Title:
TISSUE FACTORS AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/088086
Kind Code:
A1
Abstract:
The present invention relates to a pair of tissue factors and an application thereof. The tissue factors are respectively TRIM31 and RHBDF2 which are derived from hepatic cells, and the TRIM31 and the RHBDF2 have a trade-off relationship. The tissue factors can be used as a marker of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) and/or metabolic disorder, and can be used for effectively identifying NAFLD, NASH, metabolic disorder and/or hepatic cell degeneration. A promoting agent of the TRIM31 can also be used for effectively eliminating or alleviating insulin resistance, hepatic steatosis, hepatic steatoinflammation and hepatic fibrosis.
Inventors:
TAN JUN (CN)
XU MINXUAN (CN)
GE CHENXU (CN)
SUN YAN (CN)
DAI XIANLING (CN)
KUANG QIN (CN)
ZHAO JUNJIE (CN)
XU MINXUAN (CN)
GE CHENXU (CN)
SUN YAN (CN)
DAI XIANLING (CN)
KUANG QIN (CN)
ZHAO JUNJIE (CN)
Application Number:
PCT/CN2022/128995
Publication Date:
May 25, 2023
Filing Date:
November 09, 2022
Export Citation:
Assignee:
CHENGDU QUARK ZHIYUAN BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61K45/00; A61P1/16; A61P3/00; C12N9/64; C12Q1/6883
Foreign References:
| CN114150053A | 2022-03-08 |
Other References:
YAHAGHI L., YAGHMAEI PARICHEHREH, HAYATI-ROODBARI N., IRANI S., EBRAHIM-HABIBI A.: "Betanin effect on PPAR-α and SREBP-1c expression in NMRI mice model of steatohepatitis with fibrosis.", PHYSIOLOGY INTERNATIONAL, vol. 107, no. 1, 14 April 2020 (2020-04-14), pages 67 - 81, XP009545592, ISSN: 2498-602X, DOI: 10.1556/2060.2020.00001
CHOI MYUNG-SOOK, CHOI JI-YOUNG, KWON EUN-YOUNG: "Fisetin Alleviates Hepatic and Adipocyte Fibrosis and Insulin Resistance in Diet-Induced Obese Mice", JOURNAL OF MEDICINAL FOOD, MARY ANN LIEBERT, LARCHMONT, NY,, US, vol. 23, no. 10, 1 October 2020 (2020-10-01), US , pages 1019 - 1032, XP093067499, ISSN: 1096-620X, DOI: 10.1089/jmf.2019.4619
LI LING ET AL.: "Carminic acid mitigates fructose-triggered hepatic steatosis by inhibition of oxidative stress and inflammatory reaction.", BIOMEDICINE & PHARMACOTHERAPY, vol. 145, 12 November 2021 (2021-11-12), XP086898131, DOI: 10.1016/j.biopha.2021.112404
XU MINXUAN, GE CHENXU, ZHU LIANCAI, QIN YUTING, DU CHENGJIANG, LOU DESHUAI, LI QIANG, HU LINFENG, SUN YAN, DAI XIANLING, XIONG MIN: "iRhom2 Promotes Hepatic Steatosis by Activating MAP3K7-Dependent Pathway.", HEPATOLOGY, vol. 73, no. 4, 30 April 2021 (2021-04-30), pages 1346 - 1364, XP009545588, ISSN: 0270-9139, DOI: 10.1002/hep.31436
CHENG JING, XUE FEI, ZHANG MENG, CHENG CHENG, QIAO LEI, MA JING, SUI WENHAI, XU XINGLI, GAO CHENGJIANG, HAO PANPAN, ZHANG YUN: "TRIM31 Deficiency Is Associated with Impaired Glucose Metabolism and Disrupted Gut Microbiota in Mice", FRONTIERS IN PHYSIOLOGY, vol. 9, XP093067504, DOI: 10.3389/fphys.2018.00024
SONG HUI, LIU BINGYU, HUAI WANWAN, YU ZHONGXIA, WANG WENWEN, ZHAO JING, HAN LIHUI, JIANG GUOSHENG, ZHANG LINING, GAO CHENGJIANG, Z: "The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3", NATURE COMMUNICATIONS, vol. 7, no. 1, 8 December 2016 (2016-12-08), XP093067508, DOI: 10.1038/ncomms13727
LIU, BINGYU: "The Role and Molecular Mechanism of the E3 Ligase TRIM31 in the Antiviral Innate Immunity", DOCTORAL DISSERTATION, 15 August 2017 (2017-08-15), CN, pages 1 - 154, XP009545590
CHOI MYUNG-SOOK, CHOI JI-YOUNG, KWON EUN-YOUNG: "Fisetin Alleviates Hepatic and Adipocyte Fibrosis and Insulin Resistance in Diet-Induced Obese Mice", JOURNAL OF MEDICINAL FOOD, MARY ANN LIEBERT, LARCHMONT, NY,, US, vol. 23, no. 10, 1 October 2020 (2020-10-01), US , pages 1019 - 1032, XP093067499, ISSN: 1096-620X, DOI: 10.1089/jmf.2019.4619
LI LING ET AL.: "Carminic acid mitigates fructose-triggered hepatic steatosis by inhibition of oxidative stress and inflammatory reaction.", BIOMEDICINE & PHARMACOTHERAPY, vol. 145, 12 November 2021 (2021-11-12), XP086898131, DOI: 10.1016/j.biopha.2021.112404
XU MINXUAN, GE CHENXU, ZHU LIANCAI, QIN YUTING, DU CHENGJIANG, LOU DESHUAI, LI QIANG, HU LINFENG, SUN YAN, DAI XIANLING, XIONG MIN: "iRhom2 Promotes Hepatic Steatosis by Activating MAP3K7-Dependent Pathway.", HEPATOLOGY, vol. 73, no. 4, 30 April 2021 (2021-04-30), pages 1346 - 1364, XP009545588, ISSN: 0270-9139, DOI: 10.1002/hep.31436
CHENG JING, XUE FEI, ZHANG MENG, CHENG CHENG, QIAO LEI, MA JING, SUI WENHAI, XU XINGLI, GAO CHENGJIANG, HAO PANPAN, ZHANG YUN: "TRIM31 Deficiency Is Associated with Impaired Glucose Metabolism and Disrupted Gut Microbiota in Mice", FRONTIERS IN PHYSIOLOGY, vol. 9, XP093067504, DOI: 10.3389/fphys.2018.00024
SONG HUI, LIU BINGYU, HUAI WANWAN, YU ZHONGXIA, WANG WENWEN, ZHAO JING, HAN LIHUI, JIANG GUOSHENG, ZHANG LINING, GAO CHENGJIANG, Z: "The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3", NATURE COMMUNICATIONS, vol. 7, no. 1, 8 December 2016 (2016-12-08), XP093067508, DOI: 10.1038/ncomms13727
LIU, BINGYU: "The Role and Molecular Mechanism of the E3 Ligase TRIM31 in the Antiviral Innate Immunity", DOCTORAL DISSERTATION, 15 August 2017 (2017-08-15), CN, pages 1 - 154, XP009545590
Attorney, Agent or Firm:
BEIJING YUANBEN INTELLECTUAL PROPERTY LAW OFFICE (GENERAL PARTNERSHIP) (CN)
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