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Title:
TRANSDERMAL EXTENDED DOSING OF PRAMIPEXOLE FOR NEUROLOGICAL DISORDERS
Document Type and Number:
WIPO Patent Application WO/2014/188329
Kind Code:
A3
Abstract:
This disclosure relates to a transdermal therapeutic system (TTS) containing pramipexole or related compounds and methods of making the system as well as its use in administering such compounds as a single dose over an extended period, for example, one week. The system comprises an acrylic-based or silicone-based matrix layer containing pramipexole at concentrations of at least about 5 wt.% of the matrix, which is resistant to crystallizing and discoloration of the active ingredient even when stored over long periods.

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Inventors:
DESHMUKH ABHIJIT MUKUND (IN)
DIXIT AKHILESH (IN)
KUMAR PRASANNA (IN)
BINDRA VIKRAM (IN)
Application Number:
PCT/IB2014/061545
Publication Date:
March 12, 2015
Filing Date:
May 19, 2014
Export Citation:
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Assignee:
MYLAN INC (US)
International Classes:
A61F13/02; A61K9/70; A61K31/4418; A61P25/16
Foreign References:
US20060182791A12006-08-17
US7344733B22008-03-18
US6221383B12001-04-24
US20050287195A12005-12-29
US20080233179A12008-09-25
US8361493B22013-01-29
US20040253299A12004-12-16
Other References:
See also references of EP 2999444A4
Attorney, Agent or Firm:
BALTATZIS, Andreas (P.C.330 John Carlyle Street, 3rd Floo, Alexandria Virginia, US)
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