Title:
TRANSCRIPTION FACTOR SPECIFIC GUIDE RNAS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/137468
Kind Code:
A3
Abstract:
Provided herein are DNA targeting systems, related compositions and methods, for modifying a Musculoaponeurotic Fibrosarcoma (MAF) gene, a signal transducer and activator of transcription 6 (STAT6) gene, a GATA binding protein 3 (GATA3) gene or a forkhead box P3 (FOXP3) gene, and related uses thereof.
Inventors:
GOWEN BENJAMIN G (US)
JANATPOUR MARY (US)
MELTON KORY (US)
TAMBE AKSHAY (US)
WEI SPENCER (US)
JANATPOUR MARY (US)
MELTON KORY (US)
TAMBE AKSHAY (US)
WEI SPENCER (US)
Application Number:
PCT/US2023/060688
Publication Date:
September 21, 2023
Filing Date:
January 13, 2023
Export Citation:
Assignee:
SPOTLIGHT THERAPEUTICS (US)
International Classes:
A61K38/46; A61K48/00; A61P35/00; C12N15/113; C12N15/55
Domestic Patent References:
| WO2016177892A1 | 2016-11-10 |
Foreign References:
| CN114452408A | 2022-05-10 |
Other References:
BOCHARNIKOV ALEXANDRA V., KEEGAN JOSHUA, WACLECHE VANESSA S., CAO YE, FONSEKA CHAMITH Y., WANG GUOXING, MUISE ERIC S., ZHANG KELVI: "PD-1 hiCXCR5-T peripheral helper cells promote B cell responses in lupus via MAF and IL -21", JCI INSIGHT, vol. 4, no. 20, 17 October 2019 (2019-10-17), pages E130062, XP009548916, ISSN: 2379-3708, DOI: 10.1172/jci.insight.130062
Attorney, Agent or Firm:
YUNCK, Rachel E. et al. (US)
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