Title:
THIOPHENE COMPOUND
Document Type and Number:
WIPO Patent Application WO/1993/003025
Kind Code:
A1
Abstract:
A thiophene compound represented by general formula (I), a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising this compound and pharmaceutical additives, and an antipsychotic containing this compound as the active ingredient; wherein each symbol is as defined in the specification. This compound has pharmacological activities necessary for an antipsychotic, such as, inhibition of active exercise, antiapomorphine activity, methaphetamine antogonism, and potentiation of tetrabenazine-induced blepharoptosis. It is also useful as an antipsychotic which is reduced in the side effect against an extrapyramidal system and as a non-benzodiazepine ataractic.
Inventors:
NAKAO TOHRU (JP)
ONO YUJI (JP)
TANAKA HIROSHI (JP)
OBATA MINORU (JP)
ONO YUJI (JP)
TANAKA HIROSHI (JP)
OBATA MINORU (JP)
Application Number:
PCT/JP1992/001002
Publication Date:
February 18, 1993
Filing Date:
August 05, 1992
Export Citation:
Assignee:
YOSHITOMI PHARMACEUTICAL (JP)
International Classes:
C07D333/20; C07D333/34; C07D333/36; C07D409/06; C07D409/12; C07D409/14; C07D413/14; C07D417/12; C07D417/14; C07D471/20; C07D495/04; (IPC1-7): A61K31/38; A61K31/40; A61K31/44; A61K31/445; A61K31/495; A61K31/55; C07D333/20; C07D333/22; C07D333/34; C07D409/06; C07D409/12; C07D409/14; C07D417/14; C07D471/20; C07D491/048; C07D495/04
Foreign References:
| JPS5810574A | 1983-01-21 | |||
| JPS5810576A | 1983-01-21 |
Other References:
See also references of EP 0596120A4
Attorney, Agent or Firm:
Takashima, Hajime (3-9 Hiranomachi 3-chome, Chuo-k, Osaka-shi Osaka 541, JP)
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