Title:
THIOPHENE RING COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/036177
Kind Code:
A1
Abstract:
Disclosed in the present invention are a thiophene ring compound, a preparation method therefor and an application thereof. The structure of the thiophene ring compound of the present invention is as shown in formula I. The compound of the present invention has good affinity and agonistic activity against at least one of a dopamine receptor and a 5-hydroxytryptamine receptor.
Inventors:
WANG SHENG (CN)
CHENG JIANJUN (CN)
FAN LUYU (CN)
WANG HUAN (CN)
CHEN ZHANGCHENG (CN)
YU JING (CN)
DUAN WENWEN (CN)
CAO DONGMEI (CN)
CHENG JIANJUN (CN)
FAN LUYU (CN)
WANG HUAN (CN)
CHEN ZHANGCHENG (CN)
YU JING (CN)
DUAN WENWEN (CN)
CAO DONGMEI (CN)
Application Number:
PCT/CN2022/117539
Publication Date:
March 16, 2023
Filing Date:
September 07, 2022
Export Citation:
Assignee:
CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE CHINESE ACAD OF SCIENCES (CN)
UNIV SHANGHAI TECH (CN)
UNIV SHANGHAI TECH (CN)
International Classes:
C07D495/16; A61K31/4985; A61P15/10; A61P25/00; A61P35/00
Domestic Patent References:
| WO2011088838A1 | 2011-07-28 | |||
| WO2011088836A1 | 2011-07-28 | |||
| WO2008047883A1 | 2008-04-24 | |||
| WO2011088836A1 | 2011-07-28 | |||
| WO2011088838A1 | 2011-07-28 |
Foreign References:
| JP2008115172A | 2008-05-22 | |||
| JP2008239617A | 2008-10-09 | |||
| CN101258147A | 2008-09-03 | |||
| CN202111052987A | 2021-09-07 | |||
| CN202110138249A | 2021-02-01 |
Other References:
KROGSGAARD-LARSEN, NIELS ET AL.: "Novel Aza-analogous Ergoline Derived Scaffolds as Potent Serotonin 5-HT6 and Dopamine D2 Receptor Ligands.", JOURNAL OF MEDICAL CHEMISTRY, vol. 57, no. 13, 30 May 2014 (2014-05-30), pages 5823 - 5828, XP055954880, ISSN: 1520-4804, DOI: 10.1021/jm5003759
NATURE REVIEW DRUG DISCOVERY, vol. 16, 2017, pages 19 - 34
CHEMMEDCHEM, vol. 6, 2011, pages 1152 - 1162
CHEM. REV., vol. 113, 2013, pages PR123 - PR178
KROGSGAARD-LARSEN ET AL., J. MED. CHEM., vol. 57, 2014, pages 5823 - 5828
"Pharmacopoeia of the People's Republic of China", 2020
RAYMOND C ROWE: "Handbook of Pharmaceutical EMcipients", 2009
NATURE REVIEW DRUG DISCOVERY, vol. 16, 2017, pages 19 - 34
CHEMMEDCHEM, vol. 6, 2011, pages 1152 - 1162
CHEM. REV., vol. 113, 2013, pages PR123 - PR178
KROGSGAARD-LARSEN ET AL., J. MED. CHEM., vol. 57, 2014, pages 5823 - 5828
"Pharmacopoeia of the People's Republic of China", 2020
RAYMOND C ROWE: "Handbook of Pharmaceutical EMcipients", 2009
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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