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Title:
TOPICAL HAIR COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2020/234794
Kind Code:
A1
Abstract:
The present invention relates to synergistic balanced herbal composition for hair care, hair loss treatment or revitalization comprising Pisum Sativum, Azadirachta indica, Ziziphus mauritiana, Allium cepa, Elettaria cardamomum, Centella asiatica, Allium Sativum, Convolvulus pluricaulis, Eclipta prostrata, Citrous raticulata optionally along with one or more pharmaceutically acceptable naturally derived carriers or additives. The present invention is highly beneficial by preventing hair fall and greying of hair. The present invention also improves the quantity and texture of hair by making them smooth and silky.

Inventors:
MACHHAR ARVIND (IN)
KODGULE MANDAR MADHUKAR (IN)
KUMAR YATENDRA (IN)
Application Number:
IB2020/054777
Publication Date:
November 26, 2020
Filing Date:
May 20, 2020
Export Citation:
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Assignee:
MACHHAR ARVIND (IN)
International Classes:
A61K36/00
Other References:
SCHMID, DANIEL ET AL.: "Hair growth stimulated by pea sprout extract", PERSONAL CARE, March 2013 (2013-03-01), pages 73 - 75, XP055761898, Retrieved from the Internet
NIHARIKA, ANAND ET AL.: "Antifungal properties of neem (Azadirachta indica) leaves extract to treat hair dandruff", E-ISRJ, vol. 2, no. 3, 10 January 2010 (2010-01-10), pages 244 - 252, XP055761897
PALEJKAR, CAROL J. ET AL.: "A plant review on Ziziphus mauritiana", INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND LIFE SCIENCES, vol. 2, no. 2, March 2012 (2012-03-01), pages 202 - 211, XP055761890
SHARQUIE, KHALIFA E. ET AL.: "Onion juice (Allium cepa L.), a new topical treatment for alopecia areata", THE JOURNAL OF DERMATOLOGY, vol. 29.6, 2002, pages 343 - 346, XP009057832, DOI: 10.1159/000068270
SENGOTTUVELU , SINGARAVEL: "Cardamom (Elettaria cardamomum Linn. Maton) seeds in health", NUTS AND SEEDS IN HEALTH AND DISEASE PREVENTION, 2011, pages 285 - 291
CHOI, YEONG MIN ET AL.: "Titrated extract of Centella asiatica increases hair inductive property through inhibition of STAT signaling pathway in three-dimensional spheroid cultured human dermal papilla cells", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 81, no. 12, 2 December 2017 (2017-12-02), pages 2323 - 2329, XP055761881
MALUKI, AZAR H. ET AL.: "Treatment of alopecia areata with topical garlic extract", KUFA MEDICAL JOURNAL, vol. 12, no. 1, 2009, pages 330 - 336, XP055761880
AGRAWAL, MUKTA: "Top 6 Benefits Of Hair Support Capsules For Your Healthy Hair", BEAUTY, HAIR, SPORTS NUTRITON, 27 March 2018 (2018-03-27), XP055761868, Retrieved from the Internet
SINGH, JAGDEV, BHRINGRAJ (ECLIPTA PROSTRATA, 16 October 2017 (2017-10-16)
MANDARIN - BENEFITS AND USES, 13 April 2018 (2018-04-13)
ROY, RAM KUMAR ET AL.: "Development and evaluation of polyherbal formulation for hair growth-promoting activity", JOURNAL OF COSMETIC DERMATOLOGY, vol. 6, no. 2, June 2007 (2007-06-01), pages 108 - 112, XP055761859
Attorney, Agent or Firm:
KHURANA & KHURANA, ADVOCATES & IP ATTORNEYS (IN)
Download PDF:
Claims:
I Claim:

1. A synergistic balanced herbal composition for hair care, hair loss treatment or revitalization, wherein the composition comprises Pisum Sativum, Azadirachta indica, Ziziphus mauritiana, Allium cepa, Elettaria cardamomum optionally along with one or more pharmaceutically acceptable naturally derived carriers or additives.

2. The synergistic balanced herbal composition of claim 1, wherein the composition further comprises Centella asiatica, Allium Sativum, Convolvulus pluricaulis, Eclipta prostrata, Citrous raticulata and combinations thereof.

3. The synergistic balanced herbal composition of claim 1, wherein the pharmaceutically acceptable naturally derived carriers or additives is selected from the group of Xanthum gum, Aloe vera water, Glycerin, Carrageenan gum, Isopropyl Myristate, or any other carrier known in the art, and combinations thereof.

4. The synergistic balanced herbal composition of claim 1, wherein the pharmaceutically acceptable naturally derived carriers or additives are in the form of emulsifiers, preservatives, dispersants, solvents and catalytic enzyme.

5. The synergistic balanced herbal composition of claim 1, wherein the herbal composition is in the form of oil, lotion, cream, gel, paste, ointment, spray, solution, or foam.

6. The synergistic balanced herbal composition of claim 5, wherein the hair treatment or revitalization includes treatment of intense hair loss, baldness, androgenic alopecia, tinea capitis and early hair greying, dandruff and infections thereof.

7. The synergistic balanced herbal composition of claim 1, wherein the composition comprises all naturally derived ingredients and is devoid of any synthetic ingredient.

8. A hair oil composition comprises an effective amount of extracts of Pisum Sativum, Azadirachta indica, Ziziphus mauritiana, Allium cepa, Elettaria cardamomum, Centella asiatica, Allium Sativum, Convolvulus pluricaulis, Eclipta prostrata, Citrous raticulata and suitable cosmeceutically acceptable carriers or additives, wherein the composition used for the treatment of intense hair loss, baldness, androgenic alopecia, tinea capitis and early hair greying, dandruff and infections thereof.

9. A synergistic balanced hair oil used for prevention of hair loss and regeneration of new hair, wherein the said hair oil comprises an effective amount of extracts of Pisum Sativum, Azadirachta indica, Ziziphus mauritiana, Allium cepa, Elettaria cardamomum, Centella asiatica, Allium Sativum, Convolvulus pluricaulis, Eclipta prostrata, Citrous raticulata and suitable cosmeceutically acceptable carriers or additives.

10. The synergistic balanced hair oil of claim 9, wherein the hair oil was prepared by the process comprising:

(a) preparing an extract from plant species of Pisum Sativum; Azadirachta indica;

Ziziphus mauritiana; Allium cepa; Elettaria cardamomum; Centella asiatica; Allium Sativum; Convolvulus pluricaulis; Eclipta prostrata and Citrous raticulata;

(b) extracts obtained in step (a) were added together and added effective amount of glycerine to form mixture;

(c) mixture obtained in step (b) are stirred to form uniform mixture premix I;

(d) premix I was filtered through Chromatographic filter using sintered glass filtration assembly with vacuum pump;

(e) filtered composition obtained in step (d) was packed in plastic Tulip bottles with flip cap (100 mL/Bottle).

Description:
TOPICAL HAIR COMPOSITION

FIELD OF INVENTION

The present invention relates to a synergistic balanced composition for topical application on hair for promoting growth of hair, treatment of hair loss and damaged hair. The present application also discloses the method of preparing said composition.

BACKGROUND OF THE INVENTION

Hair or the skin plays an important role to show the function of human organs and the condition of the human body. Hair determines a beautiful effect in individuals and personal appearance or image. Hair grows about 0.3-0.4 mm a day by an excess of blood, but white hair or hair loss conditions appear due to various factors including a reduction in hair function by testosterone, a reduction in the metabolic function of the hair root, a reduction in the physiological function of a head, a reduction in regional cerebral blood flow that causes abnormal hair growth due to a reduction in the peripheral vascular blood flow of subcutaneous tissue of a head, nutritional deficiency, stresses, drug side effects, and genetic factors. Therefore, the speed of hair growth is based upon genetics, gender, age, hormones. It may be reduced by nutrient deficiency (i.e., anorexia, anemia, zinc deficiency) and hormonal fluctuations (i.e., menopause, polycystic ovaries, thyroid disease).

Now a days, healthy hair growth is impaired due to various factors including nutritional deficiency, the excessive intake of instant food, pollution, use of chemical compositions on hair, etc. Normal hair growth requires essential nutrients like proteins, carbohydrates, fats, vitamins and minerals in specific amount. Deficiency of essential nutrients leads to hair problems and hair damages. Healthy hair growth requires a complexity of nutrients and a ready supply of oxygen to maintain or promote hair growth. Hair nutrition is therefore a vital part of any treatment regime. A truly systematic and rigorous approach must be taken when formulating a composition for hair. A balanced, bioavailable formula to protect and maintain hair growth is vital. There are many treatments available medically and non-medically. Medically there are medicines to treat scalp conditions, recover chemical imbalance, etc. internally and non-medically there are topical solutions like hair oils, hair gels, shampoos, spa treatments, chemical masks, cosmetic preparations, etc. to prevent hair loss and re growth. There are also artificial treatments like hair weaving, hair replacement surgeries, etc. All these efforts are done to suffice the human’s intrinsic need to look desirable and good.

Medicinal treatment contains vasodilators such as carpronium chloride, minoxidil and various extracts, hormones for inhibiting testosterone action such as esterogen or estragiol, and testosterone activity inhibitors such as pentadecanoic acid or finasteride do trigger instant hair growth but once the application is stopped hair shedding increases and such treatments are costly and may require regular visits to salons or medical facility. Non-medical preparations which are available in market, only superficially delay the hair fall process by keeping the hair shafts lubricated externally but are not long-term solutions to the problem of un-timely hair loss. The surgical processes of weaving, re-installing hair are last resort where hair re-growth is not possible, and the process is very costly and not affordable by many. There are various herbal compositions available in the market for hair treatments.

There are various published patent and non-patent literature which discloses the hair care composition and hair loss treatment or revitalization by various method.

The paper entitled“Herbal Treatment for Hair Loss, Dandruff and Baldness” by Acharya et al, disclose a herbal treatment applied by tribal from Gond and Bahria communities to cure hair falling/ loss, dandruff and baldness by using coconut (Cocos nucifera) oil, Centella asiatica, Eclipta alba leaf, Emblica officinalis fruits, Azadirachta indica leaf, Balanites roxburghii leaf and Nardostachys jatamansi rhizome. The paper entitled“Formulation and evaluation of ayurvedic herbal oil” by K. D. Mali, disclose formulation of Ayurvedic herbal oil for application in hairs using various plant materials like Neem, Amla, Shankpushpi, Brahmi, Bhringaraj, Jatamansi, Nirgundi, Shatavari, Gammbhari and Pudina etc. The paper entitled “Formulation and Evaluation of a Polyherbal Hair Oil” by Prabhat Desai, disclose a polyherbal hair oil containing Neem, Shikakai, Amla, Shankpushpi, Brahmi, Bhringaraj, Jatamansi, Nirgundi, Shatavari, Gammbhari and Pudina in til and coconut oil.

US Patent No. 4511555 disclose herbal hair treatment composition for controlling dandruff comprising a cosmetically acceptable carrier and a vegetable oil extract of sage, Indian hemp, and rosemary. US Patent Publications Nos. 20130101569, US 20150297502, US 20150110905, US 20110305681, US 20100330209, US 20100092582, US 20080152731, US 20050002884, US 20080260867, US 20140322148 and US 20180318206 disclose herbal composition for the treatment of hair related diseases. Canadian Patent No. 2633503 discloses a hair growth stimulant comprising carbonized pine cone, vegetable oil, and at least one herbal medicinal extract selected from the group consisting of apricot seed, acorn, pomegranate, gromwell, pasqueflower and licorice extracts. Indian Patent Publication No. 201621030342 discloses herbal oil extracts comprising Asperagus racemosus (Shatavari), Withania soinnifera (Ashwagandha). Phyllanthus embellica (Amla), and Bacopa monnieri (Brahmi) for the treatment of diseases related to hair.

Indian Patent Publication No. 146/MUM/2005 discloses herbal hair oil composition comprising a jatamasi (Jatamashi) oil, Amla oil, Brahmi (Gratiola) extract, Bhrunjraj (Thistles) extract, Eclipta alba extract, Nagamotra (Cyperus Rotundus) extract, kapurkachori extract (Hedy Chim spicatum), Kavath extract (Feronia Elephantum), Bachi extract and til oil (Sesame). Indian Patent Publications No. 1064/DEL/2006, IN 1064/DEL/2006, IN 622/CHE/2007, IN 166/DEL/2009, IN lOl l/CHE/2014, IN 201621035264, IN 2031 /DEL/2009, IN 3061/MUM/2014, IN 1212/DEL/2009, IN 2018210215431, IN 201621035264, IN 201631024453, IN 91/DEL/2010 and IN 2022/MUM/2009 disclose herbal composition for the treatment of hair related diseases. Although the foregoing compositions available in the market have exhibited positive effects on the scalp in preventing hair loss and in promoting hair growth, the majority are meant to be applied topically to the hair or scalp, and most attack only certain causes of hair loss without acting to promote the growth of hair. Further, the compositions available in market are usually oil based, which makes them unpopular to apply them in daytime or all throughout 24hours as they affect the look and feel of the hair. Hair is an integral part of one’s personality. The look and feel of the hair is very important for individuals especially youth as it has profound impact on the personality of any individual. Usually people do not prefer to apply oil-based compositions during the daytime. Also, most of the compositions available in the market requires 3 to 4 times application on the scalp, which becomes practically unviable for individuals especially working individuals. Further, it has been observed that the compositions especially the aqueous based compositions usually contain synthetic excipients, which causes irritation and allergic reactions on application. Further, the compositions available in the market does not disclose a balanced composition which provides all the essential nutrients in a balanced amount required for the hair care, hair loss treatment or revitalization of hair yet devoid of any synthetic ingredient. Furthermore, the dietary needs of hair at daytime and night time are different as the exposure of hairs to surrounding environment in day and night time is different. In daytime, hairs are more exposed to harsh sunlight, dirt and dust. Further, the requirements of daytime and night time compositions to be applied on hair are different. Day time composition requires non-greasy, quickly absorbable compositions whereas night time compositions can be oilier. The compositions for hair available in market does not differentiate them between day time or night time compositions.

Bacterial fungal growth, dandruff, itching, etc. are common symptoms in patients suffering from hair diseases. In such conditions, maintaining goof hygiene always helps in faster relief. It has been observed that most of the compositions for hair treatment also comes in plastic bottle with or without applicator. Often one bottle of hair oils or hair composition with or without applicator is used by entire family. This often leads to cross contamination eg if a hair composition in bottle with comb like applicator is applied by one person who is having fungal infection in hair and the same hair composition from same bottle is applied by second person, the second person will get infection of first person. Also, the hands of each person come in contact with the bottle, which may often deteriorate the hair composition and can cause infection to the users/patients using the hair composition from the same bottle. The hair compositions are often not packed in packings which avoid cross contamination.

Therefore, there is a need for improved balanced hair care composition which is not only non-prescription, non-surgical, inexpensive, natural composition but also provide all the essential elements needed for easily and quickly growing healthy hair, preventing hair loss or revitalization. Also, there is need for water based balanced hair care compositions which does not alter the look and feel of the hair and also provides sustained and complete nutrition to the hair thereby promoting hair growth. Further the compositions should be packed in innovative packing which avoids cross contamination between individuals using the hair compositions from same bottle and avoids direct contact of an individual with the hair composition.

SUMMARY OF THE INVENTION

The present invention relates to a balanced herbal hair care composition used for healthy growth of hair, hair loss and for treatment of damaged hair, wherein the hair care composition provides all the necessary ingredients from natural sources required for hair care, hair loss treatment or revitalization of hair. The balanced composition of the present invention contains proteins, complex carbohydrates, vitamins and minerals in specific ratio, which provides a holistic nutrition to the hair and therefore promotes hair growth and decreases hair fall. Further, the compositions of the present invention are aqueous based compositions and therefore does not alter the look and feel of the hair on topical application even in daytime. The compositions of present invention forms a film on the scalp, thereby releasing the ingredients over a longer period of time and thus providing sustained nutrition to the hair. The present invention is prepared from all the natural components and is devoid of any synthetic ingredients. The composition of present invention is devoid of any side effects and specifically useful for topical application to normal as well as patients allergic to synthetic ingredients.

One aspect of the present invention provides a synergistic balanced herbal composition for hair care, hair loss treatment or revitalization, wherein the composition comprises Pisum Sativum, Azadirachta indica, Ziziphus mauritiana, Allium cepa, Elettaria cardamomum optionally along with one or more pharmaceutically acceptable naturally derived carriers or additives.

Another aspect of the present invention provides a herbal balanced topical composition comprising an extract prepared from plant Pisum Sativum, an extract prepared from plant Azadirachta indica, an extract prepared from plant Ziziphus mauritiana, an extract prepared from plant Allium cepa, an extract prepared from plant Elettaria cardamomum and effective amount of synergistic carrier to prepare a synergistic herbal composition used for the treatment of intense hair loss, baldness, androgenic alopecia, tinea capitis and early hair greying, dandruff and infections thereof.

Another aspect of the present invention provides a hair oil composition comprises an effective amount of extracts of Pisum Sativum, Azadirachta indica, Ziziphus mauritiana, Allium cepa, Elettaria cardamomum, Centella asiatica, Allium Sativum, Convolvulus pluricaulis, Eclipta prostrata, Citrous raticulata and suitable cosmeceutically acceptable carriers or additives, wherein the composition used for the treatment of intense hair loss, baldness, androgenic alopecia, tinea capitis and early hair greying, dandruff and infections thereof.

Another aspect of the present invention provides a synergistic balanced hair oil for topical use in day-time, wherein the hair oil comprises an effective amount of extracts of Pisum Sativum, Azadirachta indica, Ziziphus mauritiana, Allium cepa, Elettaria cardamomum, Centella asiatica, Allium Sativum, Convolvulus pluricaulis, Eclipta prostrata, Citrous raticulata and suitable cosmeceutically acceptable carriers or additives.

Another aspect of the present invention provides a synergistic balanced composition used for the treatment of intense hair loss, baldness, androgenic alopecia, tinea capitis and early hair greying, dandruff and infections thereof, wherein the composition further comprises suitable cosmeceutically acceptable carriers or additives.

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides a synergistic balanced hair care composition for topical use in day-time for hair loss treatment or revitalization of hair, wherein the composition comprises Pisum Sativum, Azadirachta indica, Ziziphus mauritiana, Allium cepa, Elettaria cardamomum optionally along with one or more pharmaceutically acceptable naturally derived carriers or additives.

The inventors of present invention have been working on providing the right balance of nourishment, manageability and feel such that hair oils could be better used by the traditional consumers while non-users or infrequent users start to use hair oils on a regular basis, so that one product is able to provide all essential elements which are required for healthy hair growth and at the same time does not alter the look and feel of the hair upon topical application.

While working on the present invention, Inventors have observed in clinical trials that when the balanced composition comprising the extract of Pisum Sativum, Azadirachta indica, Ziziphus mauritiana, Allium cepa, Elettaria cardamomum, Centella asiatica, Allium Sativum, Convolvulus pluricaulis, Eclipta prostrata and/or Citrous raticulata optionally along with one or more pharmaceutically acceptable naturally derived carriers or additives are topically applied in day-time to the skull, it results the low hair loss and generation of new healthy hair. Further, the hair care composition of present invention reduces problems related to hair like decolouration, thinning and loss of hair. The inventors of present invention observed that compositions of present invention form a film on the scalp, thereby releasing the active ingredients for longer period of time providing sustained effect. Also the compositions of present invention does not alter the look and feel of the hair upon topical application of the composition.

The term“synergistic balanced composition” includes the composition which provides all-natural essential nutrients like proteins, carbohydrates, fats, vitamins and minerals in a single formulation in a balanced proportion which are required for healthy growth and revitalization of hair.

The term "Hair oil composition" as used herein, is meant to include a composition for application to the human hair to provide nourishment for proper health of hair. Additionally, on application of the hair oil, the hair should be manageable i.e. does not get tangled, should not be too sticky and the hair should feel smooth and silky to the touch.

The term“Peas Liquid Extract” used in the present invention includes extract obtained from plant Peas. The botanical name of pea is Pisum Sativum. Pisum Sativum Peptide delivers Volumizing and antioxidant driven Anti- Aging benefits as well as film forming and conditioning benefits. Pisum Sativum Peptide’s film- forming properties render it an effective moisturizer that provides protective benefits and a silky feel to the hair or skin. Pisum Sativum Peptide reduces the damage caused by free radicals to promote the scalp and follicle health essential producing youthful, voluminous looking hair.

The amount of the Peas Liquid Extract in the composition is preferably up to about 35% by volume, more preferably from about 15% to about 30% by volume, especially from about 22% to about 26% by volume. The amount of the Peas Liquid Extract in the composition is 25% v/v.

The term“Brahmi Liquid Extract” used in the present invention includes extract obtained from plant Brahmi. The botanical name of Brahmi is Centella asiatica. Brahmi contains saponins called asictcoside and madecassoside which yield triterpene acids Asiatic acid and madecassic acid on hydrolysis. Triterpenoid, saponins, the primary constituents of Centella asiatica are mainly believed to be responsible for its wide therapeutic actions. The amount of the Brahmi Liquid Extract in the composition is preferably up to about 20% by volume, more preferably from about 8% to about 16% by volume, especially from about 11% to about 13% by volume. The amount of the Brahmi Liquid Extract in the composition is 12% v/v.

The term“Behada Liquid Extract” used in the present invention includes extract obtained from plant Behada. The botanical name of Behada is Allium Sativum and common name is Bellirica, Belleric Myrobalan. Main chemical constitutes of Behada is tannins which include B- sitosterol, gallic acid, ellagic acid, ethyl gallate, galloyl glucose and chebulaginic acid. The use of tannins tightens the surface of the scalp and hair follicles, strengthening the follicles' grasp on each hair. Terminalia bellerica promotes hair growth, adds nutrition and useful against greying. It is also used for Dandruff treatment. The amount of the Behada Liquid Extract in the composition is preferably up to about 10% by volume, more preferably from about 3% to about 8% by volume, especially from about 4% to about 6% by volume. The amount of the Behada Liquid Extract in the composition is 5% v/v.

The term“Skankhpushpi liquid Extract” used in the present invention includes extract obtained from plant Skankhpushpi. The botanical name of Skankhpushpi is Convolvulus pluricaulis. The chemical constituents in Shankhpushpi consist of carbohydrate-D-glucose, rhamnose, maltose, sucrose and starch. It also contains proteins, amino acids and the alkaloidsconvolvine, convolamine, confoline, phyllabine, convolidine, convoline, convosine, subhirsine and convolvidine along with fatty acid and wax constituents, hydrocarbons, aliphatic and sterol and certain other bio-chemicals which include scopoletin, glacial acetic acid, three coumarins, b-sitosterol, kaempferol, tropane alkaloids, linoleic acid, palmitic acid and straight chain hydrocarbon hextriacontane, 20-oxodotriacontanol, tetratriacontanoic acid and 29- oxodotriacontanol. Alcoholic extract of plant yield Di-oh-cinnamic acid, kaempferol and Betastosterolglucos steroid of microphyllic acid. Hydroxy Cinnamic acid, Octacosanol tetracosane along with glucose, sucrose also has been isolated from the plant. It improves skin texture, immunity and strength in children. It can be used in place of hair oil for kids. It is also used in Ayurvedic treatment procedures like Shirodhara, Shirobasti, etc. The amount of the Skankhpushpi liquid Extract in the composition is preferably up to about 20% by volume, more preferably from about 9% to about 16% by volume, especially from about 11% to about 15% by volume. The amount of the Skankhpushpi liquid Extract in the composition is 13% v/v.

The term“Bhringaraj liquid Extract” used in the present invention includes extract obtained from plant Bhringaraj. The botanical name of Bhringaraj is Eclipta prostrata. Bhringaraj known as the king of herbs, its literal meaning is“king of hair". The extract prepared from the Bhringraj plant is rich in a type of alkaloid known as ecliptine and the leaves contain high amount of protein. This extract is resinous in nature.

Bhringaraj contains Ecliptine (or Eclipta) that regarded as the primary reason for Bhringaraj’ s hair loss-arresting properties. Eclipta is composed of a substance called wedelolactone that mimics the action of certain hormones and is responsible for influencing hair-growth. Secondly, Bhringaraj is a natural disinfectant. It has the ability to neutralize the action of skin allergies and conditions like dermatitis that impair the action of hair follicles, causing increased hair fall. Bhringaraj has proven anti-inflammatory properties. This is particularly useful since a dry scalp is more prone to being scratched and becoming inflamed. The amount of the Bhringaraj liquid Extract in the composition is preferably up to about 25% by volume, more preferably from about 10% to about 20% by volume, especially from about 12% to about 16% by volume. The amount of the Bhringaraj liquid Extract in the composition is 15% v/v.

The term“Neem Liquid extract” used in the present invention includes extract obtained from plant Neem. The botanical name of Neem is Azadirachta indica. Neem oil limonoids containing Azadirachtin used in hair care formulations due to their antihead lice, antidandruff and antifungal activities. Neem hair has properties that can repair the damaged cuticles of hair and thus helps to get rid of split ends. The amount of the Neem Liquid extract in the composition is preferably up to about 10% by volume, more preferably from about 3% to about 8% by volume, especially from about 4% to about 6% by volume. The amount of the Neem Liquid extract in the composition is 5% v/v.

The term“Ber Patti liquid extract” used in the present invention includes extract obtained from plant Ber. The botanical name of Ber is Ziziphus mauritiana. Ziziphus mauritiana mostly contains Alkaloids, Sapogenin, Llavonoids, Triterpenoids and Phenolic compounds. It prevents scalp diseases, cleanses hair thoroughly and helps to darken the hair colour. It lengthens the hair besides thickening them. They are said to promote the growth of hair. Jujube essential oil (1%) applied to shaved skin increased the number of hair follicles and hair length in mice. The amount of the Ber Patti liquid extract in the composition is preferably up to about 10% by volume, more preferably from about 3% to about 8% by volume, especially from about 4% to about 6% by volume. The amount of the Ber Patti liquid extract in the composition is 5% v/v.

The term“Onion Liquid extract” used in the present invention includes extract obtained from plant Onion. The botanical name of Onion is Allium cepa. Onions are an important source of several phytonutrients as flavonoids, fructo oligosaccharides (LOS), and thio-sulfinates and other sulphur compounds. Flavonoids are the major phenolics in onions. Sulphur compounds active antimicrobial agents, hence, onions are used as natural preservatives to control microbial growth. Onion juice is an effective remedy for alopecia areata. Onion juice Promote hair growth, Help treat dandruff, help reverse gray hair, maintain hair colour and Eliminate head lice. The amount of the Onion Liquid extract in the composition is preferably up to about 10% by volume, more preferably from about 4% to about 9% by volume, especially from about 6% to about 8% by volume. The amount of the Onion Liquid extract in the composition is 7% v/v.

The term“Orange peel liquid extract” used in the present invention includes extract obtained from plant Orange. The botanical name of Orange is Citrous raticulata. Citrus, in addition to providing an ample supply of vitamin C, folic acid, potassium, and pectin, contains a host of active phytochemicals. It has Excellent conditioner property, stimulates hair growth and used for the treatment of dandruff. The amount of the Orange peel liquid extract in the composition is preferably up to about 9% by volume, more preferably from about 2% to about 7% by volume, especially from about 5% to about 6% by volume. The amount of the Orange peel liquid extract in the composition is 4% v/v.

The term“Cardamom liquid extract” used in the present invention includes extract obtained from plant Cardamom. The botanical name of Cardamom is Elettaria cardamomum. Cardamom contains volatile oil to the extent of 2% to 8%. the active constituent of the volatile oil is cineole. Other aromatic compounds also present like terpinyl acetate, terpineole, bomeole, terpinene, etc. The other constituents of the cardamom seeds are fixed oil, starch and proteins. Cardamom used for improvement in hair growth and the treatment of certain scalp issues. The amount of the Cardamom liquid extract in the composition is preferably up to about 9% by volume, more preferably from about 2% to about 7% by volume, especially from about 5% to about 6% by volume. The amount of the Cardamom liquid extract in the composition is 4% v/v. Glycerine has emerged as an essential ingredient for hair care purposes. Replete with powerful antioxidants, glycerine acts as a natural humectant and treats all kinds of hair-related woes. It can provide deep conditioning to scalp, prevent breakage and keep unwanted frizz at bay. The amount of the Glycerine in the composition is preferably up to about 10% by volume, more preferably from about 3% to about 8% by volume, especially from about 4% to about 6% by volume. The amount of the Glycerine in the composition is 5% v/v.

In one embodiments of present invention provides a herbal balanced topical composition comprising an extract prepared from plant Pisum Sativum, an extract prepared from plant Azadirachta indica, an extract prepared from plant Ziziphus mauritiana, an extract prepared from plant Allium cepa, an extract prepared from plant Elettaria cardamomum, an extract prepared from plant Centella asiatica, an extract prepared from plant Allium Sativum, an extract prepared from plant Convolvulus pluricaulis, an extract prepared from plant Eclipta prostrata, an extract prepared from plant Citrous raticulata and effective amount of synergistic carrier to prepare a synergistic herbal composition used for the treatment of intense hair loss, baldness, androgenic alopecia, tinea capitis and early hair greying, dandruff and infections thereof.

The hair care composition of present invention provides an herbal synergistic balanced composition comprising an extract of herbal plants, wherein the said extracts are obtained by at least one of the methods selected from the group of percolation method, hot-soxhlation method or super-critical-fluid extraction method.

In another embodiments of present invention provides a synergistic balanced hair oil used for prevention of hair loss and regeneration of new hair, wherein the said hair oil comprises an effective amount of extracts of Pisum Sativum, Azadirachta indica, Ziziphus mauritiana, Allium cepa, Elettaria cardamomum, Centella asiatica, Allium Sativum, Convolvulus pluricaulis, Eclipta prostrata, Citrous raticulata and suitable cosmeceutically acceptable carriers or additives.

The pharmaceutically acceptable naturally derived carriers or additives used in the present invention are selected from the group comprising of Xanthum gum, Aloe vera water, Glycerin, Carrageenan gum, Isopropyl Myristate, or any other carrier known in the art, and combinations thereof.

The pharmaceutically acceptable naturally derived carriers or additives used in the present invention are in the form of emulsifiers, preservatives, dispersants, solvents and catalytic enzyme.

The hair care composition of present invention is devoid of any synthetic ingredients.

The synergistic balanced hair care composition is applied in day time, so it provides non-sticky, smooth and silky hair.

In another embodiments of present invention provides a method of reducing adverse and allergic effects of topical composition for hair treatment or revitalization, wherein the method includes administering a composition comprising all natural ingredients in a balanced proportion and avoiding use of any synthetic ingredients, wherein the natural ingredients used in the composition includes an effective amount of extracts of Pisum Sativum, Azadirachta indica, Ziziphus mauritiana, Allium cepa, Elettaria cardamomum, Centella asiatica, Allium Sativum, Convolvulus pluricaulis, Eclipta prostrata, Citrous raticulata and naturally derived pharmaceutically acceptable carriers or additives.

The hair care composition of present invention is used in the form of oil, lotion, cream, gel, paste, ointment, spray, solution, or foam. In another embodiments of present invention provides a synergistic balanced hair care composition, wherein the hair care composition used for hair treatment or revitalization, wherein the hair treatment or revitalization includes treatment of intense hair loss, baldness, androgenic alopecia, tinea capitis and early hair greying, dandruff and infections thereof.

In another embodiments of present invention provides a synergistic balanced herbal composition for hair care, hair loss treatment or revitalization, wherein the composition comprises extracts of about 25 %v/v of Pisum Sativum, about 5 %v/v of Azadirachta indica, about 5% v/v of Ziziphus mauritiana, about 7% v/v of Allium cepa, about 4% v/v of Elettaria cardamomum, about 12% v/v of Centella asiatica, about 5% v/v of Allium Sativum, about 13% v/v of Convolvulus pluricaulis, about 15% v/v of Eclipta prostrata, about 4% v/v of Citrous raticulata optionally along with one or more pharmaceutically acceptable naturally derived carriers or additives.

In another embodiments of present invention provides a process of preparation of herbal hair care composition, wherein the said process comprises;

(a) preparing an extract from plant species of Pisum Sativum; Azadirachta indica;

Ziziphus mauritiana; Allium cepa; Elettaria cardamomum; Centella asiatica; Allium Sativum; Convolvulus pluricaulis; Eclipta prostrata and Citrous raticulata;

(b) extracts obtained in step (a) were added together and added effective amount of glycerine to form mixture;

(c) mixture obtained in step (b) are stirred to form uniform mixture premix I;

(d) premix I was filtered through Chromatographic filter using sintered glass filtration assembly with vacuum pump;

(e) filtered composition obtained in step (d) was packed in plastic Tulip bottles with flip cap (100 mL/Bottle).

In another embodiment of the present invention, the compositions of the present invention can be applied on hair any time of the day. In yet another embodiment of the present invention, the compositions of the present invention can be applied on hair any time of the day preferably day time.

In another embodiment of the present invention, the composition of the invention are aqueous based compositions.

In another embodiment, the composition of the present invention are devoid of any synthetic ingredient.

In another embodiment of present invention, the compositions of present invention may be used in combination of other active pharmaceutical substances used for treatment of alopecia, thinning of hair, greying of hair, growth of hair. The compositions of present invention may additionally contain applicator for topical administration.

In another embodiment of the present invention, the compositions of present invention are packed in spray or mist dispenser, which delivers the drug hygienically without cross contamination and ensures delivery of required amount of composition without any spillage.

The hair compositions of present invention are packed in spray bottles with a disperser which in turn is covered with a cap to avoid deposition of dust particle and avoid contamination. The packaging of the present invention ensures high hygienic conditions and thus provides following benefits to its users:

• Compositions of present invention are dispensed to hairs without touching the diseased surface;

• Controlled product dispensation ensures right quantity at right place, this avoids spillage and wastage; • Disperser is fully covered with Cap, which ensures that product is not contaminated from environmental (like dust and germs) pollutants even after repeated use;

• Packaging and use of product is user friendly.

The compositions of present invention may be sprayed directly on hairs or can be taken in hard and applied on hairs.

While the invention has been described in term of its specific embodiments, certain modification and equivalents will be apparent to those skilled in the art and are intended to be included within the scope of the invention.

EXAMPLE 1: Hair Care Composition

Process of Preparation of Hair Care Composition: The hair care composition was prepared by following steps: 1. The individual liquid extracts of Pisum Sativum, Azadirachta indica, Ziziphus mauritiana, Allium cepa, Elettaria cardamomum, Centella asiatica, Allium Sativum, Convolvulus pluricaulis, Eclipta prostrata, Citrous raticulata and glycerin were dispensed separately.

2. All dispensed liquid extracts were added together, and mixture stirred about lOminutes to form uniform mixture premix I.

3. Premix I formed in step 2 was filtered through chromatographic filter using sintered glass filtration assembly with vacuum pump.

4. The filtered composition obtained in step 3 was packed in plastic Tulip bottles with flip cap (100 mL/Bottle).

Example 2: Clinical Study

The study was performed on total thirty-three (33) subjects with hair fall conditions. The subjects were divided into three (03) groups. The composition of Example 1 was provided to the subjects for once a daily application. Effect of the composition on hair loss was measured using a qualitative scale. At the start of the Study, the subjects were told to rate their hair condition on scale of 1 to 5, wherein the scale of 5 means very high hair fall to 1 normal or minimal hair loss. The study was conducted for 12 weeks. Subjects were told to apply the composition disclosed in Example 1 once daily as per their convenience. Effect of the composition on hair loss and/or hair growth is measured using qualitative based on subjects objectivity. Hair fall was measured after each 2-week interval. The data obtained on scale was converted into percentages for statistical purpose. For example, suppose on inclusion hair fall scale is 4, which reduced up to 1 or 0 after 12 weeks of period, then for statistical calculation 'on inclusion' was converted to 100% and respective change/ decrease is calculated as percentage change/decrease. The results of the clinical study involving administration of composition of Example 1 are reproduced in Fig 1. The data obtained during the 12-week period showed significant decrease in hair fall. The present invention is highly advantageous as it stops hair from falling and greying. Moreover, it improves the quality of hair by providing smooth and silky texture to the hair as well as increasing the growth of hair. The present invention being an herbal composition doesn't cause any side effects or disadvantages. The herbal hair oil should be lightly massaged on hair roots for 5-10 mins for giving optimum effect.

Although the preferred embodiment as well as the construction and use have been specifically described, it should be understood that variations in the preferred embodiment could be achieved by a person skilled in the art without departing from the spirit of the invention. The invention has been described with reference to specific embodiment which is merely illustrative and not intended to limit the scope of the invention as defined in the claims.