Title:
LIVER/ADIPOSE TISSUE DUAL-TARGETING COMPOSITE NANO-DRUG-CARRIER
Document Type and Number:
WIPO Patent Application WO/2024/025321
Kind Code:
A1
Abstract:
The present invention relates to: a liver/adipose tissue dual-targeting composite nano-drug-carrier comprising drug-containing poly(L-lactide-co-glycolide) (PLGA) nanoparticles and an adipocyte targeting sequence (ATS) peptide that can target prohibitin; a method for preparing same; and uses thereof for medicines and health foods for preventing or treating obesity or obesity-induced metabolic diseases.
Inventors:
KIM YONG-HEE (KR)
HONG JU HYEONG (KR)
HONG JU HYEONG (KR)
Application Number:
PCT/KR2023/010782
Publication Date:
February 01, 2024
Filing Date:
July 26, 2023
Export Citation:
Assignee:
IUCF HYU (KR)
International Classes:
A61K9/51; A61K31/555; A61P3/00; A61P3/04
Foreign References:
| JP2005533812A | 2005-11-10 | |||
| KR102009011B1 | 2019-08-08 | |||
| KR102112702B1 | 2020-05-19 |
Other References:
XUE YUAN, XU XIAOYANG, ZHANG XUE-QING, FAROKHZAD OMID C., LANGER ROBERT: "Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 113, no. 20, 17 May 2016 (2016-05-17), pages 5552 - 5557, XP093133938, ISSN: 0027-8424, DOI: 10.1073/pnas.1603840113
ORR ALEXIS, LIU KUNLI, MULLICK ADAM E., HUANG XUEFEI, WATTS STEPHANIE W.: "Divergence of Chemerin Reduction by an ATS9R Nanoparticle Targeting Adipose Tissue In Vitro vs. In Vivo in the Rat", BIOMEDICINES, MDPI, BASEL, vol. 10, no. 7, 1 July 2022 (2022-07-01), Basel , pages 1635, XP093133940, ISSN: 2227-9059, DOI: 10.3390/biomedicines10071635
ROU-LING CHO; CHIEN-CHUNG YANG; HUI‐CHING TSENG; LI‐DER HSIAO; CHIH-CHUNG LIN; CHUEN-MAO YANG: "Haem oxygenase-1 up-regulation by rosiglitazone via ROS-dependent Nrf2-antioxidant response elements axis or PPARγ attenuates LPS-mediated lung inflammation", BRITISH JOURNAL OF PHARMACOLOGY, WILEY-BLACKWELL, UK, vol. 175, no. 20, 6 September 2018 (2018-09-06), UK , pages 3928 - 3946, XP071097474, ISSN: 0007-1188, DOI: 10.1111/bph.14465
HONG JUHYEONG, KIM YONG‐HEE: "Fatty Liver/Adipose Tissue Dual‐Targeting Nanoparticles with Heme Oxygenase‐1 Inducer for Amelioration of Obesity, Obesity‐Induced Type 2 Diabetes, and Steatohepatitis", ADVANCED SCIENCE, vol. 9, no. 33, 1 November 2022 (2022-11-01), XP093133945, ISSN: 2198-3844, DOI: 10.1002/advs.202203286
ORR ALEXIS, LIU KUNLI, MULLICK ADAM E., HUANG XUEFEI, WATTS STEPHANIE W.: "Divergence of Chemerin Reduction by an ATS9R Nanoparticle Targeting Adipose Tissue In Vitro vs. In Vivo in the Rat", BIOMEDICINES, MDPI, BASEL, vol. 10, no. 7, 1 July 2022 (2022-07-01), Basel , pages 1635, XP093133940, ISSN: 2227-9059, DOI: 10.3390/biomedicines10071635
ROU-LING CHO; CHIEN-CHUNG YANG; HUI‐CHING TSENG; LI‐DER HSIAO; CHIH-CHUNG LIN; CHUEN-MAO YANG: "Haem oxygenase-1 up-regulation by rosiglitazone via ROS-dependent Nrf2-antioxidant response elements axis or PPARγ attenuates LPS-mediated lung inflammation", BRITISH JOURNAL OF PHARMACOLOGY, WILEY-BLACKWELL, UK, vol. 175, no. 20, 6 September 2018 (2018-09-06), UK , pages 3928 - 3946, XP071097474, ISSN: 0007-1188, DOI: 10.1111/bph.14465
HONG JUHYEONG, KIM YONG‐HEE: "Fatty Liver/Adipose Tissue Dual‐Targeting Nanoparticles with Heme Oxygenase‐1 Inducer for Amelioration of Obesity, Obesity‐Induced Type 2 Diabetes, and Steatohepatitis", ADVANCED SCIENCE, vol. 9, no. 33, 1 November 2022 (2022-11-01), XP093133945, ISSN: 2198-3844, DOI: 10.1002/advs.202203286
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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