Title:
TOLERANCE DEVELOPMENT INHIBITOR FOR NARCOTIC ANALGESIC AGENT
Document Type and Number:
WIPO Patent Application WO/2006/070742
Kind Code:
A1
Abstract:
A pharmaceutical capable of inhibiting any tolerance development to analgesic effects brought about by the administration of narcotic analgesic agents, such as morphine, which pharmaceutical comprises as an active ingredient an antagonist for vasopressin receptor 1b.
Inventors:
TSUJIMOTO GOZOH (JP)
TAKANO YUKIO (JP)
HONDA KENJI (JP)
TANOUE AKITO (JP)
TAKANO YUKIO (JP)
HONDA KENJI (JP)
TANOUE AKITO (JP)
Application Number:
PCT/JP2005/023783
Publication Date:
July 06, 2006
Filing Date:
December 26, 2005
Export Citation:
Assignee:
UNIV KYOTO (JP)
UNIV FUKUOKA (JP)
JAPAN HEALTH SCIENCE FOUND (JP)
TSUJIMOTO GOZOH (JP)
TAKANO YUKIO (JP)
HONDA KENJI (JP)
TANOUE AKITO (JP)
UNIV FUKUOKA (JP)
JAPAN HEALTH SCIENCE FOUND (JP)
TSUJIMOTO GOZOH (JP)
TAKANO YUKIO (JP)
HONDA KENJI (JP)
TANOUE AKITO (JP)
International Classes:
A61K45/00; A61K31/404; A61K31/485; A61K38/00; A61P25/04
Other References:
XU Q. ET AL: "Dependency on the brain function of arginine vasopressin system of the development to and recovery from analgesic tolerance to morphine", BRAIN RES., vol. 577, 1991, pages 189 - 193, XP002995702
TAO L.T. ET AL: "The role of vasopressin on the effect of U-50,488 to block the development of morphine tolerance and physical dependence", NAUNYN-SCHMIEDEBERG'S ARCH. PHARMACOL., vol. 335, 1997, pages 281 - 287, XP002995703
SU M.T. ET AL: "Blockade of the development of morphine tolerance by U-50,448, an AVP antagonist or MK801 in the rat hipopocampal slice", BR. J. PHARMACOL., vol. 123, 1998, pages 625 - 630, XP002995704
SERRADEIL-LEGAL C.S. ET AL: "Characterization of (2S,4R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a selective and orally active vasopressin V1b receptor antagonist", J. PHARMACOL. EXP. THER., vol. 300, no. 3, 2002, pages 1122 - 1130, XP002262091
SUGIMOTO T. ET AL: "Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor", J. BIOL. CHEM., vol. 269, no. 43, 28 October 1994 (1994-10-28), pages 27088 - 27092, XP002220445
ANTONI F.A.: "Novel ligand specificity of pituitary vasopressin receptors in the rat", NEUROENDOCRINOLOGY, vol. 39, 1994, pages 186 - 188, XP002995705
RIVIER C. ET L: "Studies of the nature of the interaction between vasopressin and corticotropin-releasing factor on adrenocortitropin release in the rat", ENDOCRINOLOGY, vol. 115, no. 3, 1984, pages 882 - 886, XP002995706
RENE P. ET AL: "Nucleotide sequence and structural organization of the human vasopressin pituitary receptor (V3) gene", GENE, vol. 241, 2000, pages 57 - 64, XP002995707
VENTURA M.A. ET AL: "Gene and cDNA cloning and characterization of the mouse V3/V1b pituitary vasopressin receptor", J. MOL. ENDOCRINOL., vol. 22, 1999, pages 251 - 260, XP002995708
See also references of EP 1842555A4
TAO L.T. ET AL: "The role of vasopressin on the effect of U-50,488 to block the development of morphine tolerance and physical dependence", NAUNYN-SCHMIEDEBERG'S ARCH. PHARMACOL., vol. 335, 1997, pages 281 - 287, XP002995703
SU M.T. ET AL: "Blockade of the development of morphine tolerance by U-50,448, an AVP antagonist or MK801 in the rat hipopocampal slice", BR. J. PHARMACOL., vol. 123, 1998, pages 625 - 630, XP002995704
SERRADEIL-LEGAL C.S. ET AL: "Characterization of (2S,4R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a selective and orally active vasopressin V1b receptor antagonist", J. PHARMACOL. EXP. THER., vol. 300, no. 3, 2002, pages 1122 - 1130, XP002262091
SUGIMOTO T. ET AL: "Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor", J. BIOL. CHEM., vol. 269, no. 43, 28 October 1994 (1994-10-28), pages 27088 - 27092, XP002220445
ANTONI F.A.: "Novel ligand specificity of pituitary vasopressin receptors in the rat", NEUROENDOCRINOLOGY, vol. 39, 1994, pages 186 - 188, XP002995705
RIVIER C. ET L: "Studies of the nature of the interaction between vasopressin and corticotropin-releasing factor on adrenocortitropin release in the rat", ENDOCRINOLOGY, vol. 115, no. 3, 1984, pages 882 - 886, XP002995706
RENE P. ET AL: "Nucleotide sequence and structural organization of the human vasopressin pituitary receptor (V3) gene", GENE, vol. 241, 2000, pages 57 - 64, XP002995707
VENTURA M.A. ET AL: "Gene and cDNA cloning and characterization of the mouse V3/V1b pituitary vasopressin receptor", J. MOL. ENDOCRINOL., vol. 22, 1999, pages 251 - 260, XP002995708
See also references of EP 1842555A4
Attorney, Agent or Firm:
SIKs & Co. (Kyobashi-Nisshoku Bldg. 8-7, Kyobashi 1-chome, Chuo-k, Tokyo 31, JP)
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