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Title:
TRANSCOBALAMIN RECEPTOR BINDING CONJUGATES FOR NEUTRON CAPTURE THERAPY
Document Type and Number:
WIPO Patent Application WO2002042318
Kind Code:
A3
Abstract:
The present invention is directed to neutron capture agents, such as a molecule comprising Boron-10 or Gadolinium-157, for the treatment, prophylaxis and/or diagnosis of a proliferative disorder via a direct or indirect attachment to a compound that binds to a transport protein for vitamin B12, i.e. transcobalamin I, II or III, or intrinsic factor, (the TC- or IF-binding carrier). Subsequent initiation of neutron capture therapy will selectively destroy abnormally proliferating cells.

Inventors:
COLLINS DOUGLAS A (US)
HOGENKAMP HENRICUS P C (US)
Application Number:
US0150782W
Publication Date:
October 10, 2002
Filing Date:
October 25, 2001
Export Citation:
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Assignee:
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
REGENTS OF THE UNIVERSITY OF MINNESOTA
COLLINS, DOUGLAS, A.
HOGENKAMP, HENRICUS, P.C.
International Classes:
A61P35/00; C07H23/00; (IPC1-7): C07H23/00; A61K31/70; A61P35/00
Domestic Patent References:
WO2000045857A22000-08-10
WO2000062808A22000-10-26
Foreign References:
US5877165A1999-03-02
Other References:
HOGENKAMP H P C ET AL: "Synthesis and characterization of nido-carborane-cobalamin conjugates" NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 27, no. 1, January 2000 (2000-01), pages 89-92, XP004188293 ISSN: 0969-8051
COLLINS D A ET AL: "TRANSCOBALAMIN II RECEPTOR IMAGING VIA RADIOLABELED DIETHYLENE-TRIAMINEPENTAACETATE COBALAMIN ANALOGS" JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE. NEW YORK, US, vol. 38, no. 5, May 1997 (1997-05), pages 717-723, XP002940342 ISSN: 0161-5505
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