Title:
THROMBOMODULIN DERIVATIVES AND CONJUGATES
Document Type and Number:
WIPO Patent Application WO2005081926
Kind Code:
B1
Abstract:
The transmembrane human protein thrombomodulin (TM), as a critical regulator of the protein C pathway, represents the major anticoagulant mechanism that is operative in both normal and injured blood vessels under physiologic conditions in vivo. Compositions and methods are disclosed relating to thrombomodulin derivatives and conjugates, including methods for site-specific pegylation and compositions of a truncated thrombomodulin derivative.
Inventors:
CHAIKOF ELLIOT L (US)
CAZALIS CHRYSTELLE S (FR)
HALLER CAROLYN A (US)
CAZALIS CHRYSTELLE S (FR)
HALLER CAROLYN A (US)
Application Number:
PCT/US2005/005554
Publication Date:
October 12, 2006
Filing Date:
February 22, 2005
Export Citation:
Assignee:
UNIV EMORY (US)
CHAIKOF ELLIOT L (US)
CAZALIS CHRYSTELLE S (FR)
HALLER CAROLYN A (US)
CHAIKOF ELLIOT L (US)
CAZALIS CHRYSTELLE S (FR)
HALLER CAROLYN A (US)
International Classes:
C12P21/06
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