[Description] [Title of invention] Titanium implant for implantation of artificial dental tooth [Brief explanation] 1; A princile of water pyrolysis 2; A process of laser manufacturing 3; appearance of surface manufacturing implant in water pyrolysis after laser manufacturing 4; the depth profile after water pylolysis at 400 C lOmim 5; the depth profile after water pylolysis at 400 C 30mim 6; the depth profile after water pylolysis at 550 C lOmim 7; the depth profile after water pylolysis at 550 C 30mim 8; the comparision of removal torque 9; Micro CT diagram of machined 10; Micro CT diagram of laser treated specimen [Detaile explanation of invention] [The purpose of the invention] [The field of invention and the old technique of this filed] This is the titanium implant (root form) with the pore treated by laser and water pylolysis to make the thick oxide for more bonding strength, <BR> The problem of the present machined implant surface has low bonding strength with bone, , The water pylolysis method to the machined surface can improve the bonding strength with bone sothat reducing the healing time of implant surgery, t The terchincal subject] Recently because of biocompatibility of titanium, titanium has been used for implant materials, High biocompatibility come from the stable oxide could increase the bonding strength between implant and bone. The characteristics and composition of the titanium oxide is dependant on the surface treatment techniques In this invention, the titanium implant surface was treated by laser and then water pylolysis, to make titanium oxide more thicker sothat thicker oxide and micropore Increase the bonding strength between bone and titanium.

[The structure of the invention] Titanium screw was machined as 5mm length, diameter 3. 75mm (figl) Machinnning speed lOmm/min, rpm 3500, for the external screw, and using plastic bite Cutting speed 600mm/min, rpm 500with star CNC. Auto machine.

And then laser treated with NiYag laser 0.1 um of moving speed, 1000 used time, moter rpm 100. Water pylolysis., the furnce temperature incersed untill 500, and after reaching 500 the water spray started to make the temperature down and then furnace make the temperature up to 500 again, this cycle was repeated, When we compare the laser treated speciemen and laser treat and water pylolysis, The laser only treated specimen show diameter 34 um, depth 24 um, and the pore Interval 20 um make honeycomb apperance, Auger analysis was done after water pylolysis on the laser treated surface.

The titanium oxide was increased.

Biologic experiment of removal torque test of the laser and water pylolysis specimen 3.1-4. 0 kg whit rabbit 8 adult rabbits weighing 3.0 kg to 4.0 kg were used in this study. The animals were anesthetized using intramuscualr injections of ketamine (Ketalar, Yuhan Corporation, Seoul, Korea, 44 mg/kg) and xylazine (Rompun, Bayer Korea, Seoul, Korea, 6 to 8 mg/kg).

Prior to surgery, 1.8 MR of 2% lidocaine (Yuhan Corporation, Seoul, Korea) were injected locally into the operation sites.

Postoperatively, the animals received enofloxacine (Baytril, Bayer Korea, Seoul, Korea) at a dose of 0. 3MQ per animal and methanpyrone (Novin-50, Bayer Korea, Seoul, Korea) at 0. 3M of per animal, butaphosphan (Catosal, Bayer Korea, Seoul, Korea) at 0. 3M. 8 per animal for 3days. At eight weeks after operation, the animals were sacrificed using an overdose of carbon dioxide.

Prior to surgery, the legs of animals were shaved, washed and decontaminated with a mixture of betadine and 70% ethanol. The tibia metaphysis was exposed via a skin incision, and the muscles were dissected to allow elevation of the periosteum using sterile surgical techniques.

The flat surface on medial aspect of the proximal tibia was selected for implant placement. The implant site was drilled in the usual manner using drills with increasing diameter under profuse irrigation with sterile saline. The implants were gently screwed into place, without tapping the sites, until the implant shoulder was level with the bone surface. All implants were allowed to penetrate the first cortical layer only. One implant was placed in the right proximal Tibia and the other implant was placed left proximal tibia. Surgical Sites were primary closed by layering suture.

Postoperatively, the animals received enofloxacine (Baytril, Bayer Korea, Seoul, Korea) at a dose of 0. 3M per animal and methanpyrone (Novin-50, Bayer Korea, Seoul, Korea) at 0. 3M of per animal, butaphosphan (Catosal, Bayer Korea, Seoul, Korea) at 0. 3MQ per animal for 3days.

The remaining 2 rabbits were sacrificed without removing the implant for removal torque, surrounding tissues were sectioned and washed in saline solution and fixed in 10% buffered formalin solution. Bone implant contacts were evaluated by mico-CT (Skyscan 1072, Antwerpen, Belgium) and NIH software (Ver 1.6 ; NIH, Bethesda, MD).

[The effect of the invention Laser + water pylolysis group showed fixture head area attached cortical bone with wide range of attachment, and according to the bone marrow cell, some newly formed bone or bone marrow tissue bind with titanium screw. The second and third screw showed prominent bone formation.

Laser treated and water pylolysis specimen showed more bonding strength so that very stable artificial root form. It could be anticipate that the healing time after implantation would be remakbly reduced because of micropore made by laser and the thicker oxide made by water pylolysis.

The combined procedure 1, machining the titanium screw and laser treatment and water pylolysis 2, laser treatment and water pylolysis and laser treatment 3, water pylolysis and laser treatment