THIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES

Title:

THIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES

Document Type and Number:

WIPO Patent Application WO2002096905

Kind Code:

A8

Abstract:

The present invention provides a compound of formula I: or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3, Aurora2, and Syk mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatement of various protein kinase mediated disorders.

Inventors:

COCHRAN JOHN (US)
NANTHAKUMAR SUGANTHINI (US)
HARRINGTON EDMUND (US)
WANG JIAN (US)

Application Number:

PCT/US2002/016352

Publication Date:

July 28, 2005

Filing Date:

May 23, 2002

Export Citation:

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Assignee:

VERTEX PHARMA (US)
COCHRAN JOHN (US)
NANTHAKUMAR SUGANTHINI (US)
HARRINGTON EDMUND (US)
WANG JIAN (US)

International Classes:

A61K31/427; A61K31/506; A61P3/10; C07D405/06; C07D405/14; C07D417/04; C07D417/14; C07D487/10; C07D521/00; C07F7/18; C07F9/6561; (IPC1-7): C07D417/04; A61K31/427; A61P3/10

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