Title:
THIOLIZED INDOLIZINE COMPOUND HAVING ANTICANCER ACTIVITY AND DERIVATIVE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/232665
Kind Code:
A1
Abstract:
Probided are a hiolized indolizine compound having anticancer activity and a derivative thereof. Said compound and derivative thereof shown in formula (I) have an inhibitory effect on a purality of cancers and tumors.
Inventors:
CAO HUA (CN)
LI BIN (CN)
CHEN WEIXIN (CN)
LI BIN (CN)
CHEN WEIXIN (CN)
Application Number:
PCT/CN2018/000246
Publication Date:
December 12, 2019
Filing Date:
July 04, 2018
Export Citation:
Assignee:
GUANG DONG PHARMACEUTICAL UNIV (CN)
International Classes:
C07D471/04; A61K31/437; A61P35/00; A61P35/02
Foreign References:
| CN102458580A | 2012-05-16 |
Other References:
LI, BIN ET AL.: "Transition-Metal-Free Regioselective Cross-Coupling: Controlled Synthesis of Mono- or Dithiolation Indolizines", ORG. LETT., vol. 20, 22 May 2018 (2018-05-22), pages 3291 - 3295, XP055667249
MIREK, JULIAN ET AL.: "The Reaction of Indolizines and Acetylindolizines with Trifluoromethylsulfenyl Chloride", JOURNAL OF FLUORINE CHEMISTRY, vol. 19, no. 1, 31 December 1981 (1981-12-31), pages 67 - 70, XP001028549, DOI: 10.1016/S0022-1139(00)85240-9
COLONNA, MARTINO ET AL.: "Electron-transfer Processes. Trans-sulfenylation of Electron-rich Systems with Sulfenamides", GAZZETTA CHIMICA ITALIAN A, vol. 116, no. 8, 31 December 1986 (1986-12-31), pages 449 - 452
MIREK, JULIAN ET AL.: "The Reaction of Indolizines and Acetylindolizines with Trifluoromethylsulfenyl Chloride", JOURNAL OF FLUORINE CHEMISTRY, vol. 19, no. 1, 31 December 1981 (1981-12-31), pages 67 - 70, XP001028549, DOI: 10.1016/S0022-1139(00)85240-9
COLONNA, MARTINO ET AL.: "Electron-transfer Processes. Trans-sulfenylation of Electron-rich Systems with Sulfenamides", GAZZETTA CHIMICA ITALIAN A, vol. 116, no. 8, 31 December 1986 (1986-12-31), pages 449 - 452
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