Title:
TLR SIGNALING INHIBITORY PEPTIDE AND COMPOSITION INCLUDING SAME FOR PREVENTION OR TREATMENT OF INFLAMMATORY DISEASES
Document Type and Number:
WIPO Patent Application WO/2024/096677
Kind Code:
A1
Abstract:
The present invention relates to a peptide library derived from the vast TIR domains present across various biological species, a construction method therefor, and a novel peptide, screened from this library, which is involved in the TLR signaling pathway by binding to the human TIR domain, and a use thereof as a TLR4 signaling inhibitor.
Inventors:
SEO MOON-HYEONG (KR)
LEE WOOK-BIN (KR)
PARK KEUN-WAN (KR)
JUNG SANG-HOON (KR)
KIM MEONG-IL (KR)
LIM YUN (KR)
LEE WOOK-BIN (KR)
PARK KEUN-WAN (KR)
JUNG SANG-HOON (KR)
KIM MEONG-IL (KR)
LIM YUN (KR)
Application Number:
PCT/KR2023/017529
Publication Date:
May 10, 2024
Filing Date:
November 03, 2023
Export Citation:
Assignee:
KOREA INST SCI & TECH (KR)
International Classes:
C12N15/10; C07K14/47; C40B30/04
Foreign References:
| KR20070094802A | 2007-09-21 | |||
| KR102236773B1 | 2021-04-06 | |||
| KR20210009197A | 2021-01-26 |
Other References:
VLADIMIR Y TOSHCHAKOV: "Targeting the TLR signalosome with TIR domain-derived cell-permeable decoy peptides: the current state and perspectives", INNATE IMMUNITY, SAGE PUBLICATIONS LTD., US, vol. 26, no. 1, 1 January 2020 (2020-01-01), Us , pages 35 - 47, XP093166319, ISSN: 1753-4259, DOI: 10.1177/1753425919844310
WENJI PIAO, KARI ANN SHIREY, LISA W RU, WENDY LAI, HENRYK SZMACINSKI , GREG A SNYDER , ERIC J SUNDBERG , JOSEPH R LAKOWICZ , STEFA: "A Decoy Peptide that Disrupts TIRAP Recruitment to TLRs Is Protective in a Murine Model of Influenza", CELL REPORTS, vol. 11, 30 June 2015 (2015-06-30), pages 1941 - 1952, XP055963630
WENJI PIAO, KARI ANN SHIREY, LISA W RU, WENDY LAI, HENRYK SZMACINSKI , GREG A SNYDER , ERIC J SUNDBERG , JOSEPH R LAKOWICZ , STEFA: "A Decoy Peptide that Disrupts TIRAP Recruitment to TLRs Is Protective in a Murine Model of Influenza", CELL REPORTS, vol. 11, 30 June 2015 (2015-06-30), pages 1941 - 1952, XP055963630
Attorney, Agent or Firm:
PADO IP LAW PLLC (KR)
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