TLR-INDEPENDENT SMALL MOLECULE ADJUVANTS

Title:

TLR-INDEPENDENT SMALL MOLECULE ADJUVANTS

Document Type and Number:

WIPO Patent Application WO/2016/022700

Kind Code:

A3

Abstract:

A TLR-independent adjuvant compound that corresponds in structure to Formula I, below, or its pharmaceutically acceptable salt is disclosed in which X, Y, Z, n, R1, R2, R3, R4 and W are defined within. Also disclosed are a method of its preparation and use, as well as a pharmaceutical composition containing the same.

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Inventors:

BOGER DALE L (US)
BEUTLER BRUCE (US)

Application Number:

PCT/US2015/043830

Publication Date:

July 28, 2016

Filing Date:

August 05, 2015

Export Citation:

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Assignee:

SCRIPPS RESEARCH INST (US)
UNIV TEXAS SYSTEM AUSTIN BOARD OF REGENTS (US)

International Classes:

C07D307/78; A61K31/343; A61K31/404; C07D209/04; C07D209/12

Domestic Patent References:

WO2008112941A1	2008-09-18
WO2008112939A2	2008-09-18
WO2007024707A2	2007-03-01

Foreign References:

US20110081365A1	2011-04-07
US20120148660A1	2012-06-14

Other References:

SHAGINIAN, A. ET AL.: "Design, Synthesis, and Evaluation of an a-Helix Mime tic Library Targeting Protein-Protein Interactions", J. AM. CHEM. SOC., vol. 131, no. 15, pages 5564 - 5572, XP055091908

Attorney, Agent or Firm:

GAMSON, Edward, P. et al. (LLP120 South Riverside Plaza,Suite 220, Chicago IL, US)

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