TOTAL FLAVONOIDS EXTRACT OF GYNURA FORMOSANA KITAM. , PREPARATION METHOD THEREFOR AND USE THEREOF FOR TREATING HYPERURICEMIA

Title:

TOTAL FLAVONOIDS EXTRACT OF GYNURA FORMOSANA KITAM. , PREPARATION METHOD THEREFOR AND USE THEREOF FOR TREATING HYPERURICEMIA

Document Type and Number:

WIPO Patent Application WO/2019/052310

Kind Code:

A1

Abstract:

Disclosed is a total flavonoids extract of Gynura formosana Kitam., containing 80%-85% of rutin by weight percent content. The results of pharmacological experiments show that the extract can lower the activity of xanthine oxidase in the liver of a hyperuricemia model mouse and reduce the synthesis of uric acid to a certain degree and has a certain uric acid-lowering effect, and can be used as a potential drug for treating hyperuricemia or gout. The method for preparing the total flavonoids extract of Gynura formosana Kitam. comprises: after an extraction step, selecting a complex enzyme composed of enzymes with a specific composition and a specific ratio for enzymolosis, and further carrying out the step of extracting and concentrating with macroporous resin and isolating and purifying with macroporous resin, so that the HPLC purity of rutin in the resulting total flavonoids extract of Gynura formosana Kitam. reaches 80%-85%.

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Inventors:

YUAN HUIJUN (CN)
YIN TINGTING (CN)
HONG FEI (CN)
YU JUAN (CN)
ZENG JINXIANG (CN)
WANG SHICONG (CN)

Application Number:

PCT/CN2018/101168

Publication Date:

March 21, 2019

Filing Date:

August 17, 2018

Export Citation:

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Assignee:

ZHANGZHOU PIEN TZE HUANG PHARM (CN)

International Classes:

A61K36/28; A23L33/105; A61K9/00; A61K31/7048; A61P19/06; B01D15/08

Foreign References:

CN107582587A	2018-01-16
CN107625800A	2018-01-26
CN107582590A	2018-01-16
CN107582589A	2018-01-16
CN107582588A	2018-01-16
CN104173458A	2014-12-03

Other References:

LIN, YANYAN ET AL.: "Optimization the extraction of total flavonoids from Gynua formosana Kitam guided by ultrasound and research on its antibacterial activity in vitro", JOURNAL OF YOUJIANG MEDICAL UNIVERSITY FOR NATIONALITIES, vol. 39, no. 2, 30 April 2017 (2017-04-30), pages 90 - 93, ISSN: 1001-5817

Attorney, Agent or Firm:

GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)

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