Title:
TOTAL SYNTHESIS OF PLADIENOLIDE B AND PLADIENOLIDE D
Document Type and Number:
WIPO Patent Application WO/2007/043621
Kind Code:
A1
Abstract:
Disclosed is a process for production of a compound represented by the formula (11): (11) [wherein P1 represents a hydrogen atom or a protective group for a hydroxyl group; P7 represents a hydrogen atom or a protective group for a hydroxyl group; P8 represents a hydrogen atom, an acetyl group or a protective group for a hydroxyl group and P9 represents a hydrogen atom or a protective group for a hydroxyl group, or P8 and P9 may together form a group represented by the formula: (where R5 represents a phenyl group which may have a halogen atom; and R1 represents a hydrogen atom or a hydroxyl group)]. The process comprises the step of reacting a compound represented by the formula (12): (12) (wherein P7 and R1 are as defined above) with a compound represented by the formula (13): (13) (wherein P1, P8, P9 and R5 are as defined above) in the presence of a catalyst.
Inventors:
KANADA REGINA MIKIE (JP)
ITO DAISUKE (JP)
SAKAI TAKASHI (JP)
ASAI NAOKI (JP)
KOTAKE YOSHIHIKO (JP)
NIIJIMA JUN (JP)
ITO DAISUKE (JP)
SAKAI TAKASHI (JP)
ASAI NAOKI (JP)
KOTAKE YOSHIHIKO (JP)
NIIJIMA JUN (JP)
Application Number:
PCT/JP2006/320405
Publication Date:
April 19, 2007
Filing Date:
October 12, 2006
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
KANADA REGINA MIKIE (JP)
ITO DAISUKE (JP)
SAKAI TAKASHI (JP)
ASAI NAOKI (JP)
KOTAKE YOSHIHIKO (JP)
NIIJIMA JUN (JP)
KANADA REGINA MIKIE (JP)
ITO DAISUKE (JP)
SAKAI TAKASHI (JP)
ASAI NAOKI (JP)
KOTAKE YOSHIHIKO (JP)
NIIJIMA JUN (JP)
International Classes:
C07D407/06; C07D405/12; C07D493/04
Domestic Patent References:
| WO2002060890A1 | 2002-08-08 | |||
| WO2005073223A1 | 2005-08-11 | |||
| WO2004050890A1 | 2004-06-17 | |||
| WO2004011459A1 | 2004-02-05 | |||
| WO2003099813A1 | 2003-12-04 | |||
| WO2002060890A1 | 2002-08-08 | |||
| WO2003099813A1 | 2003-12-04 | |||
| WO2004011459A1 | 2004-02-05 | |||
| WO2004011611A2 | 2004-02-05 |
Foreign References:
| JPH04352783A | 1992-12-07 | |||
| JPH04352783A | 1992-12-07 |
Other References:
See also references of EP 1935893A4
BLAKEMORE, P.R.; COLE, W.J.; KOCIENSKY, P.J.; MORLEY, A., SYNLETT, 1998, pages 26 - 28
GREEN, T.W.; WUTS, P.G.M.: "Protective Groups in Organic Synthesis", 1999, WILEY-INTERSCIENCE
BLAKEMORE, P.R.; COLE, W.J.; KOCIENSKY, P.J.; MORLEY, A., SYNLETT, 1998, pages 26 - 28
GREEN, T.W.; WUTS, P.G.M.: "Protective Groups in Organic Synthesis", 1999, WILEY-INTERSCIENCE
Attorney, Agent or Firm:
ASAMURA, Kiyoshi et al. (New Ohtemachi Bldg. 2-1, Ohtemachi 2-chom, Chiyoda-ku Tokyo 04, JP)
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