Title:
THIODIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND DIAZOLIDINEDIONE DERIVATIVES AND THEIR USE AS ANTIDIABETIC AGENTS
Document Type and Number:
WIPO Patent Application WO2005058813
Kind Code:
A3
Abstract:
Provided herein are alkynyl derivatives, which have PPAR agonist activity, and can be used as antidiabetic compounds. Compounds disclosed herein can be used for the treatment of diabetes and diabetes-associated complications, to diseases and conditions in which insulin resistance is a pathophysiological mechanism, and to diseases or conditions such as Type II diabetes, dyslipidaemia, hypertension, coronary heart disease, cardiovascular disease, atherosclerosis, nephrosclerosis, polycystic ovarian syndrome, eating disorders, diabetes nephropathy, glomerulonephritis, glomerularsclerosis, nephrotic syndrome, psoriasis, obesity or dementia. Compounds disclosed herein also can inhibit aldose reductase. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and methods for treating diabetes mellitus and diseases and conditions mediated through insulin resistance are provided.
Inventors:
SATTIGERI JITENDRA A (IN)
SALMAN MOHAMMAD (US)
SALMAN MOHAMMAD (US)
Application Number:
PCT/IB2004/004143
Publication Date:
August 25, 2005
Filing Date:
December 15, 2004
Export Citation:
Assignee:
RANBAXY LAB LTD (IN)
SATTIGERI JITENDRA A (IN)
SALMAN MOHAMMAD (US)
SATTIGERI JITENDRA A (IN)
SALMAN MOHAMMAD (US)
International Classes:
C07D417/10; (IPC1-7): C07D417/10; A61K31/427
Foreign References:
| US5965589A | 1999-10-12 | |||
| US5910592A | 1999-06-08 | |||
| US5260445A | 1993-11-09 | |||
| US5801173A | 1998-09-01 | |||
| US5532256A | 1996-07-02 | |||
| EP1213287A1 | 2002-06-12 |
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