THROMBOXANE A2 RECEPTOR AS TARGET OF ADIPOSE-DERIVED STEM CELL FOR TREATING ISCHEMIC DISEASES

WIPO Patent Application WO/2017/008686

A1

Provided is an adipose-derived stem cell in which a thromboxane A2 receptor (TP) is deactivated or inhibited and/or the activity of a calpain is deactivated or reduced, and/or the activity of a β-catenin is enhanced. Also provided are a use of an adipose-derived stem cell in preparing drugs for treating ischemic diseases and a method of preparing a vascular endothelial cell or blood vessel from an adipose-derived stem cell. Also provided is a method of enhancing pro-angiogenic capability of an adipose-derived stem cell or promoting differentiation of an adipose-derived stem cell into a vascular endothelial cell. Also provided are uses of a TP antagonist and/or a calpain inhibitor in preparing drugs for promoting differentiation capability of an adipose-derived stem cell into a vascular endothelial cell and improving angiogenesis thereof.

YU YING (CN)
SHEN YUJUN (CN)
ZUO SHENGKAI (CN)

PCT/CN2016/089295

January 19, 2017

July 08, 2016

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SHANGHAI INST BIOLOGICAL SCIENCES CAS (CN)

C12N5/0775; A61K35/28; A61P3/10; A61P9/10; A61P25/28; C12N5/071; C12N5/10

WO2006127007A2

2006-11-30

SHEN, YUJUN ET AL.: "Effect of Thromboxane Receptor Knockout on Directional Differentiation of Adipose-Derived Stem Cells to Endothelial Cells", CHINESE JOURNAL OF PATHOPHYSIOLOGY, vol. 28, no. 11, 15 November 2012 (2012-11-15), ISSN: 1000-4718
BAO, JING ET AL.: "Progress in the Researches of Adipose-derived Stem Cells for Promoting Neovascularization", MEDICAL RECAPITULATE, vol. 16, no. 18, 20 September 2010 (2010-09-20), ISSN: 1006-2084

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