Title:
THERAPY OF CANCER BY INSECT CELLS CONTAINING RECOMBINANT BACULOVIRUS ENCODING GENES
Document Type and Number:
WIPO Patent Application WO2000055345
Kind Code:
A9
Abstract:
Provided are compositions and methods of use for insect cells comprising baculovirus encoding non-surface expressed proteins and peptides. The claimed invention particularly relates to compositions comprising insect cells containing baculovirus that express cytokines. Such compositions may be administered by, for example, direct intratumoral injection into tumors in mammals, resulting in tumor reduction or recission. Another aspect of the claimed invention concerns methods of promoting resistance to the reoccurrence of tumors in mammals who have undergone such tumor recission. In a specific aspect of the claimed invention, the mammals are human subjects presenting various forms of cancer.
Inventors:
FIDLER ISAIAH J
DHONG ZHONGYUN
LU WEIXIN
DHONG ZHONGYUN
LU WEIXIN
Application Number:
PCT/US2000/007200
Publication Date:
June 21, 2001
Filing Date:
March 17, 2000
Export Citation:
Assignee:
UNIV TEXAS (US)
International Classes:
C12N15/09; A61K35/64; A61K35/76; A61K38/00; A61K38/21; A61K39/00; A61K45/00; A61K48/00; A61P35/00; C12N5/07; A61K35/12; (IPC1-7): C12N15/866; A61K35/64; A61K38/19; A61K38/21; A61K39/39; A61K39/395; A61K48/00; A61P35/00
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