Title:
THIOL-MODIFIED HYALURONAN
Document Type and Number:
WIPO Patent Application WO2002068383
Kind Code:
A3
Abstract:
The present invention relates to biscarbodiimides, thiourea derivatives, urea derivatives, and cross-linked hyaluronan derivatives having at least one intramolecular disulfide bond, and methods of preparation thereof. The invention also includes thiolated hyaluronan derivatives and salts thereof having at least one pendant thiol group or a modified pendant thiol group, and methods of preparation thereof. An example of a modified pendant thiol group is a sulfhydryl group linked to a small molecule such as a bioactive agent, for example a drug or pharmaceutically active moiety. A hyaluronan derivative having a sulfhydryl group linked to a pharmaceutically active moiety is useful as a sustained or controlled release drug delivery vehicle. Compositions containing the hyaluronan derivatives of the invention can reversibly viscosify in vivo or in vitro, in response to mild changes in condition, and are thus useful in ophthalmic surgery and in tissue engineering.
Inventors:
BULPITT PAUL C A
SHERWOOD CHARLES H
SADOZAI KHALID K
SHERWOOD CHARLES H
SADOZAI KHALID K
Application Number:
PCT/US2002/005081
Publication Date:
February 27, 2003
Filing Date:
February 21, 2002
Export Citation:
Assignee:
ANIKA THERAPEUTICS INC (US)
International Classes:
A61K31/728; A61P27/02; A61P41/00; C07C323/25; C07C323/32; C07C323/37; C07C323/44; C07C323/45; C07C335/08; C07C335/16; C08B37/08; (IPC1-7): C07C323/25; C07C323/32; C07C335/08; C07C335/16; C07C323/44; C08B37/08; A61K31/728; A61P27/02; A61P41/00
Domestic Patent References:
| WO1988005436A1 | 1988-07-28 | |||
| WO1994002517A1 | 1994-02-03 | |||
| WO2002009792A1 | 2002-02-07 |
Foreign References:
| US2832756A | 1958-04-29 |
Other References:
A. KJAER, ET AL.: "Isothiocyanates XXVI. Straight-chain omega-methylthioalkyl isothiocyanatesa and some derivatives", ACTA CHEMICA SCANDINAVICA, vol. 11, no. 8, 1957, Munksgaard, Copenhagen, DK, pages 1298 - 1307, XP002220235, ISSN: 0904-213X
PATENT ABSTRACTS OF JAPAN vol. 006, no. 073 (C - 101) 8 May 1982 (1982-05-08)
H. WOJAHN, ET AL.: "Aromatischer Disulfid-Verbindungen mit tuberkulocider Wirkung", ARZNEIMITTEL FORSCHUNG, vol. 2, 1952, Verlag Für Naturwissenschaften GmbH, Aulendorf, DE, pages 455 - 460, XP008010364, ISSN: 0004-4172
K. SCHIMMELSCHMIDT, ET AL.: "Darstellung und Umsetzungen der 2-amino-äthylthioschwefelsäure", CHEMISCHE BERICHTE, vol. 96, no. 1, 1963, Verlag Chemie, Weinheim, DE, pages 38 - 47, XP002220236, ISSN: 0009-2940
PATENT ABSTRACTS OF JAPAN vol. 006, no. 073 (C - 101) 8 May 1982 (1982-05-08)
H. WOJAHN, ET AL.: "Aromatischer Disulfid-Verbindungen mit tuberkulocider Wirkung", ARZNEIMITTEL FORSCHUNG, vol. 2, 1952, Verlag Für Naturwissenschaften GmbH, Aulendorf, DE, pages 455 - 460, XP008010364, ISSN: 0004-4172
K. SCHIMMELSCHMIDT, ET AL.: "Darstellung und Umsetzungen der 2-amino-äthylthioschwefelsäure", CHEMISCHE BERICHTE, vol. 96, no. 1, 1963, Verlag Chemie, Weinheim, DE, pages 38 - 47, XP002220236, ISSN: 0009-2940
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