Title:
TISSUE MAPPING METHOD
Document Type and Number:
WIPO Patent Application WO/2015/198620
Kind Code:
A1
Abstract:
A tissue mapping method comprising: a section division step (SA1) for dividing a section of a biological tissue into a plurality of fragments; a gene analysis step (SA2) for molecular biologically analyzing a plurality of genes contained in each fragment; a feature amount calculation step (SA3) for calculating feature amounts from the analysis results on the individual genes and thus acquiring a plurality of feature amounts for each fragment; a fragment classification step (SA4) for classifying the fragments into one or more groups on the basis of the similarity among feature amounts thereof; and a tissue mapping step (SA5) for setting display modes for the respective groups, said display modes differing from each other, and preparing a tissue map wherein the position of each fragment and a region corresponding thereto in the section are displayed in a display mode assigned to the group to which the fragment belongs.
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Inventors:
MORIMOTO NOBUHIKO (JP)
Application Number:
PCT/JP2015/053506
Publication Date:
December 30, 2015
Filing Date:
February 09, 2015
Export Citation:
Assignee:
OLYMPUS CORP (JP)
International Classes:
C12Q1/68; C12Q1/04; G01N33/48
Domestic Patent References:
| WO2011149009A1 | 2011-12-01 |
Foreign References:
| JP2007064689A | 2007-03-15 | |||
| JP2002528095A | 2002-09-03 | |||
| JP2006209276A | 2006-08-10 |
Other References:
YOSHIKAWAL , T ET AL.: "Topographical distribution of allelic loss in individual lung adenocarcinomas with lymph node metastases", MODERN PATHOLOGY, vol. 17, no. 2, 2004, pages 204 - 213, XP055247149
SCHWAMBORN, K. ET AL.: "Identifying prostate carcinoma by MALDI-Imaging", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 20, no. 2, 2007, pages 155 - 159, XP002548367
"Spatial and Spectral Correlations in MALDI Mass Spectrometry Images by Clustering and Multivariate Analysis", ANALYTICAL CHEMISTRY, vol. 77, no. 19, 2005, pages 6118 - 6124, XP055247153
SCHWAMBORN, K. ET AL.: "Identifying prostate carcinoma by MALDI-Imaging", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 20, no. 2, 2007, pages 155 - 159, XP002548367
"Spatial and Spectral Correlations in MALDI Mass Spectrometry Images by Clustering and Multivariate Analysis", ANALYTICAL CHEMISTRY, vol. 77, no. 19, 2005, pages 6118 - 6124, XP055247153
Attorney, Agent or Firm:
UEDA, Kunio et al. (JP)
Ueda Kunio (JP)
Ueda Kunio (JP)
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