Title:
THIAZOLIDINEDIONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2021/004487
Kind Code:
A1
Abstract:
A thiazolidinedione derivative having the structure shown in formula (I) and a pharmaceutical composition comprising same, the definitions of each group and substituent being as described in the description. Also provided is a use of the compound as a peroxisome proliferator-activated receptor (PPAR) agonist, particularly a use in preventing and/or treating non-alcoholic fatty liver disease or a related disease.
Inventors:
LV BINHUA (CN)
SHENG ZELIN (CN)
PANG XUDONG (CN)
CUI DAWEI (CN)
LIU RUIFENG (CN)
SHENG ZELIN (CN)
PANG XUDONG (CN)
CUI DAWEI (CN)
LIU RUIFENG (CN)
Application Number:
PCT/CN2020/100888
Publication Date:
January 14, 2021
Filing Date:
July 08, 2020
Export Citation:
Assignee:
SUZHOU ZELGEN BIOPHARMACEUTICALS CO LTD (CN)
SHANGHAI ZELGEN PHARMA TECH CO LTD (CN)
SHANGHAI ZELGEN PHARMA TECH CO LTD (CN)
International Classes:
C07D277/34; A61K31/425; A61K31/426; A61P1/16; A61P3/10; A61P37/00; C07D277/20
Foreign References:
| CN1708486A | 2005-12-14 | |||
| CN1537002A | 2004-10-13 | |||
| CN1273528A | 2000-11-15 |
Other References:
KUMAR, ASHWANI ET AL.: "3-Aryl-2-{4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxy]-phenyl}- acrylic acid alkyl ester: synthesis and antihyperglycemic evaluation", MED CHEM RES, vol. 20, no. 6, 5 June 2010 (2010-06-05), pages 678 - 686, XP019914676, DOI: 10.1007/s00044-010-9369-3
NEOGI, PARTHA ET AL.: "Synthesis and Structure-Activity Relationship Studies of Cinnamic Acid-based Novel Thiazolidinedione Antihyperglycemic Agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, no. 18, 31 December 2003 (2003-12-31), pages 4059 - 4067, XP008095121, DOI: 10.1016/S0968-0896(03)00393-6
JIANG, WENFENG ET AL.: "Application of Deuteration in Drug Research", QILU PHARMACEUTICAL AFFAIRS, vol. 29, no. 11, 31 December 2010 (2010-12-31), pages 682 - 684, XP008173943
NEOGI, PARTHA ET AL.: "Synthesis and Structure-Activity Relationship Studies of Cinnamic Acid-based Novel Thiazolidinedione Antihyperglycemic Agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, no. 18, 31 December 2003 (2003-12-31), pages 4059 - 4067, XP008095121, DOI: 10.1016/S0968-0896(03)00393-6
JIANG, WENFENG ET AL.: "Application of Deuteration in Drug Research", QILU PHARMACEUTICAL AFFAIRS, vol. 29, no. 11, 31 December 2010 (2010-12-31), pages 682 - 684, XP008173943
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
Download PDF:
Previous Patent: AIR CONDITIONING DEVICE CONTROL METHOD AND AIR CONDITIONING DEVICE
Next Patent: DATA TRANSMISSION METHOD AND APPARATUS
Next Patent: DATA TRANSMISSION METHOD AND APPARATUS