THIAZOLIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

WIPO Patent Application WO/1994/022857

A1

A thiazolidine derivative represented by general formula (1), a salt thereof, a process for producing the same, a pharmaceutical composition containing the same as the active ingredient, and a method of treating diabetes by administering the same, wherein R1, R2 and R3 represent each independently hydrogen, halogen, optionally halogenated lower alkyl or lower alkoxy, hydroxy, nitro, amino, lower acylamino, mono- or di(lower alkyl)amino, carboxy, lower alkoxycarbonyl, cyano, 2-oxazolyl, thiazolidine-2,4-dione-5-ylidenemethyl or thiazolidine-2,4-dione-5-ylmethyl, provided R1 and R2 may be combined together to form an alkylene chain -(CH2)p- (where p represents 3, 4 or 5) or an alkylenedioxy chain -O(CH2)qO- (where q represents 1, 2 or 3) to thereby represent a ring; R4 and R5 represent each independently hydrogen or lower alkyl; X represents carbon or nitrogen; Y represents oxygen or imino; A and B represent each lower alkylene; m represents a number of 0 or 1; and the broken line indicates that there may be a double bond. This compound is excellent in the effect of lowering blood sugar and lipid levels, can well be absorbed in the living organism and retain its effect therein for long, can well be excreted, and is lowly toxic for the human body.

YANO SHINGO (JP)
OGAWA KAZUO (JP)
FUKUSHIMA MASAKAZU (JP)

PCT/JP1994/000590

October 13, 1994

April 07, 1994

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TAIHO PHARMACEUTICAL CO LTD (JP)
YANO SHINGO (JP)
OGAWA KAZUO (JP)
FUKUSHIMA MASAKAZU (JP)

C07D417/12; C07D417/14; (IPC1-7): C07D417/12; C07D417/14; A61K31/425; A61K31/44; A61K31/505

WO1992007838A1

1992-05-14

JPS649979A

1989-01-13

See also references of EP 0645387A4

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