TRANSAMINASE MUTANT AND APPLICATION THEREOF

WIPO Patent Application WO/2019/095161

A1

A transaminase mutant and an application thereof, the amino acid sequence of the transaminase mutant is an amino acid sequence in which the amino acid sequence as represented by SEQ ID NO: 1 is mutated, the mutated amino acid position being one or more selected from among F89, K193, P243, V234, I262, Q280, V379, R416, A417 and C418. The enzymatic activity and/or stability of the transaminase mutant is improved.

HONG HAO (CN)
JAMES GAGE (CN)
LU JIANGPING (CN)
XU XINGFU (CN)
YU WENYAN (CN)
HUANG XIN (CN)
MA YULEI (CN)
CHENG YIBING (CN)

PCT/CN2017/111161

May 23, 2019

November 15, 2017

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ASYMCHEM LIFE SCIENCE TIANJIN CO LTD (CN)

C12N15/54; C12N9/10; C12N15/63; C12N15/70; C12P13/00; C12R1/19

CN103827309A	2014-05-28
CN107034247A	2017-08-11

DAWID DESZCZ: "Single active-site mutants are sufficient to enhance serine:pyruvate alpha-transaminase activity in an omega-transaminase", FEBS JOURNAL, vol. 282, 6 April 2015 (2015-04-06), pages 2512 - 2526, XP055613270, ISSN: 1742-464X
AARON CHARLES WESTLAKE: "Crystallisation and Structural Studies on Omega Transaminase Enzymes", OPEN RESEARCH EXETER (ORE), 9 March 2012 (2012-03-09), XP055613273
DATABASE UniProtKB UniProt; 15 December 2003 (2003-12-15), "SubName: Full=Probable aminotransferase {ECO:0000313|EMBL:AAQ59697.1}", XP055613276, Database accession no. Q7NWG4
See also references of EP 3712262A4

KANGXIN PARTNERS, P.C. (CN)

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