TIE-2 MODULATORS AND METHODS OF USE

WIPO Patent Application WO2004092196

A3

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.

IBRAHIM MOHAMED (US)
LEAHY JAMES (US)
SANGALANG JOAN C (US)
SCHNEPP KEVIN (US)
SHI XIAN (US)
NUSS JOHN (US)

PCT/US2004/010858

March 17, 2005

April 08, 2004

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EXELIXIS INC (US)
IBRAHIM MOHAMED (US)
LEAHY JAMES (US)
SANGALANG JOAN C (US)
SCHNEPP KEVIN (US)
SHI XIAN (US)
NUSS JOHN (US)

A61K31/395; A61K31/505; C07D215/16; C07D239/95; C07D401/04; C07D401/06; C07D401/14; C07D405/04; C07D409/04; C07D409/14; C07D413/14; C07K; (IPC1-7): A61K31/395; A61K31/505; C07D239/95; C07D215/16; C07D401/04; C07D401/06; C07D405/04; C07D409/04; C07D413/14; C07D401/14; C07D409/14

US3340260A	1967-09-05
US5436233A	1995-07-25
EP0579496A1	1994-01-19
GB2295387A	1996-05-29

LEE, S.J. ET AL.: "Discovery of potent Cyclic GMP Phosphodiesterase inhibitors. 2-Pyridyl-and 2-Imidazolylquinazolines Possessing Cyclic GMP Phosphodiesterase and Thromboxane Synthesis Inhibitory Activities", J. MED. CHEM., vol. 38, no. 18, 1995, pages 3547 - 3557, XP002924368

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