Title:
THREE-DIMENSIONAL CELL CULTURE SYSTEM COMPRISING PEG-BASED HYDROGEL
Document Type and Number:
WIPO Patent Application WO/2018/080148
Kind Code:
A3
Abstract:
The present invention relates to a three-dimensional cell culture system comprising a polyethylene glycol (PEG)-based hydrogel, wherein the PEG-based hydrogel is prepared by mixing an adhesion peptide and a crosslinker to polyethylene glycol-vinylsulfone (PEG-VS) that is a PEG to which vinylsulfone is bonded. The system can cultivate dermal fibroblasts, melanocytes or keratinocytes, which are skin cells, and thus can be effectively used to measure the activity of skin cells.
Inventors:
LEE SEUNG TAE (KR)
LIM HYE WON (KR)
YUN JUNG IM (KR)
KIM MIN SEONG (KR)
LIM HYE WON (KR)
YUN JUNG IM (KR)
KIM MIN SEONG (KR)
Application Number:
PCT/KR2017/011802
Publication Date:
August 09, 2018
Filing Date:
October 25, 2017
Export Citation:
Assignee:
SHEBAHBIOTECH INC (KR)
International Classes:
C12N5/00; C12N5/071; G01N33/50
Foreign References:
| US20120202263A1 | 2012-08-09 | |||
| US20050065281A1 | 2005-03-24 |
Other References:
PATTERSON, J. ET AL.: "Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2", BIOMATERIALS, vol. 31, 2010, pages 7836 - 7845, XP027219014
KRAEHENBUEHL, THOMAS P. ET AL.: "Three-dimensional extracellular matrix-directed cardioprogenitor differentiation: systematic modulation of a synthetic cell -responsive PEG-hydrogel", BIOMATERIALS, vol. 29, 2008, pages 2757 - 2766, XP022615788
ZHU, JUNMIN: "Bioactive modification of poly (ethylene glycol) hydrogels for tissue engineering", BIOMATERIALS, vol. 31, 2010, pages 4639 - 4656, XP055532113
KRAEHENBUEHL, THOMAS P. ET AL.: "Three-dimensional extracellular matrix-directed cardioprogenitor differentiation: systematic modulation of a synthetic cell -responsive PEG-hydrogel", BIOMATERIALS, vol. 29, 2008, pages 2757 - 2766, XP022615788
ZHU, JUNMIN: "Bioactive modification of poly (ethylene glycol) hydrogels for tissue engineering", BIOMATERIALS, vol. 31, 2010, pages 4639 - 4656, XP055532113
Attorney, Agent or Firm:
KIM, Young Ho (KR)
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