Title:
THIAZOLE CYCLE POLYMERS, PROCESS FOR PRODUCING THE SAME, SYNTHESIS INTERMEDIATES THEREOF AND UTILIZATION OF THE SAME
Document Type and Number:
WIPO Patent Application WO/2004/074295
Kind Code:
A1
Abstract:
A novel thiazole cycle polymer represented by the following general formula (I) or its pharmacologically acceptable salt: (I) wherein R’s independently represent each hydrogen, optionally substituted lower alkyl, -CH2SH, formyl or carboxyl; and n is an integer of from 1 to 4. A process for producing the above compound, an intermediate in the synthesis thereof and a telomerase inhibitor and a medicinal composition containing the same. The above compound selectively acts on telomerase (i.e., having a high telomerase inhibitory effect with little inhibitory effects on Taq polymerase and other reverse transcriptases) and has no or little toxicity, which makes it highly useful as a selective telomerase inhibitor.
Inventors:
TOSHIMA KAZUNOBU (JP)
Application Number:
PCT/JP2004/001772
Publication Date:
September 02, 2004
Filing Date:
February 18, 2004
Export Citation:
Assignee:
UNIV KEIO (JP)
TOSHIMA KAZUNOBU (JP)
TOSHIMA KAZUNOBU (JP)
International Classes:
A61K31/429; A61P35/00; A61P43/00; C07D277/56; C07D513/22; (IPC1-7): C07D513/22; C07D277/56; A61K31/429; C12N9/99; A61P35/00; A61P43/00
Domestic Patent References:
| WO2002066046A1 | 2002-08-29 | |||
| WO2000024747A1 | 2000-05-04 |
Foreign References:
| JPS595193A | 1984-01-12 |
Other References:
BERTRAM A. ET AL: "Dendroamide A, nostocyclamide and related cyclopeptides from cyanobacteria. Total synthesis, together with organised and metal-templated assembly from oxazole and thiazole-based amino acids", HETEROCYCLES, vol. 58, 22 November 2002 (2002-11-22), pages 521 - 561, XP002979721
RUDI A. ET AL: "Four New Cytotoxic Cyclic Hexa- and Heptapeptides from the Marine Ascidian Didemnum molle", TETRAHEDRON, vol. 54, no. 43, 22 October 1998 (1998-10-22), pages 13203 - 13210, XP004139332
HAN H. ET AL: "G-quadruplex DNA: a potential target for anti-cancer drug design", TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 21, no. 4, April 2000 (2000-04-01), pages 136 - 142, XP004196015
RUDI A. ET AL: "Four New Cytotoxic Cyclic Hexa- and Heptapeptides from the Marine Ascidian Didemnum molle", TETRAHEDRON, vol. 54, no. 43, 22 October 1998 (1998-10-22), pages 13203 - 13210, XP004139332
HAN H. ET AL: "G-quadruplex DNA: a potential target for anti-cancer drug design", TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 21, no. 4, April 2000 (2000-04-01), pages 136 - 142, XP004196015
Attorney, Agent or Firm:
Mayama, Setsuko (4th Floor 30-1, Tsuruyacho 3-chome, Kanagawa-k, Yokohama-shi Kanagawa, JP)
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