Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
THIAZOLOPYRIMIDINONE COMPOUND AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/192667
Kind Code:
A1
Abstract:
Provided are a thiazolopyrimidinone compound represented by chemical formula (I), preparation method thereof, and use thereof in the preparation of drugs for treating central nervous system diseases, wherein X = O or S, Y = C or N, and when Y = C, R3 is selected from H, C1-C12 hydrocarbyl, phenyl, phenyl substituted by one or more of halogen, hydroxyl, carboxyl, an ester group, C1-C4 alkyl and C1-C4 alkoxy, and a five-membered or six-membered heterocycle; R2 is selected from H, C1-C12 hydrocarbyl, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkylamino, phenyl, phenyl substituted by one or more of halogen, hydroxyl, carboxy, an ester group, C1-C4 alkyl and C1-C4 alkoxy, benzyl, benzyl substituted by one or more of halogen, hydroxyl, carboxyl, ester group, C1-C4 alkyl and C1-C4 alkoxy, a five-membered or six-membered heterocycle, and a five-membered or six-membered heterocycle substituted by one or more of halogen, hydroxyl, carboxyl, an ester group, C1-C4 alkyl and C1-C4 alkoxy; and R1 is selected from H, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkylamino, phenyl, phenyl substituted by one or more of halogen, ester group, carboxyl, C1-C4 alkyl and C1-C4 alkoxy, phenylthio, phenylthio substituted by one or more of halogen, an ester group, carboxyl, C1-C4 alkyl and C1-C4 alkoxy, benzylthio, benzylthio substituted by one or more of halogen, an ester group, carboxyl, C1-C4 alkyl and C1-C4 alkoxy, arylamino, arylamino substituted by one or more of halogen, C1-C4 alkyl, C1-C4 alkoxy, a five-membered or six-membered heterocycle and a five-membered or six-membered heterocycle substituted by C1-C4 alkyl or hydroxyl, arylmethyl-hydrazide amino, and arylmethyl-hydrazide amino substituted by one or more of halogen, C1-C4 alkyl, C1-C4 alkoxy, a five-membered or six-membered heterocycle and a five-membered or six-membered heterocycle substituted by C1-C4 alkyl or hydroxyl.

Inventors:
WANG KEWEI (CN)
SUN QI (CN)
JIAO WENXUAN (CN)
TANG JINGSHU (CN)
Application Number:
PCT/CN2016/084691
Publication Date:
December 08, 2016
Filing Date:
June 03, 2016
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
UNIV BEIJING (CN)
International Classes:
C07D513/04; A61P25/28
Foreign References:
DD208355A11984-05-02
CN102666540A2012-09-12
Other References:
LIN. R. H. ET AL.: "Synthesis and evaluation of 2, 7-diamino-thiazolo[4, 5-d]pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors", BIOORGANIC&MEDICINAL CHEMISTRY LETTERS, 31 December 2009 (2009-12-31), pages 2333 - 2337, XP026079467
CHANDE. MADHUKAR S. ET AL.: "Synthesis of pyrazolothiazole and pyrimididothiazole derivatives", INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol. 34 B, no. 11, 31 December 1995 (1995-12-31), pages 985 - 989
AHLUWALIA. V. K. ET AL.: "One-step synthesis of thiazolo[4, 5-d]pyrimidines", INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol. 28 B, no. 11, 31 December 1989 (1989-12-31), pages 964 - 965
WOBIG.D.: "Thiazole derivatives. VII. Synthesis of thiazolo[4, 5-d]pyrimidine derivatives", LIEBIGS ANNALEN DER CHEMIE, 31 December 1989 (1989-12-31), pages 409 - 411
WOBIG.D.: "Thiazole derivatives. VI. Synthesis of thiazolo[4, 5-d]-v-triazin-7(6H)-ones", LIEBIGS ANNALEN DER CHEMIE, 31 December 1984 (1984-12-31), pages 1994 - 1997, XP001183045
Attorney, Agent or Firm:
PANAWELL & PARTNERS, LLC (CN)
北京泛华伟业知识产权代理有限公司 (CN)
Download PDF: