Trans-Splicing The mechanistic proof of principle using the OPA1-minigene assay revealed efficient binding domains for OPA1 trans-splicing: - BD#106 (250 nt), which is a multiple binding domain with the following sequence. In the sequence below, the sign “/” separates the different binding domains. cctaatttttattttaaaaacttgtgctaatttaaaccagtatttctaaaaccaggttat taac tttccataaatcttttccatag/ctgcttctttttttgctaattggcaagttcactatca attt ttcacatac/ctttatatgtcttaatattagtaatatttaaatactgaacagtggattaa atta g/cttaaatttcacgcatatgg/ctagtttactgtttacaaacacattttcaattctatt ag (SEQ ID NO: 6) It hybridizes to the human genome at: 3:193,637,656-3:193,637,741 & 3:193,637,282- 3:193,637,331 & 3:193,637,597-3:193,637,616 & 3:193,637,617-3:193,637,655 The corresponding 5’-3’ sequences are: ctatggaaaagatttatggaaagttaataacctggttttagaaatactggtttaaattag caca agtttttaaaataaaaattagg/gtatgtgaaaaattgatagtgaacttgccaattagca aaaa aagaagcag/ccatatgcgtgaaatttaag/ctaatagaattgaaaatgtgtttgtaaac agta aactag (SEQ ID NO: 60). - BD#114 (55 nt), which is a single binding domain and has the following sequence: ctaatttaatccactgttcagtatttaaatattactaatattaagacatataaag (SEQ ID NO: 2). It hybridizes to the human genome at: 3:193,637,542-3:193,637,596 The corresponding 5’-3’ sequence is: ctttatatgtcttaatattagtaatatttaaatactgaacagtggattaaattag (SEQ ID NO: 61). - BD#128 (86 nt), which is a single binding domain and has the following sequence: cctaatttttattttaaaaacttgtgctaatttaaaccagtatttctaaaaccaggttat taac ^{tttccataaatcttttccatag} _{(SEQ ID NO: 3).} It hybridizes to the human genome at: 3:193,637,656-3:193,637,741 The corresponding 5’-3’ sequence is: ctatggaaaagatttatggaaagttaataacctggttttagaaatactggtttaaattag caca agtttttaaaataaaaattagg (SEQ ID NO: 62). - BD#135 (105 nt), which is a double binding domain (1x antisense + 1x sense). In the sequence, the sign “/” separates the two different binding domains. ctgcttctttttttgctaattggcaagttcactatcaatttttcacatac/ctttatatg tctt aatattagtaatatttaaatactgaacagtggattaaattag _{(SEQ ID NO: 5).} It hybridizes to the human genome at: 3:193,637,282-3:193,637,331 only. The corresponding 5’-3’ sequence is: gtatgtgaaaaattgatagtgaacttgccaattagcaaaaaaagaagcag (SEQ ID NO: 63). - BD#162 (143 nt), which is a single binding domain and has the following sequence: taatgctgctctgagttttttagtcttttaaaatttctacaggtgaaaaaatattttaaa atcc gtaaaaaaatggtgattgatgcatgtgtgcacattgaaaataggaacagcaaaactataa ctgga ^{tccactgtttatag} _{(SEQ ID NO: 4).} It hybridizes to the human genome at: 3:193,637,742-3:193,637,884. The corresponding 5’-3’ sequence is: ctataaacagtggatccagttatagttttgctgttcctattttcaatgtgcacacatgca tcaa tcaccatttttttacggattttaaaatattttttcacctgtagaaattttaaaagactaa aaaa ctcagagcagcatta (SEQ ID NO: 64). Other antisense binding domains have also been generated by rational PCR. See primers used presented in Table 1. These antisense binding domains for OPA1 trans- splicing are: - BD#100 (100 nt), which is a single binding domain and has the following sequence: gcaatcatttccaacacactagtctttccagcactctgatctccaaccacaacaaccttc ccac aaaacaaagaacacttattcatatttttctgatacc (SEQ ID NO: 7). It hybridizes to the human genome at: 3:193,637,908-3:193,638,007. The corresponding 5’-3’ sequence is: ggtatcagaaaaatatgaataagtgttctttgttttgtgggaagGTTGTTGTGGTTGGAG ATCAGAGTGC TGGAAAGACTAGTGTGTTGGAAATGATTGC (SEQ ID NO: 77). - BD#130 (130 nt), which is a single binding domain and has the following sequence: ccagatcctcttgggaatattcgagcttgggcaatcatttccaacacactagtctttcca gcac tctgatctccaaccacaacaaccttcccacaaaacaaagaacacttattcatatttttct gata cc (SEQ ID NO: 8). It hybridizes to the human genome at: 3:193,637,908-3:193,638,037. The corresponding 5’-3’ sequence is: ggtatcagaaaaatatgaataagtgttctttgttttgtgggaagGTTGTTGTGGTTGGAG ATCAGAGTGC TGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAG AGGATCTGG (SEQ ID NO: 78). - BD#158 (158 nt), which is a single binding domain and has the following sequence: cttaactggagaacgtgtcatcatctccccagatcctcttgggaatattcgagcttgggc aatc atttccaacacactagtctttccagcactctgatctccaaccacaacaaccttcccacaa aaca aagaacacttattcatatttttctgatacc (SEQ ID NO: 9). It hybridizes to the human genome at: 3:193,637,908-3:193,638,065. The corresponding 5’-3’ sequence is: ggtatcagaaaaatatgaataagtgttctttgttttgtgggaagGTTGTTGTGGTTGGAG ATCAGAGTGC TGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAG AGGATCTGGGGAGATGATGACACGTTCTCCAGTTAAG (SEQ ID NO: 79). - BD#166 (166 nt), which is a single binding domain and has the following sequence: GCAATCATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACcttc ccac aaaacaaagaacacttattcatatttttctgataccaaattaaaattaaaacctatttgt aatg ctgctctgagttttttagtcttttaaaatttctacagg (SEQ ID NO: 10). It hybridizes to the human genome at: 3:193,637,842-3:193,638,007. The corresponding 5’-3’ sequence is: cctgtagaaattttaaaagactaaaaaactcagagcagcattacaaataggttttaattt taatttggtatcagaaaaatatgaataa gtgttctttgttttgtgggaagGTTGTTGTGGTTGGAGATCAGAGTGCTGGAAAGACTAG T GTGTTGGAAATGATTGC (SEQ ID NO: 80). - BD#196 (196 nt), which is a single binding domain and has the following sequence: ccagatcctcttgggaatattcgagcttgggcaatcatttccaacacactagtctttcca gcac tctgatctccaaccacaacaaccttcccacaaaacaaagaacacttattcatatttttct gata ccaaattaaaattaaaacctatttgtaatgctgctctgagttttttagtcttttaaaatt tcta cagg (SEQ ID NO: 11). It hybridizes to the human genome at: 3:193,637,842-193,638,037. The corresponding 5’-3’ sequence is: cctgtagaaattttaaaagactaaaaaactcagagcagcattacaaataggttttaattt taatttggtatcagaaaaatatgaataa gtgttctttgttttgtgggaagGTTGTTGTGGTTGGAGATCAGAGTGCTGGAAAGACTAG T GTGTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAGAGGATCTGG (SEQ ID NO: 81). - BD#224 (224 nt), which is a single binding domain and has the following sequence: cttaactggagaacgtgtcatcatctccccagatcctcttgggaatattcgagcttgggc aatg atttccaacacactagtctttccagcactctgatctccaaccacaacaaccttcccacaa aaca aagaacacttattcatatttttctgataccaaattaaaattaaaacctatttgtaatgct gctc tgagttttttagtcttttaaaatttctacagg (SEQ ID NO: 12). It hybridizes to the human genome at: 3:193,637,842-3:193,638,065. The corresponding 5’-3’ sequence is: cctgtagaaattttaaaagactaaaaaactcagagcagcattacaaataggttttaattt taatttggtatcagaaaaatatgaataa gtgttctttgttttgtgggaagGTTGTTGTGGTTGGAGATCAGAGTGCTGGAAAGACTAG T GTGTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAGAGGATCTGGGGAG ATGATGACACGTTCTCCAGTTAAG (SEQ ID NO: 82). - BD#209 (209 nt), which is a single binding domain and has the following sequence: gcaatcatttccaacacactagtctttccagcactctgatctccaaccacaacaaccttc ccac aaaacaaagaacacttattcatatttttctgataccaaattaaaattaaaacctatttgt aatg ctgctctgagttttttagtcttttaaaatttctacaggtgaaaaaatattttaaaatccg taaa aaaatggtgattgatgc (SEQ ID NO: 13). It hybridizes to the human genome at: 3:193,637,799-3:193,638,007. The corresponding 5’-3’ sequence is: gcatcaatcaccatttttttacggattttaaaatattttttcacctgtagaaattttaaa agactaaaaaactcagagcagcattacaa ataggttttaattttaatttggtatcagaaaaatatgaataagtgttctttgttttgtgg gaagGTTGTTGTGGTTGGAG ATCAGAGTGCTGGAAAGACTAGTGTGTTGGAAATGATTGC (SEQ ID NO: 83). - BD#239 (239 nt), which is a single binding domain and has the following sequence: Ccagatcctcttgggaatattcgagcttgggcaatcatttccaacacactagtctttcca gcac tctgatctccaaccacaacaaccttcccacaaaacaaagaacacttattcatatttttct gata ccaaattaaaattaaaacctatttgtaatgctgctctgagttttttagtcttttaaaatt tcta caggtgaaaaaatattttaaaatccgtaaaaaaatggtgattgatgc (SEQ ID NO: 14). It hybridizes to the human genome at: 3:193,637,799-3:193,638,037. The corresponding 5’-3’ sequence is: gcatcaatcaccatttttttacggattttaaaatattttttcacctgtagaaattttaaa agactaaaaaactcagagcagcattacaa ataggttttaattttaatttggtatcagaaaaatatgaataagtgttctttgttttgtgg gaagGTTGTTGTGGTTGGAG ATCAGAGTGCTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAA TATTCCCAAGAGGATCTGG (SEQ ID NO: 84). - BD#267 (267 nt), which is a single binding domain and has the following sequence: cttaactggagaacgtgtcatcatctccccagatcctcttgggaatattcgagcttgggc aatc atttccaacacactagtctttccagcactctgatctccaaccacaacaaccttcccacaa aaca aagaacacttattcatatttttctgataccaaattaaaattaaaacctatttgtaatgct gctc tgagttttttagtcttttaaaatttctacaggtgaaaaaatattttaaaatccgtaaaaa aatg gtgattgatgc (SEQ ID NO: 15). It hybridizes to the human genome at: 3:193,637,799-3:193,638,065. The corresponding 5’-3’ sequence is: gcatcaatcaccatttttttacggattttaaaatattttttcacctgtagaaattttaaa agactaaaaaactcagagcagcattacaa ataggttttaattttaatttggtatcagaaaaatatgaataagtgttctttgttttgtgg gaagGTTGTTGTGGTTGGAG ATCAGAGTGCTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAA TATTCCCAAGAGGATCTGGGGAGATGATGACACGTTCTCCAGTTAAG (SEQ ID NO: 85). - BD#217 (217 nt), which is a single binding domain and has the following sequence: gcaatcatttccaacacactagtctttccagcactctgatctccaaccacaacaaccttc ccac aaaacaaagaacacttattcatatttttctgataccaaattaaaattaaaacctatttgt aatg ctgctctgagttttttagtcttttaaaatttctacaggtgaaaaaatattttaaaatccg taaa aaaatggtgattgatgcatgtgtgc (SEQ ID NO: 16. It hybridizes to the human genome at: 3:193,637,791-3:193,638,007. The corresponding 5’-3’ sequence is: gcacacatgcatcaatcaccatttttttacggattttaaaatattttttcacctgtagaa attttaaaagactaaaaaactcagagcag cattacaaataggttttaattttaatttggtatcagaaaaatatgaataagtgttctttg ttttgtgggaagGTTGTTGTGGT TGGAGATCAGAGTGCTGGAAAGACTAGTGTGTTGGAAATGATTGC (SEQ ID NO: 86). - BD#247 (247 nt), which is a single binding domain and has the following sequence: ccagatcctcttgggaatattcgagcttgggcaatcatttccaacacactagtctttcca gcac tctgatctccaaccacaacaaccttcccacaaaacaaagaacacttattcatatttttct gata ccaaattaaaattaaaacctatttgtaatgctgctctgagttttttagtcttttaaaatt tcta caggtgaaaaaatattttaaaatccgtaaaaaaatggtgattgatgcatgtgtgc (SEQ ID NO: 17). It hybridizes to the human genome at: 3:193,637,791-3:193,638,037. The corresponding 5’-3’ sequence is: gcacacatgcatcaatcaccatttttttacggattttaaaatattttttcacctgtagaa attttaaaagactaaaaaactcagagcag cattacaaataggttttaattttaatttggtatcagaaaaatatgaataagtgttctttg ttttgtgggaagGTTGTTGTGGT TGGAGATCAGAGTGCTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGC TCGAATATTCCCAAGAGGATCTGG (SEQ ID NO: 87). - BD#275 (275 nt), which is a single binding domain and has the following sequence: ttacctggagaacgtgtcatcatctccccagatcctcttgggaatattcgagcttgggca atc atttccaacacactagtctttccagcactctgatctccaaccacaacaaccttcccacaa aaca aagaacacttattcatatttttctgataccaaattaaaattaaaacctatttgtaatgct gctc tgagttttttagtcttttaaaatttctacaggtgaaaaaatattttaaaatccgtaaaaa aatg gtgattgatgcatgtgtgc (SEQ ID NO: 18). It hybridizes to the human genome at: 3:193,637,791-3:193,638,060. The corresponding 5’-3’ sequence is: gcacacatgcatcaatcaccatttttttacggattttaaaatattttttcacctgtagaa attttaaaagactaaaaaactcagagcag cattacaaataggttttaattttaatttggtatcagaaaaatatgaataagtgttctttg ttttgtgggaagGTTGTTGTGGT TGGAGATCAGAGTGCTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGC TCGAATATTCCCAAGAGGATCTGGGGAGATGATGACACGTTCTCCAGTTAA G (SEQ ID NO: 88). Cloning into a Therapeutic Vector The preselected OPA1-RTMs were PCR-amplified for Gibson assembly with the optimized wild-type OPA1 cDNA sequence using the primers presented in Table 2 below. It generated OPA1 antisense binding domains fused to ISE with the sequences presented below, wherein the binding domain (BD) is in bold, the spacer is underlined, the branch point (BP) is in bold and underlined, the Poly-Pyrimidin Track (PPT) is in italics, and the 3’ Acceptor Splicing Site (3’ASS) is in italics and underlined. - BD#106+ISE (SEQ ID NO: 72): cgagctcaagcttcgaattccctaatttttattttaaaaacttgtgctaatttaaaccag tatt tctaaaaccaggttattaactttccataaatcttttccatag/ctgcttctttttttgct aatt ggcaagttcactatcaatttttcacatac/ctttatatgtcttaatattagtaatattta aata ctgaacagtggattaaattag/cttaaatttcacgcatatgg/ctagtttactgtttaca aaca cattttcaattctattagaacgagaacattattatagcgttgctcgagtactaactggta cctc ttcttttttttctgcagGTAGTAGTCGTAGGTGATCAG - BD#114+ISE (SEQ ID NO: 73): cgagctcaagcttcgaattcctaatttaatccactgttcagtatttaaatattactaata ttaa gacatataaagaacgagaacattattatagcgttgctcgagtactaactggtacctcttc tttt ttttctgcagGTAGTAGTCGTAGGTGATCAG - BD#128+ISE (SEQ ID NO: 74): cgagctcaagcttcgaattccctaatttttattttaaaaacttgtgctaatttaaaccag tatt tctaaaaccaggttattaactttccataaatcttttccatagaacgagaacattattata gcgt tgctcgagtactaactggtacctcttcttttttttctgcagGTAGTAGTCGTAGGTGATC AG - BD#135+ISE (SEQ ID NO: 75): cgagctcaagcttcgaattcctgcttctttttttgctaattggcaagttcactatcaatt tttc acatacctttatatgtcttaatattagtaatatttaaatactgaacagtggattaaatta gaac gagaacattattatagcgttgctcgagtactaactggtacctcttcttttttttctgcag GTAG TAGTCGTAGGTGATCAG - BD#162+ISE (SEQ ID NO: 76): cgagctcaagcttcgaattctaatgctgctctgagttttttagtcttttaaaatttctac aggt gaaaaaatattttaaaatccgtaaaaaaatggtgattgatgcatgtgtgcacattgaaaa tagg aacagcaaaactataactggatccactgtttatagaacgagaacattattatagcgttgc tcgag tactaactggtacctcttcttttttttctgcagGTAGTAGTCGTAGGTGATCAG It also generated a 2013 nucleotides corrective OPA1 cDNA (the modified wild-type Homo sapiens OPA1 cDNA from EXON9 to the STOP codon), which is 5’-compatible with the 3’-end of the upstream binding domains + ISE fragment for Gibson cloning assembly. ctgcagGTAGTAGTCGTAGGTGATCAGAGTGCTGGAAAGACTAGTGTGTTGGAAATGATT GCCCAAG CTCGAATATTCCCAAGAGGATCTGGGGAGATGATGACACGTTCTCCAGTTAAGGTGACTC TGAGTGA AGGTCCTCACCATGTGGCCCTATTTAAAGATAGTTCTCGGGAGTTTGATCTTACCAAAGA AGAAGAT CTTGCAGCATTAAGACATGAAATAGAACTTCGAATGAGGAAAAATGTGAAAGAAGGCTGT ACCGTTA GCCCTGAGACCATATCCTTAAATGTAAAAGGCCCTGGACTACAGAGGATGGTGCTTGTTG ACTTACC AGGTGTGATTAATACTGTGACATCAGGCATGGCTCCTGACACAAAGGAAACTATTTTCAG TATCAGC AAAGCTTACATGCAGAATCCTAATGCCATCATACTGTGTATTCAAGATGGATCTGTGGAT GCTGAAC GCAGTATTGTTACAGACTTGGTCAGTCAAATGGACCCTCATGGAAGGAGAACCATATTCG TTTTGAC CAAAGTAGACCTGGCAGAGAAAAATGTAGCCAGTCCAAGCAGGATTCAGCAGATAATTGA AGGAAAG CTCTTCCCAATGAAAGCTTTAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAACAGCTCT GAAAGCA TTGAAGCTATAAGAGAATATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTAAAGACAA GCATGCT AAAGGCACACCAAGTGACTACAAGAAATTTAAGCCTTGCAGTATCAGACTGCTTTTGGAA AATGGTA CGAGAGTCTGTTGAACAACAGGCTGATAGTTTCAAAGCAACACGTTTTAACCTTGAAACT GAATGGA AGAATAACTATCCTCGCCTGCGGGAACTTGACCGGAATGAACTATTTGAAAAAGCTAAAA ATGAAAT CCTTGATGAAGTTATCAGTCTGAGCCAGGTTACACCAAAACATTGGGAGGAAATCCTTCA ACAATCT TTGTGGGAAAGAGTATCAACTCATGTGATTGAAAACATCTACCTTCCAGCTGCGCAGACC ATGAATT CAGGAACTTTTAACACCACAGTGGATATCAAGCTTAAACAGTGGACTGATAAACAACTTC CTAATAA AGCAGTAGAGGTTGCTTGGGAGACCCTACAAGAAGAATTTTCCCGCTTTATGACAGAACC GAAAGGG AAAGAGCATGATGACATATTTGATAAACTTAAAGAGGCTGTTAAGGAAGAAAGTATTAAA CGACACA AGTGGAATGACTTTGCGGAGGACAGCTTGAGGGTTATTCAACACAATGCTTTGGAAGACC GATCCAT ATCTGATAAACAGCAATGGGATGCAGCTATTTATTTTATGGAAGAGGCTCTGCAGGCTCG TCTCAAG GATACTGAAAATGCAATTGAAAACATGGTGGGTCCAGACTGGAAAAAGAGGTGGTTATAC TGGAAGA ATCGGACCCAAGAACAGTGTGTTCACAATGAAACCAAGAATGAATTGGAGAAGATGTTGA AATGTAA TGAGGAGCACCCAGCTTATCTTGCAAGTGATGAAATAACCACAGTCCGGAAGAACCTTGA ATCCCGA GGAGTAGAAGTAGATCCAAGCTTGATTAAGGATACTTGGCATCAAGTTTATAGAAGACAT TTTTTAA AAACAGCTCTAAACCATTGTAACCTTTGTCGAAGAGGTTTTTATTACTACCAAAGGCATT TTGTAGA TTCTGAGTTGGAATGCAATGATGTGGTCTTGTTTTGGCGTATACAGCGCATGCTTGCTAT CACCGCA AATACTTTAAGGCAACAACTTACAAATACTGAAGTTAGGCGATTAGAGAAAAATGTTAAA GAGGTAT TGGAAGATTTTGCTGAAGATGGTGAGAAGAAGATTAAATTGCTTACTGGTAAACGCGTTC AACTGGC GGAAGACCTCAAGAAAGTTAGAGAAATTCAAGAAAAACTTGATGCTTTCATTGAAGCTCT TCATCAG GAGAAATAAgtcgacggtaccgcgggcccg (SEQ ID NO: 25). The most potent Homo sapiens OPA1 trans-splicing binding domains were subcloned upstream to the modified wild-type OPA1 cDNA (2013 bp) into the bicistronic mammalian expression vector pEF1α-IRES-AcGFP1 (631971, TakaraBio, see Figure 7), between EcoRI and SalI restriction sites, through the Gibson cloning assembly method. These constructs were transiently transfected in OPA1-related Dominant Optic Atrophy (ADOA) patients’ fibroblasts for OPA1 haploinsufficiency rescue and mitochondrial fusion induction assays. It generated therapeutic OPA1 pre-mRNA Trans-splicing Molecules whose sequences are: 5’-Binding Domain (BD)-Spacer-Branch Point (BP)-KpnI-PolyPyrimidin Tract (PPT)- 3’ Acceptor Splicing Site (3’ASS)-OPA1 cDNA-3’: - OPA1 RTM _th #106: cctaatttttattttaaaaacttgtgctaatttaaaccagtatttctaaaaccaggttat taac tttccataaatcttttccatag/ctgcttctttttttgctaattggcaagttcactatca attt ttcacatac/ctttatatgtcttaatattagtaatatttaaatactgaacagtggattaa atta g/cttaaatttcacgcatatgg/ctagtttactgtttacaaacacattttcaattctatt agaa cgagaacattattatagcgttgctcgagtactaactggtacctcttcttttttttctgca gGTAG TAGTCGTAGGTGATCAGAGTGCTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGCTC GAATATT CCCAAGAGGATCTGGGGAGATGATGACACGTTCTCCAGTTAAGGTGACTCTGAGTGAAGG TCCTCAC CATGTGGCCCTATTTAAAGATAGTTCTCGGGAGTTTGATCTTACCAAAGAAGAAGATCTT GCAGCAT TAAGACATGAAATAGAACTTCGAATGAGGAAAAATGTGAAAGAAGGCTGTACCGTTAGCC CTGAGAC CATATCCTTAAATGTAAAAGGCCCTGGACTACAGAGGATGGTGCTTGTTGACTTACCAGG TGTGATT AATACTGTGACATCAGGCATGGCTCCTGACACAAAGGAAACTATTTTCAGTATCAGCAAA GCTTACA TGCAGAATCCTAATGCCATCATACTGTGTATTCAAGATGGATCTGTGGATGCTGAACGCA GTATTGT TACAGACTTGGTCAGTCAAATGGACCCTCATGGAAGGAGAACCATATTCGTTTTGACCAA AGTAGAC CTGGCAGAGAAAAATGTAGCCAGTCCAAGCAGGATTCAGCAGATAATTGAAGGAAAGCTC TTCCCAA TGAAAGCTTTAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAACAGCTCTGAAAGCATTG AAGCTAT AAGAGAATATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTAAAGACAAGCATGCTAAA GGCACAC CAAGTGACTACAAGAAATTTAAGCCTTGCAGTATCAGACTGCTTTTGGAAAATGGTACGA GAGTCTG TTGAACAACAGGCTGATAGTTTCAAAGCAACACGTTTTAACCTTGAAACTGAATGGAAGA ATAACTA TCCTCGCCTGCGGGAACTTGACCGGAATGAACTATTTGAAAAAGCTAAAAATGAAATCCT TGATGAA GTTATCAGTCTGAGCCAGGTTACACCAAAACATTGGGAGGAAATCCTTCAACAATCTTTG TGGGAAA GAGTATCAACTCATGTGATTGAAAACATCTACCTTCCAGCTGCGCAGACCATGAATTCAG GAACTTT TAACACCACAGTGGATATCAAGCTTAAACAGTGGACTGATAAACAACTTCCTAATAAAGC AGTAGAG GTTGCTTGGGAGACCCTACAAGAAGAATTTTCCCGCTTTATGACAGAACCGAAAGGGAAA GAGCATG ATGACATATTTGATAAACTTAAAGAGGCTGTTAAGGAAGAAAGTATTAAACGACACAAGT GGAATGA CTTTGCGGAGGACAGCTTGAGGGTTATTCAACACAATGCTTTGGAAGACCGATCCATATC TGATAAA CAGCAATGGGATGCAGCTATTTATTTTATGGAAGAGGCTCTGCAGGCTCGTCTCAAGGAT ACTGAAA ATGCAATTGAAAACATGGTGGGTCCAGACTGGAAAAAGAGGTGGTTATACTGGAAGAATC GGACCCA AGAACAGTGTGTTCACAATGAAACCAAGAATGAATTGGAGAAGATGTTGAAATGTAATGA GGAGCAC CCAGCTTATCTTGCAAGTGATGAAATAACCACAGTCCGGAAGAACCTTGAATCCCGAGGA GTAGAAG TAGATCCAAGCTTGATTAAGGATACTTGGCATCAAGTTTATAGAAGACATTTTTTAAAAA CAGCTCT AAACCATTGTAACCTTTGTCGAAGAGGTTTTTATTACTACCAAAGGCATTTTGTAGATTC TGAGTTG GAATGCAATGATGTGGTCTTGTTTTGGCGTATACAGCGCATGCTTGCTATCACCGCAAAT ACTTTAA GGCAACAACTTACAAATACTGAAGTTAGGCGATTAGAGAAAAATGTTAAAGAGGTATTGG AAGATTT TGCTGAAGATGGTGAGAAGAAGATTAAATTGCTTACTGGTAAACGCGTTCAACTGGCGGA AGACCTC AAGAAAGTTAGAGAAATTCAAGAAAAACTTGATGCTTTCATTGAAGCTCTTCATCAGGAG AAATAA (SEQ ID NO: 26); - OPA1 RTMth#114: ctaatttaatccactgttcagtatttaaatattactaatattaagacatataaagaacga gaac attattatagcgttgctcgagtactaactggtacctcttcttttttttctgcagGTAGTA GTCGT AGGTGATCAGAGTGCTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAATATT CCCAAGA GGATCTGGGGAGATGATGACACGTTCTCCAGTTAAGGTGACTCTGAGTGAAGGTCCTCAC CATGTGG CCCTATTTAAAGATAGTTCTCGGGAGTTTGATCTTACCAAAGAAGAAGATCTTGCAGCAT TAAGACA TGAAATAGAACTTCGAATGAGGAAAAATGTGAAAGAAGGCTGTACCGTTAGCCCTGAGAC CATATCC TTAAATGTAAAAGGCCCTGGACTACAGAGGATGGTGCTTGTTGACTTACCAGGTGTGATT AATACTG TGACATCAGGCATGGCTCCTGACACAAAGGAAACTATTTTCAGTATCAGCAAAGCTTACA TGCAGAA TCCTAATGCCATCATACTGTGTATTCAAGATGGATCTGTGGATGCTGAACGCAGTATTGT TACAGAC TTGGTCAGTCAAATGGACCCTCATGGAAGGAGAACCATATTCGTTTTGACCAAAGTAGAC CTGGCAG AGAAAAATGTAGCCAGTCCAAGCAGGATTCAGCAGATAATTGAAGGAAAGCTCTTCCCAA TGAAAGC TTTAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAACAGCTCTGAAAGCATTGAAGCTAT AAGAGAA TATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTAAAGACAAGCATGCTAAAGGCACAC CAAGTGA CTACAAGAAATTTAAGCCTTGCAGTATCAGACTGCTTTTGGAAAATGGTACGAGAGTCTG TTGAACA ACAGGCTGATAGTTTCAAAGCAACACGTTTTAACCTTGAAACTGAATGGAAGAATAACTA TCCTCGC CTGCGGGAACTTGACCGGAATGAACTATTTGAAAAAGCTAAAAATGAAATCCTTGATGAA GTTATCA GTCTGAGCCAGGTTACACCAAAACATTGGGAGGAAATCCTTCAACAATCTTTGTGGGAAA GAGTATC AACTCATGTGATTGAAAACATCTACCTTCCAGCTGCGCAGACCATGAATTCAGGAACTTT TAACACC ACAGTGGATATCAAGCTTAAACAGTGGACTGATAAACAACTTCCTAATAAAGCAGTAGAG GTTGCTT GGGAGACCCTACAAGAAGAATTTTCCCGCTTTATGACAGAACCGAAAGGGAAAGAGCATG ATGACAT ATTTGATAAACTTAAAGAGGCTGTTAAGGAAGAAAGTATTAAACGACACAAGTGGAATGA CTTTGCG GAGGACAGCTTGAGGGTTATTCAACACAATGCTTTGGAAGACCGATCCATATCTGATAAA CAGCAAT GGGATGCAGCTATTTATTTTATGGAAGAGGCTCTGCAGGCTCGTCTCAAGGATACTGAAA ATGCAAT TGAAAACATGGTGGGTCCAGACTGGAAAAAGAGGTGGTTATACTGGAAGAATCGGACCCA AGAACAG TGTGTTCACAATGAAACCAAGAATGAATTGGAGAAGATGTTGAAATGTAATGAGGAGCAC CCAGCTT ATCTTGCAAGTGATGAAATAACCACAGTCCGGAAGAACCTTGAATCCCGAGGAGTAGAAG TAGATCC AAGCTTGATTAAGGATACTTGGCATCAAGTTTATAGAAGACATTTTTTAAAAACAGCTCT AAACCAT TGTAACCTTTGTCGAAGAGGTTTTTATTACTACCAAAGGCATTTTGTAGATTCTGAGTTG GAATGCA ATGATGTGGTCTTGTTTTGGCGTATACAGCGCATGCTTGCTATCACCGCAAATACTTTAA GGCAACA ACTTACAAATACTGAAGTTAGGCGATTAGAGAAAAATGTTAAAGAGGTATTGGAAGATTT TGCTGAA GATGGTGAGAAGAAGATTAAATTGCTTACTGGTAAACGCGTTCAACTGGCGGAAGACCTC AAGAAAG TTAGAGAAATTCAAGAAAAACTTGATGCTTTCATTGAAGCTCTTCATCAGGAGAAATAA (SEQ ID NO: 27); - OPA1 RTMth#128: cctaatttttattttaaaaacttgtgctaatttaaaccagtatttctaaaaccaggttat taac tttccataaatcttttccatagaacgagaacattattatagcgttgctcgagtactaact ggta cctcttcttttttttctgcagGTAGTAGTCGTAGGTGATCAGAGTGCTGGAAAGACTAGT GTGTTG GAAATGATTGCCCAAGCTCGAATATTCCCAAGAGGATCTGGGGAGATGATGACACGTTCT CCAGTTA AGGTGACTCTGAGTGAAGGTCCTCACCATGTGGCCCTATTTAAAGATAGTTCTCGGGAGT TTGATCT TACCAAAGAAGAAGATCTTGCAGCATTAAGACATGAAATAGAACTTCGAATGAGGAAAAA TGTGAAA GAAGGCTGTACCGTTAGCCCTGAGACCATATCCTTAAATGTAAAAGGCCCTGGACTACAG AGGATGG TGCTTGTTGACTTACCAGGTGTGATTAATACTGTGACATCAGGCATGGCTCCTGACACAA AGGAAAC TATTTTCAGTATCAGCAAAGCTTACATGCAGAATCCTAATGCCATCATACTGTGTATTCA AGATGGA TCTGTGGATGCTGAACGCAGTATTGTTACAGACTTGGTCAGTCAAATGGACCCTCATGGA AGGAGAA CCATATTCGTTTTGACCAAAGTAGACCTGGCAGAGAAAAATGTAGCCAGTCCAAGCAGGA TTCAGCA GATAATTGAAGGAAAGCTCTTCCCAATGAAAGCTTTAGGTTATTTTGCTGTTGTAACAGG AAAAGGG AACAGCTCTGAAAGCATTGAAGCTATAAGAGAATATGAAGAAGAGTTTTTTCAGAATTCA AAGCTCC TAAAGACAAGCATGCTAAAGGCACACCAAGTGACTACAAGAAATTTAAGCCTTGCAGTAT CAGACTG CTTTTGGAAAATGGTACGAGAGTCTGTTGAACAACAGGCTGATAGTTTCAAAGCAACACG TTTTAAC CTTGAAACTGAATGGAAGAATAACTATCCTCGCCTGCGGGAACTTGACCGGAATGAACTA TTTGAAA AAGCTAAAAATGAAATCCTTGATGAAGTTATCAGTCTGAGCCAGGTTACACCAAAACATT GGGAGGA AATCCTTCAACAATCTTTGTGGGAAAGAGTATCAACTCATGTGATTGAAAACATCTACCT TCCAGCT GCGCAGACCATGAATTCAGGAACTTTTAACACCACAGTGGATATCAAGCTTAAACAGTGG ACTGATA AACAACTTCCTAATAAAGCAGTAGAGGTTGCTTGGGAGACCCTACAAGAAGAATTTTCCC GCTTTAT GACAGAACCGAAAGGGAAAGAGCATGATGACATATTTGATAAACTTAAAGAGGCTGTTAA GGAAGAA AGTATTAAACGACACAAGTGGAATGACTTTGCGGAGGACAGCTTGAGGGTTATTCAACAC AATGCTT TGGAAGACCGATCCATATCTGATAAACAGCAATGGGATGCAGCTATTTATTTTATGGAAG AGGCTCT GCAGGCTCGTCTCAAGGATACTGAAAATGCAATTGAAAACATGGTGGGTCCAGACTGGAA AAAGAGG TGGTTATACTGGAAGAATCGGACCCAAGAACAGTGTGTTCACAATGAAACCAAGAATGAA TTGGAGA AGATGTTGAAATGTAATGAGGAGCACCCAGCTTATCTTGCAAGTGATGAAATAACCACAG TCCGGAA GAACCTTGAATCCCGAGGAGTAGAAGTAGATCCAAGCTTGATTAAGGATACTTGGCATCA AGTTTAT AGAAGACATTTTTTAAAAACAGCTCTAAACCATTGTAACCTTTGTCGAAGAGGTTTTTAT TACTACC AAAGGCATTTTGTAGATTCTGAGTTGGAATGCAATGATGTGGTCTTGTTTTGGCGTATAC AGCGCAT GCTTGCTATCACCGCAAATACTTTAAGGCAACAACTTACAAATACTGAAGTTAGGCGATT AGAGAAA AATGTTAAAGAGGTATTGGAAGATTTTGCTGAAGATGGTGAGAAGAAGATTAAATTGCTT ACTGGTA AACGCGTTCAACTGGCGGAAGACCTCAAGAAAGTTAGAGAAATTCAAGAAAAACTTGATG CTTTCAT TGAAGCTCTTCATCAGGAGAAATAA (SEQ ID NO: 28); - OPA1 RTMth#135: ctgcttctttttttgctaattggcaagttcactatcaatttttcacatacctttatatgt ctta atattagtaatatttaaatactgaacagtggattaaattagaacgagaacattattatag cgtt gctcgagtactaactggtacctcttcttttttttctgcagGTAGTAGTCGTAGGTGATCA GAGTG CTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAGAGGATCTG GGGAGAT GATGACACGTTCTCCAGTTAAGGTGACTCTGAGTGAAGGTCCTCACCATGTGGCCCTATT TAAAGAT AGTTCTCGGGAGTTTGATCTTACCAAAGAAGAAGATCTTGCAGCATTAAGACATGAAATA GAACTTC GAATGAGGAAAAATGTGAAAGAAGGCTGTACCGTTAGCCCTGAGACCATATCCTTAAATG TAAAAGG CCCTGGACTACAGAGGATGGTGCTTGTTGACTTACCAGGTGTGATTAATACTGTGACATC AGGCATG GCTCCTGACACAAAGGAAACTATTTTCAGTATCAGCAAAGCTTACATGCAGAATCCTAAT GCCATCA TACTGTGTATTCAAGATGGATCTGTGGATGCTGAACGCAGTATTGTTACAGACTTGGTCA GTCAAAT GGACCCTCATGGAAGGAGAACCATATTCGTTTTGACCAAAGTAGACCTGGCAGAGAAAAA TGTAGCC AGTCCAAGCAGGATTCAGCAGATAATTGAAGGAAAGCTCTTCCCAATGAAAGCTTTAGGT TATTTTG CTGTTGTAACAGGAAAAGGGAACAGCTCTGAAAGCATTGAAGCTATAAGAGAATATGAAG AAGAGTT TTTTCAGAATTCAAAGCTCCTAAAGACAAGCATGCTAAAGGCACACCAAGTGACTACAAG AAATTTA AGCCTTGCAGTATCAGACTGCTTTTGGAAAATGGTACGAGAGTCTGTTGAACAACAGGCT GATAGTT TCAAAGCAACACGTTTTAACCTTGAAACTGAATGGAAGAATAACTATCCTCGCCTGCGGG AACTTGA CCGGAATGAACTATTTGAAAAAGCTAAAAATGAAATCCTTGATGAAGTTATCAGTCTGAG CCAGGTT ACACCAAAACATTGGGAGGAAATCCTTCAACAATCTTTGTGGGAAAGAGTATCAACTCAT GTGATTG AAAACATCTACCTTCCAGCTGCGCAGACCATGAATTCAGGAACTTTTAACACCACAGTGG ATATCAA GCTTAAACAGTGGACTGATAAACAACTTCCTAATAAAGCAGTAGAGGTTGCTTGGGAGAC CCTACAA GAAGAATTTTCCCGCTTTATGACAGAACCGAAAGGGAAAGAGCATGATGACATATTTGAT AAACTTA AAGAGGCTGTTAAGGAAGAAAGTATTAAACGACACAAGTGGAATGACTTTGCGGAGGACA GCTTGAG GGTTATTCAACACAATGCTTTGGAAGACCGATCCATATCTGATAAACAGCAATGGGATGC AGCTATT TATTTTATGGAAGAGGCTCTGCAGGCTCGTCTCAAGGATACTGAAAATGCAATTGAAAAC ATGGTGG GTCCAGACTGGAAAAAGAGGTGGTTATACTGGAAGAATCGGACCCAAGAACAGTGTGTTC ACAATGA AACCAAGAATGAATTGGAGAAGATGTTGAAATGTAATGAGGAGCACCCAGCTTATCTTGC AAGTGAT GAAATAACCACAGTCCGGAAGAACCTTGAATCCCGAGGAGTAGAAGTAGATCCAAGCTTG ATTAAGG ATACTTGGCATCAAGTTTATAGAAGACATTTTTTAAAAACAGCTCTAAACCATTGTAACC TTTGTCG AAGAGGTTTTTATTACTACCAAAGGCATTTTGTAGATTCTGAGTTGGAATGCAATGATGT GGTCTTG TTTTGGCGTATACAGCGCATGCTTGCTATCACCGCAAATACTTTAAGGCAACAACTTACA AATACTG AAGTTAGGCGATTAGAGAAAAATGTTAAAGAGGTATTGGAAGATTTTGCTGAAGATGGTG AGAAGAA GATTAAATTGCTTACTGGTAAACGCGTTCAACTGGCGGAAGACCTCAAGAAAGTTAGAGA AATTCAA GAAAAACTTGATGCTTTCATTGAAGCTCTTCATCAGGAGAAATAA (SEQ ID NO: 29); and - OPA1 RTMth#162: taatgctgctctgagttttttagtcttttaaaatttctacaggtgaaaaaatattttaaa atcc gtaaaaaaatggtgattgatgcatgtgtgcacattgaaaataggaacagcaaaactataa ctgga tccactgtttatagaacgagaacattattatagcgttgctcgagtactaactggtacctc ttctt ttttttctgcagGTAGTAGTCGTAGGTGATCAGAGTGCTGGAAAGACTAGTGTGTTGGAA ATGATT GCCCAAGCTCGAATATTCCCAAGAGGATCTGGGGAGATGATGACACGTTCTCCAGTTAAG GTGACTC TGAGTGAAGGTCCTCACCATGTGGCCCTATTTAAAGATAGTTCTCGGGAGTTTGATCTTA CCAAAGA AGAAGATCTTGCAGCATTAAGACATGAAATAGAACTTCGAATGAGGAAAAATGTGAAAGA AGGCTGT ACCGTTAGCCCTGAGACCATATCCTTAAATGTAAAAGGCCCTGGACTACAGAGGATGGTG CTTGTTG ACTTACCAGGTGTGATTAATACTGTGACATCAGGCATGGCTCCTGACACAAAGGAAACTA TTTTCAG TATCAGCAAAGCTTACATGCAGAATCCTAATGCCATCATACTGTGTATTCAAGATGGATC TGTGGAT GCTGAACGCAGTATTGTTACAGACTTGGTCAGTCAAATGGACCCTCATGGAAGGAGAACC ATATTCG TTTTGACCAAAGTAGACCTGGCAGAGAAAAATGTAGCCAGTCCAAGCAGGATTCAGCAGA TAATTGA AGGAAAGCTCTTCCCAATGAAAGCTTTAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAA CAGCTCT GAAAGCATTGAAGCTATAAGAGAATATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTA AAGACAA GCATGCTAAAGGCACACCAAGTGACTACAAGAAATTTAAGCCTTGCAGTATCAGACTGCT TTTGGAA AATGGTACGAGAGTCTGTTGAACAACAGGCTGATAGTTTCAAAGCAACACGTTTTAACCT TGAAACT GAATGGAAGAATAACTATCCTCGCCTGCGGGAACTTGACCGGAATGAACTATTTGAAAAA GCTAAAA ATGAAATCCTTGATGAAGTTATCAGTCTGAGCCAGGTTACACCAAAACATTGGGAGGAAA TCCTTCA ACAATCTTTGTGGGAAAGAGTATCAACTCATGTGATTGAAAACATCTACCTTCCAGCTGC GCAGACC ATGAATTCAGGAACTTTTAACACCACAGTGGATATCAAGCTTAAACAGTGGACTGATAAA CAACTTC CTAATAAAGCAGTAGAGGTTGCTTGGGAGACCCTACAAGAAGAATTTTCCCGCTTTATGA CAGAACC GAAAGGGAAAGAGCATGATGACATATTTGATAAACTTAAAGAGGCTGTTAAGGAAGAAAG TATTAAA CGACACAAGTGGAATGACTTTGCGGAGGACAGCTTGAGGGTTATTCAACACAATGCTTTG GAAGACC GATCCATATCTGATAAACAGCAATGGGATGCAGCTATTTATTTTATGGAAGAGGCTCTGC AGGCTCG TCTCAAGGATACTGAAAATGCAATTGAAAACATGGTGGGTCCAGACTGGAAAAAGAGGTG GTTATAC TGGAAGAATCGGACCCAAGAACAGTGTGTTCACAATGAAACCAAGAATGAATTGGAGAAG ATGTTGA AATGTAATGAGGAGCACCCAGCTTATCTTGCAAGTGATGAAATAACCACAGTCCGGAAGA ACCTTGA ATCCCGAGGAGTAGAAGTAGATCCAAGCTTGATTAAGGATACTTGGCATCAAGTTTATAG AAGACAT TTTTTAAAAACAGCTCTAAACCATTGTAACCTTTGTCGAAGAGGTTTTTATTACTACCAA AGGCATT TTGTAGATTCTGAGTTGGAATGCAATGATGTGGTCTTGTTTTGGCGTATACAGCGCATGC TTGCTAT CACCGCAAATACTTTAAGGCAACAACTTACAAATACTGAAGTTAGGCGATTAGAGAAAAA TGTTAAA GAGGTATTGGAAGATTTTGCTGAAGATGGTGAGAAGAAGATTAAATTGCTTACTGGTAAA CGCGTTC AACTGGCGGAAGACCTCAAGAAAGTTAGAGAAATTCAAGAAAAACTTGATGCTTTCATTG AAGCTCT TCATCAGGAGAAATAA (SEQ ID NO: 30); - OPA1 RTMth#100: GCAATCATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACCTTC CCAC AAAACAAAGAACACTTATTCATATTTTTCTGATACCatcgatgttaacgagaacattatt atag cgttgctcgagtactaactggtacctcttcttttttttctgcagGTAGTAGTCGTAGGTG ATCA GAGTGCTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAGAGG ATCT GGGGAGATGATGACACGTTCTCCAGTTAAGGTGACTCTGAGTGAAGGTCCTCACCATGTG GCCC TATTTAAAGATAGTTCTCGGGAGTTTGATCTTACCAAAGAAGAAGATCTTGCAGCATTAA GACA TGAAATAGAACTTCGAATGAGGAAAAATGTGAAAGAAGGCTGTACCGTTAGCCCTGAGAC CATA TCCTTAAATGTAAAAGGCCCTGGACTACAGAGGATGGTGCTTGTTGACTTACCAGGTGTG ATTA ATACTGTGACATCAGGCATGGCTCCTGACACAAAGGAAACTATTTTCAGTATCAGCAAAG CTTA CATGCAGAATCCTAATGCCATCATACTGTGTATTCAAGATGGATCTGTGGATGCTGAACG CAGT ATTGTTACAGACTTGGTCAGTCAAATGGACCCTCATGGAAGGAGAACCATATTCGTTTTG ACCA AAGTAGACCTGGCAGAGAAAAATGTAGCCAGTCCAAGCAGGATTCAGCAGATAATTGAAG GAAA GCTCTTCCCAATGAAAGCTTTAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAACAGCTC TGAA AGCATTGAAGCTATAAGAGAATATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTAAAG ACAA GCATGCTAAAGGCACACCAAGTGACTACAAGAAATTTAAGCCTTGCAGTATCAGACTGCT TTTG GAAAATGGTACGAGAGTCTGTTGAACAACAGGCTGATAGTTTCAAAGCAACACGTTTTAA CCTT GAAACTGAATGGAAGAATAACTATCCTCGCCTGCGGGAACTTGACCGGAATGAACTATTT GAAA AAGCTAAAAATGAAATCCTTGATGAAGTTATCAGTCTGAGCCAGGTTACACCAAAACATT GGGA GGAAATCCTTCAACAATCTTTGTGGGAAAGAGTATCAACTCATGTGATTGAAAACATCTA CCTT CCAGCTGCGCAGACCATGAATTCAGGAACTTTTAACACCACAGTGGATATCAAGCTTAAA CAGT GGACTGATAAACAACTTCCTAATAAAGCAGTAGAGGTTGCTTGGGAGACCCTACAAGAAG AATT TTCCCGCTTTATGACAGAACCGAAAGGGAAAGAGCATGATGACATATTTGATAAACTTAA AGAG GCTGTTAAGGAAGAAAGTATTAAACGACACAAGTGGAATGACTTTGCGGAGGACAGCTTG AGGG TTATTCAACACAATGCTTTGGAAGACCGATCCATATCTGATAAACAGCAATGGGATGCAG CTAT TTATTTTATGGAAGAGGCTCTGCAGGCTCGTCTCAAGGATACTGAAAATGCAATTGAAAA CATG GTGGGTCCAGACTGGAAAAAGAGGTGGTTATACTGGAAGAATCGGACCCAAGAACAGTGT GTTC ACAATGAAACCAAGAATGAATTGGAGAAGATGTTGAAATGTAATGAGGAGCACCCAGCTT ATCT TGCAAGTGATGAAATAACCACAGTCCGGAAGAACCTTGAATCCCGAGGAGTAGAAGTAGA TCCA AGCTTGATTAAGGATACTTGGCATCAAGTTTATAGAAGACATTTTTTAAAAACAGCTCTA AACC ATTGTAACCTTTGTCGAAGAGGTTTTTATTACTACCAAAGGCATTTTGTAGATTCTGAGT TGGA ATGCAATGATGTGGTCTTGTTTTGGCGTATACAGCGCATGCTTGCTATCACCGCAAATAC TTTA AGGCAACAACTTACAAATACTGAAGTTAGGCGATTAGAGAAAAATGTTAAAGAGGTATTG GAAG ATTTTGCTGAAGATGGTGAGAAGAAGATTAAATTGCTTACTGGTAAACGCGTTCAACTGG CGGA AGACCTCAAGAAAGTTAGAGAAATTCAAGAAAAACTTGATGCTTTCATTGAAGCTCTTCA TCAG GAGAAATAA (SEQ ID NO: 31); - OPA1 RTMth#:130 CCAGATCCTCTTGGGAATATTCGAGCTTGGGCAATCATTTCCAACACACTAGTCTTTCCA GCAC TCTGATCTCCAACCACAACAACCTTCCCACAAAACAAAGAACACTTATTCATATTTTTCT GATA CCatcgatgttaacgagaacattattatagcgttgctcgagtactaactggtacctcttc tttt ttttctgcagGTAGTAGTCGTAGGTGATCAGAGTGCTGGAAAGACTAGTGTGTTGGAAAT GATTGCC CAAGCTCGAATATTCCCAAGAGGATCTGGGGAGATGATGACACGTTCTCCAGTTAAGGTG ACTCTGA GTGAAGGTCCTCACCATGTGGCCCTATTTAAAGATAGTTCTCGGGAGTTTGATCTTACCA AAGAAGA AGATCTTGCAGCATTAAGACATGAAATAGAACTTCGAATGAGGAAAAATGTGAAAGAAGG CTGT ACCGTTAGCCCTGAGACCATATCCTTAAATGTAAAAGGCCCTGGACTACAGAGGATGGTG CTTG TTGACTTACCAGGTGTGATTAATACTGTGACATCAGGCATGGCTCCTGACACAAAGGAAA CTAT TTTCAGTATCAGCAAAGCTTACATGCAGAATCCTAATGCCATCATACTGTGTATTCAAGA TGGA TCTGTGGATGCTGAACGCAGTATTGTTACAGACTTGGTCAGTCAAATGGACCCTCATGGA AGGA GAACCATATTCGTTTTGACCAAAGTAGACCTGGCAGAGAAAAATGTAGCCAGTCCAAGCA GGAT TCAGCAGATAATTGAAGGAAAGCTCTTCCCAATGAAAGCTTTAGGTTATTTTGCTGTTGT AACA GGAAAAGGGAACAGCTCTGAAAGCATTGAAGCTATAAGAGAATATGAAGAAGAGTTTTTT CAGA ATTCAAAGCTCCTAAAGACAAGCATGCTAAAGGCACACCAAGTGACTACAAGAAATTTAA GCCT TGCAGTATCAGACTGCTTTTGGAAAATGGTACGAGAGTCTGTTGAACAACAGGCTGATAG TTTC AAAGCAACACGTTTTAACCTTGAAACTGAATGGAAGAATAACTATCCTCGCCTGCGGGAA CTTG ACCGGAATGAACTATTTGAAAAAGCTAAAAATGAAATCCTTGATGAAGTTATCAGTCTGA GCCA GGTTACACCAAAACATTGGGAGGAAATCCTTCAACAATCTTTGTGGGAAAGAGTATCAAC TCAT GTGATTGAAAACATCTACCTTCCAGCTGCGCAGACCATGAATTCAGGAACTTTTAACACC ACAG TGGATATCAAGCTTAAACAGTGGACTGATAAACAACTTCCTAATAAAGCAGTAGAGGTTG CTTG GGAGACCCTACAAGAAGAATTTTCCCGCTTTATGACAGAACCGAAAGGGAAAGAGCATGA TGAC ATATTTGATAAACTTAAAGAGGCTGTTAAGGAAGAAAGTATTAAACGACACAAGTGGAAT GACT TTGCGGAGGACAGCTTGAGGGTTATTCAACACAATGCTTTGGAAGACCGATCCATATCTG ATAA ACAGCAATGGGATGCAGCTATTTATTTTATGGAAGAGGCTCTGCAGGCTCGTCTCAAGGA TACT GAAAATGCAATTGAAAACATGGTGGGTCCAGACTGGAAAAAGAGGTGGTTATACTGGAAG AATC GGACCCAAGAACAGTGTGTTCACAATGAAACCAAGAATGAATTGGAGAAGATGTTGAAAT GTAA TGAGGAGCACCCAGCTTATCTTGCAAGTGATGAAATAACCACAGTCCGGAAGAACCTTGA ATCC CGAGGAGTAGAAGTAGATCCAAGCTTGATTAAGGATACTTGGCATCAAGTTTATAGAAGA CATT TTTTAAAAACAGCTCTAAACCATTGTAACCTTTGTCGAAGAGGTTTTTATTACTACCAAA GGCA TTTTGTAGATTCTGAGTTGGAATGCAATGATGTGGTCTTGTTTTGGCGTATACAGCGCAT GCTT GCTATCACCGCAAATACTTTAAGGCAACAACTTACAAATACTGAAGTTAGGCGATTAGAG AAAA ATGTTAAAGAGGTATTGGAAGATTTTGCTGAAGATGGTGAGAAGAAGATTAAATTGCTTA CTGG TAAACGCGTTCAACTGGCGGAAGACCTCAAGAAAGTTAGAGAAATTCAAGAAAAACTTGA TGCT TTCATTGAAGCTCTTCATCAGGAGAAATAA (SEQ ID NO: 32); - OPA1 RTMth#158: CTTAACTGGAGAACGTGTCATCATCTCCCCAGATCCTCTTGGGAATATTCGAGCTTGGGC AATC ATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACCTTCCCACAA AACA AAGAACACTTATTCATATTTTTCTGATACCatcgatgttaacgagaacattattatagcg ttgc tcgagtactaactggtacctcttcttttttttctgcagGTAGTAGTCGTAGGTGATCAGA GTGCT GGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAGAGGATCTGGG GAGATGA TGACACGTTCTCCAGTTAAGGTGACTCTGAGTGAAGGTCCTCACCATGTGGCCCTATTTA AAGATAG TTCTCGGGAGTTTGATCTTACCAAAGAAGAAGATCTTGCAGCATTAAGACATGAAATAGA ACTTC GAATGAGGAAAAATGTGAAAGAAGGCTGTACCGTTAGCCCTGAGACCATATCCTTAAATG TAAA AGGCCCTGGACTACAGAGGATGGTGCTTGTTGACTTACCAGGTGTGATTAATACTGTGAC ATCA GGCATGGCTCCTGACACAAAGGAAACTATTTTCAGTATCAGCAAAGCTTACATGCAGAAT CCTA ATGCCATCATACTGTGTATTCAAGATGGATCTGTGGATGCTGAACGCAGTATTGTTACAG ACTT GGTCAGTCAAATGGACCCTCATGGAAGGAGAACCATATTCGTTTTGACCAAAGTAGACCT GGCA GAGAAAAATGTAGCCAGTCCAAGCAGGATTCAGCAGATAATTGAAGGAAAGCTCTTCCCA ATGA AAGCTTTAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAACAGCTCTGAAAGCATTGAAG CTAT AAGAGAATATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTAAAGACAAGCATGCTAAA GGCA CACCAAGTGACTACAAGAAATTTAAGCCTTGCAGTATCAGACTGCTTTTGGAAAATGGTA CGAG AGTCTGTTGAACAACAGGCTGATAGTTTCAAAGCAACACGTTTTAACCTTGAAACTGAAT GGAA GAATAACTATCCTCGCCTGCGGGAACTTGACCGGAATGAACTATTTGAAAAAGCTAAAAA TGAA ATCCTTGATGAAGTTATCAGTCTGAGCCAGGTTACACCAAAACATTGGGAGGAAATCCTT CAAC AATCTTTGTGGGAAAGAGTATCAACTCATGTGATTGAAAACATCTACCTTCCAGCTGCGC AGAC CATGAATTCAGGAACTTTTAACACCACAGTGGATATCAAGCTTAAACAGTGGACTGATAA ACAA CTTCCTAATAAAGCAGTAGAGGTTGCTTGGGAGACCCTACAAGAAGAATTTTCCCGCTTT ATGA CAGAACCGAAAGGGAAAGAGCATGATGACATATTTGATAAACTTAAAGAGGCTGTTAAGG AAGA AAGTATTAAACGACACAAGTGGAATGACTTTGCGGAGGACAGCTTGAGGGTTATTCAACA CAAT GCTTTGGAAGACCGATCCATATCTGATAAACAGCAATGGGATGCAGCTATTTATTTTATG GAAG AGGCTCTGCAGGCTCGTCTCAAGGATACTGAAAATGCAATTGAAAACATGGTGGGTCCAG ACTG GAAAAAGAGGTGGTTATACTGGAAGAATCGGACCCAAGAACAGTGTGTTCACAATGAAAC CAAG AATGAATTGGAGAAGATGTTGAAATGTAATGAGGAGCACCCAGCTTATCTTGCAAGTGAT GAAA TAACCACAGTCCGGAAGAACCTTGAATCCCGAGGAGTAGAAGTAGATCCAAGCTTGATTA AGGA TACTTGGCATCAAGTTTATAGAAGACATTTTTTAAAAACAGCTCTAAACCATTGTAACCT TTGT CGAAGAGGTTTTTATTACTACCAAAGGCATTTTGTAGATTCTGAGTTGGAATGCAATGAT GTGG TCTTGTTTTGGCGTATACAGCGCATGCTTGCTATCACCGCAAATACTTTAAGGCAACAAC TTAC AAATACTGAAGTTAGGCGATTAGAGAAAAATGTTAAAGAGGTATTGGAAGATTTTGCTGA AGAT GGTGAGAAGAAGATTAAATTGCTTACTGGTAAACGCGTTCAACTGGCGGAAGACCTCAAG AAAG TTAGAGAAATTCAAGAAAAACTTGATGCTTTCATTGAAGCTCTTCATCAGGAGAAATAA (SEQ ID NO: 33); - OPA1 RTMth#166: GCAATCATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACCTTC CCAC AAAACAAAGAACACTTATTCATATTTTTCTGATACCAAATTAAAATTAAAACCTATTTGT AATG CTGCTCTGAGTTTTTTAGTCTTTTAAAATTTCTACAGGatcgatgttaacgagaacatta ttat agcgttgctcgagtactaactggtacctcttcttttttttctgcagGTAGTAGTCGTAGG TGATC AGAGTGCTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAGAG GATCTGG GGAGATGATGACACGTTCTCCAGTTAAGGTGACTCTGAGTGAAGGTCCTCACCATGTGGC CCTATTT AAAGATAGTTCTCGGGAGTTTGATCTTACCAAAGAAGAAGATCTTGCAGCATTAAGACAT GAAATA GAACTTCGAATGAGGAAAAATGTGAAAGAAGGCTGTACCGTTAGCCCTGAGACCATATCC TTAA ATGTAAAAGGCCCTGGACTACAGAGGATGGTGCTTGTTGACTTACCAGGTGTGATTAATA CTGT GACATCAGGCATGGCTCCTGACACAAAGGAAACTATTTTCAGTATCAGCAAAGCTTACAT GCAG AATCCTAATGCCATCATACTGTGTATTCAAGATGGATCTGTGGATGCTGAACGCAGTATT GTTA CAGACTTGGTCAGTCAAATGGACCCTCATGGAAGGAGAACCATATTCGTTTTGACCAAAG TAGA CCTGGCAGAGAAAAATGTAGCCAGTCCAAGCAGGATTCAGCAGATAATTGAAGGAAAGCT CTTC CCAATGAAAGCTTTAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAACAGCTCTGAAAGC ATTG AAGCTATAAGAGAATATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTAAAGACAAGCA TGCT AAAGGCACACCAAGTGACTACAAGAAATTTAAGCCTTGCAGTATCAGACTGCTTTTGGAA AATG GTACGAGAGTCTGTTGAACAACAGGCTGATAGTTTCAAAGCAACACGTTTTAACCTTGAA ACTG AATGGAAGAATAACTATCCTCGCCTGCGGGAACTTGACCGGAATGAACTATTTGAAAAAG CTAA AAATGAAATCCTTGATGAAGTTATCAGTCTGAGCCAGGTTACACCAAAACATTGGGAGGA AATC CTTCAACAATCTTTGTGGGAAAGAGTATCAACTCATGTGATTGAAAACATCTACCTTCCA GCTG CGCAGACCATGAATTCAGGAACTTTTAACACCACAGTGGATATCAAGCTTAAACAGTGGA CTGA TAAACAACTTCCTAATAAAGCAGTAGAGGTTGCTTGGGAGACCCTACAAGAAGAATTTTC CCGC TTTATGACAGAACCGAAAGGGAAAGAGCATGATGACATATTTGATAAACTTAAAGAGGCT GTTA AGGAAGAAAGTATTAAACGACACAAGTGGAATGACTTTGCGGAGGACAGCTTGAGGGTTA TTCA ACACAATGCTTTGGAAGACCGATCCATATCTGATAAACAGCAATGGGATGCAGCTATTTA TTTT ATGGAAGAGGCTCTGCAGGCTCGTCTCAAGGATACTGAAAATGCAATTGAAAACATGGTG GGTC CAGACTGGAAAAAGAGGTGGTTATACTGGAAGAATCGGACCCAAGAACAGTGTGTTCACA ATGA AACCAAGAATGAATTGGAGAAGATGTTGAAATGTAATGAGGAGCACCCAGCTTATCTTGC AAGT GATGAAATAACCACAGTCCGGAAGAACCTTGAATCCCGAGGAGTAGAAGTAGATCCAAGC TTGA TTAAGGATACTTGGCATCAAGTTTATAGAAGACATTTTTTAAAAACAGCTCTAAACCATT GTAA CCTTTGTCGAAGAGGTTTTTATTACTACCAAAGGCATTTTGTAGATTCTGAGTTGGAATG CAAT GATGTGGTCTTGTTTTGGCGTATACAGCGCATGCTTGCTATCACCGCAAATACTTTAAGG CAAC AACTTACAAATACTGAAGTTAGGCGATTAGAGAAAAATGTTAAAGAGGTATTGGAAGATT TTGC TGAAGATGGTGAGAAGAAGATTAAATTGCTTACTGGTAAACGCGTTCAACTGGCGGAAGA CCTC AAGAAAGTTAGAGAAATTCAAGAAAAACTTGATGCTTTCATTGAAGCTCTTCATCAGGAG AAAT AA (SEQ ID NO: 34); - OPA1 RTM _th #196: CCAGATCCTCTTGGGAATATTCGAGCTTGGGCAATCATTTCCAACACACTAGTCTTTCCA GCAC TCTGATCTCCAACCACAACAACCTTCCCACAAAACAAAGAACACTTATTCATATTTTTCT GATA CCAAATTAAAATTAAAACCTATTTGTAATGCTGCTCTGAGTTTTTTAGTCTTTTAAAATT TCTA CAGGatcgatgttaacgagaacattattatagcgttgctcgagtactaactggtacctct tctt ttttttctgcagGTAGTAGTCGTAGGTGATCAGAGTGCTGGAAAGACTAGTGTGTTGGAA ATGATT GCCCAAGCTCGAATATTCCCAAGAGGATCTGGGGAGATGATGACACGTTCTCCAGTTAAG GTGACTC TGAGTGAAGGTCCTCACCATGTGGCCCTATTTAAAGATAGTTCTCGGGAGTTTGATCTTA CCAAAGA AGAAGATCTTGCAGCATTAAGACATGAAATAGAACTTCGAATGAGGAAAAATGTGAAAGA AGGC TGTACCGTTAGCCCTGAGACCATATCCTTAAATGTAAAAGGCCCTGGACTACAGAGGATG GTGC TTGTTGACTTACCAGGTGTGATTAATACTGTGACATCAGGCATGGCTCCTGACACAAAGG AAAC TATTTTCAGTATCAGCAAAGCTTACATGCAGAATCCTAATGCCATCATACTGTGTATTCA AGAT GGATCTGTGGATGCTGAACGCAGTATTGTTACAGACTTGGTCAGTCAAATGGACCCTCAT GGAA GGAGAACCATATTCGTTTTGACCAAAGTAGACCTGGCAGAGAAAAATGTAGCCAGTCCAA GCAG GATTCAGCAGATAATTGAAGGAAAGCTCTTCCCAATGAAAGCTTTAGGTTATTTTGCTGT TGTA ACAGGAAAAGGGAACAGCTCTGAAAGCATTGAAGCTATAAGAGAATATGAAGAAGAGTTT TTTC AGAATTCAAAGCTCCTAAAGACAAGCATGCTAAAGGCACACCAAGTGACTACAAGAAATT TAAG CCTTGCAGTATCAGACTGCTTTTGGAAAATGGTACGAGAGTCTGTTGAACAACAGGCTGA TAGT TTCAAAGCAACACGTTTTAACCTTGAAACTGAATGGAAGAATAACTATCCTCGCCTGCGG GAAC TTGACCGGAATGAACTATTTGAAAAAGCTAAAAATGAAATCCTTGATGAAGTTATCAGTC TGAG CCAGGTTACACCAAAACATTGGGAGGAAATCCTTCAACAATCTTTGTGGGAAAGAGTATC AACT CATGTGATTGAAAACATCTACCTTCCAGCTGCGCAGACCATGAATTCAGGAACTTTTAAC ACCA CAGTGGATATCAAGCTTAAACAGTGGACTGATAAACAACTTCCTAATAAAGCAGTAGAGG TTGC TTGGGAGACCCTACAAGAAGAATTTTCCCGCTTTATGACAGAACCGAAAGGGAAAGAGCA TGAT GACATATTTGATAAACTTAAAGAGGCTGTTAAGGAAGAAAGTATTAAACGACACAAGTGG AATG ACTTTGCGGAGGACAGCTTGAGGGTTATTCAACACAATGCTTTGGAAGACCGATCCATAT CTGA TAAACAGCAATGGGATGCAGCTATTTATTTTATGGAAGAGGCTCTGCAGGCTCGTCTCAA GGAT ACTGAAAATGCAATTGAAAACATGGTGGGTCCAGACTGGAAAAAGAGGTGGTTATACTGG AAGA ATCGGACCCAAGAACAGTGTGTTCACAATGAAACCAAGAATGAATTGGAGAAGATGTTGA AATG TAATGAGGAGCACCCAGCTTATCTTGCAAGTGATGAAATAACCACAGTCCGGAAGAACCT TGAA TCCCGAGGAGTAGAAGTAGATCCAAGCTTGATTAAGGATACTTGGCATCAAGTTTATAGA AGAC ATTTTTTAAAAACAGCTCTAAACCATTGTAACCTTTGTCGAAGAGGTTTTTATTACTACC AAAG GCATTTTGTAGATTCTGAGTTGGAATGCAATGATGTGGTCTTGTTTTGGCGTATACAGCG CATG CTTGCTATCACCGCAAATACTTTAAGGCAACAACTTACAAATACTGAAGTTAGGCGATTA GAGA AAAATGTTAAAGAGGTATTGGAAGATTTTGCTGAAGATGGTGAGAAGAAGATTAAATTGC TTAC TGGTAAACGCGTTCAACTGGCGGAAGACCTCAAGAAAGTTAGAGAAATTCAAGAAAAACT TGAT GCTTTCATTGAAGCTCTTCATCAGGAGAAATAA (SEQ ID NO: 35); - OPA1 RTMth#224: CTTAACTGGAGAACGTGTCATCATCTCCCCAGATCCTCTTGGGAATATTCGAGCTTGGGC AATC ATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACCTTCCCACAA AACA AAGAACACTTATTCATATTTTTCTGATACCAAATTAAAATTAAAACCTATTTGTAATGCT GCTC TGAGTTTTTTAGTCTTTTAAAATTTCTACAGGatcgatgttaacgagaacattattatag cgtt gctcgagtactaactggtacctcttcttttttttctgcagGTAGTAGTCGTAGGTGATCA GAGTG CTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAGAGGATCTG GGGAGAT GATGACACGTTCTCCAGTTAAGGTGACTCTGAGTGAAGGTCCTCACCATGTGGCCCTATT TAAAGAT AGTTCTCGGGAGTTTGATCTTACCAAAGAAGAAGATCTTGCAGCATTAAGACATGAAATA GAACT TCGAATGAGGAAAAATGTGAAAGAAGGCTGTACCGTTAGCCCTGAGACCATATCCTTAAA TGTA AAAGGCCCTGGACTACAGAGGATGGTGCTTGTTGACTTACCAGGTGTGATTAATACTGTG ACAT CAGGCATGGCTCCTGACACAAAGGAAACTATTTTCAGTATCAGCAAAGCTTACATGCAGA ATCC TAATGCCATCATACTGTGTATTCAAGATGGATCTGTGGATGCTGAACGCAGTATTGTTAC AGAC TTGGTCAGTCAAATGGACCCTCATGGAAGGAGAACCATATTCGTTTTGACCAAAGTAGAC CTGG CAGAGAAAAATGTAGCCAGTCCAAGCAGGATTCAGCAGATAATTGAAGGAAAGCTCTTCC CAAT GAAAGCTTTAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAACAGCTCTGAAAGCATTGA AGCT ATAAGAGAATATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTAAAGACAAGCATGCTA AAGG CACACCAAGTGACTACAAGAAATTTAAGCCTTGCAGTATCAGACTGCTTTTGGAAAATGG TACG AGAGTCTGTTGAACAACAGGCTGATAGTTTCAAAGCAACACGTTTTAACCTTGAAACTGA ATGG AAGAATAACTATCCTCGCCTGCGGGAACTTGACCGGAATGAACTATTTGAAAAAGCTAAA AATG AAATCCTTGATGAAGTTATCAGTCTGAGCCAGGTTACACCAAAACATTGGGAGGAAATCC TTCA ACAATCTTTGTGGGAAAGAGTATCAACTCATGTGATTGAAAACATCTACCTTCCAGCTGC GCAG ACCATGAATTCAGGAACTTTTAACACCACAGTGGATATCAAGCTTAAACAGTGGACTGAT AAAC AACTTCCTAATAAAGCAGTAGAGGTTGCTTGGGAGACCCTACAAGAAGAATTTTCCCGCT TTAT GACAGAACCGAAAGGGAAAGAGCATGATGACATATTTGATAAACTTAAAGAGGCTGTTAA GGAA GAAAGTATTAAACGACACAAGTGGAATGACTTTGCGGAGGACAGCTTGAGGGTTATTCAA CACA ATGCTTTGGAAGACCGATCCATATCTGATAAACAGCAATGGGATGCAGCTATTTATTTTA TGGA AGAGGCTCTGCAGGCTCGTCTCAAGGATACTGAAAATGCAATTGAAAACATGGTGGGTCC AGAC TGGAAAAAGAGGTGGTTATACTGGAAGAATCGGACCCAAGAACAGTGTGTTCACAATGAA ACCA AGAATGAATTGGAGAAGATGTTGAAATGTAATGAGGAGCACCCAGCTTATCTTGCAAGTG ATGA AATAACCACAGTCCGGAAGAACCTTGAATCCCGAGGAGTAGAAGTAGATCCAAGCTTGAT TAAG GATACTTGGCATCAAGTTTATAGAAGACATTTTTTAAAAACAGCTCTAAACCATTGTAAC CTTT GTCGAAGAGGTTTTTATTACTACCAAAGGCATTTTGTAGATTCTGAGTTGGAATGCAATG ATGT GGTCTTGTTTTGGCGTATACAGCGCATGCTTGCTATCACCGCAAATACTTTAAGGCAACA ACTT ACAAATACTGAAGTTAGGCGATTAGAGAAAAATGTTAAAGAGGTATTGGAAGATTTTGCT GAAG ATGGTGAGAAGAAGATTAAATTGCTTACTGGTAAACGCGTTCAACTGGCGGAAGACCTCA AGAA AGTTAGAGAAATTCAAGAAAAACTTGATGCTTTCATTGAAGCTCTTCATCAGGAGAAATA A (SEQ ID NO: 36); - OPA1 RTM _th #209: GCAATCATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACCTTC CCAC AAAACAAAGAACACTTATTCATATTTTTCTGATACCAAATTAAAATTAAAACCTATTTGT AATG CTGCTCTGAGTTTTTTAGTCTTTTAAAATTTCTACAGGTGAAAAAATATTTTAAAATCCG TAAA AAAATGGTGATTGATGCatcgatgttaacgagaacattattatagcgttgctcgagtact aact ggtacctcttcttttttttctgcagGTAGTAGTCGTAGGTGATCAGAGTGCTGGAAAGAC TAGTGT GTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAGAGGATCTGGGGAGATGATGACACG TTCTCCA GTTAAGGTGACTCTGAGTGAAGGTCCTCACCATGTGGCCCTATTTAAAGATAGTTCTCGG GAGTTTG ATCTTACCAAAGAAGAAGATCTTGCAGCATTAAGACATGAAATAGAACTTCGAATGAGGA AAAAT GTGAAAGAAGGCTGTACCGTTAGCCCTGAGACCATATCCTTAAATGTAAAAGGCCCTGGA CTAC AGAGGATGGTGCTTGTTGACTTACCAGGTGTGATTAATACTGTGACATCAGGCATGGCTC CTGA CACAAAGGAAACTATTTTCAGTATCAGCAAAGCTTACATGCAGAATCCTAATGCCATCAT ACTG TGTATTCAAGATGGATCTGTGGATGCTGAACGCAGTATTGTTACAGACTTGGTCAGTCAA ATGG ACCCTCATGGAAGGAGAACCATATTCGTTTTGACCAAAGTAGACCTGGCAGAGAAAAATG TAGC CAGTCCAAGCAGGATTCAGCAGATAATTGAAGGAAAGCTCTTCCCAATGAAAGCTTTAGG TTAT TTTGCTGTTGTAACAGGAAAAGGGAACAGCTCTGAAAGCATTGAAGCTATAAGAGAATAT GAAG AAGAGTTTTTTCAGAATTCAAAGCTCCTAAAGACAAGCATGCTAAAGGCACACCAAGTGA CTAC AAGAAATTTAAGCCTTGCAGTATCAGACTGCTTTTGGAAAATGGTACGAGAGTCTGTTGA ACAA CAGGCTGATAGTTTCAAAGCAACACGTTTTAACCTTGAAACTGAATGGAAGAATAACTAT CCTC GCCTGCGGGAACTTGACCGGAATGAACTATTTGAAAAAGCTAAAAATGAAATCCTTGATG AAGT TATCAGTCTGAGCCAGGTTACACCAAAACATTGGGAGGAAATCCTTCAACAATCTTTGTG GGAA AGAGTATCAACTCATGTGATTGAAAACATCTACCTTCCAGCTGCGCAGACCATGAATTCA GGAA CTTTTAACACCACAGTGGATATCAAGCTTAAACAGTGGACTGATAAACAACTTCCTAATA AAGC AGTAGAGGTTGCTTGGGAGACCCTACAAGAAGAATTTTCCCGCTTTATGACAGAACCGAA AGGG AAAGAGCATGATGACATATTTGATAAACTTAAAGAGGCTGTTAAGGAAGAAAGTATTAAA CGAC ACAAGTGGAATGACTTTGCGGAGGACAGCTTGAGGGTTATTCAACACAATGCTTTGGAAG ACCG ATCCATATCTGATAAACAGCAATGGGATGCAGCTATTTATTTTATGGAAGAGGCTCTGCA GGCT CGTCTCAAGGATACTGAAAATGCAATTGAAAACATGGTGGGTCCAGACTGGAAAAAGAGG TGGT TATACTGGAAGAATCGGACCCAAGAACAGTGTGTTCACAATGAAACCAAGAATGAATTGG AGAA GATGTTGAAATGTAATGAGGAGCACCCAGCTTATCTTGCAAGTGATGAAATAACCACAGT CCGG AAGAACCTTGAATCCCGAGGAGTAGAAGTAGATCCAAGCTTGATTAAGGATACTTGGCAT CAAG TTTATAGAAGACATTTTTTAAAAACAGCTCTAAACCATTGTAACCTTTGTCGAAGAGGTT TTTA TTACTACCAAAGGCATTTTGTAGATTCTGAGTTGGAATGCAATGATGTGGTCTTGTTTTG GCGT ATACAGCGCATGCTTGCTATCACCGCAAATACTTTAAGGCAACAACTTACAAATACTGAA GTTA GGCGATTAGAGAAAAATGTTAAAGAGGTATTGGAAGATTTTGCTGAAGATGGTGAGAAGA AGAT TAAATTGCTTACTGGTAAACGCGTTCAACTGGCGGAAGACCTCAAGAAAGTTAGAGAAAT TCAA GAAAAACTTGATGCTTTCATTGAAGCTCTTCATCAGGAGAAATAA (SEQ ID NO: 37); - OPA1 RTMth#239: CCAGATCCTCTTGGGAATATTCGAGCTTGGGCAATCATTTCCAACACACTAGTCTTTCCA GCAC TCTGATCTCCAACCACAACAACCTTCCCACAAAACAAAGAACACTTATTCATATTTTTCT GATA CCAAATTAAAATTAAAACCTATTTGTAATGCTGCTCTGAGTTTTTTAGTCTTTTAAAATT TCTA CAGGTGAAAAAATATTTTAAAATCCGTAAAAAAATGGTGATTGATGCatcgatgttaacg agaa cattattatagcgttgctcgagtactaactggtacctcttcttttttttctgcagGTAGT AGTCG TAGGTGATCAGAGTGCTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAATAT TCCCAAG AGGATCTGGGGAGATGATGACACGTTCTCCAGTTAAGGTGACTCTGAGTGAAGGTCCTCA CCATGTG GCCCTATTTAAAGATAGTTCTCGGGAGTTTGATCTTACCAAAGAAGAAGATCTTGCAGCA TTAAGA CATGAAATAGAACTTCGAATGAGGAAAAATGTGAAAGAAGGCTGTACCGTTAGCCCTGAG ACCA TATCCTTAAATGTAAAAGGCCCTGGACTACAGAGGATGGTGCTTGTTGACTTACCAGGTG TGAT TAATACTGTGACATCAGGCATGGCTCCTGACACAAAGGAAACTATTTTCAGTATCAGCAA AGCT TACATGCAGAATCCTAATGCCATCATACTGTGTATTCAAGATGGATCTGTGGATGCTGAA CGCA GTATTGTTACAGACTTGGTCAGTCAAATGGACCCTCATGGAAGGAGAACCATATTCGTTT TGAC CAAAGTAGACCTGGCAGAGAAAAATGTAGCCAGTCCAAGCAGGATTCAGCAGATAATTGA AGGA AAGCTCTTCCCAATGAAAGCTTTAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAACAGC TCTG AAAGCATTGAAGCTATAAGAGAATATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTAA AGAC AAGCATGCTAAAGGCACACCAAGTGACTACAAGAAATTTAAGCCTTGCAGTATCAGACTG CTTT TGGAAAATGGTACGAGAGTCTGTTGAACAACAGGCTGATAGTTTCAAAGCAACACGTTTT AACC TTGAAACTGAATGGAAGAATAACTATCCTCGCCTGCGGGAACTTGACCGGAATGAACTAT TTGA AAAAGCTAAAAATGAAATCCTTGATGAAGTTATCAGTCTGAGCCAGGTTACACCAAAACA TTGG GAGGAAATCCTTCAACAATCTTTGTGGGAAAGAGTATCAACTCATGTGATTGAAAACATC TACC TTCCAGCTGCGCAGACCATGAATTCAGGAACTTTTAACACCACAGTGGATATCAAGCTTA AACA GTGGACTGATAAACAACTTCCTAATAAAGCAGTAGAGGTTGCTTGGGAGACCCTACAAGA AGAA TTTTCCCGCTTTATGACAGAACCGAAAGGGAAAGAGCATGATGACATATTTGATAAACTT AAAG AGGCTGTTAAGGAAGAAAGTATTAAACGACACAAGTGGAATGACTTTGCGGAGGACAGCT TGAG GGTTATTCAACACAATGCTTTGGAAGACCGATCCATATCTGATAAACAGCAATGGGATGC AGCT ATTTATTTTATGGAAGAGGCTCTGCAGGCTCGTCTCAAGGATACTGAAAATGCAATTGAA AACA TGGTGGGTCCAGACTGGAAAAAGAGGTGGTTATACTGGAAGAATCGGACCCAAGAACAGT GTGT TCACAATGAAACCAAGAATGAATTGGAGAAGATGTTGAAATGTAATGAGGAGCACCCAGC TTAT CTTGCAAGTGATGAAATAACCACAGTCCGGAAGAACCTTGAATCCCGAGGAGTAGAAGTA GATC CAAGCTTGATTAAGGATACTTGGCATCAAGTTTATAGAAGACATTTTTTAAAAACAGCTC TAAA CCATTGTAACCTTTGTCGAAGAGGTTTTTATTACTACCAAAGGCATTTTGTAGATTCTGA GTTG GAATGCAATGATGTGGTCTTGTTTTGGCGTATACAGCGCATGCTTGCTATCACCGCAAAT ACTT TAAGGCAACAACTTACAAATACTGAAGTTAGGCGATTAGAGAAAAATGTTAAAGAGGTAT TGGA AGATTTTGCTGAAGATGGTGAGAAGAAGATTAAATTGCTTACTGGTAAACGCGTTCAACT GGCG GAAGACCTCAAGAAAGTTAGAGAAATTCAAGAAAAACTTGATGCTTTCATTGAAGCTCTT CATC AGGAGAAATAA (SEQ ID NO: 38); - OPA1 RTMth#267: CTTAACTGGAGAACGTGTCATCATCTCCCCAGATCCTCTTGGGAATATTCGAGCTTGGGC AATC ATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACCTTCCCACAA AACA AAGAACACTTATTCATATTTTTCTGATACCAAATTAAAATTAAAACCTATTTGTAATGCT GCTC TGAGTTTTTTAGTCTTTTAAAATTTCTACAGGTGAAAAAATATTTTAAAATCCGTAAAAA AATG GTGATTGATGCatcgatgttaacgagaacattattatagcgttgctcgagtactaactgg tacc tcttcttttttttctgcagGTAGTAGTCGTAGGTGATCAGAGTGCTGGAAAGACTAGTGT GTTGGA AATGATTGCCCAAGCTCGAATATTCCCAAGAGGATCTGGGGAGATGATGACACGTTCTCC AGTTAAG GTGACTCTGAGTGAAGGTCCTCACCATGTGGCCCTATTTAAAGATAGTTCTCGGGAGTTT GATCTTA CCAAAGAAGAAGATCTTGCAGCATTAAGACATGAAATAGAACTTCGAATGAGGAAAAATG TGAA AGAAGGCTGTACCGTTAGCCCTGAGACCATATCCTTAAATGTAAAAGGCCCTGGACTACA GAGG ATGGTGCTTGTTGACTTACCAGGTGTGATTAATACTGTGACATCAGGCATGGCTCCTGAC ACAA AGGAAACTATTTTCAGTATCAGCAAAGCTTACATGCAGAATCCTAATGCCATCATACTGT GTAT TCAAGATGGATCTGTGGATGCTGAACGCAGTATTGTTACAGACTTGGTCAGTCAAATGGA CCCT CATGGAAGGAGAACCATATTCGTTTTGACCAAAGTAGACCTGGCAGAGAAAAATGTAGCC AGTC CAAGCAGGATTCAGCAGATAATTGAAGGAAAGCTCTTCCCAATGAAAGCTTTAGGTTATT TTGC TGTTGTAACAGGAAAAGGGAACAGCTCTGAAAGCATTGAAGCTATAAGAGAATATGAAGA AGAG TTTTTTCAGAATTCAAAGCTCCTAAAGACAAGCATGCTAAAGGCACACCAAGTGACTACA AGAA ATTTAAGCCTTGCAGTATCAGACTGCTTTTGGAAAATGGTACGAGAGTCTGTTGAACAAC AGGC TGATAGTTTCAAAGCAACACGTTTTAACCTTGAAACTGAATGGAAGAATAACTATCCTCG CCTG CGGGAACTTGACCGGAATGAACTATTTGAAAAAGCTAAAAATGAAATCCTTGATGAAGTT ATCA GTCTGAGCCAGGTTACACCAAAACATTGGGAGGAAATCCTTCAACAATCTTTGTGGGAAA GAGT ATCAACTCATGTGATTGAAAACATCTACCTTCCAGCTGCGCAGACCATGAATTCAGGAAC TTTT AACACCACAGTGGATATCAAGCTTAAACAGTGGACTGATAAACAACTTCCTAATAAAGCA GTAG AGGTTGCTTGGGAGACCCTACAAGAAGAATTTTCCCGCTTTATGACAGAACCGAAAGGGA AAGA GCATGATGACATATTTGATAAACTTAAAGAGGCTGTTAAGGAAGAAAGTATTAAACGACA CAAG TGGAATGACTTTGCGGAGGACAGCTTGAGGGTTATTCAACACAATGCTTTGGAAGACCGA TCCA TATCTGATAAACAGCAATGGGATGCAGCTATTTATTTTATGGAAGAGGCTCTGCAGGCTC GTCT CAAGGATACTGAAAATGCAATTGAAAACATGGTGGGTCCAGACTGGAAAAAGAGGTGGTT ATAC TGGAAGAATCGGACCCAAGAACAGTGTGTTCACAATGAAACCAAGAATGAATTGGAGAAG ATGT TGAAATGTAATGAGGAGCACCCAGCTTATCTTGCAAGTGATGAAATAACCACAGTCCGGA AGAA CCTTGAATCCCGAGGAGTAGAAGTAGATCCAAGCTTGATTAAGGATACTTGGCATCAAGT TTAT AGAAGACATTTTTTAAAAACAGCTCTAAACCATTGTAACCTTTGTCGAAGAGGTTTTTAT TACT ACCAAAGGCATTTTGTAGATTCTGAGTTGGAATGCAATGATGTGGTCTTGTTTTGGCGTA TACA GCGCATGCTTGCTATCACCGCAAATACTTTAAGGCAACAACTTACAAATACTGAAGTTAG GCGA TTAGAGAAAAATGTTAAAGAGGTATTGGAAGATTTTGCTGAAGATGGTGAGAAGAAGATT AAAT TGCTTACTGGTAAACGCGTTCAACTGGCGGAAGACCTCAAGAAAGTTAGAGAAATTCAAG AAAA ACTTGATGCTTTCATTGAAGCTCTTCATCAGGAGAAATAA (SEQ ID NO: 39); - OPA1 RTMth#217: GCAATCATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACCTTC CCAC AAAACAAAGAACACTTATTCATATTTTTCTGATACCAAATTAAAATTAAAACCTATTTGT AATG CTGCTCTGAGTTTTTTAGTCTTTTAAAATTTCTACAGGTGAAAAAATATTTTAAAATCCG TAAA AAAATGGTGATTGATGCATGTGTGCatcgatgttaacgagaacattattatagcgttgct cgag tactaactggtacctcttcttttttttctgcagGTAGTAGTCGTAGGTGATCAGAGTGCT GGAAAG ACTAGTGTGTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAGAGGATCTGGGGAGATG ATGACAC GTTCTCCAGTTAAGGTGACTCTGAGTGAAGGTCCTCACCATGTGGCCCTATTTAAAGATA GTTCTCG GGAGTTTGATCTTACCAAAGAAGAAGATCTTGCAGCATTAAGACATGAAATAGAACTTCG AATGA GGAAAAATGTGAAAGAAGGCTGTACCGTTAGCCCTGAGACCATATCCTTAAATGTAAAAG GCCC TGGACTACAGAGGATGGTGCTTGTTGACTTACCAGGTGTGATTAATACTGTGACATCAGG CATG GCTCCTGACACAAAGGAAACTATTTTCAGTATCAGCAAAGCTTACATGCAGAATCCTAAT GCCA TCATACTGTGTATTCAAGATGGATCTGTGGATGCTGAACGCAGTATTGTTACAGACTTGG TCAG TCAAATGGACCCTCATGGAAGGAGAACCATATTCGTTTTGACCAAAGTAGACCTGGCAGA GAAA AATGTAGCCAGTCCAAGCAGGATTCAGCAGATAATTGAAGGAAAGCTCTTCCCAATGAAA GCTT TAGGTTATTTTGCTGTTGTAACAGGAAAAGGGAACAGCTCTGAAAGCATTGAAGCTATAA GAGA ATATGAAGAAGAGTTTTTTCAGAATTCAAAGCTCCTAAAGACAAGCATGCTAAAGGCACA CCAA GTGACTACAAGAAATTTAAGCCTTGCAGTATCAGACTGCTTTTGGAAAATGGTACGAGAG TCTG TTGAACAACAGGCTGATAGTTTCAAAGCAACACGTTTTAACCTTGAAACTGAATGGAAGA ATAA CTATCCTCGCCTGCGGGAACTTGACCGGAATGAACTATTTGAAAAAGCTAAAAATGAAAT CCTT GATGAAGTTATCAGTCTGAGCCAGGTTACACCAAAACATTGGGAGGAAATCCTTCAACAA TCTT TGTGGGAAAGAGTATCAACTCATGTGATTGAAAACATCTACCTTCCAGCTGCGCAGACCA TGAA TTCAGGAACTTTTAACACCACAGTGGATATCAAGCTTAAACAGTGGACTGATAAACAACT TCCT AATAAAGCAGTAGAGGTTGCTTGGGAGACCCTACAAGAAGAATTTTCCCGCTTTATGACA GAAC CGAAAGGGAAAGAGCATGATGACATATTTGATAAACTTAAAGAGGCTGTTAAGGAAGAAA GTAT TAAACGACACAAGTGGAATGACTTTGCGGAGGACAGCTTGAGGGTTATTCAACACAATGC TTTG GAAGACCGATCCATATCTGATAAACAGCAATGGGATGCAGCTATTTATTTTATGGAAGAG GCTC TGCAGGCTCGTCTCAAGGATACTGAAAATGCAATTGAAAACATGGTGGGTCCAGACTGGA AAAA GAGGTGGTTATACTGGAAGAATCGGACCCAAGAACAGTGTGTTCACAATGAAACCAAGAA TGAA TTGGAGAAGATGTTGAAATGTAATGAGGAGCACCCAGCTTATCTTGCAAGTGATGAAATA ACCA CAGTCCGGAAGAACCTTGAATCCCGAGGAGTAGAAGTAGATCCAAGCTTGATTAAGGATA CTTG GCATCAAGTTTATAGAAGACATTTTTTAAAAACAGCTCTAAACCATTGTAACCTTTGTCG AAGA GGTTTTTATTACTACCAAAGGCATTTTGTAGATTCTGAGTTGGAATGCAATGATGTGGTC TTGT TTTGGCGTATACAGCGCATGCTTGCTATCACCGCAAATACTTTAAGGCAACAACTTACAA ATAC TGAAGTTAGGCGATTAGAGAAAAATGTTAAAGAGGTATTGGAAGATTTTGCTGAAGATGG TGAG AAGAAGATTAAATTGCTTACTGGTAAACGCGTTCAACTGGCGGAAGACCTCAAGAAAGTT AGAG AAATTCAAGAAAAACTTGATGCTTTCATTGAAGCTCTTCATCAGGAGAAATAA (SEQ ID NO: 40); - OPA1 RTM _th #247: CCAGATCCTCTTGGGAATATTCGAGCTTGGGCAATCATTTCCAACACACTAGTCTTTCCA GCAC TCTGATCTCCAACCACAACAACCTTCCCACAAAACAAAGAACACTTATTCATATTTTTCT GATA CCAAATTAAAATTAAAACCTATTTGTAATGCTGCTCTGAGTTTTTTAGTCTTTTAAAATT TCTA CAGGTGAAAAAATATTTTAAAATCCGTAAAAAAATGGTGATTGATGCATGTGTGCatcga tgtt aacgagaacattattatagcgttgctcgagtactaactggtacctcttcttttttttctg cagG TAGTAGTCGTAGGTGATCAGAGTGCTGGAAAGACTAGTGTGTTGGAAATGATTGCCCAAG CTCGAAT ATTCCCAAGAGGATCTGGGGAGATGATGACACGTTCTCCAGTTAAGGTGACTCTGAGTGA AGGTCCT CACCATGTGGCCCTATTTAAAGATAGTTCTCGGGAGTTTGATCTTACCAAAGAAGAAGAT CTTGCA GCATTAAGACATGAAATAGAACTTCGAATGAGGAAAAATGTGAAAGAAGGCTGTACCGTT AGCC CTGAGACCATATCCTTAAATGTAAAAGGCCCTGGACTACAGAGGATGGTGCTTGTTGACT TACC AGGTGTGATTAATACTGTGACATCAGGCATGGCTCCTGACACAAAGGAAACTATTTTCAG TATC AGCAAAGCTTACATGCAGAATCCTAATGCCATCATACTGTGTATTCAAGATGGATCTGTG GATG CTGAACGCAGTATTGTTACAGACTTGGTCAGTCAAATGGACCCTCATGGAAGGAGAACCA TATT CGTTTTGACCAAAGTAGACCTGGCAGAGAAAAATGTAGCCAGTCCAAGCAGGATTCAGCA GATA ATTGAAGGAAAGCTCTTCCCAATGAAAGCTTTAGGTTATTTTGCTGTTGTAACAGGAAAA GGGA ACAGCTCTGAAAGCATTGAAGCTATAAGAGAATATGAAGAAGAGTTTTTTCAGAATTCAA AGCT CCTAAAGACAAGCATGCTAAAGGCACACCAAGTGACTACAAGAAATTTAAGCCTTGCAGT ATCA GACTGCTTTTGGAAAATGGTACGAGAGTCTGTTGAACAACAGGCTGATAGTTTCAAAGCA ACAC GTTTTAACCTTGAAACTGAATGGAAGAATAACTATCCTCGCCTGCGGGAACTTGACCGGA ATGA ACTATTTGAAAAAGCTAAAAATGAAATCCTTGATGAAGTTATCAGTCTGAGCCAGGTTAC ACCA AAACATTGGGAGGAAATCCTTCAACAATCTTTGTGGGAAAGAGTATCAACTCATGTGATT GAAA ACATCTACCTTCCAGCTGCGCAGACCATGAATTCAGGAACTTTTAACACCACAGTGGATA TCAA GCTTAAACAGTGGACTGATAAACAACTTCCTAATAAAGCAGTAGAGGTTGCTTGGGAGAC CCTA CAAGAAGAATTTTCCCGCTTTATGACAGAACCGAAAGGGAAAGAGCATGATGACATATTT GATA AACTTAAAGAGGCTGTTAAGGAAGAAAGTATTAAACGACACAAGTGGAATGACTTTGCGG AGGA CAGCTTGAGGGTTATTCAACACAATGCTTTGGAAGACCGATCCATATCTGATAAACAGCA ATGG GATGCAGCTATTTATTTTATGGAAGAGGCTCTGCAGGCTCGTCTCAAGGATACTGAAAAT GCAA TTGAAAACATGGTGGGTCCAGACTGGAAAAAGAGGTGGTTATACTGGAAGAATCGGACCC AAGA ACAGTGTGTTCACAATGAAACCAAGAATGAATTGGAGAAGATGTTGAAATGTAATGAGGA GCAC CCAGCTTATCTTGCAAGTGATGAAATAACCACAGTCCGGAAGAACCTTGAATCCCGAGGA GTAG AAGTAGATCCAAGCTTGATTAAGGATACTTGGCATCAAGTTTATAGAAGACATTTTTTAA AAAC AGCTCTAAACCATTGTAACCTTTGTCGAAGAGGTTTTTATTACTACCAAAGGCATTTTGT AGAT TCTGAGTTGGAATGCAATGATGTGGTCTTGTTTTGGCGTATACAGCGCATGCTTGCTATC ACCG CAAATACTTTAAGGCAACAACTTACAAATACTGAAGTTAGGCGATTAGAGAAAAATGTTA AAGA GGTATTGGAAGATTTTGCTGAAGATGGTGAGAAGAAGATTAAATTGCTTACTGGTAAACG CGTT CAACTGGCGGAAGACCTCAAGAAAGTTAGAGAAATTCAAGAAAAACTTGATGCTTTCATT GAAG CTCTTCATCAGGAGAAATAA (SEQ ID NO: 41); and - OPA1 RTMth#275: CTTAACTGGAGAACGTGTCATCATCTCCCCAGATCCTCTTGGGAATATTCGAGCTTGGGC AATC ATTTCCAACACACTAGTCTTTCCAGCACTCTGATCTCCAACCACAACAACCTTCCCACAA AACA AAGAACACTTATTCATATTTTTCTGATACCAAATTAAAATTAAAACCTATTTGTAATGCT GCTC TGAGTTTTTTAGTCTTTTAAAATTTCTACAGGTGAAAAAATATTTTAAAATCCGTAAAAA AATG GTGATTGATGCATGTGTGCatcgatgttaacgagaacattattatagcgttgctcgagta ctaa ctggtacctcttcttttttttctgcagGTAGTAGTCGTAGGTGATCAGAGTGCTGGAAAG ACTAGT GTGTTGGAAATGATTGCCCAAGCTCGAATATTCCCAAGAGGATCTGGGGAGATGATGACA CGTTCTC CAGTTAAGGTGACTCTGAGTGAAGGTCCTCACCATGTGGCCCTATTTAAAGATAGTTCTC GGGAGTT TGATCTTACCAAAGAAGAAGATCTTGCAGCATTAAGACATGAAATAGAACTTCGAATGAG GAAAA ATGTGAAAGAAGGCTGTACCGTTAGCCCTGAGACCATATCCTTAAATGTAAAAGGCCCTG GACT ACAGAGGATGGTGCTTGTTGACTTACCAGGTGTGATTAATACTGTGACATCAGGCATGGC TCCT GACACAAAGGAAACTATTTTCAGTATCAGCAAAGCTTACATGCAGAATCCTAATGCCATC ATAC TGTGTATTCAAGATGGATCTGTGGATGCTGAACGCAGTATTGTTACAGACTTGGTCAGTC AAAT GGACCCTCATGGAAGGAGAACCATATTCGTTTTGACCAAAGTAGACCTGGCAGAGAAAAA TGTA GCCAGTCCAAGCAGGATTCAGCAGATAATTGAAGGAAAGCTCTTCCCAATGAAAGCTTTA GGTT ATTTTGCTGTTGTAACAGGAAAAGGGAACAGCTCTGAAAGCATTGAAGCTATAAGAGAAT ATGA AGAAGAGTTTTTTCAGAATTCAAAGCTCCTAAAGACAAGCATGCTAAAGGCACACCAAGT GACT ACAAGAAATTTAAGCCTTGCAGTATCAGACTGCTTTTGGAAAATGGTACGAGAGTCTGTT GAAC AACAGGCTGATAGTTTCAAAGCAACACGTTTTAACCTTGAAACTGAATGGAAGAATAACT ATCC TCGCCTGCGGGAACTTGACCGGAATGAACTATTTGAAAAAGCTAAAAATGAAATCCTTGA TGAA GTTATCAGTCTGAGCCAGGTTACACCAAAACATTGGGAGGAAATCCTTCAACAATCTTTG TGGG AAAGAGTATCAACTCATGTGATTGAAAACATCTACCTTCCAGCTGCGCAGACCATGAATT CAGG AACTTTTAACACCACAGTGGATATCAAGCTTAAACAGTGGACTGATAAACAACTTCCTAA TAAA GCAGTAGAGGTTGCTTGGGAGACCCTACAAGAAGAATTTTCCCGCTTTATGACAGAACCG AAAG GGAAAGAGCATGATGACATATTTGATAAACTTAAAGAGGCTGTTAAGGAAGAAAGTATTA AACG ACACAAGTGGAATGACTTTGCGGAGGACAGCTTGAGGGTTATTCAACACAATGCTTTGGA AGAC CGATCCATATCTGATAAACAGCAATGGGATGCAGCTATTTATTTTATGGAAGAGGCTCTG CAGG CTCGTCTCAAGGATACTGAAAATGCAATTGAAAACATGGTGGGTCCAGACTGGAAAAAGA GGTG GTTATACTGGAAGAATCGGACCCAAGAACAGTGTGTTCACAATGAAACCAAGAATGAATT GGAG AAGATGTTGAAATGTAATGAGGAGCACCCAGCTTATCTTGCAAGTGATGAAATAACCACA GTCC GGAAGAACCTTGAATCCCGAGGAGTAGAAGTAGATCCAAGCTTGATTAAGGATACTTGGC ATCA AGTTTATAGAAGACATTTTTTAAAAACAGCTCTAAACCATTGTAACCTTTGTCGAAGAGG TTTT TATTACTACCAAAGGCATTTTGTAGATTCTGAGTTGGAATGCAATGATGTGGTCTTGTTT TGGC GTATACAGCGCATGCTTGCTATCACCGCAAATACTTTAAGGCAACAACTTACAAATACTG AAGT TAGGCGATTAGAGAAAAATGTTAAAGAGGTATTGGAAGATTTTGCTGAAGATGGTGAGAA GAAG ATTAAATTGCTTACTGGTAAACGCGTTCAACTGGCGGAAGACCTCAAGAAAGTTAGAGAA ATTC AAGAAAAACTTGATGCTTTCATTGAAGCTCTTCATCAGGAGAAATAA (SEQ ID NO: 42). Results in Fibroblasts from Biopsies of OPA1 Patients The results obtained are presented on Figure 8. The expression of OPA1 trans-splicing therapeutic pre-messenger RNA in fibroblasts from biopsies of OPA1 patients has established the cellular therapeutic proof of concept by: 1) Correction of OPA1 haploinsufficiency and the absence of protein overexpression (Figure 8A); 2) induction of fusion of a pathologically fragmented mitochondrial network (Figure 8B-C); 3) absence of deleterious effect on a healthy mitochondrial network (control) (Figure 8B-C).