THIOSUCCINYL-CROSSLINKED HEMOGLOBIN ANALOGS AND METHODS OF USE AND PREPARATION THEREOF

Title:

THIOSUCCINYL-CROSSLINKED HEMOGLOBIN ANALOGS AND METHODS OF USE AND PREPARATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2021/037109

Kind Code:

A1

Abstract:

Provided herein are thiosuccinyl-crosslinked hemoglobin analogs useful as blood replacement agents, pharmaceutical compositions comprising the same and the methods of use and preparation thereof.

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Inventors:

BUTT KWOK CHU (CN)
WAI NORMAN FUNG-MAN (CN)
CHONG HIU CHI (CN)
WU WING FUNG (CN)
YEH COLIN PAK FAI (CN)
WAI BENJAMIN CHI YIN (CN)

Application Number:

PCT/CN2020/111595

Publication Date:

March 04, 2021

Filing Date:

August 27, 2020

Export Citation:

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Assignee:

BILLION KING INT LTD (CN)

International Classes:

C07K14/805; A61K38/42; A61P7/08; A61P35/00; C07K1/107

Domestic Patent References:

WO1984004248A1	1984-11-08
WO2008051689A2	2008-05-02

Foreign References:

CN103169954A	2013-06-26
CN103796671A	2014-05-14

Other References:

FRONTICELLI, C. ; SATO, T. ; ORTH, C. ; BUCCI, E.: "Bovine hemoglobin as a potential source of hemoglobin-based oxygen carriers: crosslinking with bis(2,3-dibromosalycyl)fumarate", BIOCHIMICA ET BIOPHYSICA ACTA. PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY,, vol. 874, no. 1, 7 November 1986 (1986-11-07), ELSEVIER, AMSTERDAM; NL, pages 76 - 81, XP025420382, ISSN: 0167-4838, DOI: 10.1016/0167-4838(86)90104-4

Attorney, Agent or Firm:

BEIJING PAT SF INTELLECTUAL PROPERTY AGENCY CO. LTD (CN)

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