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Title:
THIOETHER PRECURSORS FOR FRAGRANT KETONES AND ALDEHYDES
Document Type and Number:
WIPO Patent Application WO/2019/166314
Kind Code:
A1
Abstract:
Disclosed is a compound of formula (I), a fragrance ingredient comprising a compound of formula (I), the use of a compound of formula (I) and a method for producing a compound of formula (I).

Inventors:
FLACHSMANN, Felix (Langhagweg 2, 8600 Duebendorf, 8600, CH)
Application Number:
EP2019/054294
Publication Date:
September 06, 2019
Filing Date:
February 21, 2019
Export Citation:
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Assignee:
GIVAUDAN SA (Chemin de la Parfumerie 5, 1214 Vernier, 1214, CH)
International Classes:
C07C319/06; C07C323/22; C11B9/00; C11D3/50
Domestic Patent References:
WO2016135193A12016-09-01
WO2012113746A12012-08-30
WO2003049666A22003-06-19
WO2013139766A12013-09-26
Foreign References:
US20140323383A12014-10-30
GB1457089A1976-12-01
US4560799A1985-12-24
CN103073454A2013-05-01
Other References:
MADDALENA, U. ET AL.: "Thioether Profragrances: Parameters Influencing the Performance of Precursor-Based Fragrance Delivery in Functional Perfumery", CHEMISTRY & BIODIVERSITY, vol. 11, no. 11, 2014, pages 1700 - 1733, XP055502263, ISSN: 1612-1872, DOI: 10.1002/cbdv.201400023
OHASHI, S. ET AL.: "Asymmetric addition catalyzed by optically active polymers. III.", MAKROMOL. CHEM AND PHYSICS, vol. 160, no. 1, 1972, pages 69 - 81, XP055502387, ISSN: 0025-116X, DOI: 10.1002/macp.1972.021600105
CIGANEK, E.: "Electrophilic amination of carbanions, enolates, and their surrogates", CAPLUS, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, 2013, XP002784204
CATCH, J.R. ET AL: "320. Syntheses of some amino-acids, including methionine", JOURNAL OF THE CHEMICAL SOCIETY (RESUMED), 1947, pages 1609, XP055085742, ISSN: 0368-1769, DOI: 10.1039/jr9470001609
PENG, A. ET AL.: "Conjugate addition of unactivated thiols to alpha,beta-unsaturated ketones catalyzed by a bifunctional rhenium(V)-oxo complex", TETRAHEDRON LETTERS, vol. 53, no. 22, 2012, pages 2712 - 2714, XP028419281, ISSN: 0040-4039, [retrieved on 20120326], DOI: 10.1016/J.TETLET.2012.03.075
SIROTANOVIC, K.D. ET AL.: "ADDITION OF MERCAPTANS TO UNSATURATED ALDEHYDES. III. PREPARATION OF BISURETHANES AND BISAMIDES OF beta-ALKYLMERCAPTO-ALDEHYDES AND beta-ARYLMERCAPTO-ALDEHYDES", GLASNIK HEMIJSKOG DRUSTVA BEOGRAD, vol. 31, no. 7-8, 1966, pages 49 (339) - 58 (349), XP009507636, ISSN: 0017-0941, Retrieved from the Internet
MATSUO, J.-I. ET AL.: "Brønsted Acid Catalyzed Asymmetric Reduction of Ketones and Acyl Silanes Using Chiral anti-Pentane-2,4-diol", ORGANIC LETTERS, vol. 12, no. 10, 2010, pages 2294 - 2297, XP055502012, ISSN: 1523-7060, DOI: 10.1021/ol1006532
MATSUO, J.-I. ET AL.: "Asymmetric reduction of aliphatic ketones and acyl silanes using chiral anti-pentane-2,4-diol and a catalytic amount of 2,4-dinitrobenzenesulfonic acid", TETRAHEDRON, vol. 66, no. 32, 2010, pages 6062 - 6069, XP027142126, ISSN: 0040-4020, [retrieved on 20100610]
ZDANSKY, G. ET AL.: "5-(Benzylthioalkyl)- and 5-(benzylselenoalkyl)-substituted hydantoins. Some notes on the hydantoin synthesis for the preparation of selenoamino acids", ARKIV FOER KEMI, vol. 29, no. 4, 1968, pages 56 - 47, XP009507637, ISSN: 0365-6128
WABNITZ, T.C. ET AL.: "A General, Brønsted Acid-Catalyzed Hetero-Michael Addition of Nitrogen, Oxygen, and Sulfur Nucleophiles", ORGANIC LETTERS, vol. 5, no. 12, 2003, pages 2141 - 2144, XP055501960, ISSN: 1523-7060, DOI: 10.1021/ol034596h
RAMACHARY, D.B. ET AL.: "Direct organocatalytic hydroalkoxylation of alpha,beta-unsaturated ketones", TETRAHEDRON LETTERS, vol. 47, no. 44, 2006, pages 7689 - 7693, XP025003078, ISSN: 0040-4039, [retrieved on 20061030], DOI: 10.1016/J.TETLET.2006.08.134
EMORI, E. ET AL.: "A Catalytic Michael Addition of Thiols to alpha,beta-Unsaturated Carbonyl Compounds: Asymmetric Michael Additions and Asymmetric Protonations", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 120, no. 16, 1998, pages 4043 - 4044, XP055501712, ISSN: 0002-7863, DOI: 10.1021/ja980397v
GARG, S.K. ET AL.: "Copper(II) tetrafluoroborate as a novel and highly efficient catalyst for Michael addition of mercaptans to alpha,beta-unsaturated carbonyl compounds", TETRAHEDRON LETTERS, vol. 46, no. 10, 2005, pages 1721 - 1724, XP027862306, ISSN: 0040-4039, [retrieved on 20050307]
BONOLLO, S. ET AL.: "Sc(III)-Catalyzed Enantioselective Addition of Thiols to alpha,beta-Unsaturated Ketones in Neutral Water", ORGANIC LETTERS, vol. 13, no. 9, 2011, pages 2150 - 2152, XP055501946, ISSN: 1523-7060, DOI: 10.1021/ol200379r
TIAN, X. ET AL.: "Diastereodivergent Asymmetric Sulfa-Michael Additions of alpha-Branched Enones using a Single Chiral Organic Catalyst", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 133, no. 44, 2011, pages 17934 - 17941, XP055034494, ISSN: 0002-7863, DOI: 10.1021/ja207847p
LANARI, D. ET AL.: "JandaJel as a polymeric support to improve the catalytic efficiency of immobilized-1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) under solvent-free conditions", GREEN CHEMISTRY, vol. 13, no. 11, 2011, pages 3181 - 3186, XP055501950, ISSN: 1463-9262, DOI: 10.1039/c1gc15790f
Attorney, Agent or Firm:
GLOBAL PATENTS (Givaudan International SA, Kemptpark 50, 8310 Kemptthal, 8600, CH)
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Claims:
Claims

Use of a compound of formula (I) as a precursor for generating a compound of formula (II) and/or a compound of formula (III)

wherein

RT is H or Ci-5-alky I;

R2 is H or Ci-5-alky I;

R3 is H or Ci-s-alky I; and R4 is CT -e-alky I ; or

RT and R4 together with the carbon atoms to which they and R2 are attached form a 5, 6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether;

R2 is H or C1-4-alkyl; and R3 is H or C1-4-alkyl; or and R2 together with the carbon atoms to which they are attached form a 5, 6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether;

R3 is selected from the group consisting of H, methyl and ethyl; and R4 is methyl or ethyl; or

R2 and R4 together with the carbon atoms to which they are attached form a 5, 6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether; RT is H or Ci-3-alky I; and

R3 is H or Ci-3-alky I; and wherein

R5 is H or a residue comprising 1 to 20 carbon atoms; and R6 is a residue comprising 3 to 20 carbon atoms; or

R5 and R6 together with the carbon atom to which they are attached form a 5, 6 or 7 membered ring preferably a hydrocarbon ring, a lactone or a cyclic ether.

2. A composition of matter comprising a compound of formula (I) and a compound of formula (A)

wherein

RT is H or Ci-s-alky I;

R2 is H or C1-5-alkyl; R3 is H or Ci-s-alky I; and

R4 is CT -e-alky I ; or

RT and R4 together with the carbon atoms to which they and R2 are attached form a 5, 6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether;

R2 is H or C1-4-alkyl; and

R3 is H or C1-4-alkyl; or RT and R2 together with the carbon atoms to which they are attached form a 5,

6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether;

R3 is selected from the group consisting of H, methyl and ethyl; and R4 is methyl or ethyl; or

R2 and R4 together with the carbon atoms to which they are attached form a 5,

6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether;

RT is H or Ci-3-alky I; and R3 is H or C1-3-alkyl; and wherein

R5 is H or a residue comprising 1 to 20 carbon atoms; and R6 is a residue comprising 3 to 20 carbon atoms; or

R5 and R6 together with the carbon atom to which they are attached form a 5, 6 or 7 membered ring preferably a hydrocarbon ring, a lactone or a cyclic ether, wherein the amount of the compound of formula (A) in relation to the total amount of the compound of formula (I) and the compound of formula (A) is 0.1 to 3.0 wt.-% , preferably 0.3 to 1.2 wt.-% , even more preferably 0.6 to 1.0 wt.- %.

3. A fragrance ingredient comprising a compound of formula (I)

wherein

RT is H or C1-4-alkyl;

R2 is H or C1-4-alkyl; R3 is H or Ci-4-alky I; and

R4 is CT -4-alky I ; or

RT and R4 together with the carbon atoms to which they and R2 are attached form a 5, 6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether;

R2 is H or C1-4-alkyl; and R3 is H or C1-4-alkyl; or and R2 together with the carbon atoms to which they are attached form a 5,

6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether;

R3 is selected from the group consisting of H, methyl and ethyl; and R4 is methyl or ethyl; or

R2 and R4 together with the carbon atoms to which they are attached form a 5,

6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether; alkyl; and R3 is H or C^-alkyl; and wherein

R5 is H or a residue comprising 1 to 20 carbon atoms; and R6 is a residue comprising 6 to 20 carbon atoms; or

R5 and R6 together with the carbon atom to which they are attached form a 5, 6 or 7 membered ring, preferably a non-aromatic ring, in particular a hydrocarbon ring, a lactone or a cyclic ether; wherein the total combined number of carbon atoms of R1 : R2, R3 and R4 is 1 to 4, preferably 1 to 3, if R5 is H and R6 is selected from a group consisting of octyl, undecyl and heptadecyl. 4. A fragrance ingredient according to claim 3, wherein R5 is a residue comprising 4 to 18 carbon atoms, preferably 6 to 1 6 carbon atoms.

5. A fragrance ingredient according to one of claims 3 or 4, wherein R5 is an alkyl, alkenyl or arom atic residue.

6. A fragrance ingredient according to one of claims 3 to 5, wherein R6 is a residue com prising 7 to 16 carbon atoms, preferably 8 to 14 carbon atoms, even more preferably 9 to 13 carbon atoms.

7. A fragrance ingredient according to one of claims 3 to 6, wherein R6 is an alkyl, alkenyl or arom atic residue.

8. A fragrance ingredient according to claim 7, wherein the compound of form ula ( I ) is selected from the group consisting of 3-(octylthio)butanal, 4-m ethyl-4- (octylthio)pentan-2-one, 3-(decylthio)butanal, 4-(decylthio)-4-methylpentan-2- one, 4-(dodecylthio)pentan-2-one, 4-(dodecylthio)-4-m ethylpentan-2-one, 4- (dodecylthio)-3-methylpentan-2-one, 3-(dodecylthio)-3-m ethylbutanal, 3- (dodecylthio)butanal, 3-(dodecylthio)-3-m ethylcyclohexan- 1 -one, 3- (dodecylthio)-3-methylcyclopentan- 1 -one, 3-(tetradecylthio)butanal and 4- m ethyl-4-(tetradecylthio)pentan-2-one, 4-m ethyl-4-((6-m ethyloctyl)thio) pentan-2-one, 3-((3-(4-isobutyl-2-methylphenyl)propyl)thio)butanal and 4-((3- (4-isobutyl-2-m ethylphenyl)propyl)thio)-4-methylpentan-2-one.

9. A compound of form ula ( I )

wherein

RT is H or Ci-s-alky I;

R2 is H or Ci-5-alky I; R3 is H or Ci-s-alky I; and

R4 is CT -e-alky I ; or

RT and R4 together with the carbon atoms to which they and R2 are attached form a 5, 6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether;

R2 is H or C1-4-alkyl; and R3 is H or C1-4-alkyl; or and R2 together with the carbon atoms to which they are attached form a 5, 6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether;

R3 is selected from the group consisting of H, methyl and ethyl; and R4 is methyl or ethyl; or

R2 and R4 together with the carbon atoms to which they are attached form a 5, 6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether; alkyl; and R3 is H or C^-alkyl; and wherein R5 is H; and

R6 is selected from the group consisting of 4-isobutylphenethyl, 1 - (4- (tert- butyl)phenyl)propan-2-yl, 4-(tert-butyl)phenethyl, (E)-styryl, phenethyl, (E)- hex-3-en-1 -yl, (Z)-pent-2-en-1 -yl, 1 -(4-isopropylphenyl)propan-2-yl, 4- isobutyl-2-methylphenethyl, 2-(3-isopropylphenyl)propyl, (Z)-oct-5-en-1 -yl, (Z)-dec-8-en-1 -yl, (Z)-non-7-en-1 -yl, (E)-dodec-1 -en-1 -yl, (1 E,5Z)-octa-1 ,5- dien-1-yl, 7,11 -dimethyldodec-10-en-2-yl, nonyl, 4-(4-methylpent-3-en-1 - yl)cyclohex-3-en-1 -yl, tridecyl and benzyl; or substructure (IV) of formula (I)

is selected from the group consisting of the following substructures:

A fragrance ingredient comprising a compound of formula (I) according to claim

11. A consumer product comprising a composition of matter according to claim 2 or a fragrance ingredient according to one of claims 3 to 8 or 10.

12. A consumer product according to claim 11 , wherein the concentration of the compound of formula (I) is 0.1% to 10%, preferably 0.2% to 5%, even more preferably 0.5% to 3%.

13. A compound according to claim 9, wherein is selected from the group

consisting of methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, tert-butyl and pentyl.

14. A compound according to one of claims 9 or 13, wherein R2 is selected from the group consisting of methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, tert- butyl and pentyl.

15. A compound according to one of claims 9, 13 or 14, wherein F¾ is selected from the group consisting of methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, tert-butyl and pentyl.

16. A compound according to one of claims 9 or 13 to 15, wherein R4 is selected from the group consisting of methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec- butyl, tert-butyl, pentyl and hexyl.

17. A compound according to one of claims 9 or 13 to 16, wherein is H and R4 is H.

18. A compound according to one of claims 9 or 13 to 16, wherein RT is H and R4 is methyl.

19. A compound according to one of claims 9 or 13 to 16, wherein Ri is methyl and R4 is H.

20. A compound according to one of claims 9 or 13 to 16, wherein RT is methyl and R4 is methyl. 21. A compound according to claim 20, wherein RT is H; R2 is H; R3 is H; and R4 is methyl.

22. A compound according to claim 21 , selected from the group consisting of 3-((3- (4-(tert-butyl)phenyl)propyl)thio)butanal, 3-((2-methylundecyl)thio)butanal, 3- (phenethylthio)butanal, 3-((4-oxobutan-2-yl)thio)hexyl acetate, 3-((1- phenylethyl)thio)butanal, 3-((1 -(3,3-dimethylcyclohexyl)ethyl)thio)butanal, (Z)-

3-(hex-3-en-1 -ylthio)butanal, 3-((6-methyloctyl)thio)butanal, (Z)-3-(non-6-en- 1 -ylthio) but anal, 3-((3-ethoxy-4-hydroxybenzyl)thio)butanal, 3- ((3- (4- isobutylphenyl)propyl)thio)butanal, 3- ((3- (4- (tert-butyl) phenyl) -2- methylpropyl)thio)butanal, 3-(((4-(4-methylpent-3-en-1 -yl)cyclohex-3-en-1 - yl)methyl)thio)butanal, 3-((3-(4-(tert-butyl)phenyl)propyl)thio)butanal, 3-((3-

(3-isopropylphenyl)butyl)thio)butanal, 3-((3-(4-isobutyl-2- methylphenyl)propyl)thio)butanal, 3-((3-(4-isopropylphenyl)-2- methylpropyl)thio)butanal, 3-(cinnamylthio)butanal, (Z)-3-(undec-9-en-1 - y Ith io) butanal, ( E) -3- ( hept-4- en- 1 -ylthio) butanal, (Z)-3-(non-6-en-1 - y Ith io) butanal, (Z)-3-(dec-8-en-1 -ylthio)butanal, 3-(phenethylthio)butanal, 3-

((3-phenylpropyl)thio)butanal, 3- ((2, 7,11 -trimethyldodec-10-en-1 - y I) thio) butanal, (Z) -3- ( hex-3- en-1 -ylthio) butanal, 3-(((2E,6Z)-nona-2,6-dien-1 - y I) thio) butanal, ( E) -3- (tridec-2- en-1 -ylthio) but anal, 3- ((2- (2- (4- methylcyclohex-3-en-1 -y I) propyl) cyclopentyl) thio) butanal, 3-((7-methyl-3,4- dihydro-2H-benzo[b][ 1 ,4]dioxepin-3-yl)thio)butanal, (E)-3-((1-(2,6,6- trimethylcyclohex-3-en-1 -yl)but-2-en-1 -yl)thio)butanal, 3-((1-(spiro[4.5]dec-7- en-7-yl)pent-4-en-1 -yl)thio)butanal, 3-((2,3,3-trimethyl-2,3-dihydro-1 H-inden- 1 -yl)thio) but anal, 3- ((6- isobutyl-2- methyl-2, 3-dihydro- 1 H-inden-1 - yl)thio)butanal, (Z)-3-((3-methylcyclotetradec-5-en-1 -yl)thio)butanal, (E)-3- ((4-(2,6,6-trimethylcyclohex-2-en-1 -yl)but-3-en-2-yl)thio)butanal, 3- ((4- (2,2- dimethyl-6-methylenecyclohexyl)butan-2-yl)thio)butanal, (E) -3- ((4- (2, 6, 6- trimethylcyclohex-1 -en-1 -yl)but-3-en-2-yl)thio) but anal, (E) -3- ((4- (2,2- dimethyl-6-methylenecyclohexyl)but-3-en-2-yl)thio) but anal, 3- ((4- (2, 6, 6- trimethylcyclohex-1 - en-1 -yl)butan-2-yl)thio)butanal and 3- ((4- (2, 6, 6- trimethylcyclohex-2-en-1 -yl)butan-2-yl)thio)butanal.

A compound according to claim 18, wherein is H; R2 is H; R3 is methyl; and R4 is methyl.

A compound according to claim 20, wherein RT is methyl; R2 is H; R3 is H; and R4 is methyl.

A compound according to claim 20, wherein RT is methyl; R2 is H; R3 is methyl; and R4 is methyl.

A compound according to claim 25, selected from the group consisting of 4-((3- (4-(tert-butyl)phenyl)propyl)thio)-4-methylpentan-2-one, 4-methyl-4-((2- methylundecyl)thio)pentan-2-one, 4-methyl-4-(phenethylthio)pentan-2-one, 3- ((2-methyl-4-oxopentan-2-yl)thio)hexyl acetate, 4-methyl-4-((1 - phenylethyl)thio)pentan-2-one, 4-((1 - (3,3-dim ethylcyclohexyl)ethyl)thio)-4- methylpentan-2-one, (Z)-4-(hex-3-en-1 -ylthio)-4-methylpentan-2-one, 4- methyl-4-((6-methyloctyl)thio)pentan-2-one, (Z)-4-methyl-4-(non-6-en-1 - y It hio) pen tan- 2 -one, 4- ((3- ethoxy- 4- hydroxy benzyl) thio) -4- met hylpent any one, 4-((3-(4-isobutylphenyl)propyl)thio)-4-methylpentan-2-one, 4- ((3- (4- (tert-butyl)phenyl)-2-methylpropyl)thio)-4-methylpentan-2-one, 4-((3-(4-(tert- butyl)phenyl)propyl)thio)-4-methylpentan-2-one, 4- ((3- (3- isopropylphenyl)butyl)thio)-4-methylpentan-2-one, 4-((3-(4-isobutyl-2- methylphenyl)propyl)thio)-4-methylpentan-2-one, 4-((3-(4-isopropylphenyl)-2- methylpropyl)thio)-4-methylpentan-2-one, 4-methyl-4-(((4-(4-methylpent-3- en-1 -y I) cyclohex- 3- en- 1 -y I) methyl) thio) pent an -2- one, 4-(cinnamylthio)-4- methylpentan-2-one, (Z)-4-methyl-4-(undec-9-en-1 - y It hio) pen tan -2- one, (E)- 4-(hept-4-en-1 -ylthio)-4-methylpentan-2-one, (Z)-4-methyl-4-(non-6-en-1- y It hio) pen tan- 2 -one, (Z)-4-(dec-8-en-1-ylthio)-4-methylpentan-2-one, 4- methyl-4-((3-phenylpropyl)thio)pentan-2-one, 4-methyl-4-((2,7,11 - trimethyldodec-10-en-1 -yl)thio)pentan-2-one, (Z)-4-(hex-3-en-1 -ylthio)-4- methylpentan-2-one, 4-methyl-4-(((2E,6Z)-nona-2,6-dien-1 - y I) t hio) pent an- 2- one, (E)-4-methyl-4-(tridec-2-en-1 - ylthio)pentan-2-one, 4-methyl-4- (phenethylthio)pentan-2-one, 4-methyl-4-((2-(2-(4-methylcyclohex-3-en-1 - yl)propyl)cyclopentyl)thio)pentan-2-one, 4-methyl-4-((7-methyl-3,4-dihydro-

2H-benzo[b][ 1 ,4]dioxepin-3-yl)thio)pentan-2-one, (E)-4-methyl-4-((1 -(2, 6,6- trim ethylcyclohex-3-en-1 -yl)but-2-en-1 - yl)thio)pentan-2-one, 4-methyl-4-((1 - (spiro[4.5]dec-7-en-7-yl)pent-4-en-1 -yl)thio)pentan-2-one, 4-methyl-4- ((2,3,3-trimethyl-2,3-dihydro-1 H-inden-1 -yl)thio)pentan-2-one, 4- ((6- isobutyl- 2- m et hy 1-2,3-dihydro- 1 H-inden-1 - y I) t hio) -4- met hylpentan-2-one, (Z)-4- methyl-4-((3-methylcyclotetradec-5-en-1 -yl)thio)pentan-2-one, (E)-4-methyl- 4-((4-(2,6,6-trimethylcyclohex-2-en-1 -yl)but-3-en-2-yl)thio)pentan-2-one, (E)- 4-methyl-4-((4-(2,6,6-trimethylcyclohex-1 -en-1 -yl)but-3-en-2-yl)thio)pentan- 2 -one, (E)-4-((4-(2,2-dimethyl-6-methylenecyclohexyl)but-3-en-2-yl)thio)-4- methylpentan-2-one, 4-((4-(2,2-dimethyl-6-methylenecyclohexyl)butan-2- yl)thio)-4-methylpentan-2-one, 4-methyl-4-((4-(2,6,6-trimethylcyclohex-1 -en- 1 -yl)butan-2-yl)thio)pentan-2-one and 4-methyl-4-((4-(2, 6,6- trim ethylcyclohex-2- en-1 -yl)butan-2-yl)thio)pentan-2-one.

27. A method for producing a compound according to one of claims 9 or 13 to 26 by reaction of a compound of formula (A) with a compound of formula (B).

28. A method according to claim 27, comprising the step of forming a mixture of the compound of formula (A) with the compound of formula (B) in a solvent, wherein the solvent is preferably an alcohol or an ether, in particular selected from the group consisting of methanol, ethanol, n-propanol, iso-propanol, n- butanol, sec-butanol, tert-butanol, diethyl ether, diisopropyl ether, di-n-butyl ether, methyl tert-butyl ether, tetrahydrofuran and 2-methyl tetrahydrofuran.

29. A method according to claim one of claims 27 or 28, wherein the reaction of a compound of formula (A) with a compound of formula (B) is conducted in the substantial absence of a solvent.

30. A method according to one of claims 27 to 29, wherein the reaction of the

compound of formula (A) with the compound of formula (B) is conducted in the presence of a base, preferably selected from the group consisting of 1,8- diazabicyclo(5.4.0)undec-7-ene, trimethylamine, trimethylam ine, N,N- diisopropylethylamine and urotropine.

31. A method according to one of claims 27 to 30, wherein, in the reaction of the compound of formula (A) with the compound of formula (B), the molar ratio of the compound of formula (A) and the compound of formula (B) is between 5:1 and 1:1, preferably between 2:1 and 1.05: 1.

32. A method according to one of claims 27 to 31 , comprising the step of purifying the compound of formula (I) obtained, preferably by distillation, in particular wipe film distillation, or chromatography.

Description:
THIOETHER PRECURSORS FOR FRAGRANT KETONES AND ALDEHYDES

The present invention relates to a use of a compound of formula (I), to a composition of matter comprising a compound of formula (I), to afragrance ingredient comprising a compound of formula (I), to a compound of formula (I) and to a method for producing a compound of formula (I) according to the independent claims.

Fruity, exotic, blackcurrant or passionfruit notes are popular in perfumery and constitute attractive alternatives to hesperidic-citrus, lavender or aldehydic scents.

They are not only used in fine fragrances but also in other applications, such as cosmetic, laundry and cleaning products. Representative examples of this kind of fragrance ingredient include Corps Cassis (4-(methylthio)-4-methyl-2-pentanone), Oxane ((2R, 4S)-2-methyl-4-propyl-1 ,3-oxathiane) and Cassyrane (5-tert-butyl-2-methyl-5- propyl-2FI-furan). Generally, blackcurrant notes are top notes that consist of small molecules with a relatively low molecular weight that evaporate quickly. Since they are perceived immediately after application of a perfume, top notes are important for the initial impression thereof.

Flowever, top notes also have a relatively low persistence and are often perceived only over a short period of time. High volatility and poor substantivity can be a problem when a prolonged effect of a fragrance is required, both in fine and functional perfumery. By way of example, laundry applications require continuous effectiveness of a perfume over a certain period of time after washing and drying of the textiles. Also in household care applications a prolonged effectiveness of perfumes can be required.

It is therefore a problem underlying the present invention to overcome these drawbacks in the prior art. In particular, it is a problem underlying the present invention to provide blackcurrant or passionfruit notes for fragrances that have an increased persistence and can be perceived over a prolonged period of time.

Additionally, these notes should be versatile in application and inexpensive in production.

These problems are solved by use of a compound of formula (I) according to claim 1. Specifically, the compound of formula (I) is used as a precursor for generating a compound of formula (II) and/or a compound of formula (III).

(I) (ii) (III)

In the above formulas (I), (II) and (III), is H or C^s-alkyl; R 2 is H or C^s-alkyl; R 3 is H or C T -5 - alkyl ; and R 4 is C^e-alkyl; or

R T and R 4 together with the carbon atoms to which they and R 2 are attached form a 5,

6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether; R 2 is H or C 1-4 -alkyl; and R 3 is H or C 1-4 -alkyl; or

R T and R 2 together with the carbon atoms to which they are attached form a 5, 6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether; R 3 is selected from the group consisting of H, methyl and ethyl; and R 4 is methyl or ethyl; or

R 2 and R 4 together with the carbon atoms to which they are attached form a 5, 6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether; is H or C T _ 3 - alkyl ; and R 3 is H or C^-alkyl.

Furthermore, R 5 is FI or a residue comprising 1 to 20 carbon atoms; and R 6 is a residue comprising 3 to 20 carbon atoms; or

R 5 and R 6 together with the carbon atom to which they are attached form a 5, 6 or 7 membered ring preferably a hydrocarbon ring, a lactone or a cyclic ether. b-Thiocarbonyl compounds are known in the prior art as precursors for the generation of fragrance molecules, as for instance described in WO 2003/049666 A2. However, only cleavage of the bond between the sulfur atom and the carbon atom in b-position to the carbonyl group (herein referred to as“y-cleavage”) has been reported in the literature. This reaction pathway generally leads to the liberation of a corresponding a,b-unsaturated carbonyl compound (not shown here).

It has now been found that b-thiocarbonyl compounds according to the present invention undergo cleavage of the bond between the sulfur atom and the carbon atom in d-position to the carbonyl group (herein referred to as“d-cleavage”) .

This newly discovered reactivity allows for use of a compound of formula (I) as a precursor for generating a compound of formula (II), namely a b-thiocarbonyl compound. This is particularly useful for release of fragrance notes with an exotic, fruity, blackcurrant or passionfruit character, as discussed in further detail herein below. Depending on the structure of residues to R 4 , the odor properties of the compound of formula (II) can be adapted according to a specific application.

Another aspect of the present invention relates to the discovery that with compounds of formula (I) also carbonyl compounds of formula (III) are generated. This allows for use of a compound of formula (I) as a precursor for generating a compound of formula (III), in particular an aldehyde or a ketone. Since many perfume ingredients comprising a carbonyl group are known in the prior art, depending on the structure of residues R 5 and R 6 , the odor properties of the compound of formula (III) can be adapted according to a specific application.

The compound of formula (I) can therefore also be used as a precursor for a carbonyl compound of formula (III). In a particularly useful embodiment, the compound of formula (I) can also be used as a precursor for compounds of formulas (II) and (III).

In the present context, such a precursor is referred to as a“bifragrant precursor”. The structure of residues R^ to R 6 plays an important role with respect to the kinetics for the release of the compounds of formula (II) and/or formula (III). In the context of the present invention, the compound of formula (I) may in addition to d-cleavage also undergo y-cleavage. By careful choice of the residues R^ to R 6 , it is possible to tune the fragrance release properties of a compound of formula (I). The person skilled in the art is familiar with the conditions under which fragrance precursors are generally used. More specifically, use of a compound of formula (I) according to the present invention commonly takes place under ambient air at a temperature of -20 °Cto 100 °C, preferably -10 °Cto 60 °C, even more preferably 0 °Cto 40 °C, in particular at room temperature. Another aspect of the present invention relates to a method for generating a compound of formula (II) and/or a compound of formula (III) by decomposition of a compound of formula (I). The compounds of formula (I), (II) and (III) have the structures as defined herein above. A further aspect of the present invention refers to a composition of matter comprising a compound of formula (I) and a compound of formula (A).

(I) (A)

In the above formulas (I) and (A), FT is H or C^s-alkyl; R 2 is H or C^s-alkyl; R 3 is H or C T -5 - alkyl ; and R 4 is C^e-alkyl; or R^ and R 4 together with the carbon atoms to which they and R 2 are attached form a 5,

6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether; R 2 is H or C 1-4 -alkyl; and R 3 is H or C 1-4 -alkyl; or

R-i and R 2 together with the carbon atoms to which they are attached form a 5, 6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether; R 3 is selected from the group consisting of H, methyl and ethyl; and R 4 is methyl or ethyl; or

R 2 and R 4 together with the carbon atoms to which they are attached form a 5, 6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether; R^ is H or C T _ 3 - alkyl ; and R 3 is H or C^-alkyl; and wherein

R 5 is H or a residue comprising 1 to 20 carbon atoms; and R 6 is a residue comprising 3 to 20 carbon atoms; or

R 5 and R 6 together with the carbon atom to which they are attached form a 5, 6 or 7 membered ring preferably a hydrocarbon ring, a lactone or a cyclic ether.

In the context of the present application, a curly bond (of. R 3 in formula (A)) means that the configuration at a given center is undefined. The double bond in formula (A) may thus be either (E) or (Z).

In a composition of matter as specified herein above, R 1: R 2 , R 3 , R 4 , R 5 and R 6 can be the same for both of the compound of formula (I) and the compound of formula (A), or they can be different. Preferably, they are the same. In compositions of matter as specified herein above, it has been found that the occurrence of thiol off-odors is suppressed when a compound of formula (A) is present. Consequently, beneficial olfactory properties can be achieved.

In case the proportion of the compound of formula (A) is increased over a certain level, its odor can become prevalent and disturb the overall olfactory appearance of the composition. Thus, the amount of the compound of formula (A) in relation to the total amount of the compound of formula (I) and the compound of formula (A) is 0.1-3.0 wt.-%, preferably 0.3-1.2 wt.-%, even more preferably 0.6-1.0 wt.-%.

In yet another aspect, the present invention refers to a fragrance ingredient

comprising a compound of formula (I).

In the above formula (I), FT is H or C 1-4 -alkyl; R 2 is H or C 1-4 -alkyl; R 3 is H or C 1-4 -alkyl; and R 4 is C 1-4 -alkyl; or

R T and R 4 together with the carbon atoms to which they and R 2 are attached form a 5, 6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether; R 2 is H or C 1-4 -alkyl; and R 3 is H or C 1-4 -alkyl; or

R-i and R 2 together with the carbon atoms to which they are attached form a 5, 6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether; R 3 is selected from the group consisting of H, methyl and ethyl; and R 4 is methyl or ethyl; or R 2 and R 4 together with the carbon atoms to which they are attached form a 5, 6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether; R^ is H or C T _ 3 - alkyl ; and R 3 is H or C^-alkyl.

Furthermore, R 5 is FI or a residue comprising 1 to 20 carbon atoms; and R 6 is a residue comprising 6 to 20 carbon atoms; or R 5 and R 6 together with the carbon atom to which they are attached form a 5, 6 or 7 membered ring, preferably a non-aromatic ring, in particular a hydrocarbon ring, a lactone or a cyclic ether; wherein the total combined number of carbon atoms of R 1: R 2 , R 3 and R 4 is 1 to 4, preferably 1 to 3, if R 5 is FI and R 6 is selected from a group consisting of octyl, undecyl and heptadecyl.

In a use of a compound of formula (I), in a composition of matter comprising a compound of formula (I) and a compound of formula (A), and/or in a fragrance ingredient comprising a compound of formula (I) as specified herein above, the total combined number of carbon atoms of R 1: R 2 , R 3 and R 4 can also be 1 to 6, preferably 1 to 5, more preferably 1 to 4, even more preferably 1 to 3, irrespective of the nature of R 5 and R 6 .

This selection of residues R 1: R 2 , R 3 and R 4 has the advantage that compounds of formula (II) generated, due to their low molecular weight, generally have a high vapor pressure which leads to an increased perception of their odor. This is particularly useful when strong fruity, blackcurrant notes are to be generated.

In a use of a compound of formula (I), in a composition of matter comprising a compound of formula (I) and a compound of formula (A), and/or in a fragrance ingredient comprising a compound of formula (I) as specified herein above, R 5 and R 6 can have the following structural features, either alone or in combination:

- R 5 can be a residue comprising 4 to 18 carbon atoms, preferably 6 to 16 carbon atoms;

- R 5 can be an alkyl, alkenyl or aromatic residue;

- R 6 can be a residue comprising 7 to 16 carbon atoms, preferably 8 to 14 carbon atoms, even more preferably 9 to 13 carbon atoms;

- R 6 can be an alkyl, alkenyl or aromatic residue.

In R 5 and/or R 6 , the alkyl or alkenyl residues can be linear, cyclic or branched.

R 5 and/or R 6 can be hydrocarbon residues. However, they can also have one or more heteroatoms, in particular one, two or three oxygen atoms. The oxygen atoms can be part of ether and ester groups.

In a use of a compound of formula (I), in a composition of matter comprising a compound of formula (I) and a compound of formula (A), and/or in a fragrance ingredient comprising a compound of formula (I) according to the present invention, the compound of formula (I) can be selected from the group consisting of 3- (octylthio)butanal, 4-methyl-4-(octylthio)pentan-2-one, 3-(decylthio)butanal, 4- (decylthio)-4-methylpentan-2-one, 4-(dodecylthio)pentan-2-one, 4-(dodecylthio)-4- methylpentan-2-one, 4-(dodecylthio)-3-methylpentan-2-one, 3-(dodecylthio)-3- methylbutanal, 3-(dodecylthio)butanal, 3-(dodecylthio)-3-methylcyclohexan-1 -one, 3- (dodecylthio)-3-methylcyclopentan-1 -one, 3-(tetradecylthio)butanal and 4-methyl-4- (tetradecylthio)pentan-2-one, 4-methyl-4-((6-methyloctyl)thio) pentan-2-one, 3-((3- (4- isobutyl-2- methylphenyl) propy I) t h io) but anal and 4-((3-(4-isobutyl-2-methylphenyl) propyl)thio)-4-methylpentan-2-one.

These compounds can be prepared in an efficient and inexpensive manner by 1 ,4- addition of a linear alky It hiol to an a,b-unsaturated carbonyl compound, as will be discussed in more detail herein below. When y-cleavage occurs as a side reaction, the thiols generated have a low vapor pressure and are therefore not perceived as a disturbing off-odor. Furthermore, the aldehydes of formula (III) that can be

concomitantly generated have by themselves an odor profile that is useful in perfumery. By means of simultaneous release, a particular impression of freshness can be achieved.

A further aspect of the present invention refers to a compound of formula (I).

In the above formula (I), is H or C^s-alkyl; R 2 is H or C^s-alkyl; R 3 is H or C^s-alkyl; and R 4 is C^-alkyl; or R T and R 4 together with the carbon atoms to which they and R 2 are attached form a 5,

6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether; R 2 is FI or C 1-4 -alkyl; and R 3 is FI or C 1-4 -alkyl; or

R T and R 2 together with the carbon atoms to which they are attached form a 5, 6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether; R 3 is selected from the group consisting of H, methyl and ethyl; and R 4 is methyl or ethyl; or

R 2 and R 4 together with the carbon atoms to which they are attached form a 5, 6 or 7 membered ring, preferably a hydrocarbon ring, a lactone or a cyclic ether; is FI or C T _ 3 - alkyl ; and R 3 is FI or C^-alkyl;

Furthermore, R 5 is H; and R 6 is selected from the group consisting of 4- isobutylphenethyl, 1 -(4-(tert-butyl)phenyl)propan-2-yl, 4-(tert-butyl)phenethyl, (E)- styryl, phenethyl, (E)-hex-3-en-1 -yl, (Z)-pent-2-en-1 -yl, 1 -(4-isopropylphenyl)propan- 2-yl, 4-isobutyl-2-methylphenethyl, 2-(3-isopropylphenyl)propyl, (Z)-oct-5-en-1 -yl, (Z)-dec-8-en-1 -yl, (Z)-non-7-en-1 -yl, (E)-dodec-1 -en-1 -yl, (1 E,5Z)-octa-1 ,5-dien-1 - yl, 7,11 -dimethyldodec-10-en-2-yl, nonyl, 4-(4-methylpent-3-en-1 -yl)cyclohex-3-en- 1 -yl, tridecyl and benzyl; or substructure (IV) of formula (I)

is selected from the group consisting of the following substructures:

The above-mentioned compounds have the advantage that they can generate carbonyl compounds of formula (III) with particularly beneficial olfactory properties.

The present invention also refers to a fragrance ingredient comprising a compound of formula (I) or a composition of matter comprising a compound of formula (I) and a compound of formula (A) as herein specified. Yet another aspect of the present invention refers to a fragrance oil or a fragrance composition comprising any kind of fragrance ingredient as herein defined.

In the context of the present invention, the term“fragrance oil” is to be understood as a mixture of fragrance ingredients.

In the context of the present invention, a“fragrance composition” is to be understood as a fragrance ingredient or a fragrance oil that has been mixed with a base material. The base material can comprise a diluent, such as diethyl phthalate (DEP), dipropylene glycol (DPG), isopropyl myristate (I PM), triethyl citrate (TEC) or an alcohol, for instance ethanol. Optionally, the base material may also comprise an anti-oxidant. A composition of matter comprising a compound of formula (I) and a compound of formula (A), a fragrance ingredient comprising a compound of formula (I), and/or a compound of formula (I) as described herein above may be used in combination with known fragrance ingredients or fragrance oils, such as:

Essential oils and extracts, e.g. castoreum, costus root oil, oak moss absolute, geranium oil, tree moss absolute, basil oil, fruit oils, such as bergamot oil and mandarine oil, myrtle oil, palmarose oil, patchouli oil, petitgrain oil, jasmine oil, rose oil, sandalwood oil, wormwood oil, lavender oil and / or ylang-ylang oil;

Alcohols, e.g. cinnamic alcohol ((E)-3-phenylprop-2-en-1-ol), cis-3-hexenol ((Z)-hex-3-en-1-ol), citronellol (3,7-dimethyloct-6-en-1-ol), dihydro myrcenol (2,6-dimethyloct-7-en-2-ol), Ebanol™ ((E)-3-methyl-5-(2, 2,3- trim ethy lcyclopent-3-en- 1 -y I) pent-4-en-2-ol) , eugenol (4- ally I-2- methoxyphenol) , ethyl linalool ((E)-3,7-dimethylnona-1 ,6-dien-3-ol) , farnesol ((2E,6Z)-3,7,11 - trim ethy ldodeca-2,6, 10-trien-1 -ol), geraniol ( ( E) - 3 , 7 - dimethylocta-2,6-dien-1 -ol), Super Muguet™ ((E)-6-ethyl-3-methyloct-6-en-1 - ol), linalool (3,7-dimethylocta-1 ,6-dien-3-ol) , menthol (2-isopropyl-5- methylcyclohexanol), Nerol (3,7-dimethyl-2,6-octadien-1 -ol), phenyl ethyl alcohol (2-phenylethanol), Rhodinol™ (3,7-dimethyloct-6-en-1 -ol), Sandalore™ (3- methyl- 5- (2,2,3- trimethylcyclopent-3-en-1 -yl)pentan-2-ol) , terpineol (2- (4- methylcyclohex-3-en-1 -yl)propan-2-ol), Timberol™ (1 -(2,2,6- trim et hy Icy cloh exy I) hexan-3-ol) , 2,4,7-trimethylocta-2,6-dien-1 -ol, and/or [1- methyl-2(5-methylhex-4-en-2-yl)cyclopropyl] - methanol;

Aldehydes and ketones, e.g. anisaldehyde (4-methoxybenzaldehyde) , alpha amyl cinnamic aldehyde (2-benzylideneheptanal) , Georgywood™ (1-(1 ,2,8,8- tet ram ethy 1-1 ,2,3,4,5,6,7,8-octahydronaphthalen-2-yl)ethanone) ,

Hydroxycitronellal (7-hydroxy-3,7-dimethyloctanal) , Iso E Super™ (1-(2,3,8,8- tet ram ethy 1-1 ,2,3,4,5,6,7,8-octahydronaphthalen-2-yl)ethanone) , Isoraldeine ((E)-3-methyl-4-(2,6,6-trimethylcyclohex-2-en-1 -yl)but-3-en-2-one) , Hedione (methyl 3-oxo-2-pentylcyclopentaneacetate) , 3-(4-isobutyl-2- methylphenyl)propanal, maltol, methyl cedryl ketone, methylionone, verbenone, 2,6,10-trimethylundeca-5,9-dienal, 3-(4-ethylphenyl)-2,2- dimethylpropanal, 1 -methyl-4-(4-methylpent-3-en-1 -yl)cyclohex-3-ene-1 - carbaldehyde, and/or vanillin;

Ether and acetals, e.g. Ambrox® (3a,6,6,9a-tetramethyl-2,4,5,5a,7,8,9,9b- octahydro-1H-benzo[e][1]benzofuran), geranyl methyl ether ((2E)-1 -methoxy- 3, 7-dimethylocta-2, 6-diene), rose oxide (4-methyl-2-(2-methylprop-1 -en-1 - yl)tetrahydro-2H-pyran), and / or Spirambrene® ( 2 ' , 2’ , 3 , 7 , 7- pentamethylspiro[bicyclo[4.1.0] heptane-2,5'-[ 1 ,3]dioxane]) ;

- Esters and lactones, e.g. benzyl acetate, cedryl acetate ((1 S,6R,8aR)-1 ,4,4,6- tetramethyloctahydro-1 H-5,8a-methanoazulen-6-yl acetate), decalactone (6- pentyltetrahydro-2H-pyran-2-one), Helvetolide® (2-(1 -(3,3- dim ethylcyclohexy I) et hoxy ) -2- m et hy Ipropy I propionate), undecalactone (5- heptyloxolan-2-one), and/or vetiveryl acetate ((4,8-dimethyl-2-propan-2- ylidene-3,3a,4,5,6,8a-hexahydro-1 H-azulen-6-y I) acetate) ;

- Macrocycles, e.g. Ambrettolide ((Z)-oxacycloheptadec-l 0-en-2-one), ethylene brassylate (1 ,4-dioxacycloheptadecane-5,17-dione), and/or Exaltolide® (16- oxacyclohexadecan-1 -one) ;

- Heterocycles, e.g. isobutylquinoline (2-isobutylquinoline) .

The present invention also relates to a consumer product comprising a compound of formula (I), a fragrance ingredient, or a composition of matter comprising a compound of formula (I) and a compound of formula (A) as herein specified. As used herein, a “consumer product” means an article intended to be used or consumed in the form in which it is sold, and not intended for subsequent commercial manufacture or modification. In such a consumer product, the concentration of the compound of formula (I) can be 0.1 to 10 wt.-%, preferably 0.2 to 5 wt.-%, even more preferably 0.5 to 3 wt.-% .

The consumer product can be a personal care product, a laundry care product or a household care product. Examples of such products include cosmetics, shampoos, shower gels, deodorants, antiperspirants, laundry detergents, rinse conditioners, fabric softeners, detergents for dishwashers, surface cleaners, in particular for hard and soft surfaces and air care products.

In certain embodiments, a consumer product according to the present invention can, in addition to the compound of formula (I), additionally comprise at least one further compound capable to release at last one molecule having beneficial olfactory properties. Hence, the present invention also relates to mixtures of precursors. On one hand, the at least one further compound can also be a compound of formula (I) but chemically different from the first compound. On the other hand, the at least one further compound can also be of different type, as for instance described in EP 0936 211 A2, WO 2007/143873, A1 WO 2012/085287 A1 , WO 2016/091894 A1 , WO 2016/091899 A1 , WO 2016/074695 A1 , WO 2016/074699 A1 , WO 2018/096176 A1 , WO 2008/093272 A2, WO 2008/ 142591 A2, WO 2009/ 118219 A1 , WO 2010/020954 A1 , WO 2010/029462 A1 , WO 2010/066486 A2, WO 2010/094356 A1 , WO

2010/105873 A2, WO 2010/105874 A1 , WO 2011 / 101179 A1 , WO 2011 / 101180 A1 , WO 2012/126675 A1 , WO 2012/130739 A1 , WO 2012/139912 A1 , WO 2014/180782 A1 , WO 2014/180791 A1 , WO 2015/032885 A1 , WO 2015/093572 A1 , WO

2016/116420 A1 , WO 2016/096539 A1 , WO 2016/096540 A1 , WO 2016/ 135193 A1 or those cited in A. Herrmann, Angew. Chem Int. Ed.2007, 46 5836-5863. But the present invention also relates to mixtures of the aforementioned precursors in general. By using combinations of precursors, the olfactory perception of a fragrance

composition over time can be modulated in accordance to the needs of a given application.

In a use of a compound of formula (I), in a composition of matter comprising a compound of formula (I) and a compound of formula (A), in a fragrance ingredient comprising a compound of formula (I), and/or in a compound of formula (I) as described herein above, R 1: R 2 , R 3 and R 4 can have the following structures, either alone or in combination:

- R T can be selected from the group consisting of methyl, ethyl, n-propyl, iso propyl, n-butyl, sec-butyl and tert-butyl;

- R 2 can be selected from the group consisting of methyl, ethyl, n-propyl, iso propyl, n-butyl, sec-butyl and tert-butyl; - R 3 can be selected from the group consisting of methyl, ethyl, n-propyl, iso propyl, n-butyl, sec-butyl and tert-butyl;

- R 4 can be selected from the group consisting of methyl, ethyl, n-propyl, iso propyl, n-butyl, sec-butyl and tert-butyl.

In a use of a compound of formula (I), in a composition of matter comprising a compound of formula (I) and a compound of formula (A), in a fragrance ingredient comprising a compound of formula (I), and/or in a compound of formula (I) as described herein above, the following combinations of and R 4 are particularly preferred:

- Ri is H and R 4 is H; - Ri is H and R 4 is methyl;

R T is methyl and R 4 is H;

R T is methyl and R 4 is methyl. In a use of a compound of formula (I), in a composition of matter comprising a compound of formula (I) and a compound of formula (A), in a fragrance ingredient comprising a compound of formula (I), and/or in a compound of formula (I) as described herein above, the following combination of R 1: R 2 , R 3 and R 4 is particularly preferred:

- R T is H; R 2 is H; R 3 is H; and R 4 is methyl

Within this combination, the compound of formula (I) can be selected from the group consisting of 3-((3-(4-(tert-butyl)phenyl)propyl)thio)butanal, 3-((2- methylundecyl)thio) but anal, 3-(phenethylthio)butanal, 3-((4-oxobutan-2-yl)thio)hexyl acetate, 3-((1 -phenylethyl)thio)butanal, 3-((1 -(3,3- dim ethylcyclohexy l)et hy I) t hio) butanal, (Z)-3-(hex-3-en-1 -ylthio)butanal, 3-((6- methyloctyl)thio)butanal, (Z) -3- (non- 6- en- 1 -y It hio) butanal, 3-((3-ethoxy-4- hydroxybenzyl)t hio) butanal, 3-((3-(4-isobutylphenyl)propyl)thio)butanal, 3- ((3- (4- (tert-butyl)phenyl)-2-methylpropyl)thio)butanal, 3-(((4-(4-methylpent-3-en-1- yl)cyclohex-3-en-1 -y I) methyl) t hio) butanal, 3-((3-(4-(tert- butyl)phenyl)propyl)t hio) but anal, 3-((3-(3-isopropylphenyl)butyl)thio)butanal, 3-((3-

(4-isobutyl-2-methylphenyl)propyl)t hio) but anal, 3-((3-(4-isopropylphenyl)-2- methylpropyl)thio)butanal, 3- (cinnamy It hio) butanal, (Z)-3-(undec-9-en-1 - y It hio) but anal, ( E) -3- ( hept-4- en- 1 -y It hio) butanal, (Z) -3- (non- 6- en- 1 -y It hio) but anal,

(Z)-3-(dec-8-en-1 -y It hio) but anal, 3-(phenethylthio)butanal, 3-((3- pheny Ipropy I) t hio) butanal, 3- ((2, 7,11 -trimethyldodec-10-en-1 -yl)t hio) but anal, (Z)-3-

( hex-3- en- 1 -y It hio) but anal, 3-(((2E,6Z)-nona-2,6-dien-1 -yl)t hio) butanal, (E)-3-

(tridec-2-en-1 -y It hio) butanal, 3-((2-(2-(4-methylcyclohex-3-en-1 - yl)propyl)cyclopentyl)thio)butanal, 3- ((7- met hyl-3, 4-dihydro-2 IH- benzoI b][ 1 ,4]dioxepin-3-yl)thio)butanal, (E)-3-((1-(2,6,6-trimethylcyclohex-3-en-1- yl)but-2-en-1 -yl)t hio) but anal, 3-((1-(spiro[4.5]dec-7-en-7-yl)pent-4-en-1- y I) t hio) butanal, 3- ((2,3,3- trim ethyl-2, 3-dihydro- 1 El- inden-1 -y I) t hio) but anal, 3-((6- isobutyl-2-methyl-2,3-dihydro-1 EH-inden-1 -yl)thio)butanal, (Z)-3-((3- methylcyclotetradec-5-en-1 -y I) t hio) butanal, (E)-3-((4-(2,6,6-trimethylcyclohex-2-en-

1 -yl)but-3-en-2-yl)t hio) butanal, 3-((4-(2,2-dimethyl-6-methylenecyclohexyl)butan-2- y I) t hio) butanal, (E)-3-((4-(2,6,6-trimethylcyclohex-1 -en-1 -yl)but-3-en-2- y I) t hio) butanal, (E)-3-((4-(2,2-dimethyl-6-methylenecyclohexyl)but-3-en-2- y I) t hio) butanal, 3-((4-(2,6,6-trimethylcyclohex-1 -en-1 -yl)butan-2-yl)t hio) but anal and

3-((4-(2,6,6-trimethylcyclohex-2-en-1 -yl)butan-2-yl)t hio) but anal.

These compounds show a preferred release profile for ketones and aldehydes, which have proven to be useful in perfumery due their beneficial organoleptic properties. In a use of a compound of formula (I), in a composition of matter comprising a compound of formula (I) and a compound of formula (A), in a fragrance ingredient comprising a compound of formula (I), and/or in a compound of formula (I) as described herein above, the following combinations of R R 2 , R 3 and R 4 are also particularly preferred:

- R T is H; R 2 is H; R 3 is methyl; and R 4 is methyl;

- R T is methyl; R 2 is H; R 3 is H; and R 4 is methyl;

- R T is methyl; R 2 is H; R 3 is methyl; and R 4 is methyl.

The third combination of residues leads to the generation of the fruity, exotic, blackcurrant and passionfruit fragrance note 4-mercapto-4-methyl-2-pentanone when d-cleavage occurs.

Within all three combinations, the compound of formula (I) can be selected from the group consisting of 4-((3-(4-(tert-butyl)phenyl)propyl)thio)-4-methylpentan-2-on e, 4- methyl-4-((2-methylundecyl)thio)pentan-2-one, 4- methyl- 4- (phenethy It hio) pent an -2- one, 3-((2-methyl-4-oxopentan-2-yl)thio)hexyl acetate, 4-methyl-4-((1 - phenylethyl)thio)pentan-2-one, 4-((1 - (3,3-dim ethylcyclohexyl)ethyl)thio)-4- methylpentan-2-one, (Z)-4-(hex-3-en-1-ylthio)-4-methylpentan-2-one, 4-methyl-4- ((6-methyloctyl)thio)pentan-2-one, (Z)-4-methyl-4-(non-6-en-1 -ylthio)pentan-2-one, 4- ((3- ethoxy-4- hydroxy benzy I) t hio) -4- methylpentan-2-one, 4- ((3- (4- isobutylphenyl)propyl)thio)-4-methylpentan-2-one, 4- ( (3- (4- (tert- butyl) phenyl) -2- methylpropyl)thio)-4-methylpentan-2-one, 4-((3-(4-(tert-butyl)phenyl)propyl)thio)-4- methylpentan-2-one, 4-((3-(3-isopropylphenyl)butyl)thio)-4-methylpentan-2-one, 4- ((3-(4-isobutyl-2-methylphenyl)propyl)thio)-4-methylpentan-2 -one, 4- ((3- (4- isopropylphenyl)-2-methylpropyl)thio)-4-methylpentan-2-one, 4- methyl-4- (((4- (4- methylpent-3-en-1 - yl)cyclohex-3-en-1 - yl)methyl)thio)pentan-2-one, 4-(cinnamylthio)- 4-methylpentan-2-one, (Z)-4-methyl-4-(undec-9-en-1 -y It hio) pent an- 2- one, (E)-4- (hept-4-en-1 -ylthio)-4-methylpentan-2-one, (Z) -4- methyl-4- (non- 6- en- 1 - y It hio) pen tan- 2 -one, (Z)-4-(dec-8-en-1 - ylthio)-4-methylpentan-2-one, 4-methyl-4- ((3-phenylpropyl)thio)pentan-2-one, 4-methyl-4-((2,7,11 -trimethyldodec-10-en-1 - y I) t hio) pen tan -2- one, (Z)-4-(hex-3-en-1 - ylthio)-4-methylpentan-2-one, 4-methyl-4- (((2E,6Z)-nona-2,6-dien-1 -y I) t hio) pent an- 2 -one, (E)-4-methyl-4-(tridec-2-en-1 - y It hio) pen tan- 2 -one, 4- methyl- 4- (phenethy It hio) pen tan -2- one, 4- methyl- 4- ((2- (2- (4- methylcyclohex-3-en-1 -y I) propyl) cyclopentyl) t hio) pentan-2-one, 4-methyl-4-((7- methyl-3,4-dihydro-2H-benzo[b][ 1 ,4]dioxepin-3-yl)thio)pentan-2-one, (E)-4-methyl- 4-((1 -(2,6,6-trimethylcyclohex-3-en-1 -yl)but-2-en-1 - y I) t hio) pen tan -2- one, 4- methyl- 4-((1 - (spiro[4.5]dec-7-en-7-yl)pent-4-en-1 -yl)thio)pentan-2-one, 4- met hy I-4- ( (2, 3,3- trim ethy l-2,3-dihydro-1 H-inden-1 -yl)thio)pentan-2-one, 4- ((6- isobutyl- 2- met hy I- 2 , 3 - dihydro- 1 H-inden-1 -yl)thio)-4-methylpentan-2-one, (Z) -4- methyl-4- ((3- methylcyclotetradec-5-en-1 -yl)thio)pentan-2-one, (E)-4-methyl-4-((4-(2,6,6- trimethylcyclohex-2-en-1 -yl)but-3-en-2-yl)thio)pentan-2-one, (E)- 4- methyl- 4- ((4- (2,6,6-trimethylcyclohex-1 -en-1 -yl)but-3-en-2-yl)thio)pentan-2-one, (E)-4-((4-(2,2- dimethyl-6-methylenecyclohexyl)but-3-en-2-yl)thio)-4-methylp entan-2-one, 4-((4- (2,2-dimethyl-6-methylenecyclohexyl)butan-2-yl)thio)-4-methy lpentan-2-one, 4- methyl-4-((4-(2,6,6-trimethylcyclohex-1 - en-1 - yl)butan-2-yl)thio)pentan-2-one and 4- methyl-4-((4-(2,6,6-trimethylcyclohex-2-en-1 -yl)butan-2-yl)thio)pentan-2-one.

These compounds are particular examples of bifragrant precursors, which on one hand, as discussed herein above, generate 4-mercapto-4-methyl-2-pentanone and, on the other hand, lead to the formation of ketones and aldehydes, which have proven to be useful in perfumery due their beneficial organoleptic properties. With this simultaneous release, a particular impression of freshness can be achieved.

A further aspect of the present invention refers to a method for producing a compound of formula (I) by reaction of a compound of formula (A) with a compound of formula (B).

(A) (B) (I) The above-mentioned method can comprise the step of forming a mixture of the compound of formula (A) with the compound of formula (B) in a solvent, wherein the solvent is preferably an alcohol or an ether, in particular selected from the group consisting of methanol, ethanol, n-propanol, iso-propanol, n-butanol, sec-butanol, tert- butanol, diethyl ether, diisopropyl ether, di-n-butyl ether, methyl tert-butyl ether, tetrahydrofuran and 2-methyl tetrahydrofuran.

On the other hand, reaction of a compound of formula (A) with a compound of formula (B) can also be conducted in the substantial absence of a solvent.

The reaction of a compound of formula (A) with a compound of formula (B) can be conducted in the presence of a base, preferably selected from the group consisting of DBU (1 ,8-diazabicyclo(5.4.0)undec-7-ene), trimethylamine, trimethylam ine, N,N- diisopropylethylamine and urotropine. When Fh is H, it is preferred to conduct the reaction in the substantial absence of any base and in a protic solvent, preferably an alcohol, in particular selected from the group consisting of methanol, ethanol, n-propanol, iso-propanol, n-butanol, sec- butanol, tert-butanol. In the reaction of the compound of formula (A) with the compound of formula (B), the molar ratio of the compound of formula (A) and the compound of formula (B) can be between 5:1 and 1:1, preferably between 2:1 and 1.05: 1. This has the advantage that removal of a large excess of the compound of formula (B) is avoided.

The above-mentioned method can further comprise the step of purifying the compound of formula (I) obtained, preferably by distillation, in particular wiped film distillation, or chromatography.

Further advantages and particular features of the present invention become apparent form the following discussion of several examples and from the figures.

Example 1: 4-f Dodecylthio1-4-methylpentan-2-one

1 -Dodecanethiol (30.0 g, 148 mmol, 1 equiv.), 4-methylpent-3-en-2-one (29.1 g, 2 equiv.) and DBU (22.6 g, 1 equiv.) were dissolved in THF (200 mL) and the solution was stirred for 24 h at room temperature, after which it was diluted with hexane (200 mL) and poured on 2M aqueous HCI-solution (400 mL). The organic layer was separated, washed with water and brine (pH 6), dried over MgS0 4 , filtered by suction and evaporated in a rotatory evaporator. The resulting liquid was further dried under high vacuum at 60°C/0.08 mbar to yield 4-(dodecylthio)-4-methylpentan-2-one as a clear, yellow liquid (44.5 g, 100%).

Odor (1% wt/vol in EtOH on blotter after 24 h): cassis, mango, passionfruit, juicy, lindenblossom

1 H-NMR (CDCI 3 , 400MHz): 2.69 (s, 2H), 2.54 (t, J=7.3 Hz, 2H), 2.20 (s, 3H), 1.51- 1.62 (m, 2H) , 1.42 (s, 6H), 1.34-1.23 (m, 18H), 0.88 (t, J=6.6 Hz, 3H). 13 C-NMR (CDCI 3 , 101MHz): 206.9 (s), 54.7 (t), 43.3 (s), 32.3 (q), 31.9 (t), 29.6 (3 t), 29.5 (2 t), 29.4 (t), 29.3 (2 t), 28.5 (2 q), 28.1 (t), 22.7 (t), 14.1 (q). MS (El, 70 eV): 300 (2, M + ), 98 (15), 83 (34), 69 (16), 57 (15), 56 (15), 55 (41), 43 (100), 41 (36), 39 (16), 29 (23).

Example 2: 4-Methyl-4-((2-methylundecvDthio)pentan-2-one

The procedure described in Example 1 was repeated with 2-methylundecane-1 -thiol (preparation see B. Hache, Y. Gareau, Tet. Lett.1994, 35 1837), (8.0 g, 39.5 mmol,

1 equiv.), 4-methylpent-3-en-2-one (7.76 g, 2 equiv.) and DBU (6.0 g, 1 equiv.) in THF (80 mL). The crude product was purified by FC with hexane/MTBE 96:4 to yield 4- methyl-4-((2-methylundecyl)thio)pentan-2-one as a colorless liquid (5.95 g, 50%).

Odor (1% wt/vol in EtOH on blotter after 24 h): green, tomato leaves, cassis

1 H-NMR (CDCIg, 400MHz): 2.69 (s, 2 H), 2.53 (dd, J= 11.4, 5.7 Hz, 1 H), 2.38 (dd,

J= 11.2, 7.3 Hz, 1 H), 2.20 (br s, 3 H) , 1.56 - 1.71 (m , 1 H) , 1.42 (br s, 6 H), 1.24 - 1.30 (m, 16 H), 0.98 (d, J=6.6 Hz, 3 H), 0.89 (t, J=6.6 Hz, 3 H). 13 C-NMR (CDCIg, 101MHz): 207.0 (s), 54.7 (t), 43.1 (s), 36.5 (t), 35.4 (t), 33.5 (d), 32.4 (q), 31.9 (t), 29.8 (t), 29.6 (t), 29.6 (t), 29.3 (t), 28.5 (2q), 27.0 (t), 22.7 (t), 19.7 (q), 14.1 (q).

MS (El, 70 eV): 300 (2, M + ), 201(16), 99 (22), 83 (29), 69 (15), 57 (26), 56 (15), 55 (31), 43 (100), 41 (33), 29 (19).

Example 3: 3- f4-itert-Butvnphenvnpropynthio1butanal

3a) Preparation of 3-(4-(tert-butyl)phenyl)propane-1 -thiol

This thiol was prepared by tosylation of the corresponding alcohol, nucleophilic substitution with potassium thioacetate and reduction of the thioester to the free thiol as described in the following: 3-(4-(tert-Butyl)phenyl)propan-1 -ol (32.7 g, 1 70 m mol, 1 equiv.) was dissolved in MTBE (1 00 m L) and tosyl chloride (33.5 g, 1 equiv.) was added. The solution was cooled to 5° C, then pyridine (29.0 g, 2.1 equiv.) was added dropwise over 15 m in. The cooling bath was removed and the solution was heated to 60°C for 6 h under stirring. The solution was diluted with water and extracted with MTBE. The com bined organic layers were washed with 0.5 M HCI, then with water and brine and dried over MgS0 4 . The solvents were removed by rotary evaporation, and the residue was dried at room tem perature at 0.08 mbar. The tosylate, a slightly yellow, viscous oil, was dissolved in DMF ( 170 m L) and potassium thioacetate (39.2 g, 2.0 equiv.) was added and the resulting brown suspension was heated to 80° C for 2 h, cooled to room temperature and left stirring for 1 6 h. The suspension was then diluted with MTBE/hexane 1 : 1 and washed with brine/water 1 : 1 , then with brine. The organic layer was separated and dried over MgS0 4 . After evaporation of the solvent, a dark red-brown oil was obtained (36 g) with intense sulfury sm ell. This product was dissolved in diethyl ether (200 m L) and added dropwise to a cooled (- 1 0° C) suspension of LiAIH 4 (5.46 g, 144 m mol) in diethyl ether ( 100 m L) during 20 m in. The tem perature rose to 5°C. The resulting suspension was further stirred for 2 h at 5° C, then cooled to -5°C. Saturated aqueous NH 4 CI solution (50 m L) was added dropwise, which caused a strong hydrogen evolution. Upon the addition of 2 M aqueous HCI solution (80 m L) , a volum inous precipitate was formed. The slurry was diluted with MTBE and water and the aqueous layer was further extracted with MTBE. The com bined organic layers were washed with brine and dried over MgS0 4 . The crude light brown oil (25.3 g) with strong sulfury smell obtained after removal of the solvent was used directly for the preparation of the subsequent 1 ,4-addition reactions.

3b) Preparation of 3-((3-(4-(tert-butyl)phenyl)propyl)thio)butanal

3-(4-(tert-Butyl)phenyl)propane- 1 -thiol (2.14 g, 1 0.2 m mol, 1 equiv.) was dissolved in EtOH (5 m L) and the solution of ( E)-but-2-enal (0.9 g, 1 .2 equiv.) in EtOH (3 m L) was added dropwise. The resulting solution was stirred for 3 days at room temperature, then concentrated in a rotatory evaporator under reduced pressure and the residue was purified by FC using hexane/MTBE 9 : 1 to yield 3-((3-(4-(tert-butyl)phenyl) propyl)thio)butanal (2.1 5 g, 75% ) as a colorless oil.

Odor ( 1 % wt/vol in EtOH on blotter after 24 h) : aldehydic, fruity, cassis 1 H-NMR (CDCI 3 , 400MHz): 9.79 (t, J= 1.9 Hz, 1 H), 7.33 - 7.39 (m , 2 H) , 7.14 - 7.19 (m, 2 H), 3.31 (sxt, J=6.9 Hz, 1 H), 2.57 - 2.77 (m, 6 H), 1.95 (quin, J=7.5 Hz, 2 H), 1.38 (d, J= 6.8 Hz, 3 H), 1.36 (s, 9 H).

13 C-NMR (CDCI 3 , 101MHz): 201.0 (s), 149.2 (s), 138.7 (s), 128.5 (2d), 125.7 (2d), 50.9 (t), 34.8 (s), 34.7 (t), 34.5 (d), 31.9 (3q), 31.6 (t), 30.5 (t), 22.2 (q).

MS (El, 70 eV): 278 (2, M + ), 208 (27), 193 (100), 159 (62), 131 (43), 117 (49), 115 (25), 91 (31), 57 (18), 41 (30), 39 (17).

Example 4: 4-((3-(4-(tert-Butyl)phenyl)propyl)thio)-4-methylpentan-2-on e

The procedure described in Example 1 was repeated with 3- (4- (tert- butyl)phenyl)propane-1 -thiol (prepared in example 3a) (2.12 g, 10.2 mmol, 1 equiv.), 4-methylpent-3-en-2-one (1.0 g, 1 equiv.) and DBU (1.54 g, 1 equiv.) in ethanol (5 mL). The crude product was purified by FC with hexane/MTBE 19:1 to yield 4-((3-(4- (tert-butyl)phenyl)propyl)thio)-4-methylpentan-2-one as a colorless liquid (2.22 g, 71%).

Odor (1% wt/vol in EtOH on blotter after 24 h): fruity, cassis

1 H-NMR (CDCIg, 400MHz): 7.31 - 7.37 (m, 2 H), 7.13 - 7.19 (m, 2 H), 2.69 - 2.76 (m, 4 H), 2.60 (t, J= 7.3 Hz, 2 H), 2.20 (s, 3 H), 1.92 (quin, J=7.3 Hz, 2 H), 1.44 (s, 6 H), 1.34 (s, 9 H).

13 C-NMR (CDCI 3 , 101MHz): 207.3 (s), 149.1 (s), 138.8 (s), 128.5 (2d), 125.7 (2d), 55.1 (t), 43.9 (s), 35.0 (t), 34.8 (s), 32.8 (q), 31.8 (3q), 31.5 (t), 28.9 (2q), 28.0 (t).

MS (El, 70 eV): 306 (3, M + ), 208 (30), 193 (100), 159 (81), 131 (42), 117 (68), 91 (39), 83 (32), 57 (42), 55 (34), 43 (75).

Example 5: 4-Methyl-4-f phenethylthioloentan-2-one The procedure described in Example 1 was repeated with 2-phenylethane-1 -thiol (5.0 g, 36.2 mmol, 1 equiv.), 4-methylpent-3-en-2-one (5.5 g, 1 equiv.) and DBU (7.1 g, 2 equiv.) in THF (60 mL). The crude product was purified by FC with hexane/MTBE 96:4 to yield 4-methyl-4-(phenethylthio)pentan-2-one as a colorless liquid (6.33 g, 74%). Odor (1% wt/vol in EtOH on blotter after 24 h): bee’s wax, fruity, cassis

1 H-NMR (CDCIg, 400MHz): 7.31 - 7.36 (m, 2 H), 7.22 - 7.28 (m, 3 H), 2.79 - 2.92 (m, 4 H), 2.71 (s, 2 H), 2.19 (s, 3 H), 1.46 (s, 6 H).

13 C-NMR (CDCIg, 101MHz): 206.8 (s), 140.7 (s), 128.5 (2d), 128.5 (2d), 126.4 (d), 54.6 (t), 43.7 (s), 36.0 (t), 32.3 (q), 29.9 (t), 28.5 (2q). MS (El, 70 eV): 236 (4, M + ), 145 (18), 138 (16), 105 (31), 104 (47), 103 (12), 99 (30), 91 (65), 83 (11), 77 (14), 43 (100).

Example 6: 4-f ( 1 -i3.3-Dimethylcvclohexyhethvnthio1-4-methylpentan-2-one

6a) 1 -(3,3-Dimethylcyclohexyl)ethane-1 -thiol

This thiol was prepared according to the procedure described in example 3a) from 1- (3,3-dimethylcyclo-hexyl)ethanol and used without purification for the subsequent reaction described in Example 6b) below.

6b) 4-((1 -(3,3-Dimethylcyclohexyl)ethyl)thio)-4-methylpentan-2-one

The procedure described in Example 1 was repeated with 1 - (3 ,3- dim et hy Icy cloh exy I) ethane-1 - thiol (6.9 g, 40 mmol, 1 equiv.), 4-methylpent-3-en-2- one (7.86 g, 2 equiv.) and DBU (6.1 g, 1 equiv.) in THF (80 mL). The crude product was purified by FC with hexane/MTBE 96:4 to yield 4-((1 - (3,3- dimethylcyclohexyl)ethyl)thio)-4-methylpentan-2-one as a colorless liquid (6.06 g, 56%, mixture of 2 diastereomers 96:4).

Odor (1% wt/vol in EtOH on blotter after 24 h): fruity, cassis, passionfruit 1 H-NMR (CDCIs, 400MHz): (major diastereomer) 2.71 (s, 2 H), 2.57 - 2.65 (m, 1 H), 2.18 (s, 3 H), 1.54 - 1.81 (m, 3 H), 1.43 (2s, together 6 H), 1.31 - 1.40 (m, 3 H), 1.29 (d, J= 7.1 Hz, 3 H), 0.93 - 1.13 (m, 3 H), 0.90 (d, J=12.2 Hz, 6 H).

13 C-NMR (CDCI S , 101MHZ): 206.9 (s), 55.4 (t), 44.3 (s), 43.2 (d), 42.4 (t), 40.2 (d), 39.2 (t), 33.5 (q), 32.4 (q), 30.8 (s), 29.8 (t), 28.9 (2q), 24.8 (q), 22.4 (t), 21.5 (q).

MS (El, 70 eV): 270 (3, M + ), 171 (18), 138 (17), 123 (18), 99 (50), 95 (20), 83 (36), 69 (44), 55 (31), 43 (100), 41 (27).

Example 7: (Z)-4-Methyl-4-(non-6-en-1 -ylthio)pentan-2-one

7a) (Z)-Non-6-ene-1 -thiol

This thiol was prepared according to the procedure described in example 3a) from (Z)- non-6-en-1 -ol and used without purification for the subsequent reaction described in Example 7b) below.

7 b) (Z)-4-Methyl-4-(non-6-en-1 -y It hio) pent an- 2 -one

The procedure described in Example 1 was repeated with (Z)-non-6-ene-1 -thiol (6.2 g, 39.2 mmol, 1 equiv.), 4-methylpent-3-en-2-one (7.69 g, 2 equiv.) and DBU (5.96 g, 1 equiv.) in THF (80 mL). The crude product was purified by FC with hexane/MTBE 96:4 to yield 4-((1 -(3,3-dimethylcyclohexyl)ethyl) thio)-4-methylpentan-2-one as a colorless liquid (6.12 g, 61%).

Odor (1% wt/vol in EtOH on blotter after 24 h): green, fruity, cassis

1 H-NMR (CDCIs, 400MHz): 5.25 - 5.45 (m, 2 H), 2.69 (s, 2 H), 2.54 (t, J=7.6 Hz, 2 H), 2.20 (s, 3 H), 1.97 - 2.10 (m, 4 H), 1.52 - 1.64 (m, 2 H), 1.42 (s, 6 H), 1.34 - 1.45 (m, 4 H), 0.96 (t, J=7.5 Hz, 3 H).

13 C-NMR (CDCI S , 101 MHZ): 206.9 (s), 131.8 (d), 128.9 (d), 54.7 (t), 43.3 (s), 32.3 (q), 29.4 (t), 29.4 (t), 28.9 (t), 28.5 (2q), 28.1 (t), 26.9 (t), 20.5 (t), 14.4 (q).

MS (El, 70 eV): 157 (31), 101 (16), 99 (22), 87 (20), 83 (17), 67 (16), 55 (27), 43 (100), 41 (30), 39 (15). Example 8: 4-(Hex-3-en-1 -ylthio1-4-methylpentan-2-one

8a) (Z)-Hex-3-ene-1 -thiol

This thiol was prepared according to the procedure described in example 3a) from (Z)- hex-3-en-1 -ol and used without purification for the subsequent reaction described in Example 8b) below.

8b) (Z)-4-(Hex-3-en-1 -ylthio)-4-methylpentan-2-one

The procedure described in Example 1 was repeated with (Z)-Hex-3-ene-1 -thiol (2.8 g, 24.1 mmol, 1 equiv.), 4-methylpent-3-en-2-one (4.73 g, 2 equiv.) and DBU (3.67 g, 1 equiv.) in THF (60 mL). The crude product was purified by FC with hexane/MTBE 96:4 to yield (Z)-4-(hex-3-en-1 -ylthio)-4-methylpentan-2-one as a slightly yellow liquid (2.23 g, 43%).

Odor (1% wt/vol in EtOH on blotter after 24 h): fresh green, fruity, cassis 1 H-NMR (CDCIs, 400MHz): 5.31 - 5.50 (m, 2 H), 2.70 (s, 2 H), 2.55 - 2.59 (m, 2 H), 2.26 - 2.34 (m, 2 H), 2.19 (s, 3 H), 2.00 - 2.10 (m, 2 H), 1.43 (s, 6 H), 0.97 (t, J=7.5 Hz, 3 H).

13 C-NMR (CDCI S , 101 MHZ): 206.8 (s), 133.2 (d), 126.9 (d), 54.6 (t), 43.4 (s), 32.3 (q), 28.5 (2q), 28.2 (t), 27.2 (t), 20.6 (t), 14.2 (q). MS (El, 70 eV): 115 (48), 99 (31), 87 (10), 83 (8), 82 (9), 67 (11), 55 (14), 43 (100), 41 (22), 39 (12).

Example 9: 4-f Dodecylthio)-3-methylpentan-2-one The procedure described in Example 1 was repeated with 1 -dodecanethiol (7.0 g, 34.6 mmol, 1 equiv.), (E)-3-methylpent-3-en-2-one (6.79 g, 2 equiv.) and DBU (5.27 g, 1 equiv.) in THF (60 mL). The crude product was purified by FC with hexane/MTBE 95:5 to yield 4-(dodecylthio)-3-methylpentan-2-one as a colorless liquid (9.4 g, 90%). Odor (1% wt/vol in EtOH on blotter after 24 h): fruity, cassis

1 H-NMR (CDCIs, 400MHz): (mixture of 2 diastereomers 48:52) 2.96 - 3.13 (m, 1 H), 2.57 - 2.73 (m, 1 H), 2.53 (t, J=7.5 Hz, 2 H), 2.22 (s, 1.5H), 2.21 (s, 1.5H), 1.53 - 1.63 (m, 2 H), 1.30 (d, J=6.8 Hz, 1.5 H), 1.25-1.40 (m, 18 H), 1.23 (d, J= 7.0,1.5 H), 1.22 (d, J= 7.0 , 1.5 H), 1.13 (d, J=6.8 Hz, 1.5 H), 0.87 - 0.92 (m, 3 H).

13 C-NMR (CDCIg, 101MHz): (mixture of 2 diastereomers 48:52) 211.1 (s) , 210.7 (s) , 52.5 (d), 51.9 (d), 42.6 (d), 41.1 (d), 31.9 (t), 31.4 (t), 31.0 (t), 29.8 (t), 29.7 (t), 29.7 (t), 29.6 (t), 29.6 (t), 29.5 (t), 29.3 (t), 29.2 (t), 29.0 (t), 22.7 (t), 20.5 (q),

18.0 (q), 14.4 (q), 14.1 (q), 12.8 (q). MS (El, 70 eV): 300 (5, M + ), 229 (20), 99 (40), 98 (24), 83 (29), 69 (25), 57 (19), 55 (51), 43 (100), 41 (40), 29 (24).

Example 10: 3-f Dodecylthiol-3-methylbutanal The procedure described in Example 1 was repeated with 1 -dodecanethiol (24.1 g, 119 mmol, 1 equiv.), 3-methylbut-2-enal (10.0 g, 1 equiv.) and DBU (18.1 g, 1 equiv.) without solvent. The crude product was purified by FC with hexane/MTBE 95:5 to yield 3-(dodecylthio)-3-methylbutanal as a colorless liquid (7.0 g, 21%).

Odor (1% wt/vol in EtOH on blotter after 24 h): cassis, sulfury 1 H-NMR (CDCI 3 , 400MHz): 9.87 (t, J=2.9 Hz, 1 H), 2.53 - 2.58 (m, 4 H), 1.52 - 1.63 (m, 2 H), 1.45 (s, 6 H), 1.28-1.41 (m, 18 H), 0.90 (t, J=6.8 Hz, 3 H).

13 C-NMR (CDCI 3 , 101MHz): 202.0 (d), 54.6 (t), 42.7 (s), 32.3 (t), 30.0 (t), 30.0 (t), 30.0 (t), 29.9 (t), 29.8 (t), 29.7 (2q), 29.6 (2t), 29.6 (s), 28.4 (t), 23.1 (t), 14.5 (q).

MS (El, 70 eV): 286 (2, M + ), 97 (35), 84 (50), 83 (54), 70 (32), 69 (47), 57 (89), 56 (73), 55 (100), 43 (53), 41 (77). Example 11: 3-f Dodecylthio1-3-methylcvclohexan-1 -one

The procedure described in Example 1 was repeated with 1 -dodecanethiol (7.7 g, 38.0 mmol, 1 equiv.), 3-methyl-2-cyclohexen-1 -one (5.03 g, 1.2 equiv.) and DBU (5.79 g, 1 equiv.) in THF (60 mL) during 4 days at room temperature. The crude product was purified by FC with hexane to hexane/MTBE 9: 1 to yield 3-(dodecylthio)-3- methylcyclohexan-1 -one as a colorless liquid (3.09 g, 26%).

Odor (1% wt/vol in EtOH on blotter after 24 h): aldehydic, floral, green, slightly sulfury

1 H-NMR (CDCIs, 400MHz): 2.53 - 2.58 (m, 1 H), 2.44 - 2.52 (m, 2 H), 2.34 - 2.43 (m, 2 H), 2.08 - 2.30 (m, 2 H), 1.77 - 2.01 (m, 3 H), 1.51 - 1.61 (m, 2 H), 1.40 (s, 3 H), 1.27-1.42 (m, 18 H), 0.89 (t, J=6.8 Hz, 3 H).

13 C-NMR (CDCI S , 101 MHZ): 208.9 (s), 53.5 (t), 48.3 (s), 40.3 (t), 36.8 (t), 31.9 (t), 29.6 (t), 29.6 (t), 29.6 (t), 29.5 (t), 29.4 (t), 29.3 (t), 29.2 (t), 29.2 (t), 28.8 (q),

27.4 (t), 22.7 (t), 22.1 (t), 14.1 (q). MS (El, 70 eV): 312 (1, M + ), 112 (21), 111 (100), 110 (36), 83 (30), 82 (56), 69 (29), 55 (78), 43 (32), 41 (42), 39 (22).

Example 12: 3-iDodecylthio1-3-methylcvclopentan-1 -one The procedure described in Example 1 was repeated with 1 -dodecanethiol (8.7 g, 43.0 mmol, 1 equiv.), 3-methylcyclopent-2-enone (4.96 g, 1.2 equiv.) and DBU (6.54 g, 1 equiv.) in THF (60 mL) during 4 days at room temperature. The crude product was purified by FC with hexane to hexane/MTBE 9: 1 to yield 3-(dodecylthio)-3- methylcyclopentan-1 -one as a colourless liquid (0.68 g, 5%). Odor (1% wt/vol in EtOH on blotter after 24 h): fruity, sulfury

1 H-NMR (CDCIs, 400MHz): 2.44 - 2.63 (m , 4 H) , 2.16 - 2.37 (m, 3 H), 1.93 - 2.05 (m, 1 H), 1.56 (s, 3 H), 1.54-1.63 (m, 2 H), 1.28-1.38 (m, 18 H), 0.90 (t, J=6.6 Hz, 3 H). 13 C-NMR (CDCI 3 , 101MHz): 216.9 (s), 52.7 (t), 49.1 (s), 36.9 (t), 36.1 (t), 31.9 (t),

29.6 (t), 29.6 (t), 29.6 (t), 29.5 (t), 29.3 (t), 29.2 (t), 29.2 (t), 28.8 (t), 28.3 (q),

22.7 (t), 14.1 (q).

MS (El, 70 eV): 298 (4, M + ), 201 (19), 97 (100), 96 (41), 83 (19), 69 (52), 67 (19), 55 (35), 43 (32), 41 (48), 39 (18).

Example 13: 5-(Dodecylthio1-5-methylhexan-3-one

The procedure described in Example 1 was repeated with 1 -dodecanethiol (4.9 g, 24.2 mmol, 1 equiv.), 5-methylhex-4-en-3-one (5.43 g, 2 equiv.) and DBU (3.69 g, 1 equiv.) in THF (80 mL) during 20 h at room temperature. The crude product was purified by FCwith hexane/MTBE 96:4 to yield 5-(dodecylthio)-5-methylhexan-3-one as a colourless liquid (3.45 g, 46%).

Odor (1% wt/vol in EtOH on blotter after 24 h): fruity, sulfury, slightly aldehydic 1 H-NMR (CDCIg, 400MHz): 2.68 (s, 2 H), 2.54 (t, J=7.3 Hz, 2 H), 2.50 (q, J=7.3 Hz, 2 H), 1.52 - 1.62 (m, 2 H), 1.43 (s, 6 H), 1.27 (1.42-1.20, m, 18 H), 1.05 (t, J=7.2 Hz,

3 H), 0.89 (t, J= 6.6 Hz, 3 H).

13 C-NMR (CDCI 3 , 101MHz): 209.5 (s), 53.6 (t), 43.5 (s), 38.2 (t), 31.9 (t), 29.7 (t), 29.6 (t), 29.6 (t), 29.6 (t), 29.5 (t), 29.3 (t), 29.3 (2t), 28.6 (2q), 28.2 (t), 22.7 (t), 14.1 (q), 7.6 (q).

MS (El, 70 eV): 314 (3, M+), 257 (3), 243 (7), 201 (8), 113 (11), 97 (13), 83 (57), 69 (17), 57 (100), 43 (31), 29 (29).

Example 14: 4-f Decylthio1-4-methylpentan-2-one

The procedure described in Example 1 was repeated with 1 -decanethiol (10.0 g, 57.4 mmol, 1 equiv.), 4-methylpent-3-en-2-one (11.26 g, 2 equiv.) and DBU (8.73 g, 1 equiv.) in THF (80 mL) during 24 h at room temperature. The crude product was purified by FCwith hexane/MTBE 95: 5 to yield 4-(decylthio)-4-methylpentan-2-one as a colourless liquid (14.12 g, 90%).

Odor (1% wt/vol in EtOH on blotter after 24 h): fruity, sulfury, slightly aldehydic.

1 H-NMR (CDCI3, 400MHz): 2.70 (s, 2 H), 2.54 (t, J=7.8 Hz, 2 H), 2.20 (s, 3 H), 1.52 - 1.62 (m, 2 H), 1.43 (s, 6 H), 1.27 (1.43 - 1.23, m , 14 H), 0.89 (t, J=6.6 Hz, 3 H).

13 C-NMR (CDCI3, 101MHz): 206.9 (s), 54.7 (t), 43.3 (s), 32.4 (q), 31.9 (t), 29.5 (t), 29.5 (t), 29.5 (t), 29.3 (t), 29.3 (t), 29.3 (t), 28.5 (2q), 28.1 (t), 22.7 (t), 14.1 (q).

MS (El, 70 eV): 272 (6, M+), 173 (17), 140 (4), 99 (26), 83 (24), 69 (9), 55 (23), 43 (100), 29 (11).

Example 15: 4-Methyl-4-ftetradecylthio1pentan-2-one

The procedure described in Example 1 was repeated with 1 -tetradecanethiol (4.16 g, 18.1 mmol, 1 equiv.), 4-methylpent-3-en-2-one (3.54 g, 2 equiv.) and DBU (2.75 g, 1 equiv.) in THF (50 mL) during 24 h at room temperature. The crude product was purified by FCwith hexane/MTBE 95: 5 to yield 4-methyl-4-(tetradecylthio)pentan-2- one as a colourless liquid (3.21 g, 54%).

Odor (1% wt/vol in EtOH on blotter after 24 h): fruity, sulfury, slightly aldehydic.

1 H-NMR (CDCIs, 400MHz): 2.70 (s, 2 H), 2.54 (t, J=7.6 Hz, 2 H), 2.21 (s, 3 H), 1.53 - 1.62 (m, 2 H), 1.43 (s, 6 H), 1.25 - 1.42 (m, 22 H), 0.89 (t, J=6.8 Hz, 3 H).

13 C-NMR (CDCI S , 101 MHZ): 206.9 (s), 54.7 (t), 43.3 (s), 32.4 (q), 31.9 (t), 29.7 (t),

29.7 (t), 29.7 (2t) , 29.6 (t), 29.5 (t), 29.5 (t), 29.4 (t), 29.3 (2t), 28.5 (2q), 28.1 (t),

22.7 (t), 14.1 (q).

MS (El, 70 eV): 328 (3, M+), 285 (4), 271 (3) , 229 ( 11 ) , 168 (2) , 111 (8), 99 (27), 83 (46), 69 (21), 55 (39), 43 (100), 29 (15). Example 16: 4-Methyl-4- methyloctvhthiolpentan-2-one

The procedure described in Example 1 was repeated with 6-methyloctane-1 -thiol (prepared according to Example 3a) from 6-methyl octanol; 8.5 g, 53 mmol, 1 equiv.), 4-methylpent-3-en-2-one (10.4 g, 2 equiv.) and DBU (8.07 g, 1 equiv.) in THF (120 mL). The crude product was purified by FC with hexane/MTBE 96:4 to yield 4-methyl- 4-((6-methyloctyl)thio)pentan-2-one as a clear, colorless liquid (9.3 g, 68%).

Odor (1% wt/vol in EtOH on blotter after 24 h): fruity, cassis, slightly aldehydic.

1 H-NMR (CDCIg, 400 MHz): 2.69 (s, 2 H), 2.59 (br. t, J = 7.5 Hz, 2 H), 2.19 (s, 3 H), 1.52 - 1.63 (m, 2 H), 1.42 (s, 6 H), 1.22 - 1.41 (m, 7 H), 1.06 - 1.19 (m, 2 H), 0.85 (t, J = 7.2 Hz, 3H) , 0.84 (d, J = 6.0 Hz, 3H).

13 C-NMR (CDCIg, 101 MHz): 206.9 (s), 54.7 (t), 43.3 (s), 36.4 (t), 34.3 (d), 32.3 (q), 29.6 (t), 29.6 (t), 29.4 (t), 28.5 (2q), 28.1 (t), 26.7 (t), 19.2 (q), 11.4 (q).

MS (El, 70 eV): 258 (3, M + ), 159 (12), 99 (22), 97 (15), 83 (22), 69 ( 11 ) , 57 ( 16) , 55 (28), 43 (100), 41 (25), 29 (19).

Example 17: 3-f f3-f4-lsobutyl-2-methylphenvhpropyhthio1butanal

The procedure described in Example 3b) was repeated with 3-(4-isobutyl-2- methylphenyl)propane-1 -thiol (prepared according to Example 3a) from 3-(4-isobutyl- 2-methylphenyl)propan-1 -ol { prepared as described in WO 2014/180945 A1 } ; 5.1 g, 22.9 mmol, 1 equiv.) and (E)-but-2-enal (3.21 g, 2 equiv.). The crude product was purified by FCwith hexane/MTBE 94: 6 to yield 3-((3-(4-isobutyl-2-methylphenyl) propyl)thio)butanal as a clear, colorless liquid (0.39g, 6%). Odor (1% wt/vol in EtOH on blotter after 24 h): aldehydic, sulfury.

1 H-NMR (CDCIg, 400 MHz): 9.80 (t, J=2.0 Hz, 1 H), 7.06 (d, J=7.6 Hz, 1 H), 6.92 - 6.98 (m, 2 H), 3.32 (sxt, J=6.8 Hz, 1 H), 2.58 - 2.74 (m, 6 H), 2.44 (d, J= 7.1 Hz, 2 H), 2.32 (s, 3 H), 1.83 - 1.94 (m, 3 H), 1.38 (d, J=6.6 Hz, 3 H), 0.93 (d, J=6.6 Hz, 6 H).

13 C-NMR (CDCI S , 101 MHz): 200.6 (d), 139.4 (s), 136.7 (s), 135.4 (s), 131.1 (d), 128.6 (d), 126.7 (d), 50.5 (t), 45.0 (t), 34.1 (d), 32.0 (t), 30.4 (t), 30.2 (d), 30.1 (t), 21.7 (2q) , 22.5 (q), 19.4 (q).

MS (El, 70 eV): 292 (5, M + ), 222 (35), 188 (17), 179 (47), 161 (36), 145 (100), 131 (43), 119 (41), 105 (19), 91 (15), 61 (9), 41 (24).

Example 18: 4-((3-(4-lsobutyl-2-methylphenyl)propyl)thio)-4-methylpentan -2-one

The procedure described in Example 1 was repeated with 3-(4-isobutyl-2- methylphenyl)propane-1 -thiol (prepared according to Example 3a) from 3-(4-isobutyl- 2-methylphenyl)propan-1 -ol { prepared as described in WO 2014/180945 A1 } ; 5.1 g, 22.9 mmol, 1 equiv.), 4-methylpent-3-en-2-one (4.5 g, 2 equiv.) and DBU (3.49 g, 1 equiv.) in THF (50 mL). The crude product was purified by Kugelrohr distillation (140- 165°C, 0.02 mbar) to yield 4-((3-(4-isobutyl-2-methylphenyl)propyl) t hio) -4- methylpentan-2-one as a clear, colorless liquid (3.6 g, 49%).

Odor (1% wt/vol in EtOH on blotter after 24 h): fruity, cassis, sulfury.

1 H-NMR (CDCIs, 400 MHz): 7.06 (d, J=7.6 Hz, 1 H), 6.91 - 6.97 (m, 2 H), 2.68 - 2.74 (m, 4 H), 2.62 (t, J=7.3 Hz, 2 H), 2.43 (d, J=7.3 Hz, 2 H), 2.31 (s, 3 H), 2.21 (s, 3 H), 1.82 - 1.92 (m, 3 H), 1.45 (s, 6 H), 0.92 (d, J=6.6 Hz, 6 H).

13 C-NMR (CDCI S , 101 MHz): 206.9 (s), 139.4 (s), 136.8 (s), 135.4 (s), 131.1 (d),

128.6 (d), 126.6 (d), 54.7 (t), 45.0 (t), 43.5 (s), 32.3 (d), 32.3 (t), 30.2 (q), 30.1 (t), 28.5 (2q) , 27.9 (t), 22.4 (2q), 19.3 (q). MS (El, 70 eV): 320 (6, M + ), 222 (27), 188 (44), 179 (37), 161 (50), 145 (100), 131 (60), 119 (43), 105 (20), 83 (24), 57 (14), 55 (23), 41 (79). Exam ple 19 : Release of odoriferous volatiles from 4- -4-m 2 one

A 1 0% wt/wt solution of 4-(dodecylthio)-4-methylpentan-2-one (prepared according to Exam ple 1 ) in MTBE (200 mI , 16.3 mg) was applied on a paper blotter (4x1 .2 cm 2 , conditioned by rinsing with MeOH and vacuum drying) . After 5 m in evaporation of the solvent in open air, the blotter was placed at the bottom of a 2 L glass jar closed with a lid containing two openings which were sealed with Parafilm . The glass jar was left for 48 h at 25° C in a cabinet lit with a fluorescent UV A/B-light source (ca. 0.8 mW/cm 2 ) .

Then a stainless steel tube (length 25 cm , i.d. 0.8 m m) with a Porapak Q filter (of. R. Kaiser,“Meaningful Scents around the World”, Helvetica Chim ica Acta, Zurich 2006, chapter 1 .3.) attached to its tip with shrinking tube and secured with Parafilm , was introduced into the jar through one of the openings, to which it was attached by an air tight Teflon joint. The tube was attached to a peristaltic pump with a thin rubber hose and the other opening of the jar (the air inlet) was equipped with a charcoal filter. An air volume of 2 L was drawn through the filter with a flow of 1 0 m L/m in. The trapped volatiles were desorbed with 100 mI_ of MTBE and the liquid sam ple was analysed by GC/MS and GC-sniff. As shown in Fig. 1 , the presence of the odorants 4-mercapto-4- m ethylpentan-2-one and dodecanal was detected among the volatiles released from 4- (dodecylthio)-4-m ethylpentan-2-one.

Exam ple 20 : Release of odoriferous volatiles from 3- envDpropyl) thiolbutanal

Exam ple 19 was repeated with 3-((3-(4-(tert-butyl)phenyl)propyl)thio)butanal. The presence of the odorant 3-(4-(tert-butyl)phenyl)propanal was detected among the volatiles released from 3-((3-(4-(tert-butyl)phenyl)propyl)thio)butanal ( Fig. 2) .

Exam ple 21 : Release of odoriferous volatiles from 4-((3-(4-(tert-butvhDhenvhDropyh thio1-4-methyloentan-2-one Exam ple 1 was repeated with 4-((3-(4-(tert-butyl)phenyl)propyl)thio)-4-m ethylpentan- 2-one. The presence of the odorants 4-mercapto-4-methylpentan-2-one and 3-(4- (tert-butyl)phenyl)propanal was detected among the volatiles released from 4-((3-(4- (tert-butyl)phenyl)propyl)thio)-4-m ethylpentan-2-one ( Fig. 3) . Example 19: A fresh clean citrus fragrance for an all-purpose cleaner

The following fragrance accord has been created for an all-purpose cleaner and is to be assessed at 0.3% in the unperfumed product base.

Amount parts

CAS number I ngredient name

wt/wt

140-11-4 Benzyl acetate 15

80-26-2 Terpenyl Acetate 60

101-86-0 alpha Hexyl Cinnam ic Aldehyde 30

112-31-2 Decanal 18

67634-00-8 Ally I amyl glycolate 3

1092785-58-4 Cassyrane™ (Givaudan) 0.5

106-22-9 Citronellol 20

68039-49-6 Cyclal C 5

57378-68-4 delta Damascone 1

65405-70-1 4-E-Decenal 0.2

18479-58-8 Dihydro Myrcenol 60

8000-48-4 Eucalyptus Essence 10

67634-14-4 Floralozone 3

125109-85-5 Florhydral 2

14765-30-1 Freskomenthe 5

54464-57-2 Iso E Super 20

20665-85-4 Isobutavan 0.2

1335-46-2 Isoraldeine 70 10

198404-98-7 Javanol 1

81783-01-9 Labienoxime 1 % in TEC/I PM 3

61792-11-8 Lemonile 35

73018-51-6 Lime Oxide 20

78-70-6 Linalool 90

39255-32-8 Manzanate 2

37677-14-8 Myraldene 10

1637294-12-2 Nympheal 8 68647-72-3 Orange Terpenes 300

916887-53- 1 Petalia™ (Givaudan) 7

Pharaone™ (Givaudan) 1 0% in

313973-37-4 DPG 4

82461 - 14- 1 Rhubafuran 0.5

1 655500-83-6 Rosyfolia™ (Givaudan) 3

1 6510-27-3 Toscanol™ (Givaudan) 1

Reference Accord Accord Accord A B

4-(dodecylthio)-4-m ethylpentan- 2-one ( Example 1 ) 0 2 1 0

25265-71 -8 Dipropylene Glycol 252.6 250.6 242.6

Total parts wt/wt 1 000 1 000 1 000

The olfactory character imparted to the product by the reference accord is citrus and fresh floral aldehydic, with a watery facette.

Addition of 0.2% of 4-(dodecylthio)-4-methylpentan-2-one ( Example 1 ) enhances the citrus odor aspect, while addition of 1 % renders the accord more intense citrus and enhances the juicy aspect. After 24 hours application on a floor tile, the perfum e is slightly more intense with the addition of 0.2% 4-(dodecylthio)-4-methylpentan-2-one and clearly more intense, fresher and juicier than the reference with 1 % .

Exam ple 23 : Olfacive evaluation of com pound according to Example 1 and m ixtures thereof with mesityl oxide

Mixtures of the com pound according to Example 1 (4-(dodecylthio)-4-m ethylpentan-2- one) with mesityl oxide were prepared in different ratios and subjected to olfactive evaluation. All samples were assessed as 10% solutions in ethanol on a fresh blotter.

The above results show that there is an optim um ratio between 4-(dodecylthio)-4- methylpentan-2-one and mesityl oxide, in which the m ixture shows superior olfactive properties.

Exam ple 24: Application in liquid detergent 1

Three sam ples of liquid detergent samples (34 g each) were prepared by adding 0.2 wt.-% of the following precursors according to the present invention to a non fragranced heavy duty liquid detergent base (pH 8.4) : 4-(decylthio)-4-m ethylpentan- 2-one ( Example 14) , 4-(dodecylthio)-4-methylpentan-2-one ( Exam ple 1 ) and 4- m ethyl-4-(tetradecylthio)pentan-2-one ( Example 15) . The samples were used to wash a load of 5 cotton terry towels (ca. 200 g dry weight each, 1 .1 kg total load) in a standard frontloading washing m achine. The wash cycle was carried out at 40°C, followed by two cold rinse cycles and spinning at 1 000 rpm . The washed towels were assessed blind by a panel of 6 experienced evaluators for fragrance intensity on wet towel and after 24 h line dry at room temperature. The intensity was indicated on a scale from 0 (odorless) to 5 (very strong) .

As can be seen from the results provided in the table above, the comparative study of three precursors according to the present invention with = R 3 = R 4 = m ethyl, R 2 = R 5 = H and R 6 = nonyl, undecyl or tridecyl, the strongest precursor effect was observed with R 6 = undecyl. The observed differencies between R 6 = undecyl and R 6 = nonyl or R 6 = tridecyl were significant at confidence levels of 99.8% and 96% , respectively.

Due to the high volatility and water solubility of the released odorant 4-m ercapto-4- m ethyl-2- pentanone (clogP = 1 .0, as compared to clogP = 7.2 for 4-(dodecylthio)-4- m ethylpentan-2-one) , it would not have been technically possible to deposit a sufficient amount of the material on fabric to trigger a fragrance im pact.

Exam ple 25: Application in liquid detergent 2 a) General As series of experim ents was conducted in order to determ ine whether fragrance ingredients according to the present invention show intensity benefits in fabric detergents. The com pound of Exam ple 1 (4-(dodecylthio)-4-m ethylpentan-2-one) was tested with two fragrances A and B, which had different olfactive profiles. The products were assessed on wet cloth and on 1 day, 3 days and 7 days dried cloth. The mem bers of a sensory analysis panel were selected on a basis of their olfactory sensory acuity and then trained for several months. Their training enabled them to identify individual odor characteristics and score their perceived intensity against given standards in a consistent m anner.

The fabrics were washed in European washing m achines (40° C - 1 ,000 spin/m in) with one unit dose per wash load. For the wet stage, after washing, the cloths were placed into 500 m L wide necked glass jars ready for assessment. For the dry cloth assessm ent, the cloth was lined-dried and left overnight in a perfum e free room at 25 ° C. Cloths washed with fragrance A were used as the control.

For all stages the overall perceived intensity was assessed by the trained sensory panel using a 0- 1 00 linear scale. All overall perceived intensities were scaled against a reference sam ple A, for which the overall perceived intensity was set at 35 for wet cloth assessm ent and 1 0 for the dry cloth assessm ents where the reference sam ple was a 1 day dry cloth. The reference sam ple A was presented in the sam e form at as the test sam ples for the wet cloth and dry cloth assessm ent.

For the wet cloth assessm ent , each sam ple was assessed twice by 20 panellists, thus giving 40 assessm ents per product. For the 1 day, 3 days and 7 days dry cloth assessm ents, each sam ple was assessed twice by 1 4 panellists, thus giving 28 assessm ents per product.

The estim ated product m eans are reported on the next pages, together with any statistically significant differences between products. b) Wet Cloth

Where the sam e letter is shown in the“significance of differences” colum n there are no statistically significant differences between the relevant figu res.

When assessed from wet cloth, cloth washed with Fragrance B or Fragrance B + 2% precu rsor were not perceived to be significantly different, but were perceived to be significantly stronger than cloth washed with Fragrance A or Fragrance A + 2% precu rsor, which were also not perceived to be significantly different to each other. c) Dry cloth 1 day

Where the same letter is shown in the“significance of differences” colum n there are no statistically significant differences between the relevant figures.

When assessed from 1 day dry cloth, cloth washed with Fragrance A + precursor was perceived to be significantly stronger than cloth washed with Fragrance A. Cloth washed with Fragrance B was perceived to be significantly weaker than cloth washed with Fragrance B + precursor. d) Dry cloth 3 days

Where the same letter is shown in the“significance of differences” colum n there are no statistically significant differences between the relevant figures.

When assessed from 3 day dry cloth, cloth washed with Fragrance B + 2% precursor was perceived to be significantly stronger than cloth washed with any of the other products. Whereas, cloth washed with Fragrance A was perceived to be significantly weaker than cloth washed with any of the other products. e) Dry cloth 7 days

Where the same letter is shown in the“significance of differences” colum n there are no statistically significant differences between the relevant figures.

When assessed from 7 day dry cloth, cloth washed with Fragrance A + 2% precursor or Fragrance B + 2% precursor were not perceived to be significantly different, but were perceived to be significantly stronger than cloth washed Fragrance A or Fragrance B which were also not perceived to be significantly different to each other. f) Conclusion

When assessed from wet cloth, for both Fragrance A and Fragrance B, the cloth washed with product containing the precursor was com parable in terms of strength to cloth washed with product not containing the precursor. When assessed from 1 day, 3 day and 7 day dry cloth, for both Fragrance A and Fragrance B, the cloth washed with product containing the precursor was perceived to be significantly stronger than the same fragrance without the precursor.

Exam ple 26: Application in all-purpose cleaner a) General

As series of experim ents was conducted in order to determ ine whether fragrance ingredients according to the present invention show intensity benefits in all purpose cleaners (APCs) . The compound of Example 1 (4-(dodecylthio)-4-m ethylpentan-2-one) was tested with two fragrances A and B, which had different olfactive profiles. The products were assessed in booths on the floor at fresh (tim e = 0) and after 1 hour, 2 hours and 4 hours application.

The mem bers of a sensory analysis panel were selected on a basis of their olfactory sensory acuity and then trained for several months. Their training enabled them to identify individual odor characteristics and score their perceived intensity against given standards in a consistent m anner.

The testing was carried out in sm all booths ( 1 0 m 3 booths, 21 °C, 50% RFI) specifically designed. The booths were closed during testing, with the doors sealed. The APC products were diluted at 1 .2% in warm water (45°C + /- 2° C) . 60 m L of the diluted product was applied directly to the booth floor. It was evenly spread using a gloved hand, over an area of 65 cm x 65 cm.

The system was assessed through a porthole in the door of the booth. The overall perceived intensity was assessed by the trained sensory panel using a 0-100 line scale. The dilution assessment was conducted over four sessions. The Fresh (time = 0), 1 hour and 4 hour stages were assessed by 16 panelists, thus giving 32 assessments per product. The 2 hour stage was assessed by 17 panelists, thus giving 34 assessments per product.

The estimated product means are reported on the next pages, together with any statistically significant differences between products. b) Fresh (time = 0) bloom from floor assessment

Where the same letter is shown in the“significance of differences” column there are no statistically significant differences between the relevant figures.

When the products were assessed fresh (time = 0), there was no perceived significant difference between the booths containing any of the five products tested. c) One hour bloom from floor assessment

Where the same letter is shown in the“significance of differences” column there are no statistically significant differences between the relevant figures. When the products were assessed after 1 hour application, booths containing

Fragrance B + 8% precursor or Fragrance A + 5% precursor were not perceived to be significantly different to booths containing Fragrance B + 4% precursor, but were perceived to be significantly stronger than booths containing Fragrance A or Fragrance B. d) Two hour bloom from floor assessm ent

Where the same letter is shown in the“significance of differences” colum n there are no statistically significant differences between the relevant figures.

When the products were assessed after 2 hours application, the booths containing Fragrance A + 5% precursor or Fragrance B + 8% precursor, which were not perceived to be significantly different, were perceived to be significantly stronger than the booths containing Fragrance A, Fragrance B or Fragrance B + 4% precursor, which were also not perceived to be significantly different to each other. e) Four hour bloom from floor assessm ent

Where the same letter is shown in the“significance of differences” colum n there are no statistically significant differences between the relevant figures.

When the products were assessed after 4 hours application, the booths containing Fragrance B + 8% precursor or Fragrance A + 5% precursor, which were not perceived to be significantly different, were perceived to be significantly stronger than booths containing Fragrance A or Fragrance B + 4% precursor, which were also not perceived to be significantly different to each other. Furthermore, booths containing Fragrance B were perceived to be significantly weaker than the booths containing any of the other four products tested. f) Conclusion

Fragrance A + 5% precursor was comparable in terms of strength to Fragrance A at fresh (time = 0), but was perceived to be significantly stronger than Fragrance A when assessed 1 hour, 2 hours and 4 hours after application. The Fragrance B + 8% precursor was comparable in terms of strength to Fragrance B at fresh (time = 0) but was perceived to be significantly stronger than Fragrance B when assessed 1 hour, 2 hours and 4 hours after application. Whereas Fragrance B + 4% precursor was comparable in terms of strength to Fragrance B at the fresh, 1 hour and 2 hour assessments, but was perceived to be significantly stronger than Fragrance B when assessed 4 hours after application.

Furthermore, Fragrance A + 5% precursor and Fragrance B + 8% precursor were comparable in terms of strength when assessed at all time points (0, 1, 2 and 4 hours).