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Title:
THIOPHENE AMIDE COMPOUNDS FOR USE IN THE TREATMENT OR PROPHYLAXIS OF CANCERS
Document Type and Number:
WIPO Patent Application WO2006040569
Kind Code:
A8
Abstract:
The invention provides the use of a compound for the manufacture of a medicament for the prophylaxis or treatment of a cancer or a para-neoplastic effect associated with a cancer, the para-neoplastic effect being other than cachexia, and the compound being a compound of the formula (I), or a salt, solvate or N-oxide thereof, wherein: R1 and R2 are the same or different and each is selected from hydrogen, C1-4 hydrocarbyl, halogen and cyano; X is selected from C=O, C=S, C(=O)NH, C(=S)NH, C(=O)O, C(=O)S, C(=S)O and C(=S)S; R3 is an aryl or heteroaryl group of 5 to 12 ring members optionally substituted by one or more substituent groups R7 wherein R7 is as defined in the claims; R4 is a group YR5 or a group R6; Y is NH, O or S; R5 is selected from (a) optionally substituted carbocyclic and heterocyclic groups having from 3 to 12 ring members; and (b) optionally substituted C1-8 hydrocarbyl 20 groups; and R6 is an optionally substituted heterocyclic group having from 4 to 12 ring members and containing at least one ring nitrogen atom through which R6 is linked to the adjacent carbonyl group.

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Inventors:
GILL ADRIAN LIAM (GB)
LYONS JOHN FRANCIS (GB)
THOMPSON NEIL THOMAS (GB)
Application Number:
PCT/GB2005/003957
Publication Date:
April 26, 2007
Filing Date:
October 14, 2005
Export Citation:
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Assignee:
ASTEX THERAPEUTICS LTD (GB)
GILL ADRIAN LIAM (GB)
LYONS JOHN FRANCIS (GB)
THOMPSON NEIL THOMAS (GB)
International Classes:
A61K31/5386; A61K31/4155; A61K31/4439; A61K31/496; A61K31/5377; A61P35/00
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