Title:
THYMIDYLATE SYNTHASE
Document Type and Number:
WIPO Patent Application WO2002072805
Kind Code:
A3
Abstract:
This invention relates to a Mycobacterium tuberculosis protein designated TSG1 and defined by EMBL accession number CAA16069.1, herein identified as a thymidylate synthase and to the use of this protein and nucleic acid sequence from the encoding gene in the diagnosis, prevention and treatment of disease.
Inventors:
FAGAN RICHARD JOSEPH (GB)
PHELPS CHRISTOPHER BENJAMIN (GB)
GUTTERIDGE ALEX (GB)
PHELPS CHRISTOPHER BENJAMIN (GB)
GUTTERIDGE ALEX (GB)
Application Number:
PCT/GB2002/001043
Publication Date:
February 06, 2003
Filing Date:
March 07, 2002
Export Citation:
Assignee:
INPHARMATICA LTD (GB)
FAGAN RICHARD JOSEPH (GB)
PHELPS CHRISTOPHER BENJAMIN (GB)
GUTTERIDGE ALEX (GB)
FAGAN RICHARD JOSEPH (GB)
PHELPS CHRISTOPHER BENJAMIN (GB)
GUTTERIDGE ALEX (GB)
International Classes:
C12N9/10; C12N15/31; C12N15/54; G01N33/569; A61K38/00; A61K39/00; (IPC1-7): C07K14/35; C12N9/10; C12N15/31; C12N15/54; C12N5/10; C07K16/40; C07K16/12; A61K38/45; A61K39/04; A61K31/70; A01K67/00; G01N33/68
Other References:
COLE S T ET AL: "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 393, 11 June 1998 (1998-06-11), pages 537 - 544, XP002087941, ISSN: 0028-0836
DATABASE SWISSPROT 1 June 1998 (1998-06-01), "Hypothetical protein Rv2492 from Mycobacteriun tuberculosis", XP002213900, Database accession no. O53217
DATABASE EMBL 14 January 1998 (1998-01-14), COLE ST ET AL, PARKHILL J.: "Mycobacterium tuberculosis H37Rv complete genome; segment 108/162", XP002213901, Database accession no. AL021246; AL123456
DATABASE SWISSPROT 30 May 2000 (2000-05-30), COLE ST ET AL.: "Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) from Mycobacterium tuberculosis", XP002213921, Database accession no. O33306
DATABASE EMBL 18 November 1997 (1997-11-18), COLE ST. AND PARKHILL J.: "Mycobacterium tuberculosis H37Rv complete genome; segment 122/162", XP002213922, Database accession no. AL008967
SCUDERI J D: "Molecular genetic and biochemical analysis of thymidylate synthase and dihydrofolate reductasedihydrofolate reductase from mycobacteria", UMI DISSERTATION SERVICES, XX, XX, 1996, pages COMPLETE110, XP002171046
SCUDERI J D: "MOLECULAR GENETIC AND BIOCHEMICAL ANALYSIS OF THYMIDYLATE SYNTHASE AND DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIA", DISSERTATION ABSTRACTS, UNIVERSITY MICROFILMS, ANN HARBOR,, US, vol. 57, no. 8B, 1996, pages 1 - 2, XP000853784, ISSN: 0099-3123
CHO SUNGAE ET AL: "Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 97, no. 22, 24 October 2000 (2000-10-24), October 24, 2000, pages 12210 - 12215, XP001093705, ISSN: 0027-8424
CHO SUNGAE ET AL: "MHC class I-restricted CD8+ CTL responses to Mycobacterium tuberculosis infection.", FASEB JOURNAL, vol. 15, no. 4, 7 March 2001 (2001-03-07), Annual Meeting of the Federation of American Societies for Experimental Biology on Experimental Biology 2001;Orlando, Florida, USA; March 31-April 04, 2001, pages A307, XP001105275, ISSN: 0892-6638
DATABASE SWISSPROT 1 June 1998 (1998-06-01), "Hypothetical protein Rv2492 from Mycobacteriun tuberculosis", XP002213900, Database accession no. O53217
DATABASE EMBL 14 January 1998 (1998-01-14), COLE ST ET AL, PARKHILL J.: "Mycobacterium tuberculosis H37Rv complete genome; segment 108/162", XP002213901, Database accession no. AL021246; AL123456
DATABASE SWISSPROT 30 May 2000 (2000-05-30), COLE ST ET AL.: "Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) from Mycobacterium tuberculosis", XP002213921, Database accession no. O33306
DATABASE EMBL 18 November 1997 (1997-11-18), COLE ST. AND PARKHILL J.: "Mycobacterium tuberculosis H37Rv complete genome; segment 122/162", XP002213922, Database accession no. AL008967
SCUDERI J D: "Molecular genetic and biochemical analysis of thymidylate synthase and dihydrofolate reductasedihydrofolate reductase from mycobacteria", UMI DISSERTATION SERVICES, XX, XX, 1996, pages COMPLETE110, XP002171046
SCUDERI J D: "MOLECULAR GENETIC AND BIOCHEMICAL ANALYSIS OF THYMIDYLATE SYNTHASE AND DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIA", DISSERTATION ABSTRACTS, UNIVERSITY MICROFILMS, ANN HARBOR,, US, vol. 57, no. 8B, 1996, pages 1 - 2, XP000853784, ISSN: 0099-3123
CHO SUNGAE ET AL: "Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 97, no. 22, 24 October 2000 (2000-10-24), October 24, 2000, pages 12210 - 12215, XP001093705, ISSN: 0027-8424
CHO SUNGAE ET AL: "MHC class I-restricted CD8+ CTL responses to Mycobacterium tuberculosis infection.", FASEB JOURNAL, vol. 15, no. 4, 7 March 2001 (2001-03-07), Annual Meeting of the Federation of American Societies for Experimental Biology on Experimental Biology 2001;Orlando, Florida, USA; March 31-April 04, 2001, pages A307, XP001105275, ISSN: 0892-6638
Download PDF:
Previous Patent: NOVEL GENES FOR CONDITIONAL CELL ABLATION
Next Patent: VARIANT GLUTARYL AMIDASE &lpar CEPHALOSPORIN ACYLASE&rpar AND USES THEREOF
Next Patent: VARIANT GLUTARYL AMIDASE &lpar CEPHALOSPORIN ACYLASE&rpar AND USES THEREOF