Title:
THIADIAZOLONE DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2008/038841
Kind Code:
A1
Abstract:
Disclosed is a compound represented by the general formula [I], a pharmaceutically
acceptable salt thereof, or a solvate of the compound or the salt. The compound
is excellent in selective TACE-inhibiting activity. Therefore, a pharmaceutical
composition comprising the compound can be used as a pharmaceutical agent effective
for the prevention or treatment of a disease associated with TNF-α such,
as rheumatoid arthritis and inflammatory bowel disease (IBD).
[I] wherein each symbol is as defined in the description.
Inventors:
KIKUCHI SHINICHI (JP)
MATSUI TAKUYA (JP)
INOUE TERUHIKO (JP)
TERASHITA MASAKAZU (JP)
MIURA TOMOYA (JP)
MIMURA TAKAYUKI (JP)
FUKUI KENJI (JP)
TAKAHASHI AKIHIKO (JP)
MATSUI TAKUYA (JP)
INOUE TERUHIKO (JP)
TERASHITA MASAKAZU (JP)
MIURA TOMOYA (JP)
MIMURA TAKAYUKI (JP)
FUKUI KENJI (JP)
TAKAHASHI AKIHIKO (JP)
Application Number:
PCT/JP2007/069519
Publication Date:
April 03, 2008
Filing Date:
September 28, 2007
Export Citation:
Assignee:
JAPAN TOBACCO INC (JP)
KIKUCHI SHINICHI (JP)
MATSUI TAKUYA (JP)
INOUE TERUHIKO (JP)
TERASHITA MASAKAZU (JP)
MIURA TOMOYA (JP)
MIMURA TAKAYUKI (JP)
FUKUI KENJI (JP)
TAKAHASHI AKIHIKO (JP)
KIKUCHI SHINICHI (JP)
MATSUI TAKUYA (JP)
INOUE TERUHIKO (JP)
TERASHITA MASAKAZU (JP)
MIURA TOMOYA (JP)
MIMURA TAKAYUKI (JP)
FUKUI KENJI (JP)
TAKAHASHI AKIHIKO (JP)
International Classes:
C07D285/13; A61K31/433; A61K31/437; A61K31/4439; A61K31/4709; A61K31/496; A61K31/5377; A61K45/00; A61P1/04; A61P13/12; A61P19/02; A61P29/00; A61P43/00; C07D417/12; C07D417/14; C07D471/04
Domestic Patent References:
| WO2004032846A2 | 2004-04-22 |
Attorney, Agent or Firm:
TAKASHIMA, Hajime (Midosuji Bldg. 1-1,Fushimimachi 4-chome,Chuo-ku, Osaka-shi, Osaka 44, JP)
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