Title:
TOTALLY-MESOPOROUS ZIRCONIA NANOPARTICLES, USE AND METHOD FOR PRODUCING THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/120795
Kind Code:
A1
Abstract:
The present invention relates to novel totally-mesoporous zirconium oxide nanoparticles as well as a sol-gel synthesis process thereof which include an innovative nanoparticles purification step. Said nanoparticles are characterized by a totally-mesoporous structure i.e. a distribution of pores within the so-called the mesoporous range uniformly distributed throughout the entire nanoparticle volume. Furthermore, said nanoparticles are non-cytotoxic and present a high surface area, which make particularly suitable in both biomedical and industrial applications (e.g. drug delivery, heavy metals ion sequestration). The manufacturing method is simple and advantageously allows for high control over the shape and diameter of the nanoparticles as well as over the nanoparticles pores.
Inventors:
SPONCHIA GABRIELE (IT)
BENEDETTI ALVISE (IT)
RIELLO PIETRO (IT)
BENEDETTI ALVISE (IT)
RIELLO PIETRO (IT)
Application Number:
PCT/IB2016/050394
Publication Date:
August 04, 2016
Filing Date:
January 27, 2016
Export Citation:
Assignee:
UNI CA FOSCARI (IT)
International Classes:
C01G25/02; A61K9/00
Domestic Patent References:
| WO1997043040A1 | 1997-11-20 |
Foreign References:
| US20100051877A1 | 2010-03-04 | |||
| US20130122298A1 | 2013-05-16 | |||
| US20140170088A1 | 2014-06-19 | |||
| US20100051877A1 | 2010-03-04 |
Other References:
SHAOHENG TANG ET AL: "Hollow Mesoporous Zirconia Nanocapsules for Drug Delivery", ADVANCED FUNCTIONAL MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 20, no. 15, 9 August 2010 (2010-08-09), pages 2442 - 2447, XP001556978, ISSN: 1616-301X, DOI: 10.1002/ADFM.201000647
DEHONG CHEN ET AL: "Facile Synthesis of Monodisperse Mesoporous Zirconium Titanium Oxide Microspheres with Varying Compositions and High Surface Areas for Heavy Metal Ion Sequestration", ADVANCED FUNCTIONAL MATERIALS, vol. 22, no. 9, 9 May 2012 (2012-05-09), DE, pages 1966 - 1971, XP055221472, ISSN: 1616-301X, DOI: 10.1002/adfm.201102878
X. WANG ET AL.: "Mesoporous Titanium Zirconium Oxide Nanospheres with Potential for Drug Delivery Applications", ACS APPLIED MATERIALS AND INTERFACES, vol. 5, 22 October 2013 (2013-10-22), pages 10926 - 10932, XP002747316, DOI: 10.1021/am4031104
CHEN ET AL., FACILE SYNTHESIS OF MONODISPERSE MESOPOROUS ZIRCONIUM TITANIUM OXIDE MICROSPHERES WITH VARYING COMPOSITIONS AND HIGH SURFACE AREAS FOR HEAVY METAL ION SEQUESTRATION
SHAOHENG TANG ET AL.: "Hollow Mesoporous Zirconia Nanocapsules for Drug Delivery", ADV. FUNCT. MATER., vol. 20, 2010, pages 2442 - 2447
TA-CHEN WEI, SUPERFICIALLY POROUS METAL OXIDE PARTICLES, METHODS FOR MAKING THEM, AND SEPARATION DEVICES USING THEM
GABRIELE SPONCHIA ET AL.: "Biocompatible tailored zirconia mesoporous nanoparticles with high surface area for theranostic applications", J. MATER. CHEM. B, vol. 3, 2015, pages 7300
WANG ET AL., MESOPOROUS TITANIUM ZIRCONIUM OXIDE NANOSPHERES WITH POTENTIAL FOR DRUG DELIVERY APPLICATIONS, vol. 5, no. 21, 22 October 2013 (2013-10-22)
"Alginate-Based Biomaterials for Regenerative Medicine Applications", MATERIALS, vol. 6, 2013, pages 1285 - 1309
DEHONG CHEN ET AL: "Facile Synthesis of Monodisperse Mesoporous Zirconium Titanium Oxide Microspheres with Varying Compositions and High Surface Areas for Heavy Metal Ion Sequestration", ADVANCED FUNCTIONAL MATERIALS, vol. 22, no. 9, 9 May 2012 (2012-05-09), DE, pages 1966 - 1971, XP055221472, ISSN: 1616-301X, DOI: 10.1002/adfm.201102878
X. WANG ET AL.: "Mesoporous Titanium Zirconium Oxide Nanospheres with Potential for Drug Delivery Applications", ACS APPLIED MATERIALS AND INTERFACES, vol. 5, 22 October 2013 (2013-10-22), pages 10926 - 10932, XP002747316, DOI: 10.1021/am4031104
CHEN ET AL., FACILE SYNTHESIS OF MONODISPERSE MESOPOROUS ZIRCONIUM TITANIUM OXIDE MICROSPHERES WITH VARYING COMPOSITIONS AND HIGH SURFACE AREAS FOR HEAVY METAL ION SEQUESTRATION
SHAOHENG TANG ET AL.: "Hollow Mesoporous Zirconia Nanocapsules for Drug Delivery", ADV. FUNCT. MATER., vol. 20, 2010, pages 2442 - 2447
TA-CHEN WEI, SUPERFICIALLY POROUS METAL OXIDE PARTICLES, METHODS FOR MAKING THEM, AND SEPARATION DEVICES USING THEM
GABRIELE SPONCHIA ET AL.: "Biocompatible tailored zirconia mesoporous nanoparticles with high surface area for theranostic applications", J. MATER. CHEM. B, vol. 3, 2015, pages 7300
WANG ET AL., MESOPOROUS TITANIUM ZIRCONIUM OXIDE NANOSPHERES WITH POTENTIAL FOR DRUG DELIVERY APPLICATIONS, vol. 5, no. 21, 22 October 2013 (2013-10-22)
"Alginate-Based Biomaterials for Regenerative Medicine Applications", MATERIALS, vol. 6, 2013, pages 1285 - 1309
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