Title:
THIAZOLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2007/026761
Kind Code:
A1
Abstract:
[PROBLEMS] To provide a compound which is useful as a GK activator. [MEANS FOR SOLVING PROBLEMS] As a result of an extensive study on thiazole derivatives, it is found that a compound having an oxamoyl group, a glycol group or the like on a thiazole ring and a compound having an acetamide group substituted by a dicyclic heteroaryl group such as a quinolyl have a good GK activation effect. These compounds are useful as therapeutic agents for diabetes, particularly type 2 diabetes.
Inventors:
HAYAKAWA MASAHIKO (JP)
NIGAWARA TAKAHIRO (JP)
TSUCHIYA KAZUYUKI (JP)
ISHIBASHI NAOKI (JP)
OKUMURA MITSUAKI (JP)
KAWAMOTO YUICHIRO (JP)
NAGAYOSHI AKIRA (JP)
NIGAWARA TAKAHIRO (JP)
TSUCHIYA KAZUYUKI (JP)
ISHIBASHI NAOKI (JP)
OKUMURA MITSUAKI (JP)
KAWAMOTO YUICHIRO (JP)
NAGAYOSHI AKIRA (JP)
Application Number:
PCT/JP2006/317102
Publication Date:
March 08, 2007
Filing Date:
August 30, 2006
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
HAYAKAWA MASAHIKO (JP)
NIGAWARA TAKAHIRO (JP)
TSUCHIYA KAZUYUKI (JP)
ISHIBASHI NAOKI (JP)
OKUMURA MITSUAKI (JP)
KAWAMOTO YUICHIRO (JP)
NAGAYOSHI AKIRA (JP)
HAYAKAWA MASAHIKO (JP)
NIGAWARA TAKAHIRO (JP)
TSUCHIYA KAZUYUKI (JP)
ISHIBASHI NAOKI (JP)
OKUMURA MITSUAKI (JP)
KAWAMOTO YUICHIRO (JP)
NAGAYOSHI AKIRA (JP)
International Classes:
C07D277/20; A61K31/426; A61K31/4709; A61K31/517; A61P3/10; A61P43/00; C07D277/44; C07D277/56; C07D417/04; C07D417/12
Domestic Patent References:
WO2004052869A1 | 2004-06-24 | |||
WO2003095438A1 | 2003-11-20 | |||
WO2004063194A1 | 2004-07-29 | |||
WO2000058293A2 | 2000-10-05 | |||
WO2001083465A2 | 2001-11-08 | |||
WO2001085706A1 | 2001-11-15 | |||
WO2001085707A1 | 2001-11-15 | |||
WO2002008209A1 | 2002-01-31 | |||
WO2002014312A1 | 2002-02-21 | |||
WO2003095438A1 | 2003-11-20 | |||
WO2004072066A1 | 2004-08-26 | |||
WO2004050645A1 | 2004-06-17 | |||
WO2006058923A1 | 2006-06-08 |
Foreign References:
US20040186290A1 | 2004-09-23 | |||
JP2004521095A | 2004-07-15 |
Other References:
DIABETES, vol. 53, 2004, pages 2521 - 2528
PROG. MED., vol. 5, 1985, pages 2157 - 2161
HIROKAWA SHOTEN, MOLECULAR DESIGN, vol. 7, 1990, pages 163 - 198
GREENE; WUTS: "Protective Groups in Organic Synthesis", 1999
SCIENCE, vol. 301, 2003, pages 370 - 373
PROG. MED., vol. 5, 1985, pages 2157 - 2161
HIROKAWA SHOTEN, MOLECULAR DESIGN, vol. 7, 1990, pages 163 - 198
GREENE; WUTS: "Protective Groups in Organic Synthesis", 1999
SCIENCE, vol. 301, 2003, pages 370 - 373
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (Intellectual Property 3-1, Nihonbashi-Honcho 2-chome Chuo-ku Tokyo 11, JP)
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