Title:
TISSUE FIXATION WITH CROSS-LINKING COMPOUNDS
Document Type and Number:
WIPO Patent Application WO1998050082
Kind Code:
A3
Abstract:
Crosslinking to prepare fixed tissue or to crosslink modification molecules to tissue is carried out with an apparatus and method wherein diffusion through a semipermeable is used to provide a selected molecular weight distribution of oligomers of a crosslinking compound that polymerizes spontaneously in solution to produce oligomers such as glutaraldehyde. The membrane has a molecular weight exclusion limit that prevents oligomers above a certain molecular weight from passing. Tissues treated with the size selected oligomers have improved properties. In the apparatus, the membrane separates a solution containing the crosslinking compound and oligomers from a solution in which crosslinking is carried out. The selected molecular weight distribution of oligomers diffuses through the membrane into the solution where tissue is crosslinked or a beneficial molecule is crosslinked to tissue.
Inventors:
OGLE MATTHEW F
SCHROEDER RICHARD E
SCHROEDER RICHARD E
Application Number:
PCT/US1998/008533
Publication Date:
February 04, 1999
Filing Date:
April 30, 1998
Export Citation:
Assignee:
ST JUDE MEDICAL (US)
International Classes:
A61L27/36; A61L27/38; (IPC1-7): A61L/
Foreign References:
| EP0411925A2 | 1991-02-06 | |||
| EP0457430A2 | 1991-11-21 | |||
| US4729139A | 1988-03-08 |
Other References:
LOKE, WENG KEONG ET AL.: "HYBRID BIOMATERIALS BASED ON THE INTERACTION OF POLYURETHANE OLIGOMERS WITH PORCINE PERICARDIUM", BIOMATERIALS, vol. 17, no. 22, 1996, pages 2163 - 2172, XP002084091
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