|1.||Patent of pharmaceutical formulation containing 5 ingradients . Acetic acid , Thymol , Vanillin , very small dose of one of High potency corticosteroid for example ( clobetasole . propionate , betamethasone propionate . etc ) Rose oil or lemon oil , in addition to trace of antioxidant , vitamines this patent is manufactured in the form of Cream .ointment , Emulsion , Lotion , solution and spray . this patent indicated for , all forms of Psoriasis ,all forms of Eczema, all forms of ulceration ( leg ulcer, bed ulcer ) all forms of Burns. acetic acid 96% : its dose from 0.5% to 2% gm in each 100 gm w/w of ointment (ointment , cream , solution , lotion , emultion ,spray), it has anti inflammatory , anti pruritic , keratolytic as well as bactericidal and fungicidal action. vanillin is a potent fungicidal and anti inflammatory its dose from 0.5% to 3% gm in each lOOgm w/w (ointment , cream , solution , lotion , emultion .spray). Rose oil or lemon oil is soothing agent and lubricant its dose from 0.5 gm to 4gm in each 100 gm w/w of (ointment , cream . solution , lotion , emultion ,spray).|
|2.||High potency corticosteroid for ex .( clobetasole. Propionate , betamethasome dipropionate etc . ) it is anti inflammatory, anti pruritic its dose from.|
|3.||mg to 7 mg in each 100 gram w\w (ointment , cream , solution , lotion , emultion .spray). Thymol it is antiseptic and anti inflammatory its dose from 25 mg to 150 mg in each 100 gram w\w (ointment , cream , solution , lotion , emultion ,spray).|
Pharmaceutical preparation patent for dermatological use only
Treatments applied directly to the skin are sometimes effective in clearing psoriasis.
Sunlight -daily- regular, short doses of sunlight without burning clears psoriasis in many people with the disease
UV light from the sun stimulates production of vitamin D by the skin which slows the overproduction of skin cells that causes scaling, daily , short , nonburning exposure to sunlight clears or improves psoriasis in some people therefore : sunlight may be included among initial treatments for the disease . A more controlled artificial light treatment may be used in mild psoriasis ( UVB phototherapy or in more server or extensive psoriasis ( psoralen and ultraviolet PUVA therapy ) .
UVB phototherapy - artificial sources of UVB light are similar to sunlight . some physicians will start with UVB treatments instead of topical agents. UVB phototherapy also is used to treat widespread psoriasis and lesions that resist topical treatment . This type of phototherapy is normally administered in a doctor's office by using a light panel or light box . Although with a doctor's guidance , some patients can use UVB light boxes at home .
Corticosteroids- available in different strengths, corticosteroids
( cortisone ) are usually applied twice each day . short-term treatment is often effective . if less than 10 percent of the body's skin is involved . some doctors will begin treatment with a high-potency corticosteroid ointment ( for example , diprolene . temovate, ultravate or psorcon ) .
high-potency steroids may also be used for treatment resistant plaques, particularly those on the hands or feet .
Calcipotriene - this drugs is a synthetic form of vitamins D3 (this is not the same as vitamins D supplements) application of calcipotriene ointment (for example, dovonex ) twice daily controls the excessive production of skin cells in psoriasis
Coal tar - coal tar may be applied directly to the skin, used in a bath solution, or used as a shampoo for the scalp, it is available in different strengths
Anthralin-doctors sometimes use a 15- to 30- minute application of anthralin ointment, cream, or paste to treat chronic psoriasis lesions .
Salicylic acid - used to remove scales, salicylic acid is usually more effective when combined with topical steroids, anthralin , or coal tar .
Bath solutions - people with psoriasis may find that bathing in water with oil added then applying a moisturizer, can soothe the skin , scakes can be removed and itching reduced by soaking 15 minutes in water containing coal tar solution , oiled oatmeal , Epsom salts , or dead sea salts .
Moisturizers: when applied regularly over a long period, moisturizers have cosmetic and soothing effect . Preparations that are thick and greasy usually work best because they lock water into the skin
Doctors sometimes prescribe medicines that are taken internally for more severe forms of psoriasis , particularly when more than 10 percent of the body is involved .
Retinoids - these drugs are derived from vitamin A and include etretinate
( tegison ) and isotretinoin ( accutane ) . etretinate is most effective against pustular psoriasis .
Methotrexate - this treatment , which can be taken by pill or injection ,
Hydroxyurea ( hydrea ) - compared with methotrexate . hydroxyurea is less toxic but also less effective . hydroxyurea is sometimes combined
PUVA or retinoids .
Sunlight may be included among initial treatment for the disease
It is associated with more side effects, including nausea .headache , fatigue , burning , and itching . long -term treatment is associated with irregular skin pigmentation . Corticosteroids
Long-term use or overuse of high-potency corticosteroids can lead to thinning of skin , internal side effects , resistance to the treatment's benefits, and worsening of the psoriasis the international dose from the high- potency is 50 m/g for each 100g/m of ointment w/w for example ( dermovite ointment or cream each 100g/m provides 5OnVg high potency clobetasole propionate , each lOOgm of elcon cream or ointment provides 100 mg high- potency corticosteroids w/w , each lOOgm . ointment of diprosalic provides 50m.g w/w of Beta methasone dipropionat (high- potency corticosteroids ) Calcipotriene - The safety of using the drugs for psoriasis affecting more than 20 percent of the body's skin is unknown : use on widespread - area of skin may raise the amount of calcium in the body to unhealthy levels Coal tar : Less effective and thus is not popular with many patients . other drawbacks include its failure to provide long-term help for most patients , it's strong ouder , and its tendency to stain skin . Anthralin
This treatment often fails to adequately clear lesions , it irritates the skin , and it stains skin and clothing brown or purple . in additions unsuitable for acute or actively inflamed eruptions Salicylic acid : Overuse cause salicyism
Retinoids : And include etertinate ( tegison ) and isortetinoin ( accutane )
Both drug can cause birth defects and are not recommende for women of childbearing age , at high doses , etretinete can effect liver function , therefore it is often combined with UVB phototherapy PUVA so that a lower , less toxic , does can be taken . Methotrexate - this treatment , which can be taken by pill or injection , slows down cell production and suppresses the immune system . patients taking methorexate must be closely carrying red blood cells , infection - fighting white blood cells , and clot-enhancing platelets . as a precaution , doctors do not prescribe the drug for people with long term livers disease or anemia . also , methotrexate should not be used by pregnant women , by women who are planning to get pregnant , or by their male partners
Disclosure of invention
Composition: active ingredients, acetic acid , thymol , vanillin , high potency corticosteroid for example ( clobetasole propionate , betamethasone dipropionate .
!0 etc ) rose oil or lemon oil and antioxidant trace. High potency corticosteroids actions has anti inflammatory, anti pruritic, Acetic acid has keratolytic as well as bactericidal and fungicidal actions . Vanillin has potent fungicidal and falvouring agent . Thymol has antiseptic propriety . rose oil or lemon oil has soothing effect for skin . the patent demonstrates these actions in a sustained manners there by
:5 permitting twice a day application . Indications and usage :
The patent is indicated for the relief of the inflammatory manifestations of hyper keratolytic and dry corticosteroid - responsive dermatoses such as psoriasis , chronic a topic dermatitis , new dermatitis ( lichen simplex chronicus ) licken planus ,
30 eczyma ( including nummular eczema , hard eczema , eczematous dermatitis , dysludrosis seborrhaic dermatitis of tiie scalp ichthyosis vulgaris and other ichthyolic conditions . it is also indicated for relief of scaling and flaking associated with skin conditions . also indicated for bed ulcer , leg ulcer , all forms of burns and ulceration
5 Dosage and administration :
In form of ( ointment ,cream , solution , lotion , emultion , spray ) a thin film should be applied to cover completely the affected area twice daily in the morning and at night
In form of ( spray ) shaken it before use and spray just to cover the affective area
0 with a fine coat products twice daily .
The patent provides in each 100 gram of ( ointment , cream , solution , lotion , emultion ,spray) from 2mg to 7 mg w\w high potency corticosteroid consequently adverse reactions that have been reported with the use of topical corticosteroids ( include . burning , itching . irritation , dryness , eruptions , hypopigmentation ,
5 dermatitis ) completely disappear and therefore must be born in mind when long- term continouse therapy is very safe . where no possible particularly in infants and children as adrenal suppression can occur . use these patent for treating such conditions as psoriasis , discoid lupus erythematosus and sever eczyma is also very