THYROID RECEPTOR MODULATORS

WIPO Patent Application WO/2010/086878

A3

The present invention relates to novel compounds of general formula (I) which are thyroid receptor ligands and are preferably selective for the thyroid hormone receptor beta. Further, the present invention relates to processes of preparing such compounds, their tautomeric forms, novel intermediates involved in their synthesis, their pharmaceutically acceptable salts, methods for using such compounds and pharmaceutical compositions containing them.

RAVAL SAURIN (IN)
RAVAL PREETI (IN)
JAIN MUKUL R (IN)

PCT/IN2010/000009

October 21, 2010

January 06, 2010

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CADILA HEALTHCARE LTD (IN)
RAVAL SAURIN (IN)
RAVAL PREETI (IN)
JAIN MUKUL R (IN)

C07C233/51; A61K31/16; A61P5/14; C07C233/63; C07C233/83; C07C235/56; C07C259/06; C07C275/36; C07C311/29; C07D211/46; C07D295/192; C07D295/205; C07D295/26; C07D307/68; C07D333/40

WO2008062469A2	2008-05-29
WO2004067482A2	2004-08-12

YOKOYAMA N: "Synthesis and structure-activity relationships of oxamic acid and acetic acid derivatives related to L-thyronine", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US LNKD- DOI:10.1021/JM00004A015, vol. 38, 1 January 1995 (1995-01-01), pages 695 - 707, XP002080908, ISSN: 0022-2623
MALM J: "Therapeutic thyroid hormone ligand patents 1998-2003", EXPERT OPINION ON THERAPEUTIC PATENTS, INFORMA HEALTHCARE, GB, vol. 14, no. 8, 1 January 2004 (2004-01-01), pages 1169 - 1183, XP002582602, ISSN: 1354-3776

SUBRAMANIAM, Hariharan (Nataraj & AssociatesE-556, Greater Kailash-ll, New Delhi - 8, IN)

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