Title:
THERMAL DEHYDROBORATION OF HYDROXY ARENE BORONIC ACID COMPOUND, AND METHOD FOR PREPARING HYDROXY ARENE COMPOUND IN WHICH FUNCTIONAL GROUP IS INTRODUCED TO ORTHO OR META POSITION OF PHENOLIC COMPOUND, USING THERMAL DEHYDROBORATION
Document Type and Number:
WIPO Patent Application WO/2015/030440
Kind Code:
A1
Abstract:
The present invention relates to a method for preparing hydroxy arene in which a functional group is introduced to an ortho or meta position of a phenolic compound, using a thermal dehydroboration of a hydroxy arene boronic acid compound and, more specifically, relates to a method for preparing a hydroxy arene compound in which a functional group is introduced to an ortho or meta position from a phenol, by substituting the ortho or para position of the phenol with a boronic acid, then introducing the functional group to the ortho or meta position and preparing a hydroxy arene boronic acid compound, and removing the boronic acid using thermal dehydroboration. The method for preparing the hydroxyl arene compound, according to the present invention, is economical because the method does not require any metal catalyst, such as palladium or iridium, and does not require demanding processes such as strong acid or base conditions, low temperature reactions, or reactions of anhydrous conditions. In addition, it is possible to simply prepare the hydroxyl arene compound in which the functional group is introduced to the ortho or para position from the phenol.
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Inventors:
CHEON CHEOL-HONG (KR)
LEE CHUN YOUNG (KR)
AHN SU-JIN (KR)
LEE CHUN YOUNG (KR)
AHN SU-JIN (KR)
Application Number:
PCT/KR2014/007860
Publication Date:
March 05, 2015
Filing Date:
August 25, 2014
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
C07C37/88; C07C39/04; C07C39/26
Domestic Patent References:
| WO2012073038A2 | 2012-06-07 |
Foreign References:
| JPH1025261A | 1998-01-27 |
Other References:
MICHAEL A. BECKETT ET AL.: "Protodeboronation of arylboronic acids and triarylboroxines in Bu20/THF", JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol. 455, 1993, pages 47 - 49
STEFAN NAVE ET AL.: "Protodeboronation of Tertiary Boronic Esters: Asymmetric Synthesis of Tertiary Alkyl Stereogenic Centers", J. AM. CHEM. SOC., vol. 132, 2010, pages 17096 - 17098
STEFAN NAVE ET AL.: "Protodeboronation of Tertiary Boronic Esters: Asymmetric Synthesis of Tertiary Alkyl Stereogenic Centers", J. AM. CHEM. SOC., vol. 132, 2010, pages 17096 - 17098
Attorney, Agent or Firm:
CHUNG HYUN PATENT & LAW FIRM (KR)
특허법인 충현 (KR)
특허법인 충현 (KR)
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