Title:
PET/CT TRACER HAVING SELECTIVITY FOR DIFFERENT LUNG CANCER CELLS, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/036022
Kind Code:
A1
Abstract:
A PET/CT tracer having selectivity for different lung cancer cells, a preparation method therefor and use thereof. The PET/CT tracer is a compound represented by formula I, or a salt or stereoisomer thereof, wherein R1 and R2 are each independently selected from H or C1-C5 alkyl, and X is independently selected from 11C, 18F, 19F, 15O, or 13N. The prepared 18F-PET/CT tracer can be selectively taken in by different carcinogenic driver gene mutant lung cancer cells. Test results show that the 18F-PET/CT tracer is expected to achieve high quality imaging in an NRas Q61K tumor model, and has certain selectivity for different carcinogenic driver gene mutant lung cancers. The tracer is different from 18F-FDG that may lead to high-concentration imaging in any lesion due to increased glucose metabolism, and is expected to make up for the deficiency of imaging by using 18F-FDG alone. Therefore, the 18F-PET/CT tracer is expected to be applied to PET/CT iconography and change the situation of lack of tracers on lung cancers.
Inventors:
HE YANG (CN)
LI WEIMIN (CN)
ZHOU XINGLONG (CN)
WU QIONG (CN)
WU XIAOAI (CN)
CHEN HAI (CN)
HUANG RIDONG (CN)
CHAI YINGYING (CN)
LI WEIMIN (CN)
ZHOU XINGLONG (CN)
WU QIONG (CN)
WU XIAOAI (CN)
CHEN HAI (CN)
HUANG RIDONG (CN)
CHAI YINGYING (CN)
Application Number:
PCT/CN2019/119751
Publication Date:
March 04, 2021
Filing Date:
November 20, 2019
Export Citation:
Assignee:
WEST CHINA HOSPITAL SICHUAN UNIV (CN)
WEST CHINA PRECISION MEDICINE INDUSTRIAL TECH INSTITUTE (CN)
WEST CHINA PRECISION MEDICINE INDUSTRIAL TECH INSTITUTE (CN)
International Classes:
C07D487/04; A61K51/04; A61K101/00; A61K101/02
Domestic Patent References:
| WO2010020000A1 | 2010-02-25 | |||
| WO2010092111A2 | 2010-08-19 |
Foreign References:
| CN106008527A | 2016-10-12 | |||
| CN106008527A | 2016-10-12 | |||
| CN109503590A | 2019-03-22 | |||
| CN109734720A | 2019-05-10 | |||
| CN102115474A | 2011-07-06 |
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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