Title:
TOPICAL PHARMACEUTICAL COMPOSITION COMPRISING A CHOLINERGIC AGENT OR A CALCIUM CHANNEL BLOCKER
Document Type and Number:
WIPO Patent Application WO1998036733
Kind Code:
A3
Abstract:
Nifedipine, optionally in combination with bethanechol, is administered locally to the anus for the treatment of benign anal disorders, in particular anal fissures and haemorrhoids. The agents induce a reduction in the mean and resting pressure, thereby assisting in the healing of anal fissures and haemorrhoids. Optionally, the active agents may be co-administered with a steroid, such as hydrocortisone.
Inventors:
KAMM MICHAEL ALBERT (GB)
PHILLIPS ROBIN KENNETH STEWART (GB)
PHILLIPS ROBIN KENNETH STEWART (GB)
Application Number:
PCT/GB1998/000575
Publication Date:
November 26, 1998
Filing Date:
February 23, 1998
Export Citation:
Assignee:
KAMM MICHAEL ALBERT (GB)
PHILLIPS ROBIN KENNETH STEWART (GB)
PHILLIPS ROBIN KENNETH STEWART (GB)
International Classes:
A61K9/00; A61K31/56; A61K9/06; A61K31/16; A61K31/221; A61K31/222; A61K31/27; A61K31/275; A61K31/4422; A61K31/55; A61K31/5513; A61K31/554; A61K31/573; A61K45/00; A61P1/00; A61P9/00; A61P9/14; A61P17/02; A61P43/00; C07D211/90; C07J5/00; A61K47/10; A61K47/14; A61K47/20; (IPC1-7): A61K9/06
Domestic Patent References:
| WO1995006466A1 | 1995-03-09 |
Foreign References:
| EP0275054A1 | 1988-07-20 | |||
| EP0301392A1 | 1989-02-01 | |||
| US5084281A | 1992-01-28 | |||
| FR2074627A1 | 1971-10-08 |
Other References:
CHRYSOS E ET AL: "EFFECT OF NIFEDIPINE ON RECTOANAL MOTILITY", DISEASES OF THE COLON AND RECTUM, vol. 39, no. 2, February 1996 (1996-02-01), pages 212 - 216, XP002069983
Download PDF: